Scholars@Duke
Cameron C McIntyre

Cameron C McIntyre

Professor of Biomedical Engineering
Biomedical Engineering

Scholarly Works - Journal articles

Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.

Journal article Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · June 2026 ObjectiveLocal field potentials (LFPs) exhibit abnormally elevated beta-band power in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD). To better understand these signals, we coupled advanced biophysical models with experime ... Full text Cite

Comprehensive map of axonal pathway activation as a function of subthalamic deep brain stimulation location and parameter settings.

Journal article Brain stimulation · January 2026 BackgroundDeep brain stimulation (DBS) of the subthalamic region is an established therapy for the treatment of Parkinson's disease (PD). Computational models of subthalamic DBS are commonly used in the clinical literature to estimate the brain co ... Full text Cite

Comparison of structural connectomes for modeling deep brain stimulation pathway activation.

Journal article NeuroImage · May 2025 IntroductionStructural connectivity models of the brain are commonly employed to identify pathways that are directly activated during deep brain stimulation (DBS). However, various connectomes differ in the technical parameters, parcellation schem ... Full text Cite

Model-Based Analysis of Pathway Recruitment During Subthalamic Deep Brain Stimulation.

Journal article Neuromodulation : journal of the International Neuromodulation Society · April 2024 BackgroundSubthalamic deep brain stimulation (DBS) is an established clinical therapy, but an anatomically clear definition of the underlying neural target(s) of the stimulation remains elusive. Patient-specific models of DBS are commonly used too ... Full text Cite

Dissecting deep brain stimulation evoked neural activity in the basal ganglia.

Journal article Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · April 2024 Deep brain stimulation (DBS) is an established therapeutic tool for the treatment of Parkinson's disease (PD). The mechanisms of DBS for PD are likely rooted in modulation of the subthalamo-pallidal network. However, it can be difficult to electrophysiolog ... Full text Cite

Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning.

Journal article Brain stimulation · November 2023 BackgroundConnectomic modeling studies are expanding understanding of the brain networks that are modulated by deep brain stimulation (DBS) therapies. However, explicit integration of these modeling results into prospective neurosurgical planning ... Full text Cite

Comparison of Anatomical Pathway Models with Tractography Estimates of the Pallidothalamic, Cerebellothalamic, and Corticospinal Tracts.

Journal article Brain connectivity · May 2023 Introduction: Models of structural connectivity in the human brain are typically simulated using tractographic approaches. However, the nonlinear fitting of anatomical pathway atlases to de novo subject brains represents a simpler alte ... Full text Cite

Evolving characterization of the human hyperdirect pathway.

Journal article Brain structure & function · March 2023 The hyperdirect pathway (HDP) represents the main glutamatergic input to the subthalamic nucleus (STN), through which the motor and prefrontal cerebral cortex can modulate basal ganglia activity. Further, direct activation of the motor HDP is thought to be ... Full text Cite