Overview
We study the pathways by which microorganisms cross cellular barriers and the mechanisms by which these barriers restrict microbial infections. Our studies primarily focus on the epithelium that lines the gastrointestinal tract and on placental trophoblasts, the cells that comprise a key cellular barrier of the human placenta. Our work is highly multidisciplinary and encompasses aspects of cell biology, immunology, and microbiology. Our long-term goals are to identify pathogen- and host-specific therapeutic targets to prevent or treat microbial infections and ultimately to alleviate the morbidity and mortality caused by these infections.
Current Appointments & Affiliations
George Barth Geller Distinguished Professor of Immunology
·
2022 - Present
Integrative Immunobiology,
Basic Science Departments
Professor of Integrative Immunobiology
·
2023 - Present
Integrative Immunobiology,
Basic Science Departments
Professor of Pathology
·
2022 - Present
Pathology,
Clinical Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Professor of Molecular Genetics and Microbiology
·
2025 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Member in the Duke Human Vaccine Institute
·
2021 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Member of the Duke Cancer Institute
·
2021 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
DUX4-stimulated genes define an antiviral defense program in human placental trophoblasts.
Journal Article J Exp Med · December 1, 2025 The placenta combats mother-to-fetus transmission of viruses through the antiviral activities of fetal-derived trophoblasts. Placental trophoblasts employ specialized antiviral strategies to protect against infection while preventing maternal immune reject ... Full text Link to item CiteComparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentation.
Journal Article Dev Cell · October 30, 2025 Throughout evolution, the placenta has diversified in structure and composition while maintaining its essential role in supporting fetal development. Trophoblasts, cells responsible for nutrient exchange and immune modulation, are a conserved feature of al ... Full text Link to item CiteHumoral correlates of protection in a mouse model of echovirus infection.
Journal Article bioRxiv · September 26, 2025 Echoviruses commonly infect humans and can cause severe outcomes, including meningitis and liver failure, especially in neonates and immunocompromised individuals. Although recent progress has been made in understanding acute pathogenesis and innate immuni ... Full text Link to item CiteRecent Grants
Model Systems Core (MODS Core)
ResearchPrincipal Investigator · Awarded by Weill Cornell Medicine · 2024 - 2029Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatis
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2028Design and testing picornavirus vaccine candidates
ResearchPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2024 - 2028View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
2003
Ph.D.