Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 2003
• 

  Previous Appointments & Affiliations

  • Instructor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2021 - 2022
• Recognition
• 

  In the News

  • MAY 18, 2022

    University Awards 24 New Distinguished Professorships
• Expertise
• 

  Subject Headings

  • Enterovirus
  • Gastrointestinal system
  • Immunity, Innate
  • Organoids
  • Placental Biology
  • Virology
• Research
• 

  Selected Grants

  • Enterovirus Infection of Polarized Intestinal Cells awarded by National Institutes of Health 2021 - 2025
  • The Role of FcRn in Echovirus Entry and Pathogenesis awarded by National Institutes of Health 2022 - 2025
  • Innate immune signaling in placental antiviral defenses awarded by National Institutes of Health 2021 - 2024
  • Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2024
  • Antiviral Countermeasure Development Center (AC DC) awarded by Emory University 2022 - 2023
  • Placental resistance and response to the teratogenic pathogen Toxoplasma gondii awarded by University of Pittsburgh 2022 - 2023
  • Live-attenuated Rift Valley fever vaccines: comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetuses awarded by University of Pittsburgh 2021 - 2022
• 

  External Relationships

  • University of Pittsburgh
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yang, Liheng, Eleanor C. Semmes, Cristian Ovies, Christina Megli, Sallie Permar, Jennifer B. Gilner, and Carolyn B. Coyne. “Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface.” Elife 11 (August 17, 2022). https://doi.org/10.7554/eLife.79794.
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    • Wells, Alexandra I., and Carolyn B. Coyne. “An In Vivo Model of Echovirus-Induced Meningitis Defines the Differential Roles of Type I and Type III Interferon Signaling in Central Nervous System Infection.” J Virol 96, no. 13 (July 13, 2022): e0033022. https://doi.org/10.1128/jvi.00330-22.
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    • Wells, Alexandra I., Kalena A. Grimes, and Carolyn B. Coyne. “Enterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract.” Mbio 13, no. 3 (June 28, 2022): e0044322. https://doi.org/10.1128/mbio.00443-22.
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    • Zhang, Yang, Pengfei Liang, Liheng Yang, Ke Zoe Shan, Liping Feng, Yong Chen, Wolfgang Liedtke, Carolyn B. Coyne, and Huanghe Yang. “Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.” Elife 11 (June 7, 2022). https://doi.org/10.7554/eLife.78840.
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    • Megli, Christina J., and Carolyn B. Coyne. “Infections at the maternal-fetal interface: an overview of pathogenesis and defence.” Nat Rev Microbiol 20, no. 2 (February 2022): 67–82. https://doi.org/10.1038/s41579-021-00610-y.
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    • Semmes, Eleanor C., and Carolyn B. Coyne. “Innate immune defenses at the maternal-fetal interface.” Curr Opin Immunol 74 (February 2022): 60–67. https://doi.org/10.1016/j.coi.2021.10.007.
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    • Rudzki, Elizabeth N., Stephanie E. Ander, Rachel S. Coombs, Hisham S. Alrubaye, Leah F. Cabo, Matthew L. Blank, Nicolás Gutiérrez-Melo, J. P. Dubey, Carolyn B. Coyne, and Jon P. Boyle. “Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse.” Mbio 12, no. 6 (December 21, 2021): e0159121. https://doi.org/10.1128/mBio.01591-21.
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    • Roberts, Drucilla J., Andrea G. Edlow, Roberto J. Romero, Carolyn B. Coyne, David T. Ting, Jason L. Hornick, Sherif R. Zaki, et al. “A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop.” Am J Obstet Gynecol 225, no. 6 (December 2021): 593.e1-593.e9. https://doi.org/10.1016/j.ajog.2021.07.029.
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    • Ovies, Cristian, Eleanor C. Semmes, and Carolyn B. Coyne. “Pregnancy influences immune responses to SARS-CoV-2.” Sci Transl Med 13, no. 617 (October 27, 2021): eabm2070. https://doi.org/10.1126/scitranslmed.abm2070.
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    • Freeman, Megan Culler, Alexandra I. Wells, Jessica Ciomperlik-Patton, Michael M. Myerburg, Liheng Yang, Jennifer Konopka-Anstadt, and Carolyn B. Coyne. “Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates.” Elife 10 (July 1, 2021). https://doi.org/10.7554/eLife.66687.
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    • Wells, Alexandra I., and Carolyn B. Coyne. “Uterine NK cell education: Learning the ropes in pregnancy.” Immunity 54, no. 6 (June 8, 2021): 1102–4. https://doi.org/10.1016/j.immuni.2021.05.009.
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    • Evans, Azia S., Nicholas J. Lennemann, and Carolyn B. Coyne. “BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection.” J Cell Sci 134, no. 5 (February 25, 2021). https://doi.org/10.1242/jcs.251835.
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    • Megli, Christina, Stefanie Morosky, Dhivyaa Rajasundaram, and Carolyn B. Coyne. “Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection.” J Exp Med 218, no. 1 (January 4, 2021). https://doi.org/10.1084/jem.20200649.
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    • Megli, Christina, and Carolyn B. Coyne. “Gatekeepers of the fetus: Characterization of placental macrophages.” J Exp Med 218, no. 1 (January 4, 2021). https://doi.org/10.1084/jem.20202071.
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    • Wells, Alexandra I., Kalena A. Grimes, Kenneth Kim, Emilie Branche, Christopher J. Bakkenist, William H. DePas, Sujan Shresta, and Carolyn B. Coyne. “Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice.” Plos Pathog 17, no. 1 (January 2021): e1009252. https://doi.org/10.1371/journal.ppat.1009252.
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    • Njue, Annete, Carolyn Coyne, Andrea V. Margulis, Dai Wang, Morgan A. Marks, Kevin Russell, Rituparna Das, and Anushua Sinha. “The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms.” Viruses 13, no. 1 (December 24, 2020). https://doi.org/10.3390/v13010020.
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    • Ferrari, Matteo, Alessandra Zevini, Enrico Palermo, Michela Muscolini, Magdalini Alexandridi, Marilena P. Etna, Eliana M. Coccia, et al. “Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication.” J Virol 94, no. 24 (November 23, 2020). https://doi.org/10.1128/JVI.01551-20.
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    • Krawczynski, Kamil, Yingshi Ouyang, Jean-Francois Mouillet, Tianjiao Chu, Carolyn B. Coyne, and Yoel Sadovsky. “Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a.” J Cell Sci 134, no. 5 (November 19, 2020). https://doi.org/10.1242/jcs.246769.
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    • Wells, Alexandra I., and Carolyn B. Coyne. “Inhibiting Ebola virus and SARS-CoV-2 entry.” Science 370, no. 6513 (October 9, 2020): 167–68. https://doi.org/10.1126/science.abe2977.
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    • Lennemann, Nicholas J., Azia S. Evans, and Carolyn B. Coyne. “Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells.” Viruses 12, no. 10 (September 25, 2020). https://doi.org/10.3390/v12101074.
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    • Coyne, Carolyn, Jimmy D. Ballard, and Ira J. Blader. “Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us.” Plos Biol 18, no. 8 (August 2020): e3000889. https://doi.org/10.1371/journal.pbio.3000889.
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    • Wong, Zhee S., Sarah L Sokol Borrelli, Carolyn C. Coyne, and Jon P. Boyle. “Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.” Int J Parasitol 50, no. 5 (May 2020): 423–31. https://doi.org/10.1016/j.ijpara.2020.05.001.
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    • Evans, Azia S., Nicholas J. Lennemann, and Carolyn B. Coyne. “BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication.” J Virol 94, no. 9 (April 16, 2020). https://doi.org/10.1128/JVI.00029-20.
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    • Kim, Arthur S., Ofer Zimmerman, Julie M. Fox, Christopher A. Nelson, Katherine Basore, Rong Zhang, Lorellin Durnell, et al. “An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.” Cell Host Microbe 27, no. 3 (March 11, 2020): 428-440.e9. https://doi.org/10.1016/j.chom.2020.01.008.
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    • Wells, Alexandra I., and Carolyn B. Coyne. “Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion.” Viruses 11, no. 5 (May 21, 2019). https://doi.org/10.3390/v11050460.
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    • Good, Charles, Alexandra I. Wells, and Carolyn B. Coyne. “Type III interferon signaling restricts enterovirus 71 infection of goblet cells.” Sci Adv 5, no. 3 (March 2019): eaau4255. https://doi.org/10.1126/sciadv.aau4255.
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    • Morosky, Stefanie, Alexandra I. Wells, Kathryn Lemon, Azia S. Evans, Sandra Schamus, Christopher J. Bakkenist, and Carolyn B. Coyne. “The neonatal Fc receptor is a pan-echovirus receptor.” Proc Natl Acad Sci U S A 116, no. 9 (February 26, 2019): 3758–63. https://doi.org/10.1073/pnas.1817341116.
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    • Freeman, Megan Culler, Carolyn B. Coyne, Michael Green, John V. Williams, and Laurie A. Silva. “Emerging arboviruses and implications for pediatric transplantation: A review.” Pediatr Transplant 23, no. 1 (February 2019): e13303. https://doi.org/10.1111/petr.13303.
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    • Caine, Elizabeth A., Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, and Michael S. Diamond. “Interferon lambda protects the female reproductive tract against Zika virus infection.” Nat Commun 10, no. 1 (January 17, 2019): 280. https://doi.org/10.1038/s41467-018-07993-2.
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    • Evans, Azia S., and Carolyn B. Coyne. “RIPK3: Beyond Necroptosis.” Immunity 50, no. 1 (January 15, 2019): 1–3. https://doi.org/10.1016/j.immuni.2018.12.031.
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    • Ander, Stephanie E., Michael S. Diamond, and Carolyn B. Coyne. “Immune responses at the maternal-fetal interface.” Sci Immunol 4, no. 31 (January 11, 2019). https://doi.org/10.1126/sciimmunol.aat6114.
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    • McMillen, Cynthia M., Nitin Arora, Devin A. Boyles, Joseph R. Albe, Michael R. Kujawa, Jeffrey F. Bonadio, Carolyn B. Coyne, and Amy L. Hartman. “Rift Valley fever virus induces fetal demise in Sprague-Dawley rats through direct placental infection.” Sci Adv 4, no. 12 (December 2018): eaau9812. https://doi.org/10.1126/sciadv.aau9812.
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    • Zimmerman, Matthew G., Kendra M. Quicke, Justin T. O’Neal, Nitin Arora, Deepa Machiah, Lalita Priyamvada, Robert C. Kauffman, et al. “Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.” Cell Host Microbe 24, no. 5 (November 14, 2018): 731-742.e6. https://doi.org/10.1016/j.chom.2018.10.008.
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    • Barrila, Jennifer, Aurélie Crabbé, Jiseon Yang, Karla Franco, Seth D. Nydam, Rebecca J. Forsyth, Richard R. Davis, et al. “Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age.” Infect Immun 86, no. 11 (November 2018). https://doi.org/10.1128/IAI.00282-18.
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    • Coyne, Carolyn B. “Horsepox: Framing a dual use research of concern debate.” Plos Pathog 14, no. 10 (October 2018): e1007344. https://doi.org/10.1371/journal.ppat.1007344.
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    • Wells, Alexandra I., and Carolyn B. Coyne. “Type III Interferons in Antiviral Defenses at Barrier Surfaces.” Trends Immunol 39, no. 10 (October 2018): 848–58. https://doi.org/10.1016/j.it.2018.08.008.
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    • Coyne, Carolyn B. “STING'ing Zika virus in neurons.” Nat Microbiol 3, no. 9 (September 2018): 975–76. https://doi.org/10.1038/s41564-018-0232-5.
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    • Lanik, Wyatt E., Madison A. Mara, Belgacem Mihi, Carolyn B. Coyne, and Misty Good. “Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.” Viruses 10, no. 3 (March 10, 2018). https://doi.org/10.3390/v10030124.
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    • Diamond, Michael S., and Carolyn B. Coyne. “Vaccines in 2017: Closing in on a Zika virus vaccine.” Nat Rev Immunol 18, no. 2 (February 2018): 89–90. https://doi.org/10.1038/nri.2017.132.
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    • Platt, Derek J., Amber M. Smith, Nitin Arora, Michael S. Diamond, Carolyn B. Coyne, and Jonathan J. Miner. “Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.” Sci Transl Med 10, no. 426 (January 31, 2018). https://doi.org/10.1126/scitranslmed.aao7090.
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    • Ander, Stephanie E., Elizabeth N. Rudzki, Nitin Arora, Yoel Sadovsky, Carolyn B. Coyne, and Jon P. Boyle. “Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines.” Mbio 9, no. 1 (January 9, 2018). https://doi.org/10.1128/mBio.01678-17.
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    • Yockey, Laura J., Kellie A. Jurado, Nitin Arora, Alon Millet, Tasfia Rakib, Kristin M. Milano, Andrew K. Hastings, et al. “Type I interferons instigate fetal demise after Zika virus infection.” Sci Immunol 3, no. 19 (January 5, 2018). https://doi.org/10.1126/sciimmunol.aao1680.
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    • Bayer, Avraham, Nicholas J. Lennemann, Yingshi Ouyang, Elena Sadovsky, Megan A. Sheridan, R Michael Roberts, Carolyn B. Coyne, and Yoel Sadovsky. “Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.” Placenta 61 (January 2018): 33–38. https://doi.org/10.1016/j.placenta.2017.11.004.
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    • Delorme-Axford, Elizabeth, Emma Abernathy, Nicholas J. Lennemann, Amélie Bernard, Aileen Ariosa, Carolyn B. Coyne, Karla Kirkegaard, and Daniel J. Klionsky. “The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy.” Autophagy 14, no. 5 (2018): 898–912. https://doi.org/10.1080/15548627.2018.1441648.
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    • Jagger, Brett W., Jonathan J. Miner, Bin Cao, Nitin Arora, Amber M. Smith, Attila Kovacs, Indira U. Mysorekar, Carolyn B. Coyne, and Michael S. Diamond. “Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero.” Cell Host Microbe 22, no. 3 (September 13, 2017): 366-376.e3. https://doi.org/10.1016/j.chom.2017.08.012.
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    • Corry, Jacqueline, Nitin Arora, Charles A. Good, Yoel Sadovsky, and Carolyn B. Coyne. “Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface.” Proc Natl Acad Sci U S A 114, no. 35 (August 29, 2017): 9433–38. https://doi.org/10.1073/pnas.1707513114.
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    • Chang, Guojing, Jean-François Mouillet, Takuya Mishima, Tianjiao Chu, Elena Sadovsky, Carolyn B. Coyne, W Tony Parks, Urvashi Surti, and Yoel Sadovsky. “Expression and trafficking of placental microRNAs at the feto-maternal interface.” Faseb J 31, no. 7 (July 2017): 2760–70. https://doi.org/10.1096/fj.201601146R.
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    • Arora, Nitin, Yoel Sadovsky, Terence S. Dermody, and Carolyn B. Coyne. “Microbial Vertical Transmission during Human Pregnancy.” Cell Host Microbe 21, no. 5 (May 10, 2017): 561–67. https://doi.org/10.1016/j.chom.2017.04.007.
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    • Bramley, John C., Coyne G. Drummond, Nicholas J. Lennemann, Charles A. Good, Kwang Sik Kim, and Carolyn B. Coyne. “A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier.” Msphere 2, no. 3 (May 2017). https://doi.org/10.1128/mSphere.00206-17.
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    • Dumont, Tina M. F., Jean-Francois Mouillet, Avaraham Bayer, Christina L. Gardner, William B. Klimstra, Dana G. Wolf, Simcha Yagel, et al. “The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.” Placenta 53 (May 2017): 23–29. https://doi.org/10.1016/j.placenta.2017.03.011.
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    • Drummond, Coyne G., Alexa M. Bolock, Congrong Ma, Cliff J. Luke, Misty Good, and Carolyn B. Coyne. “Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner.” Proc Natl Acad Sci U S A 114, no. 7 (February 14, 2017): 1672–77. https://doi.org/10.1073/pnas.1617363114.
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    • Lennemann, Nicholas J., and Carolyn B. Coyne. “Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.” Autophagy 13, no. 2 (February 2017): 322–32. https://doi.org/10.1080/15548627.2016.1265192.
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    • Rausch, Keiko, Brent A. Hackett, Nathan L. Weinbren, Sophia M. Reeder, Yoel Sadovsky, Christopher A. Hunter, David C. Schultz, Carolyn B. Coyne, and Sara Cherry. “Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.” Cell Rep 18, no. 3 (January 17, 2017): 804–15. https://doi.org/10.1016/j.celrep.2016.12.068.
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    • Coyne, Carolyn B., and Helen M. Lazear. “Zika virus - reigniting the TORCH.” Nat Rev Microbiol 14, no. 11 (November 2016): 707–15. https://doi.org/10.1038/nrmicro.2016.125.
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    • Ouyang, Yingshi, Avraham Bayer, Tianjiao Chu, Vladimir A. Tyurin, Valerian E. Kagan, Adrian E. Morelli, Carolyn B. Coyne, and Yoel Sadovsky. “Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.” Placenta 47 (November 2016): 86–95. https://doi.org/10.1016/j.placenta.2016.09.008.
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    • Olagnier, David, Michela Muscolini, Carolyn B. Coyne, Michael S. Diamond, and John Hiscott. “Mechanisms of Zika Virus Infection and Neuropathogenesis.” Dna Cell Biol 35, no. 8 (August 2016): 367–72. https://doi.org/10.1089/dna.2016.3404.
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    • Morosky, Stefanie, Nicholas J. Lennemann, and Carolyn B. Coyne. “BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication.” J Virol 90, no. 10 (May 15, 2016): 5098–5107. https://doi.org/10.1128/JVI.00170-16.
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    • Bayer, Avraham, Nicholas J. Lennemann, Yingshi Ouyang, John C. Bramley, Stefanie Morosky, Ernesto Torres De Azeved Marques, Sara Cherry, Yoel Sadovsky, and Carolyn B. Coyne. “Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection.” Cell Host Microbe 19, no. 5 (May 11, 2016): 705–12. https://doi.org/10.1016/j.chom.2016.03.008.
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    • Cuevas, Rolando A., Arundhati Ghosh, Christina Wallerath, Veit Hornung, Carolyn B. Coyne, and Saumendra N. Sarkar. “MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.” J Immunol 196, no. 9 (May 1, 2016): 3877–86. https://doi.org/10.4049/jimmunol.1501359.
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    • McCormick, Kevin D., Arundhati Ghosh, Sumita Trivedi, Lin Wang, Carolyn B. Coyne, Robert L. Ferris, and Saumendra N. Sarkar. “Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma.” Carcinogenesis 37, no. 5 (May 2016): 522–29. https://doi.org/10.1093/carcin/bgw032.
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    • Coyne, Carolyn B. “The Tree(s) of Life: The Human Placenta and My Journey to Learn More about It.” Plos Pathog 12, no. 4 (April 2016): e1005515. https://doi.org/10.1371/journal.ppat.1005515.
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    • McConkey, Cameron A., Elizabeth Delorme-Axford, Cheryl A. Nickerson, Kwang Sik Kim, Yoel Sadovsky, Jon P. Boyle, and Carolyn B. Coyne. “A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.” Sci Adv 2, no. 3 (March 2016): e1501462. https://doi.org/10.1126/sciadv.1501462.
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    • Hendricks, Matthew R., Lauren P. Lashua, Douglas K. Fischer, Becca A. Flitter, Katherine M. Eichinger, Joan E. Durbin, Saumendra N. Sarkar, Carolyn B. Coyne, Kerry M. Empey, and Jennifer M. Bomberger. “Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity.” Proc Natl Acad Sci U S A 113, no. 6 (February 9, 2016): 1642–47. https://doi.org/10.1073/pnas.1516979113.
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    • Drummond, Coyne G., Cheryl A. Nickerson, and Carolyn B. Coyne. “A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells.” Msphere 1, no. 1 (January 2016). https://doi.org/10.1128/mSphere.00030-15.
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    • Mouillet, Jean-François, Yingshi Ouyang, Carolyn B. Coyne, and Yoel Sadovsky. “MicroRNAs in placental health and disease.” Am J Obstet Gynecol 213, no. 4 Suppl (October 2015): S163–72. https://doi.org/10.1016/j.ajog.2015.05.057.
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    • Shu, Qian, Nicholas J. Lennemann, Saumendra N. Sarkar, Yoel Sadovsky, and Carolyn B. Coyne. “ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.” Plos Pathog 11, no. 9 (September 2015): e1005150. https://doi.org/10.1371/journal.ppat.1005150.
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    • Harris, Katharine G., Stefanie A. Morosky, Coyne G. Drummond, Maulik Patel, Chonsaeng Kim, Donna B. Stolz, Jeffrey M. Bergelson, Sara Cherry, and Carolyn B. Coyne. “RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells.” Cell Host Microbe 18, no. 2 (August 12, 2015): 221–32. https://doi.org/10.1016/j.chom.2015.07.007.
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    • Rosenthal, Ann K., Claudia M. Gohr, Elizabeth Mitton-Fitzgerald, Rupinder Grewal, James Ninomiya, Carolyn B. Coyne, and William T. Jackson. “Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.” J Biol Chem 290, no. 21 (May 22, 2015): 13028–38. https://doi.org/10.1074/jbc.M114.630558.
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    • Sadovsky, Yoel, Jean-Francois Mouillet, Yingshi Ouyang, Avraham Bayer, and Carolyn B. Coyne. “The Function of TrophomiRs and Other MicroRNAs in the Human Placenta.” Cold Spring Harb Perspect Med 5, no. 8 (April 15, 2015): a023036. https://doi.org/10.1101/cshperspect.a023036.
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    • Lennemann, Nicholas J., and Carolyn B. Coyne. “Catch me if you can: the link between autophagy and viruses.” Plos Pathog 11, no. 3 (March 2015): e1004685. https://doi.org/10.1371/journal.ppat.1004685.
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    • Bayer, Avraham, Elizabeth Delorme-Axford, Christie Sleigher, Teryl K. Frey, Derek W. Trobaugh, William B. Klimstra, Lori A. Emert-Sedlak, et al. “Human trophoblasts confer resistance to viruses implicated in perinatal infection.” Am J Obstet Gynecol 212, no. 1 (January 2015): 71.e1-71.e8. https://doi.org/10.1016/j.ajog.2014.07.060.
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    • Harris, Katharine G., and Carolyn B. Coyne. “Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases.” Plos One 10, no. 10 (2015): e0141383. https://doi.org/10.1371/journal.pone.0141383.
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    • Delorme-Axford, Elizabeth, Stefanie Morosky, Jennifer Bomberger, Donna B. Stolz, William T. Jackson, and Carolyn B. Coyne. “BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery.” Mbio 5, no. 6 (December 9, 2014): e02147. https://doi.org/10.1128/mBio.02147-14.
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    • Delorme-Axford, Elizabeth, Yoel Sadovsky, and Carolyn B. Coyne. “The Placenta as a Barrier to Viral Infections.” Annu Rev Virol 1, no. 1 (November 2014): 133–46. https://doi.org/10.1146/annurev-virology-031413-085524.
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    • Harris, Katharine G., and Carolyn B. Coyne. “Death waits for no man--does it wait for a virus? How enteroviruses induce and control cell death.” Cytokine Growth Factor Rev 25, no. 5 (October 2014): 587–96. https://doi.org/10.1016/j.cytogfr.2014.08.002.
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    • Zhu, Jianzhong, Yugen Zhang, Arundhati Ghosh, Rolando A. Cuevas, Adriana Forero, Jayeeta Dhar, Mikkel Søes Ibsen, et al. “Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.” Immunity 40, no. 6 (June 19, 2014): 936–48. https://doi.org/10.1016/j.immuni.2014.05.007.
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    • Ouyang, Y., J. -. F. Mouillet, C. B. Coyne, and Y. Sadovsky. “Review: placenta-specific microRNAs in exosomes - good things come in nano-packages.” Placenta 35 Suppl (February 2014): S69–73. https://doi.org/10.1016/j.placenta.2013.11.002.
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    • Jacobs, Jana L., Jianzhong Zhu, Saumendra N. Sarkar, and Carolyn B. Coyne. “Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.” J Biol Chem 289, no. 3 (January 17, 2014): 1604–16. https://doi.org/10.1074/jbc.M113.520254.
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    • Mouillet, Jean-Francois, Yingshi Ouyang, Avraham Bayer, Carolyn B. Coyne, and Yoel Sadovsky. “The role of trophoblastic microRNAs in placental viral infection.” Int J Dev Biol 58, no. 2–4 (2014): 281–89. https://doi.org/10.1387/ijdb.130349ys.
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    • Jacobs, Jana L., and Carolyn B. Coyne. “Mechanisms of MAVS regulation at the mitochondrial membrane.” J Mol Biol 425, no. 24 (December 13, 2013): 5009–19. https://doi.org/10.1016/j.jmb.2013.10.007.
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    • Delorme-Axford, Elizabeth, Avraham Bayer, Yoel Sadovsky, and Carolyn B. Coyne. “Autophagy as a mechanism of antiviral defense at the maternal-fetal interface.” Autophagy 9, no. 12 (December 2013): 2173–74. https://doi.org/10.4161/auto.26558.
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    • Harris, Katharine G., and Carolyn B. Coyne. “Enter at your own risk: how enteroviruses navigate the dangerous world of pattern recognition receptor signaling.” Cytokine 63, no. 3 (September 2013): 230–36. https://doi.org/10.1016/j.cyto.2013.05.007.
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    • Delorme-Axford, Elizabeth, Yoel Sadovsky, and Carolyn B. Coyne. “Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts.” J Virol 87, no. 15 (August 2013): 8569–81. https://doi.org/10.1128/JVI.00708-13.
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    • Delorme-Axford, Elizabeth, Rogier B. Donker, Jean-Francois Mouillet, Tianjiao Chu, Avraham Bayer, Yingshi Ouyang, Tianyi Wang, et al. “Human placental trophoblasts confer viral resistance to recipient cells.” Proc Natl Acad Sci U S A 110, no. 29 (July 16, 2013): 12048–53. https://doi.org/10.1073/pnas.1304718110.
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    • Tang, Daolin, Rui Kang, Carolyn B. Coyne, Herbert J. Zeh, and Michael T. Lotze. “PAMPs and DAMPs: signal 0s that spur autophagy and immunity.” Immunol Rev 249, no. 1 (September 2012): 158–75. https://doi.org/10.1111/j.1600-065X.2012.01146.x.
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    • Bozym, Rebecca A., Elizabeth Delorme-Axford, Katharine Harris, Stefanie Morosky, Mine Ikizler, Terence S. Dermody, Saumendra N. Sarkar, and Carolyn B. Coyne. “Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.” Cell Host Microbe 11, no. 2 (February 16, 2012): 153–66. https://doi.org/10.1016/j.chom.2012.01.008.
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    • Delorme-Axford, Elizabeth, and Carolyn B. Coyne. “The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.” Viruses 3, no. 12 (December 2011): 2462–77. https://doi.org/10.3390/v3122462.
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    • Zhu, Jianzhong, Carolyn B. Coyne, and Saumendra N. Sarkar. “PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin.” Embo J 30, no. 23 (September 27, 2011): 4838–49. https://doi.org/10.1038/emboj.2011.351.
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    • Bozym, Rebecca A., Kunal Patel, Carl White, King-Ho Cheung, Jeffrey M. Bergelson, Stefanie A. Morosky, and Carolyn B. Coyne. “Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells.” Mol Biol Cell 22, no. 17 (September 2011): 3010–21. https://doi.org/10.1091/mbc.E11-02-0094.
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    • Morosky, Stefanie A., Jianzhong Zhu, Amitava Mukherjee, Saumendra N. Sarkar, and Carolyn B. Coyne. “Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling.” J Biol Chem 286, no. 32 (August 12, 2011): 28574–83. https://doi.org/10.1074/jbc.M111.227942.
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    • Mukherjee, Amitava, Stefanie A. Morosky, Elizabeth Delorme-Axford, Naomi Dybdahl-Sissoko, M Steven Oberste, Tianyi Wang, and Carolyn B. Coyne. “The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling.” Plos Pathog 7, no. 3 (March 2011): e1001311. https://doi.org/10.1371/journal.ppat.1001311.
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    • Coyne, Carolyn B., Rebecca Bozym, Stefanie A. Morosky, Sheri L. Hanna, Amitava Mukherjee, Matthew Tudor, Kwang Sik Kim, and Sara Cherry. “Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers.” Cell Host Microbe 9, no. 1 (January 20, 2011): 70–82. https://doi.org/10.1016/j.chom.2011.01.001.
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    • Coyne, Carolyn B., and Sara Cherry. “RNAi screening in mammalian cells to identify novel host cell molecules involved in the regulation of viral infections.” Methods Mol Biol 721 (2011): 397–405. https://doi.org/10.1007/978-1-61779-037-9_25.
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    • Bozym, Rebecca A., Stefanie A. Morosky, Kwang S. Kim, Sara Cherry, and Carolyn B. Coyne. “Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells.” Plos Pathog 6, no. 10 (October 7, 2010): e1001135. https://doi.org/10.1371/journal.ppat.1001135.
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    • Long, Kimberly R., Yasunori Yamamoto, Adam L. Baker, Simon C. Watkins, Carolyn B. Coyne, James F. Conway, and Meir Aridor. “Sar1 assembly regulates membrane constriction and ER export.” J Cell Biol 190, no. 1 (July 12, 2010): 115–28. https://doi.org/10.1083/jcb.201004132.
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    • Moser, Theresa S., Russell G. Jones, Craig B. Thompson, Carolyn B. Coyne, and Sara Cherry. “A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.” Plos Pathog 6, no. 6 (June 17, 2010): e1000954. https://doi.org/10.1371/journal.ppat.1000954.
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    • Patel, Kunal P., Carolyn B. Coyne, and Jeffrey M. Bergelson. “Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells.” J Virol 83, no. 21 (November 2009): 11064–77. https://doi.org/10.1128/JVI.01016-09.
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    • Mukherjee, Amitava, Stefanie A. Morosky, Le Shen, Christopher R. Weber, Jerrold R. Turner, Kwang Sik Kim, Tianyi Wang, and Carolyn B. Coyne. “Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions.” J Biol Chem 284, no. 10 (March 6, 2009): 6486–94. https://doi.org/10.1074/jbc.M807547200.
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    • Liu, Shufeng, Wei Yang, Le Shen, Jerrold R. Turner, Carolyn B. Coyne, and Tianyi Wang. “Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.” J Virol 83, no. 4 (February 2009): 2011–14. https://doi.org/10.1128/JVI.01888-08.
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    • Coyne, Carolyn B. “The distinct roles of JAM-A in reovirus pathogenesis.” Cell Host Microbe 5, no. 1 (January 22, 2009): 3–5. https://doi.org/10.1016/j.chom.2008.12.009.
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    • Yang, Wei, Chao Qiu, Nabanita Biswas, Jing Jin, Simon C. Watkins, Ronald C. Montelaro, Carolyn B. Coyne, and Tianyi Wang. “Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus.” J Biol Chem 283, no. 13 (March 28, 2008): 8643–53. https://doi.org/10.1074/jbc.M709824200.
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    • Coyne, Carolyn B., Le Shen, Jerrold R. Turner, and Jeffrey M. Bergelson. “Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.” Cell Host Microbe 2, no. 3 (September 13, 2007): 181–92. https://doi.org/10.1016/j.chom.2007.07.003.
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    • Coyne, Carolyn B., Kwang S. Kim, and Jeffrey M. Bergelson. “Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.” Embo J 26, no. 17 (September 5, 2007): 4016–28. https://doi.org/10.1038/sj.emboj.7601831.
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  • Book Sections

    • Bergelson, Jeffrey M., and Carolyn B. Coyne. “Picornavirus entry.,” 790:24–41, 2013. https://doi.org/10.1007/978-1-4614-7651-1_2.
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  • Other Articles

    • Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.
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  • Conference Papers

    • Megli, Christina, Pallavi Karunakaran, Azia Evans, and Carolyn Coyne. “IL-11 Is Regulated by TGF beta in the Human Amnion and Is Induced by Teratogenic Viruses.” In Reproductive Sciences, 28:179A-180A, 2021.
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    • Megli, Christina, Steve Caritis, and Carolyn B. Coyne. “Mid-gestation cervicovaginal cytokines correlate with gestational age at delivery in women with prior preterm birth.” In American Journal of Obstetrics and Gynecology, 224:S445–S445, 2021.
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    • Ouyang, Yingshi, Hui Li, Kamil Krawczynski, Jean-Francois Mouillet, Carolyn Coyne, Alexander Sorkin, and Yoel Sadovsky. “B-101 Placental exosomes in maternal-placental-fetal communication and viral resistance.” In Jaids Journal of Acquired Immune Deficiency Syndromes, 81:35–35. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.1097/01.qai.0000557950.13625.84.
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    • Ouyang, Yingshi, Jean-Francois Mouillet, Guojing Chang, Tianjiao Chu, Elena Sadovsky, Avraham Bayer, Takuya Mishima, Carolyn B. Coyne, and Yoel Sadovsky. “MiRNA trafficking across the maternal-placental-fetal compartments.” In Placenta, 36:481–481. Elsevier BV, 2015. https://doi.org/10.1016/j.placenta.2015.01.422.
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    • Ouyang, Yingshi, Jean-Francois Mouillet, Guojing Chang, Tianjiao Chu, Elena Sadovsky, Avraham Bayer, Takuya Mishima, Carolyn Coyne, and Yoel Sadovsky. “MiRNA nano-packages for maternal-placental-fetal communication.” In Placenta, 35:A5–A5. Elsevier BV, 2014. https://doi.org/10.1016/j.placenta.2014.06.016.
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    • Chang, Guojing, Yoel Sadovsky, Jean-Francois Mouillet, Takuya Mishima, Yingshi Ouyang, Tianjiao Chu, and Carolyn Coyne. “162: Unprecedented communication of microRNAs at the feto-maternal interface.” In American Journal of Obstetrics and Gynecology, 210:S93–94. Elsevier BV, 2014. https://doi.org/10.1016/j.ajog.2013.10.195.
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    • Cuevas, Rolando, Veit Hornung, Carolyn Coyne, and Saumendra Sarkar. “MOV10 provides antiviral activity against RNA viruses by enhancing IFN induction through IKK epsilon and IRF3.” In Journal of Immunology, Vol. 192, 2014.
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    • Zhu, Jianzhong, Yugeng Zhang, Rolando Cuevas, Adriana Forero, Jayeeta Dhar, Mikkel Ibsen, Jonathan Schmid-Burgk, et al. “Antiviral activity of human OASL is mediated by mimicking ubiquitin chains to activate RIG-I pathway.” In Journal of Immunology, Vol. 192, 2014.
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    • Sarkar, Saumendra, Yugen Zhang, Jianzhong Zhu, Adriana Forero, Madhavi Ganapathiraju, Rune Hartmann, and Carolyn Coyne. “The oligoadenylate synthetase-like protein enhances cellular antiviral activity through RIG-I pathway.” In Journal of Immunology, Vol. 188, 2012.
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  • Preprints

    • Coyne, Carolyn. “Passaging of trophoblast organoids from full-term placental tissue. v1.” ZappyLab, Inc., August 17, 2022. https://doi.org/10.17504/protocols.io.e6nvwkx8dvmk/v1.
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• Teaching & Mentoring
• 

  Recent Courses

  • BIOTRAIN 720: Grant Writing for Biomedical Scientists 2022
  • CMB 710D: Cell & Molecular Biology Module IV 2022
  • PATHOL 793: Research Independent Study 2022

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