Carolyn Coyne | Scholars@Duke

Carolyn Coyne
George Barth Geller Distinguished Professor of Immunology

We study the pathways by which microorganisms cross cellular barriers and the mechanisms by which these barriers restrict microbial infections. Our studies primarily focus on the epithelium that lines the gastrointestinal tract and on placental trophoblasts, the cells that comprise a key cellular barrier of the human placenta. Our work is highly multidisciplinary and encompasses aspects of cell biology, immunology, and microbiology. Our long-term goals are to identify pathogen- and host-specific therapeutic targets to prevent or treat microbial infections and ultimately to alleviate the morbidity and mortality caused by these infections.

Current Research Interests

Current Appointments & Affiliations

George Barth Geller Distinguished Professor of Immunology, Molecular Genetics and Microbiology, Basic Science Departments 2022
Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2022
Professor of Pathology, Pathology, Clinical Science Departments 2022
Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Member in the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2021

Contact Information

3130 MSRB III Bx 3054, 3 Genome Court, Durham, NC 27710
3130 MSRB III, Box 3054, Durham, NC 27710
carolyn.coyne@duke.edu (919) 668-7812
coynelab.com

Background
Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2003
Previous Appointments & Affiliations
- Instructor in the Department of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2021 - 2022
Recognition
In the News
- MAY 18, 2022
  
  University Awards 24 New Distinguished Professorships
Expertise
Subject Headings
Research
Selected Grants
- Control of virus induced type I interferon signaling during pregnancy awarded by National Institutes of Health 2022 - 2027
- Enterovirus Infection of Polarized Intestinal Cells awarded by National Institutes of Health 2021 - 2025
- Antiviral Countermeasure Development Center (AC DC) awarded by Emory University 2022 - 2025
- The Role of FcRn in Echovirus Entry and Pathogenesis awarded by National Institutes of Health 2022 - 2025
- Innate immune signaling in placental antiviral defenses awarded by National Institutes of Health 2021 - 2024
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2024
- Identifying and modeling immune correlates of protection against congenital CMV transmission after primary maternal infection awarded by Weill Cornell Medicine 2023 - 2024
- Innate Immune Regulation of Zika Virus Infection awarded by University of Washington 2023 - 2024
- Placental resistance and response to the teratogenic pathogen Toxoplasma gondii awarded by University of Pittsburgh 2022 - 2024
- Live-attenuated Rift Valley fever vaccines: comparative mechanisms of trans-placental transmission and vaccine efficacy for developing fetuses awarded by University of Pittsburgh 2021 - 2024
- Development of vaccine platforms for echovirus-associated IBS awarded by Moderna Therapeutics, Inc. 2023 - 2024
External Relationships
- Modera
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Trimarco, Joseph D., Sarah L. Nelson, Ryan R. Chaparian, Alexandra I. Wells, Nathan B. Murray, Parastoo Azadi, Carolyn B. Coyne, and Nicholas S. Heaton. “Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection.” Nat Commun 13, no. 1 (October 29, 2022): 6456. https://doi.org/10.1038/s41467-022-34111-0.
    Full Text Link to Item
  - Frank, John A., Manvendra Singh, Harrison B. Cullen, Raphael A. Kirou, Meriem Benkaddour-Boumzaouad, Jose L. Cortes, Jose Garcia Pérez, Carolyn B. Coyne, and Cédric Feschotte. “Evolution and antiviral activity of a human protein of retroviral origin.” Science 378, no. 6618 (October 28, 2022): 422–28. https://doi.org/10.1126/science.abq7871.
    Full Text Link to Item
  - Yang, Liheng, Eleanor C. Semmes, Cristian Ovies, Christina Megli, Sallie Permar, Jennifer B. Gilner, and Carolyn B. Coyne. “Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface.” Elife 11 (August 17, 2022). https://doi.org/10.7554/eLife.79794.
    Full Text Link to Item
  - Wells, Alexandra I., and Carolyn B. Coyne. “An In Vivo Model of Echovirus-Induced Meningitis Defines the Differential Roles of Type I and Type III Interferon Signaling in Central Nervous System Infection.” J Virol 96, no. 13 (July 13, 2022): e0033022. https://doi.org/10.1128/jvi.00330-22.
    Full Text Link to Item
  - Zhang, Yang, Pengfei Liang, Liheng Yang, Ke Zoe Shan, Liping Feng, Yong Chen, Wolfgang Liedtke, Carolyn B. Coyne, and Huanghe Yang. “Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.” Elife 11 (June 7, 2022). https://doi.org/10.7554/eLife.78840.
    Full Text Open Access Copy Link to Item
  - Wells, Alexandra I., Kalena A. Grimes, and Carolyn B. Coyne. “Enterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract.” Mbio 13, no. 3 (June 2022): e0044322. https://doi.org/10.1128/mbio.00443-22.
    Full Text
  - Megli, Christina J., and Carolyn B. Coyne. “Infections at the maternal-fetal interface: an overview of pathogenesis and defence.” Nat Rev Microbiol 20, no. 2 (February 2022): 67–82. https://doi.org/10.1038/s41579-021-00610-y.
    Full Text Link to Item
  - Semmes, Eleanor C., and Carolyn B. Coyne. “Innate immune defenses at the maternal-fetal interface.” Curr Opin Immunol 74 (February 2022): 60–67. https://doi.org/10.1016/j.coi.2021.10.007.
    Full Text Link to Item
  - Heckenberg, Emma, Justin T. Steppe, and Carolyn B. Coyne. “Enteroviruses: The role of receptors in viral pathogenesis.” Adv Virus Res 113 (2022): 89–110. https://doi.org/10.1016/bs.aivir.2022.09.002.
    Full Text Link to Item
  - Rudzki, Elizabeth N., Stephanie E. Ander, Rachel S. Coombs, Hisham S. Alrubaye, Leah F. Cabo, Matthew L. Blank, Nicolás Gutiérrez-Melo, J. P. Dubey, Carolyn B. Coyne, and Jon P. Boyle. “Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction of the Regulatory Chemokine CCL22 in Human and Mouse.” Mbio 12, no. 6 (December 21, 2021): e0159121. https://doi.org/10.1128/mBio.01591-21.
    Full Text Link to Item
  - Roberts, Drucilla J., Andrea G. Edlow, Roberto J. Romero, Carolyn B. Coyne, David T. Ting, Jason L. Hornick, Sherif R. Zaki, et al. “A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop.” Am J Obstet Gynecol 225, no. 6 (December 2021): 593.e1-593.e9. https://doi.org/10.1016/j.ajog.2021.07.029.
    Full Text Link to Item
  - Ovies, Cristian, Eleanor C. Semmes, and Carolyn B. Coyne. “Pregnancy influences immune responses to SARS-CoV-2.” Sci Transl Med 13, no. 617 (October 27, 2021): eabm2070. https://doi.org/10.1126/scitranslmed.abm2070.
    Full Text Link to Item
  - Freeman, Megan Culler, Alexandra I. Wells, Jessica Ciomperlik-Patton, Michael M. Myerburg, Liheng Yang, Jennifer Konopka-Anstadt, and Carolyn B. Coyne. “Respiratory and intestinal epithelial cells exhibit differential susceptibility and innate immune responses to contemporary EV-D68 isolates.” Elife 10 (July 1, 2021). https://doi.org/10.7554/eLife.66687.
    Full Text Link to Item
  - Wells, Alexandra I., and Carolyn B. Coyne. “Uterine NK cell education: Learning the ropes in pregnancy.” Immunity 54, no. 6 (June 8, 2021): 1102–4. https://doi.org/10.1016/j.immuni.2021.05.009.
    Full Text Link to Item
  - Evans, Azia S., Nicholas J. Lennemann, and Carolyn B. Coyne. “BPIFB3 interacts with ARFGAP1 and TMED9 to regulate non-canonical autophagy and RNA virus infection.” J Cell Sci 134, no. 5 (February 25, 2021). https://doi.org/10.1242/jcs.251835.
    Full Text Link to Item
  - Megli, Christina, Stefanie Morosky, Dhivyaa Rajasundaram, and Carolyn B. Coyne. “Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection.” J Exp Med 218, no. 1 (January 4, 2021). https://doi.org/10.1084/jem.20200649.
    Full Text Open Access Copy Link to Item
  - Megli, Christina, and Carolyn B. Coyne. “Gatekeepers of the fetus: Characterization of placental macrophages.” J Exp Med 218, no. 1 (January 4, 2021). https://doi.org/10.1084/jem.20202071.
    Full Text Open Access Copy Link to Item
  - Wells, Alexandra I., Kalena A. Grimes, Kenneth Kim, Emilie Branche, Christopher J. Bakkenist, William H. DePas, Sujan Shresta, and Carolyn B. Coyne. “Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice.” Plos Pathog 17, no. 1 (January 2021): e1009252. https://doi.org/10.1371/journal.ppat.1009252.
    Full Text Link to Item
  - Njue, Annete, Carolyn Coyne, Andrea V. Margulis, Dai Wang, Morgan A. Marks, Kevin Russell, Rituparna Das, and Anushua Sinha. “The Role of Congenital Cytomegalovirus Infection in Adverse Birth Outcomes: A Review of the Potential Mechanisms.” Viruses 13, no. 1 (December 24, 2020). https://doi.org/10.3390/v13010020.
    Full Text Open Access Copy Link to Item
  - Ferrari, Matteo, Alessandra Zevini, Enrico Palermo, Michela Muscolini, Magdalini Alexandridi, Marilena P. Etna, Eliana M. Coccia, et al. “Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication.” J Virol 94, no. 24 (November 23, 2020). https://doi.org/10.1128/JVI.01551-20.
    Full Text Link to Item
  - Krawczynski, Kamil, Yingshi Ouyang, Jean-Francois Mouillet, Tianjiao Chu, Carolyn B. Coyne, and Yoel Sadovsky. “Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a.” J Cell Sci 134, no. 5 (November 19, 2020). https://doi.org/10.1242/jcs.246769.
    Full Text Link to Item
  - Wells, Alexandra I., and Carolyn B. Coyne. “Inhibiting Ebola virus and SARS-CoV-2 entry.” Science 370, no. 6513 (October 9, 2020): 167–68. https://doi.org/10.1126/science.abe2977.
    Full Text Open Access Copy Link to Item
  - Lennemann, Nicholas J., Azia S. Evans, and Carolyn B. Coyne. “Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells.” Viruses 12, no. 10 (September 25, 2020). https://doi.org/10.3390/v12101074.
    Full Text Open Access Copy Link to Item
  - Coyne, Carolyn, Jimmy D. Ballard, and Ira J. Blader. “Recommendations for future university pandemic responses: What the first COVID-19 shutdown taught us.” Plos Biol 18, no. 8 (August 2020): e3000889. https://doi.org/10.1371/journal.pbio.3000889.
    Full Text Open Access Copy Link to Item
  - Wong, Zhee S., Sarah L Sokol Borrelli, Carolyn C. Coyne, and Jon P. Boyle. “Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.” Int J Parasitol 50, no. 5 (May 2020): 423–31. https://doi.org/10.1016/j.ijpara.2020.05.001.
    Full Text Open Access Copy Link to Item
  - Evans, Azia S., Nicholas J. Lennemann, and Carolyn B. Coyne. “BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication.” J Virol 94, no. 9 (April 16, 2020). https://doi.org/10.1128/JVI.00029-20.
    Full Text Link to Item
  - Kim, Arthur S., Ofer Zimmerman, Julie M. Fox, Christopher A. Nelson, Katherine Basore, Rong Zhang, Lorellin Durnell, et al. “An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.” Cell Host Microbe 27, no. 3 (March 11, 2020): 428-440.e9. https://doi.org/10.1016/j.chom.2020.01.008.
    Full Text Open Access Copy Link to Item
  - Wells, Alexandra I., and Carolyn B. Coyne. “Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion.” Viruses 11, no. 5 (May 21, 2019). https://doi.org/10.3390/v11050460.
    Full Text Open Access Copy Link to Item
  - Good, Charles, Alexandra I. Wells, and Carolyn B. Coyne. “Type III interferon signaling restricts enterovirus 71 infection of goblet cells.” Sci Adv 5, no. 3 (March 2019): eaau4255. https://doi.org/10.1126/sciadv.aau4255.
    Full Text Link to Item
  - Morosky, Stefanie, Alexandra I. Wells, Kathryn Lemon, Azia S. Evans, Sandra Schamus, Christopher J. Bakkenist, and Carolyn B. Coyne. “The neonatal Fc receptor is a pan-echovirus receptor.” Proc Natl Acad Sci U S A 116, no. 9 (February 26, 2019): 3758–63. https://doi.org/10.1073/pnas.1817341116.
    Full Text Link to Item
  - Freeman, Megan Culler, Carolyn B. Coyne, Michael Green, John V. Williams, and Laurie A. Silva. “Emerging arboviruses and implications for pediatric transplantation: A review.” Pediatr Transplant 23, no. 1 (February 2019): e13303. https://doi.org/10.1111/petr.13303.
    Full Text Open Access Copy Link to Item
  - Caine, Elizabeth A., Suzanne M. Scheaffer, Nitin Arora, Konstantin Zaitsev, Maxim N. Artyomov, Carolyn B. Coyne, Kelle H. Moley, and Michael S. Diamond. “Interferon lambda protects the female reproductive tract against Zika virus infection.” Nat Commun 10, no. 1 (January 17, 2019): 280. https://doi.org/10.1038/s41467-018-07993-2.
    Full Text Link to Item
  - Evans, Azia S., and Carolyn B. Coyne. “RIPK3: Beyond Necroptosis.” Immunity 50, no. 1 (January 15, 2019): 1–3. https://doi.org/10.1016/j.immuni.2018.12.031.
    Full Text Open Access Copy Link to Item
  - Ander, Stephanie E., Michael S. Diamond, and Carolyn B. Coyne. “Immune responses at the maternal-fetal interface.” Sci Immunol 4, no. 31 (January 11, 2019). https://doi.org/10.1126/sciimmunol.aat6114.
    Full Text Link to Item
  - McMillen, Cynthia M., Nitin Arora, Devin A. Boyles, Joseph R. Albe, Michael R. Kujawa, Jeffrey F. Bonadio, Carolyn B. Coyne, and Amy L. Hartman. “Rift Valley fever virus induces fetal demise in Sprague-Dawley rats through direct placental infection.” Sci Adv 4, no. 12 (December 2018): eaau9812. https://doi.org/10.1126/sciadv.aau9812.
    Full Text Link to Item
  - Zimmerman, Matthew G., Kendra M. Quicke, Justin T. O’Neal, Nitin Arora, Deepa Machiah, Lalita Priyamvada, Robert C. Kauffman, et al. “Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.” Cell Host Microbe 24, no. 5 (November 14, 2018): 731-742.e6. https://doi.org/10.1016/j.chom.2018.10.008.
    Full Text Open Access Copy Link to Item
  - Barrila, Jennifer, Aurélie Crabbé, Jiseon Yang, Karla Franco, Seth D. Nydam, Rebecca J. Forsyth, Richard R. Davis, et al. “Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age.” Infect Immun 86, no. 11 (November 2018). https://doi.org/10.1128/IAI.00282-18.
    Full Text Link to Item
  - Coyne, Carolyn B. “Horsepox: Framing a dual use research of concern debate.” Plos Pathog 14, no. 10 (October 2018): e1007344. https://doi.org/10.1371/journal.ppat.1007344.
    Full Text Open Access Copy Link to Item
  - Wells, Alexandra I., and Carolyn B. Coyne. “Type III Interferons in Antiviral Defenses at Barrier Surfaces.” Trends Immunol 39, no. 10 (October 2018): 848–58. https://doi.org/10.1016/j.it.2018.08.008.
    Full Text Open Access Copy Link to Item
  - Coyne, Carolyn B. “STING'ing Zika virus in neurons.” Nat Microbiol 3, no. 9 (September 2018): 975–76. https://doi.org/10.1038/s41564-018-0232-5.
    Full Text Open Access Copy Link to Item
  - Lanik, Wyatt E., Madison A. Mara, Belgacem Mihi, Carolyn B. Coyne, and Misty Good. “Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.” Viruses 10, no. 3 (March 10, 2018). https://doi.org/10.3390/v10030124.
    Full Text Open Access Copy Link to Item
  - Diamond, Michael S., and Carolyn B. Coyne. “Vaccines in 2017: Closing in on a Zika virus vaccine.” Nat Rev Immunol 18, no. 2 (February 2018): 89–90. https://doi.org/10.1038/nri.2017.132.
    Full Text Open Access Copy Link to Item
  - Platt, Derek J., Amber M. Smith, Nitin Arora, Michael S. Diamond, Carolyn B. Coyne, and Jonathan J. Miner. “Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice.” Sci Transl Med 10, no. 426 (January 31, 2018). https://doi.org/10.1126/scitranslmed.aao7090.
    Full Text Link to Item
  - Ander, Stephanie E., Elizabeth N. Rudzki, Nitin Arora, Yoel Sadovsky, Carolyn B. Coyne, and Jon P. Boyle. “Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines.” Mbio 9, no. 1 (January 9, 2018). https://doi.org/10.1128/mBio.01678-17.
    Full Text Link to Item
  - Yockey, Laura J., Kellie A. Jurado, Nitin Arora, Alon Millet, Tasfia Rakib, Kristin M. Milano, Andrew K. Hastings, et al. “Type I interferons instigate fetal demise after Zika virus infection.” Sci Immunol 3, no. 19 (January 5, 2018). https://doi.org/10.1126/sciimmunol.aao1680.
    Full Text Link to Item
  - Bayer, Avraham, Nicholas J. Lennemann, Yingshi Ouyang, Elena Sadovsky, Megan A. Sheridan, R Michael Roberts, Carolyn B. Coyne, and Yoel Sadovsky. “Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.” Placenta 61 (January 2018): 33–38. https://doi.org/10.1016/j.placenta.2017.11.004.
    Full Text Open Access Copy Link to Item
  - Delorme-Axford, Elizabeth, Emma Abernathy, Nicholas J. Lennemann, Amélie Bernard, Aileen Ariosa, Carolyn B. Coyne, Karla Kirkegaard, and Daniel J. Klionsky. “The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy.” Autophagy 14, no. 5 (2018): 898–912. https://doi.org/10.1080/15548627.2018.1441648.
    Full Text Link to Item
  - Jagger, Brett W., Jonathan J. Miner, Bin Cao, Nitin Arora, Amber M. Smith, Attila Kovacs, Indira U. Mysorekar, Carolyn B. Coyne, and Michael S. Diamond. “Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero.” Cell Host Microbe 22, no. 3 (September 13, 2017): 366-376.e3. https://doi.org/10.1016/j.chom.2017.08.012.
    Full Text Open Access Copy Link to Item
  - Corry, Jacqueline, Nitin Arora, Charles A. Good, Yoel Sadovsky, and Carolyn B. Coyne. “Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface.” Proc Natl Acad Sci U S A 114, no. 35 (August 29, 2017): 9433–38. https://doi.org/10.1073/pnas.1707513114.
    Full Text Link to Item
  - Chang, Guojing, Jean-François Mouillet, Takuya Mishima, Tianjiao Chu, Elena Sadovsky, Carolyn B. Coyne, W Tony Parks, Urvashi Surti, and Yoel Sadovsky. “Expression and trafficking of placental microRNAs at the feto-maternal interface.” Faseb J 31, no. 7 (July 2017): 2760–70. https://doi.org/10.1096/fj.201601146R.
    Full Text Link to Item
  - Arora, Nitin, Yoel Sadovsky, Terence S. Dermody, and Carolyn B. Coyne. “Microbial Vertical Transmission during Human Pregnancy.” Cell Host Microbe 21, no. 5 (May 10, 2017): 561–67. https://doi.org/10.1016/j.chom.2017.04.007.
    Full Text Link to Item
  - Dumont, Tina M. F., Jean-Francois Mouillet, Avaraham Bayer, Christina L. Gardner, William B. Klimstra, Dana G. Wolf, Simcha Yagel, et al. “The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.” Placenta 53 (May 2017): 23–29. https://doi.org/10.1016/j.placenta.2017.03.011.
    Full Text Link to Item
  - Drummond, Coyne G., Alexa M. Bolock, Congrong Ma, Cliff J. Luke, Misty Good, and Carolyn B. Coyne. “Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner.” Proc Natl Acad Sci U S A 114, no. 7 (February 14, 2017): 1672–77. https://doi.org/10.1073/pnas.1617363114.
    Full Text Link to Item
  - Lennemann, Nicholas J., and Carolyn B. Coyne. “Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B.” Autophagy 13, no. 2 (February 2017): 322–32. https://doi.org/10.1080/15548627.2016.1265192.
    Full Text Link to Item
  - Rausch, Keiko, Brent A. Hackett, Nathan L. Weinbren, Sophia M. Reeder, Yoel Sadovsky, Christopher A. Hunter, David C. Schultz, Carolyn B. Coyne, and Sara Cherry. “Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus.” Cell Rep 18, no. 3 (January 17, 2017): 804–15. https://doi.org/10.1016/j.celrep.2016.12.068.
    Full Text Link to Item
  - Bramley, John C., Coyne G. Drummond, Nicholas J. Lennemann, Charles A. Good, Kwang Sik Kim, and Carolyn B. Coyne. “A Three-Dimensional Cell Culture System To Model RNA Virus Infections at the Blood-Brain Barrier.” Msphere 2, no. 3 (2017). https://doi.org/10.1128/mSphere.00206-17.
    Full Text Link to Item
  - Coyne, Carolyn B., and Helen M. Lazear. “Zika virus - reigniting the TORCH.” Nat Rev Microbiol 14, no. 11 (November 2016): 707–15. https://doi.org/10.1038/nrmicro.2016.125.
    Full Text Link to Item
  - Ouyang, Yingshi, Avraham Bayer, Tianjiao Chu, Vladimir A. Tyurin, Valerian E. Kagan, Adrian E. Morelli, Carolyn B. Coyne, and Yoel Sadovsky. “Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.” Placenta 47 (November 2016): 86–95. https://doi.org/10.1016/j.placenta.2016.09.008.
    Full Text Link to Item
  - Olagnier, David, Michela Muscolini, Carolyn B. Coyne, Michael S. Diamond, and John Hiscott. “Mechanisms of Zika Virus Infection and Neuropathogenesis.” Dna Cell Biol 35, no. 8 (August 2016): 367–72. https://doi.org/10.1089/dna.2016.3404.
    Full Text Link to Item
  - Morosky, Stefanie, Nicholas J. Lennemann, and Carolyn B. Coyne. “BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication.” J Virol 90, no. 10 (May 15, 2016): 5098–5107. https://doi.org/10.1128/JVI.00170-16.
    Full Text Link to Item
  - Bayer, Avraham, Nicholas J. Lennemann, Yingshi Ouyang, John C. Bramley, Stefanie Morosky, Ernesto Torres De Azeved Marques, Sara Cherry, Yoel Sadovsky, and Carolyn B. Coyne. “Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection.” Cell Host Microbe 19, no. 5 (May 11, 2016): 705–12. https://doi.org/10.1016/j.chom.2016.03.008.
    Full Text Link to Item
  - Cuevas, Rolando A., Arundhati Ghosh, Christina Wallerath, Veit Hornung, Carolyn B. Coyne, and Saumendra N. Sarkar. “MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.” J Immunol 196, no. 9 (May 1, 2016): 3877–86. https://doi.org/10.4049/jimmunol.1501359.
    Full Text Link to Item
  - McCormick, Kevin D., Arundhati Ghosh, Sumita Trivedi, Lin Wang, Carolyn B. Coyne, Robert L. Ferris, and Saumendra N. Sarkar. “Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma.” Carcinogenesis 37, no. 5 (May 2016): 522–29. https://doi.org/10.1093/carcin/bgw032.
    Full Text Link to Item
  - Coyne, Carolyn B. “The Tree(s) of Life: The Human Placenta and My Journey to Learn More about It.” Plos Pathog 12, no. 4 (April 2016): e1005515. https://doi.org/10.1371/journal.ppat.1005515.
    Full Text Open Access Copy Link to Item
  - McConkey, Cameron A., Elizabeth Delorme-Axford, Cheryl A. Nickerson, Kwang Sik Kim, Yoel Sadovsky, Jon P. Boyle, and Carolyn B. Coyne. “A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.” Sci Adv 2, no. 3 (March 2016): e1501462. https://doi.org/10.1126/sciadv.1501462.
    Full Text Open Access Copy Link to Item
  - Hendricks, Matthew R., Lauren P. Lashua, Douglas K. Fischer, Becca A. Flitter, Katherine M. Eichinger, Joan E. Durbin, Saumendra N. Sarkar, Carolyn B. Coyne, Kerry M. Empey, and Jennifer M. Bomberger. “Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity.” Proc Natl Acad Sci U S A 113, no. 6 (February 9, 2016): 1642–47. https://doi.org/10.1073/pnas.1516979113.
    Full Text Link to Item
  - Drummond, Coyne G., Cheryl A. Nickerson, and Carolyn B. Coyne. “A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells.” Msphere 1, no. 1 (2016). https://doi.org/10.1128/mSphere.00030-15.
    Full Text Open Access Copy Link to Item
  - Mouillet, Jean-François, Yingshi Ouyang, Carolyn B. Coyne, and Yoel Sadovsky. “MicroRNAs in placental health and disease.” Am J Obstet Gynecol 213, no. 4 Suppl (October 2015): S163–72. https://doi.org/10.1016/j.ajog.2015.05.057.
    Full Text Link to Item
  - Shu, Qian, Nicholas J. Lennemann, Saumendra N. Sarkar, Yoel Sadovsky, and Carolyn B. Coyne. “ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.” Plos Pathog 11, no. 9 (September 2015): e1005150. https://doi.org/10.1371/journal.ppat.1005150.
    Full Text Open Access Copy Link to Item
  - Harris, Katharine G., Stefanie A. Morosky, Coyne G. Drummond, Maulik Patel, Chonsaeng Kim, Donna B. Stolz, Jeffrey M. Bergelson, Sara Cherry, and Carolyn B. Coyne. “RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells.” Cell Host Microbe 18, no. 2 (August 12, 2015): 221–32. https://doi.org/10.1016/j.chom.2015.07.007.
    Full Text Link to Item
  - Rosenthal, Ann K., Claudia M. Gohr, Elizabeth Mitton-Fitzgerald, Rupinder Grewal, James Ninomiya, Carolyn B. Coyne, and William T. Jackson. “Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.” J Biol Chem 290, no. 21 (May 22, 2015): 13028–38. https://doi.org/10.1074/jbc.M114.630558.
    Full Text Link to Item
  - Sadovsky, Yoel, Jean-Francois Mouillet, Yingshi Ouyang, Avraham Bayer, and Carolyn B. Coyne. “The Function of TrophomiRs and Other MicroRNAs in the Human Placenta.” Cold Spring Harb Perspect Med 5, no. 8 (April 15, 2015): a023036. https://doi.org/10.1101/cshperspect.a023036.
    Full Text Link to Item
  - Lennemann, Nicholas J., and Carolyn B. Coyne. “Catch me if you can: the link between autophagy and viruses.” Plos Pathog 11, no. 3 (March 2015): e1004685. https://doi.org/10.1371/journal.ppat.1004685.
    Full Text Open Access Copy Link to Item
  - Bayer, Avraham, Elizabeth Delorme-Axford, Christie Sleigher, Teryl K. Frey, Derek W. Trobaugh, William B. Klimstra, Lori A. Emert-Sedlak, et al. “Human trophoblasts confer resistance to viruses implicated in perinatal infection.” Am J Obstet Gynecol 212, no. 1 (January 2015): 71.e1-71.e8. https://doi.org/10.1016/j.ajog.2014.07.060.
    Full Text Link to Item
  - Harris, Katharine G., and Carolyn B. Coyne. “Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases.” Plos One 10, no. 10 (2015): e0141383. https://doi.org/10.1371/journal.pone.0141383.
    Full Text Open Access Copy Link to Item
  - Delorme-Axford, Elizabeth, Stefanie Morosky, Jennifer Bomberger, Donna B. Stolz, William T. Jackson, and Carolyn B. Coyne. “BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery.” Mbio 5, no. 6 (December 9, 2014): e02147. https://doi.org/10.1128/mBio.02147-14.
    Full Text Open Access Copy Link to Item
  - Delorme-Axford, Elizabeth, Yoel Sadovsky, and Carolyn B. Coyne. “The Placenta as a Barrier to Viral Infections.” Annu Rev Virol 1, no. 1 (November 2014): 133–46. https://doi.org/10.1146/annurev-virology-031413-085524.
    Full Text Link to Item
  - Harris, Katharine G., and Carolyn B. Coyne. “Death waits for no man--does it wait for a virus? How enteroviruses induce and control cell death.” Cytokine Growth Factor Rev 25, no. 5 (October 2014): 587–96. https://doi.org/10.1016/j.cytogfr.2014.08.002.
    Full Text Link to Item
  - Zhu, Jianzhong, Yugen Zhang, Arundhati Ghosh, Rolando A. Cuevas, Adriana Forero, Jayeeta Dhar, Mikkel Søes Ibsen, et al. “Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.” Immunity 40, no. 6 (June 19, 2014): 936–48. https://doi.org/10.1016/j.immuni.2014.05.007.
    Full Text Link to Item
  - Ouyang, Y., J. -. F. Mouillet, C. B. Coyne, and Y. Sadovsky. “Review: placenta-specific microRNAs in exosomes - good things come in nano-packages.” Placenta 35 Suppl (February 2014): S69–73. https://doi.org/10.1016/j.placenta.2013.11.002.
    Full Text Link to Item
  - Jacobs, Jana L., Jianzhong Zhu, Saumendra N. Sarkar, and Carolyn B. Coyne. “Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78.” J Biol Chem 289, no. 3 (January 17, 2014): 1604–16. https://doi.org/10.1074/jbc.M113.520254.
    Full Text Link to Item
  - Mouillet, Jean-Francois, Yingshi Ouyang, Avraham Bayer, Carolyn B. Coyne, and Yoel Sadovsky. “The role of trophoblastic microRNAs in placental viral infection.” Int J Dev Biol 58, no. 2–4 (2014): 281–89. https://doi.org/10.1387/ijdb.130349ys.
    Full Text Link to Item
  - Jacobs, Jana L., and Carolyn B. Coyne. “Mechanisms of MAVS regulation at the mitochondrial membrane.” J Mol Biol 425, no. 24 (December 13, 2013): 5009–19. https://doi.org/10.1016/j.jmb.2013.10.007.
    Full Text Link to Item
  - Delorme-Axford, Elizabeth, Avraham Bayer, Yoel Sadovsky, and Carolyn B. Coyne. “Autophagy as a mechanism of antiviral defense at the maternal-fetal interface.” Autophagy 9, no. 12 (December 2013): 2173–74. https://doi.org/10.4161/auto.26558.
    Full Text Link to Item
  - Harris, Katharine G., and Carolyn B. Coyne. “Enter at your own risk: how enteroviruses navigate the dangerous world of pattern recognition receptor signaling.” Cytokine 63, no. 3 (September 2013): 230–36. https://doi.org/10.1016/j.cyto.2013.05.007.
    Full Text Link to Item
  - Delorme-Axford, Elizabeth, Yoel Sadovsky, and Carolyn B. Coyne. “Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts.” J Virol 87, no. 15 (August 2013): 8569–81. https://doi.org/10.1128/JVI.00708-13.
    Full Text Link to Item
  - Delorme-Axford, Elizabeth, Rogier B. Donker, Jean-Francois Mouillet, Tianjiao Chu, Avraham Bayer, Yingshi Ouyang, Tianyi Wang, et al. “Human placental trophoblasts confer viral resistance to recipient cells.” Proc Natl Acad Sci U S A 110, no. 29 (July 16, 2013): 12048–53. https://doi.org/10.1073/pnas.1304718110.
    Full Text Link to Item
  - Tang, Daolin, Rui Kang, Carolyn B. Coyne, Herbert J. Zeh, and Michael T. Lotze. “PAMPs and DAMPs: signal 0s that spur autophagy and immunity.” Immunol Rev 249, no. 1 (September 2012): 158–75. https://doi.org/10.1111/j.1600-065X.2012.01146.x.
    Full Text Open Access Copy Link to Item
  - Bozym, Rebecca A., Elizabeth Delorme-Axford, Katharine Harris, Stefanie Morosky, Mine Ikizler, Terence S. Dermody, Saumendra N. Sarkar, and Carolyn B. Coyne. “Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.” Cell Host Microbe 11, no. 2 (February 16, 2012): 153–66. https://doi.org/10.1016/j.chom.2012.01.008.
    Full Text Link to Item
  - Delorme-Axford, Elizabeth, and Carolyn B. Coyne. “The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells.” Viruses 3, no. 12 (December 2011): 2462–77. https://doi.org/10.3390/v3122462.
    Full Text Open Access Copy Link to Item
  - Zhu, Jianzhong, Carolyn B. Coyne, and Saumendra N. Sarkar. “PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin.” Embo J 30, no. 23 (September 27, 2011): 4838–49. https://doi.org/10.1038/emboj.2011.351.
    Full Text Link to Item
  - Bozym, Rebecca A., Kunal Patel, Carl White, King-Ho Cheung, Jeffrey M. Bergelson, Stefanie A. Morosky, and Carolyn B. Coyne. “Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells.” Mol Biol Cell 22, no. 17 (September 2011): 3010–21. https://doi.org/10.1091/mbc.E11-02-0094.
    Full Text Link to Item
  - Morosky, Stefanie A., Jianzhong Zhu, Amitava Mukherjee, Saumendra N. Sarkar, and Carolyn B. Coyne. “Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling.” J Biol Chem 286, no. 32 (August 12, 2011): 28574–83. https://doi.org/10.1074/jbc.M111.227942.
    Full Text Link to Item
  - Mukherjee, Amitava, Stefanie A. Morosky, Elizabeth Delorme-Axford, Naomi Dybdahl-Sissoko, M Steven Oberste, Tianyi Wang, and Carolyn B. Coyne. “The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling.” Plos Pathog 7, no. 3 (March 2011): e1001311. https://doi.org/10.1371/journal.ppat.1001311.
    Full Text Link to Item
  - Coyne, Carolyn B., Rebecca Bozym, Stefanie A. Morosky, Sheri L. Hanna, Amitava Mukherjee, Matthew Tudor, Kwang Sik Kim, and Sara Cherry. “Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers.” Cell Host Microbe 9, no. 1 (January 20, 2011): 70–82. https://doi.org/10.1016/j.chom.2011.01.001.
    Full Text Link to Item
  - Coyne, Carolyn B., and Sara Cherry. “RNAi screening in mammalian cells to identify novel host cell molecules involved in the regulation of viral infections.” Methods Mol Biol 721 (2011): 397–405. https://doi.org/10.1007/978-1-61779-037-9_25.
    Full Text Link to Item
  - Bozym, Rebecca A., Stefanie A. Morosky, Kwang S. Kim, Sara Cherry, and Carolyn B. Coyne. “Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells.” Plos Pathog 6, no. 10 (October 7, 2010): e1001135. https://doi.org/10.1371/journal.ppat.1001135.
    Full Text Link to Item
  - Long, Kimberly R., Yasunori Yamamoto, Adam L. Baker, Simon C. Watkins, Carolyn B. Coyne, James F. Conway, and Meir Aridor. “Sar1 assembly regulates membrane constriction and ER export.” J Cell Biol 190, no. 1 (July 12, 2010): 115–28. https://doi.org/10.1083/jcb.201004132.
    Full Text Link to Item
  - Moser, Theresa S., Russell G. Jones, Craig B. Thompson, Carolyn B. Coyne, and Sara Cherry. “A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics.” Plos Pathog 6, no. 6 (June 17, 2010): e1000954. https://doi.org/10.1371/journal.ppat.1000954.
    Full Text Link to Item
  - Patel, Kunal P., Carolyn B. Coyne, and Jeffrey M. Bergelson. “Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells.” J Virol 83, no. 21 (November 2009): 11064–77. https://doi.org/10.1128/JVI.01016-09.
    Full Text Link to Item
  - Mukherjee, Amitava, Stefanie A. Morosky, Le Shen, Christopher R. Weber, Jerrold R. Turner, Kwang Sik Kim, Tianyi Wang, and Carolyn B. Coyne. “Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions.” J Biol Chem 284, no. 10 (March 6, 2009): 6486–94. https://doi.org/10.1074/jbc.M807547200.
    Full Text Link to Item
  - Liu, Shufeng, Wei Yang, Le Shen, Jerrold R. Turner, Carolyn B. Coyne, and Tianyi Wang. “Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.” J Virol 83, no. 4 (February 2009): 2011–14. https://doi.org/10.1128/JVI.01888-08.
    Full Text Link to Item
  - Coyne, Carolyn B. “The distinct roles of JAM-A in reovirus pathogenesis.” Cell Host Microbe 5, no. 1 (January 22, 2009): 3–5. https://doi.org/10.1016/j.chom.2008.12.009.
    Full Text Link to Item
  - Yang, Wei, Chao Qiu, Nabanita Biswas, Jing Jin, Simon C. Watkins, Ronald C. Montelaro, Carolyn B. Coyne, and Tianyi Wang. “Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus.” J Biol Chem 283, no. 13 (March 28, 2008): 8643–53. https://doi.org/10.1074/jbc.M709824200.
    Full Text Link to Item
  - Coyne, Carolyn B., Le Shen, Jerrold R. Turner, and Jeffrey M. Bergelson. “Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5.” Cell Host Microbe 2, no. 3 (September 13, 2007): 181–92. https://doi.org/10.1016/j.chom.2007.07.003.
    Full Text Link to Item
  - Coyne, Carolyn B., Kwang S. Kim, and Jeffrey M. Bergelson. “Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2.” Embo J 26, no. 17 (September 5, 2007): 4016–28. https://doi.org/10.1038/sj.emboj.7601831.
    Full Text Link to Item
- Book Sections
  - Bergelson, Jeffrey M., and Carolyn B. Coyne. “Picornavirus entry.,” 790:24–41, 2013. https://doi.org/10.1007/978-1-4614-7651-1_2.
    Full Text Link to Item
- Other Articles
  - Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.
    Full Text Link to Item
- Conference Papers
  - Megli, Christina, Pallavi Karunakaran, Azia Evans, and Carolyn Coyne. “IL-11 Is Regulated by TGF beta in the Human Amnion and Is Induced by Teratogenic Viruses.” In Reproductive Sciences, 28:179A-180A, 2021.
    Link to Item
  - Megli, Christina, Steve Caritis, and Carolyn B. Coyne. “Mid-gestation cervicovaginal cytokines correlate with gestational age at delivery in women with prior preterm birth.” In American Journal of Obstetrics and Gynecology, 224:S445–S445, 2021.
    Link to Item
  - Ouyang, Yingshi, Hui Li, Kamil Krawczynski, Jean-Francois Mouillet, Carolyn Coyne, Alexander Sorkin, and Yoel Sadovsky. “B-101 Placental exosomes in maternal-placental-fetal communication and viral resistance.” In Jaids Journal of Acquired Immune Deficiency Syndromes, 81:35–35. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.1097/01.qai.0000557950.13625.84.
    Full Text
  - Ouyang, Yingshi, Jean-Francois Mouillet, Guojing Chang, Tianjiao Chu, Elena Sadovsky, Avraham Bayer, Takuya Mishima, Carolyn B. Coyne, and Yoel Sadovsky. “MiRNA trafficking across the maternal-placental-fetal compartments.” In Placenta, 36:481–481. Elsevier BV, 2015. https://doi.org/10.1016/j.placenta.2015.01.422.
    Full Text
  - Ouyang, Yingshi, Jean-Francois Mouillet, Guojing Chang, Tianjiao Chu, Elena Sadovsky, Avraham Bayer, Takuya Mishima, Carolyn Coyne, and Yoel Sadovsky. “MiRNA nano-packages for maternal-placental-fetal communication.” In Placenta, 35:A5–A5. Elsevier BV, 2014. https://doi.org/10.1016/j.placenta.2014.06.016.
    Full Text
  - Chang, Guojing, Yoel Sadovsky, Jean-Francois Mouillet, Takuya Mishima, Yingshi Ouyang, Tianjiao Chu, and Carolyn Coyne. “162: Unprecedented communication of microRNAs at the feto-maternal interface.” In American Journal of Obstetrics and Gynecology, 210:S93–94. Elsevier BV, 2014. https://doi.org/10.1016/j.ajog.2013.10.195.
    Full Text
  - Cuevas, Rolando, Veit Hornung, Carolyn Coyne, and Saumendra Sarkar. “MOV10 provides antiviral activity against RNA viruses by enhancing IFN induction through IKK epsilon and IRF3.” In Journal of Immunology, Vol. 192, 2014.
    Link to Item
  - Zhu, Jianzhong, Yugeng Zhang, Rolando Cuevas, Adriana Forero, Jayeeta Dhar, Mikkel Ibsen, Jonathan Schmid-Burgk, et al. “Antiviral activity of human OASL is mediated by mimicking ubiquitin chains to activate RIG-I pathway.” In Journal of Immunology, Vol. 192, 2014.
    Link to Item
  - Sarkar, Saumendra, Yugen Zhang, Jianzhong Zhu, Adriana Forero, Madhavi Ganapathiraju, Rune Hartmann, and Carolyn Coyne. “The oligoadenylate synthetase-like protein enhances cellular antiviral activity through RIG-I pathway.” In Journal of Immunology, Vol. 188, 2012.
    Link to Item
- Preprints
  - Yang, Liheng, Pengfei Liang, Huanghe Yang, and Carolyn B. Coyne. “Trophoblast organoids with physiological polarity model placental structure and function.,” January 12, 2023. https://doi.org/10.1101/2023.01.12.523752.
    Full Text Link to Item
  - Coyne, Carolyn. “Passaging of trophoblast organoids from full-term placental tissue. v1.” ZappyLab, Inc., August 17, 2022. https://doi.org/10.17504/protocols.io.e6nvwkx8dvmk/v1.
    Full Text
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Other Articles

Conference Papers

Preprints

Recent Courses