Carolyn Coyne

Preprint · July 9, 2025 The placenta combats mother-to-fetus transmission of viruses through the antiviral activities of fetal-derived trophoblasts. Placental trophoblasts employ specialized antiviral strategies to protect against infection while preventing maternal immune reject ... Full text Link to item Cite

Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing.

Preprint · May 27, 2025 The syncytiotrophoblast (STB) is a multinucleated cell layer that forms the outer surface of human chorionic villi. Its unusual structure, with billions of nuclei in a single cell, makes it difficult to resolve using conventional single-cell methods. To be ... Full text Link to item Cite

In utero human cytomegalovirus infection expands NK cell-like FcγRIII-expressing CD8+ T cells that mediate antibody-dependent functions.

Preprint · September 11, 2023 Full text Link to item Cite

Trophoblast organoids with physiological polarity model placental structure and function.

Preprint · July 17, 2023 Human trophoblast organoids (TOs) are a three-dimensional ex vivo culture model that can be used to study various aspects of placental development, physiology, and pathology. Previously, we showed that TOs derived from full-term human placental tissue coul ... Full text Link to item Cite

Passaging of trophoblast organoids from full-term placental tissue. v1

Preprint · August 17, 2022 Full text Cite

Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

Preprint · March 30, 2021 Full text Cite