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Carolyn Glass

Associate Professor of Pathology
Pathology
214D Davison Building, 40 Duke Medicine Circle, Box #3712 DUHS, Durham, NC 27710

Overview


Division Chief, Cardiovascular Pathology 
Co-Director, Division of Artificial Intelligence and Computational Pathology
Associate Director, Residency Program  

Dr. Glass completed medical residency in Anatomic Pathology at the Brigham and Women’s Hospital/Harvard Medical School followed by fellowships in Cardiothoracic Pathology also at Brigham and Women’s Hospital/Harvard Medical School and Pulmonary/Cardiac Transplant Pathology at the University of Texas Southwestern Medical Center. Dr. Glass initially trained as a vascular surgeon with a focus on endovascular/interventional procedures through the 0+5 Integrated Vascular Surgery Program at the University of Rochester Medical Center from 2007-2011.  As a recipient of the NIH National Lung Blood Institute T32 Ruth Kirschstein National Service Research Award, she completed a Ph.D with a concentration in Genomics and Epigenetics in 2014. Dr. Glass serves as P.I. of multiple NIH grants, including U54 and SBIR.

As a thoracic surgical pathologist, Dr. Glass diagnoses complex heart transplant rejection and thoracic malignancies. She works closely with the Duke Thoracic Oncology Group, DCI Center for Cancer Immunotherapy, Duke Division of Cardiovascular Medicine and Cardiothoracic Surgery and Pratt School of Biomedical Engineering. 

Dr. Glass is the recipient of the Society of Cardiovascular Pathology (SCVP) Young Investigator’s Award, the William von Liebig Vascular Biology Research Fellowship at the Harvard Institutes of Medicine, the Duke Pathology Salvatore V. Pizzo Faculty Research Mentor Award, the Duke Department of Pathology Early Career Research Achievement Award and is author of over 100 publications (including book chapters in the recent W.H.O. Classification Tumours of the Lung, Pleura, Thymus and Heart) and 50 national presentations in cardiovascular disease, thoracic malignancies, surgery and machine learning. 

In addition to her clinical and research activities, Dr. Glass has served on the Executive/National Committees for the Society of Cardiovascular Pathology, College of American Pathology Artificial Intelligence Committee and the Duke School of Medicine Executive Admissions Committee. 

Current Appointments & Affiliations


Associate Professor of Pathology · 2022 - Present Pathology, Clinical Science Departments
Assistant Professor in Surgery · 2023 - Present Surgery, Cardiovascular and Thoracic Surgery, Surgery
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published March 20, 2025
Duke Scientists Study Long COVID at the Tissue Level
Published January 20, 2021
At Duke, the Future of Pathology Lies in AI

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Recent Publications


Single-cell and spatial detection of senescent cells using DeepScence.

Journal Article Cell Genom · December 10, 2025 Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence ... Full text Link to item Cite

Advancing biological understanding of cellular senescence with computational multiomics.

Journal Article Nat Genet · October 2025 Cellular senescence is a complex biological process that plays a pathophysiological role in aging and age-related diseases. The biological understanding of senescence at the cellular and tissue levels remains incomplete due to the lack of specific biomarke ... Full text Link to item Cite

Single-cell and spatial detection of senescent cells using DeepScence.

Journal Article bioRxiv · April 23, 2025 Accurately identifying senescent cells is essential for studying their spatial and molecular features. We developed DeepScence, a method based on deep neural networks, to identify senescent cells in single-cell and spatial transcriptomics data. DeepScence ... Full text Link to item Cite
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Recent Grants


Promoting Cardiac Allograft Tolerance with PD-L1 Gene Therapy in a Preclinical Porcine Model

ResearchCollaborator · Awarded by American Heart Association · 2026 - 2026

NIH Recover: A Multisite Pathology Study of Post-Acute Sequelae of SARS-CoV2 Infection

ResearchPrincipal Investigator · Awarded by New York University · 2024 - 2026

A digital polarization microscopy platform to enhance pathologist workflow

ResearchCo-Principal Investigator · Awarded by North Carolina Biotechnology Center · 2024 - 2026

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Education


University of Texas Medical Branch, School of Medicine · 2007 M.D.