Chenkai Wu
Assistant Professor of Global Health at Duke Kunshan University
Dr. Wu is an Assistant Professor in the Global Health Research Center at Duke Kunshan University and was a faculty in the Department of Epidemiology at New York Medical College. His current research focuses on (i) measurement, epidemiology, and clinical implications of frailty, (ii) prevention of cardiovascular morbidity and mortality, and (iii) quantification and risk factors for healthy aging. Dr. Wu has published over 10 peer-reviewed papers in the fields of epidemiology, gerontology, and cardiovascular disease. His work has been featured in major national and international media, including Harvard Business Review, the Wall Street Journal, the Guardian, and National Public Radio.
Current Research Interests
I have interest in many fields pertaining to aging research. Specifically, my main research focuses on prevention of cardiovascular disease, frailty, and disability and promotion of healthy aging and longevity with 3 foci:
- Assessments, epidemiology, and clinical implications of frailty
- Novel risk factors for cardiovascular morbidity and mortality (e.g., blood pressure variability, blood pressure trajectory)
- Measurements and determinants of healthy aging and longevity
Current Appointments & Affiliations
- Assistant Professor of Global Health at Duke Kunshan University, DKU Faculty, Duke Kunshan University 2018
- Adjunct Assistant Professor of Global Health in the Duke Global Health Institute (DGHI), Duke Global Health Institute, University Institutes and Centers 2022
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., Oregon State University 2017
- Recognition
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In the News
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JUL 1, 2017 Harvard Men's Health Watch -
JUN 1, 2016 Harvard Business Review -
MAY 9, 2016 National Public Radio -
MAY 2, 2016 The Gurdian -
MAY 2, 2016 The Wall Street Journal
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- Expertise
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Global Scholarship
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Teaching
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- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Tan, Jie, Chenxinan Ma, Chonglin Zhu, Yin Wang, Xiaoshuang Zou, Han Li, Jiarun Li, Yanxuan He, and Chenkai Wu. “Prediction models for depression risk among older adults: systematic review and critical appraisal.” Ageing Research Reviews 83 (January 2023): 101803. https://doi.org/10.1016/j.arr.2022.101803.Full Text Open Access Copy
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Jin, Haiyu, Yanfang Su, Yongjing Ping, Sarah Pickersgill, Xi Chen, Xiaoting Liu, David Watkins, Yan Li, Hua Liu, and Chenkai Wu. “Projecting Long-Term Care Costs for Home and Community-Based Services in China from 2005 to 2050.” Journal of the American Medical Directors Association, December 2022, S1525-8610(22)00882-9. https://doi.org/10.1016/j.jamda.2022.11.005.Full Text
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Chen, Shu, Yafei Si, Katja Hanewald, Bingqin Li, Hazel Bateman, Xiaochen Dai, Chenkai Wu, and Shenglan Tang. “Disease burden of ageing, sex and regional disparities and health resources allocation: a longitudinal analysis of 31 provinces in Mainland China.” Bmj Open 12, no. 11 (November 16, 2022): e064641. https://doi.org/10.1136/bmjopen-2022-064641.Full Text Link to Item
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Zhang, Kehan, Gina S. Lovasi, Michelle C. Odden, Yvonne L. Michael, Anne B. Newman, Alice M. Arnold, Dae Hyun Kim, and Chenkai Wu. “Association of Retail Environment and Neighborhood Socioeconomic Status With Mortality Among Community-Dwelling Older Adults in the United States: Cardiovascular Health Study.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 77, no. 11 (November 2022): 2240–47. https://doi.org/10.1093/gerona/glab319.Full Text
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Zhou, Jiayi, Melissa Y. Wei, Jingyi Zhang, Hua Liu, and Chenkai Wu. “Association of multimorbidity patterns with incident disability and recovery of independence among middle-aged and older adults.” Age and Ageing 51, no. 8 (August 2022): afac177. https://doi.org/10.1093/ageing/afac177.Full Text
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Tan, Jie, MinHong Wang, XiaoRui Pei, Quan Sun, ChongJun Lu, Ying Wang, Li Zhang, and Chenkai Wu. “Continue or not to continue? Attitudes towards deprescribing among community-dwelling older adults in China.” Bmc Geriatrics 22, no. 1 (June 2022): 492. https://doi.org/10.1186/s12877-022-03184-3.Full Text
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Wang, Wenxin, Jie Chen, Xurui Jin, Yongjing Ping, and Chenkai Wu. “Association between indoor ventilation frequency and cognitive function among community-dwelling older adults in China: results from the Chinese longitudinal healthy longevity survey.” Bmc Geriatrics 22, no. 1 (February 2022): 106. https://doi.org/10.1186/s12877-022-02805-1.Full Text
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Wu, C., T. -. Z. Lin, and J. L. Sanders. “A Simplified Approach for Classifying Physical Resilience among Community-Dwelling Older Adults: The Health, Aging, and Body Composition Study.” The Journal of Frailty & Aging 11, no. 3 (January 2022): 281–85. https://doi.org/10.14283/jfa.2022.38.Full Text
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Zeki Al Hazzouri, Adina, Michelle R. Caunca, Neal Jawadekar, Leslie Grasset, Tali Elfassy, Michelle C. Odden, Chenkai Wu, Martine Elbejjani, Lenore Launer, and Kristine Yaffe. “Associations Between 20-Year Lipid Variability Throughout Young Adulthood and Midlife Cognitive Function and Brain Integrity.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 77, no. 1 (January 2022): 114–21. https://doi.org/10.1093/gerona/glab108.Full Text
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Chen, Yan, Man Guo, Hanzhang Xu, Zuyun Liu, Lisa C. Barry, and Chenkai Wu. “Association between early life circumstances and depressive symptoms among Chinese older adults: Results from China health and retirement longitudinal study: Early life circumstances and depression.” J Affect Disord 292 (September 1, 2021): 345–51. https://doi.org/10.1016/j.jad.2021.05.067.Full Text Link to Item
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Zhang, Tianhang, Lijing L. Yan, Hua-Shuai Chen, Hai-Yu Jin, and Chenkai Wu. “Association between allostatic load and mortality among Chinese older adults: the Chinese Longitudinal Health and Longevity Study.” Bmj Open 11, no. 8 (August 2021): e045369. https://doi.org/10.1136/bmjopen-2020-045369.Full Text
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Wu, Chenkai, Kehan Zhang, Michelle C. Odden, Anna M. Kucharska-Newton, Priya Palta, Kunihiro Matsushita, Rebecca F. Gottesman, and B Gwen Windham. “Subclinical Vascular Disease Burden and Premature Mortality Among Middle-aged Adults: the Atherosclerosis Risk in Communities Study.” Journal of General Internal Medicine 36, no. 7 (July 2021): 2048–54. https://doi.org/10.1007/s11606-020-06398-6.Full Text
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Liu, Yangyujin, Haoxue Li, Bei Wu, Xiaoting Liu, Honglin Chen, Hai-Yu Jin, and Chenkai Wu. “Association between primary caregiver type and mortality among Chinese older adults with disability: a prospective cohort study.” Bmc Geriatrics 21, no. 1 (April 2021): 268. https://doi.org/10.1186/s12877-021-02219-5.Full Text
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Häberle, Astrid D., Mary L. Biggs, Mary Cushman, Bruce M. Psaty, Anne B. Newman, Michael G. Shlipak, John Gottdiener, et al. “Level and Change in N-Terminal Pro-B-Type Natriuretic Peptide and Kidney Function and Survival to Age 90.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 76, no. 3 (February 2021): 478–84. https://doi.org/10.1093/gerona/glaa124.Full Text
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Zammit, Andrea R., Andrea M. Piccinin, Emily C. Duggan, Andriy Koval, Sean Clouston, Annie Robitaille, Cassandra L. Brown, et al. “A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults.” The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 76, no. 2 (January 2021): 229–41. https://doi.org/10.1093/geronb/gbz072.Full Text
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Cao, Xinqi, Guanglai Yang, Xurui Jin, Liu He, Xueqin Li, Zhoutao Zheng, Zuyun Liu, and Chenkai Wu. “A machine learning based aging measure among middle-aged and older Chinese adults: the China Health and Retirement Longitudinal Study,” 2021. https://doi.org/10.1101/2021.04.16.21255644.Full Text
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Jin, Xurui, Yiyang Sun, Tinglong Zhu, Yu Leng, Shuyi Guan, Kehan Zhang, Kangshuo Li, et al. “Machine Learning and Prediction of All-Cause Mortality among Chinese Older Adults,” 2021. https://doi.org/10.1101/2021.04.21.21255843.Full Text
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Fang, Evandro F., Chenglong Xie, Joseph A. Schenkel, Chenkai Wu, Qian Long, Honghua Cui, Yahyah Aman, et al. “A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks.” Ageing Research Reviews 64 (December 2020): 101174. https://doi.org/10.1016/j.arr.2020.101174.Full Text
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Jin, Haiyu, Jingyi Zhou, and Chenkai Wu. “Prevalence and health correlates of reduced kidney function among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study.” Bmj Open 10, no. 12 (December 2020): e042396. https://doi.org/10.1136/bmjopen-2020-042396.Full Text
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Wang, Ying, Yong-Jing Ping, Hai-Yu Jin, Ning Ge, and Chenkai Wu. “Prevalence and health correlates of anaemia among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study.” Bmj Open 10, no. 10 (October 2020): e038147. https://doi.org/10.1136/bmjopen-2020-038147.Full Text
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Wu, Chenkai, Ya-Xi Li, Megan M. Marron, Michelle C. Odden, Anne B. Newman, and Jason L. Sanders. “Quantifying and Classifying Physical Resilience Among Older Adults: The Health, Aging, and Body Composition Study.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 10 (September 2020): 1960–66. https://doi.org/10.1093/gerona/glz247.Full Text
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Jin, Hai-Yu, Xiaoting Liu, Qian-Li Xue, Shu Chen, and Chenkai Wu. “The Association between Frailty and Healthcare Expenditure among Chinese Older Adults.” Journal of the American Medical Directors Association 21, no. 6 (June 2020): 780–85. https://doi.org/10.1016/j.jamda.2020.03.008.Full Text
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Xu, Weihao, Yulun Cai, Hongbin Liu, Li Fan, and Chenkai Wu. “Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis.” Wiener Klinische Wochenschrift 132, no. 11–12 (June 2020): 301–9. https://doi.org/10.1007/s00508-020-01650-9.Full Text
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Zhu, Anna, Lijing Yan, Chenkai Wu, and John S. Ji. “Residential Greenness and Frailty Among Older Adults: A Longitudinal Cohort in China.” Journal of the American Medical Directors Association 21, no. 6 (June 2020): 759-765.e2. https://doi.org/10.1016/j.jamda.2019.11.006.Full Text
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Xu, Weihao, Ya-Xi Li, Yixin Hu, and Chenkai Wu. “Association of Frailty with recovery from disability among community-dwelling Chinese older adults: China health and retirement longitudinal study.” Bmc Geriatrics 20, no. 1 (March 2020): 119. https://doi.org/10.1186/s12877-020-01519-6.Full Text
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Zhang, Tianhang, Lijing Yan, Huashuai Chen, Haiyu Jin, and Chenkai Wu. “The Association between Allostatic Load and Mortality among Chinese Older Adults: The Chinese Longitudinal Health and Longevity Study,” 2020. https://doi.org/10.21203/rs.3.rs-31124/v1.Full Text
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Fan, Li, Weihao Xu, Yulun Cai, Yixin Hu, and Chenkai Wu. “Sleep Duration and the Risk of Dementia: A Systematic Review and Meta-analysis of Prospective Cohort Studies.” Journal of the American Medical Directors Association 20, no. 12 (December 2019): 1480-1487.e5. https://doi.org/10.1016/j.jamda.2019.06.009.Full Text
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Xu, Weihao, Ya-Xi Li, and Chenkai Wu. “Incidence of frailty among community-dwelling older adults: a nationally representative profile in China.” Bmc Geriatrics 19, no. 1 (December 2019): 378. https://doi.org/10.1186/s12877-019-1393-7.Full Text
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Wu, Chenkai, and Yixin Hu. “Blood pressure management in older adults: A multiple-choice question?” Journal of Clinical Hypertension (Greenwich, Conn.) 21, no. 11 (November 2019): 1645–46. https://doi.org/10.1111/jch.13697.Full Text
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Duggan, Emily C., Andrea M. Piccinin, Sean Clouston, Andriy V. Koval, Annie Robitaille, Andrea R. Zammit, Chenkai Wu, et al. “A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74, no. 11 (October 2019): 1793–1804. https://doi.org/10.1093/gerona/glz057.Full Text
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Wu, Chenkai. “Commentary: Impact of new hypertension guideline among people living with HIV in Ghana.” Journal of Clinical Hypertension (Greenwich, Conn.) 21, no. 6 (June 2019): 851–52. https://doi.org/10.1111/jch.13559.Full Text
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Wu, Chenkai, Dae H. Kim, Qian-Li Xue, David S. H. Lee, Ravi Varadhan, and Michelle C. Odden. “Association of Frailty With Recovery From Disability Among Community-Dwelling Older Adults: Results From Two Large U.S. Cohorts.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74, no. 4 (March 2019): 575–81. https://doi.org/10.1093/gerona/gly080.Full Text
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Wu, Chenkai, G John Geldhof, Qian-Li Xue, Dae H. Kim, Anne B. Newman, and Michelle C. Odden. “Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts.” American Journal of Epidemiology 187, no. 8 (August 2018): 1752–62. https://doi.org/10.1093/aje/kwy041.Full Text
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Wu, Chenkai, Anne B. Newman, Bi-Rong Dong, and Michelle C. Odden. “Index of Healthy Aging in Chinese Older Adults: China Health and Retirement Longitudinal Study.” Journal of the American Geriatrics Society 66, no. 7 (July 2018): 1303–10. https://doi.org/10.1111/jgs.15390.Full Text
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Wu, Chenkai, Kimlin Tam Ashing, Veronica C. Jones, and Lisa Barcelo. “The association of neighborhood context with health outcomes among ethnic minority breast cancer survivors.” Journal of Behavioral Medicine 41, no. 1 (February 2018): 52–61. https://doi.org/10.1007/s10865-017-9875-6.Full Text Open Access Copy
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Wu, Chenkai, Carmen A. Peralta, and Michelle C. Odden. “Reply to: Systolic Blood Pressure and Mortality: Role of Reverse Causation.” Journal of the American Geriatrics Society 66, no. 1 (January 2018): 206–7. https://doi.org/10.1111/jgs.15180.Full Text
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Wu, Chenkai, Ellen Smit, Qian-Li Xue, and Michelle C. Odden. “Prevalence and Correlates of Frailty Among Community-Dwelling Chinese Older Adults: The China Health and Retirement Longitudinal Study.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 73, no. 1 (December 2017): 102–8. https://doi.org/10.1093/gerona/glx098.Full Text Open Access Copy
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Wu, Chenkai, Ellen Smit, Jason L. Sanders, Anne B. Newman, and Michelle C. Odden. “A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 72, no. 10 (October 2017): 1437–44. https://doi.org/10.1093/gerona/glw334.Full Text Open Access Copy
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Wu, Chenkai, Ellen Smit, Carmen A. Peralta, Harini Sarathy, and Michelle C. Odden. “Functional Status Modifies the Association of Blood Pressure with Death in Elders: Health and Retirement Study.” Journal of the American Geriatrics Society 65, no. 7 (July 2017): 1482–89. https://doi.org/10.1111/jgs.14816.Full Text Open Access Copy
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Wu, Chenkai, Michael G. Shlipak, Robert S. Stawski, Carmen A. Peralta, Bruce M. Psaty, Tamara B. Harris, Suzanne Satterfield, et al. “Visit-to-Visit Blood Pressure Variability and Mortality and Cardiovascular Outcomes Among Older Adults: The Health, Aging, and Body Composition Study.” American Journal of Hypertension 30, no. 2 (February 2017): 151–58. https://doi.org/10.1093/ajh/hpw106.Full Text Open Access Copy
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Odden, Michelle C., Chenkai Wu, Michael G. Shlipak, Bruce M. Psaty, Ronit Katz, William B. Applegate, Tamara Harris, Anne B. Newman, Carmen A. Peralta, and Carmen A. Health ABC Study. “Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 71, no. 12 (December 2016): 1688–94. https://doi.org/10.1093/gerona/glw076.Full Text Open Access Copy
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Wu, Chenkai, Michelle C. Odden, Gwenith G. Fisher, and Robert S. Stawski. “Association of retirement age with mortality: a population-based longitudinal study among older adults in the USA.” Journal of Epidemiology and Community Health 70, no. 9 (September 2016): 917–23. https://doi.org/10.1136/jech-2015-207097.Full Text Open Access Copy
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Conference Papers
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Barcelo, Lisa, Mayra Serrano, Chenkai Wu, and Kimlin Ashing. “THE EFFECT OF NEIGHBORHOOD CONTEXT ON PHYSICAL AND MENTAL HEALTH IN MINORITY BREAST CANCER SURVIVORS.” In Annals of Behavioral Medicine, 49:S227–S227. SPRINGER, 2015.Link to Item
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Preprints
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Wu, Chenkai, Lijing Yan, Qian Long, Yunguo Liu, Jie Tan, Zhexun Lou, and Shenglan Tang. “Trends in Global Health Research among Universities in China: A Bibliometric Analysis.” Research Square, 2022. https://doi.org/10.21203/rs.3.rs-2267301/v1.Full Text
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- Teaching & Mentoring
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Recent Courses
- GLHLTH 707K: Biostatistics and Epidemiology for Global Health Science II 2023
- GLHLTH 781K: Ungraded Research in Global Health 2023
- GLHLTH 700K: Global Health Field Research: Planning and Skill Development 2022
- GLHLTH 705K: Biostatistics and Epidemiology for Global Health Science I 2022
- GLHLTH 707K: Biostatistics and Epidemiology for Global Health Science II 2022
- GLHLTH 700K: Global Health Field Research: Planning and Skill Development 2021
- GLHLTH 705K: Biostatistics and Epidemiology for Global Health Science I 2021
- GLHLTH 781K: Ungraded Research in Global Health 2021
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