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Christina Kelsey Zigler

Adjunct Associate Professor in Population Health Sciences
Population Health Sciences
DUMC Box 104023, Durham, NC 27708
215 Morris Street, Suite 210, Durham, NC 27708

Overview


Dr. Zigler is an independent investigator dedicated to improving the ways we measure patient-centered, meaningful health states, specializing in pediatrics, rare diseases, and clinical trials. She also is a methodological co-investigator who supports the application of novel statistical approaches and measurement strategies across a diverse array of studies.

Her methodological expertise includes established qualitative and quantitative techniques (i.e. concept elicitation, cognitive testing, classical test theory, item-response theory) alongside innovative methods (i.e. novel ways to identify meaningful change), to ensure the measures are ultimately centered in the patients’ meaningful experiences. Further, she works in a variety of populations and contexts, including pediatrics, where patient-reported outcome measures empower children to report directly on their own health status, and rare diseases, where a creative and pragmatic approach to measure development is necessary and patient-centeredness is essential.

Areas of Expertise: Health Measurement, Health Behavior, and Health Services Research

Current Duke Appointments & Affiliations


Adjunct Associate Professor in Population Health Sciences · 2024 - Present Population Health Sciences, Basic Science Departments

Recent Scholarly Works


Item comprehension and content coverage of patient-reported outcome measures for long COVID: a qualitative study.

Journal article Qual Life Res · July 23, 2026 PURPOSE: Fit-for-purpose clinical outcome assessments are essential to inform medical product development, but outcome measures for Long COVID, a new and devastating phenomenon, have not yet been established. The objective of this study was to evaluate ite ... Full text Link to item Cite
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Recent Grants


Clinical Outcome Assessments for Acute Pain Therapeutics in Infants and your Children (COA APTIC)

ResearchCo Investigator · Awarded by Food and Drug Administration · 2019 - 2027

Collaboratory Resource Coordinating Center for Pragmatic and Implementation Studies for the Management of Pain (PRISM) (U24)

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2024

Facilitating international, multi-disciplinary collaboration in pediatric localized scleroderma research: International validation of outcome measures

ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2021 - 2024

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Education


University of Pittsburgh · 2017 Ph.D.
University of Miami · 2010 M.S.Ed.