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Christina Kelsey Zigler

Adjunct Associate Professor in Population Health Sciences
Population Health Sciences
DUMC Box 104023, Durham, NC 27708
215 Morris Street, Suite 210, Durham, NC 27708

Overview


Dr. Zigler is an independent investigator dedicated to improving the ways we measure patient-centered, meaningful health states, specializing in pediatrics, rare diseases, and clinical trials. She also is a methodological co-investigator who supports the application of novel statistical approaches and measurement strategies across a diverse array of studies.

Her methodological expertise includes established qualitative and quantitative techniques (i.e. concept elicitation, cognitive testing, classical test theory, item-response theory) alongside innovative methods (i.e. novel ways to identify meaningful change), to ensure the measures are ultimately centered in the patients’ meaningful experiences. Further, she works in a variety of populations and contexts, including pediatrics, where patient-reported outcome measures empower children to report directly on their own health status, and rare diseases, where a creative and pragmatic approach to measure development is necessary and patient-centeredness is essential.

Areas of Expertise: Health Measurement, Health Behavior, and Health Services Research

Current Appointments & Affiliations


Adjunct Associate Professor in Population Health Sciences · 2024 - Present Population Health Sciences, Basic Science Departments

Recent Publications


Collection of Patient-Reported Outcome Measures in Rural and Underserved Populations.

Journal Article Appl Clin Inform · March 2025 BACKGROUND:  The NIH Pragmatic Trials Collaboratory supports the design and conduct of 31 embedded pragmatic clinical trials, and many of these trials use patient-reported outcome measures (PROMs) to provide valuable information about the patients' health ... Full text Link to item Cite

Evaluating anchor variables and variation in meaningful score differences for PROMIS® Pediatric measures in children and adolescents living with a rheumatic disease.

Journal Article Qual Life Res · December 2024 PURPOSE: Meaningful score differences (MSDs), as defined by recent FDA guidance, can improve the interpretation of outcome measure scores and score changes. Well-accepted methods for estimating MSDs typically rely on external anchor variables, but the appl ... Full text Link to item Cite
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Recent Grants


Clinical Outcome Assessments for Acute Pain Therapeutics in Infants and your Children (COA APTIC)

ResearchCo Investigator · Awarded by Food and Drug Administration · 2019 - 2025

Collaboratory Resource Coordinating Center for Pragmatic and Implementation Studies for the Management of Pain (PRISM) (U24)

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2024

View All Grants

Education, Training & Certifications


University of Pittsburgh · 2017 Ph.D.
University of Miami · 2010 M.S.Ed.