Christina Kelsey Zigler | Scholars@Duke

Christina Kelsey Zigler
Assistant Professor in Population Health Sciences

Dr. Zigler is an Assistant Professor in the Department of Population Health Sciences and part of the Center for Health Measurement. A psychometrician and statistician by training, she is an expert in the development and evaluation of clinical outcome measures. Her particular specialty is in designing patient-centered tools for children with rare diseases. She recently developed a patient-reported outcome measure to capture quality of life impact in children and adolescents with localized scleroderma, and is collaborating with a multidisciplinary team to adapt the measure for adults. She also is working with the Foundation for Angelman Syndrome Therapeutics (FAST) to design and evaluate a caregiver-reported measure to assess communication changes in individuals with Angelman Syndrome. The resulting tool will serve as an outcome measure in future clinical trials.

Dr. Zigler received her PhD in Research Methodology from the University of Pittsburgh and her MSEd in Counseling Psychology from the University of Miami. She has been involved in research for over 12 years and has published applied work in rheumatology, pediatrics, human engineering, veterans’ affairs, and rehabilitation science. Her other methodological interests include multilevel modeling, structural equation modeling, small sample size statistical methods, and anchoring vignettes.

Areas of Expertise: Health Measurement, Health Behavior, and Health Services Research

Current Appointments & Affiliations

Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2019

Contact Information

215 Morris Street, Suite 210, Durham, NC 27708
DUMC Box 104023, Durham, NC 27708
christina.zigler@duke.edu
The Department of Population Health Sciences' Center for Health Measurement

Background
Education, Training, & Certifications
- Ph.D., University of Pittsburgh 2017
- M.S.Ed., University of Miami 2010
Duke Appointment History
- Instructor in the Department of Population Health Sciences, Population Health Sciences, Basic Science Departments 2018 - 2019
Academic Positions Outside Duke
- Biostatistician, University of Pittsburgh. 2017 - 2018
Expertise
Subject Headings
Research
Selected Grants
External Relationships
- Boston Children's Hospital
- Pattern Health
- Pediatric Rheumatology European Society/Paediatric Rheumatology INternational Trials Organisation
- University of Pittsburgh
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bailes, Anna H., Rohit Navlani, Stephen Koscumb, Amanda Malecky, Oscar C. Marroquin, Ajay D. Wasan, Howard B. Gutstein, et al. “USE OF HEALTHCARE RESOURCES IN PATIENTS WITH LOW BACK PAIN AND COMORBID DEPRESSION OR ANXIETY.” The Spine Journal, March 2021. https://doi.org/10.1016/j.spinee.2021.03.031.
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  - Pruitt, David W., Christina K. Zigler, Teresa L. Massagli, and Amy J. Houtrow. “Assessing the Field of Pediatric Rehabilitation Medicine's Interest in Expanding Fellowship Training to Pediatricians.” Pm R, January 5, 2021. https://doi.org/10.1002/pmrj.12549.
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  - Zigler, C. K., and A. Roberts. “A child's experience of itch: the first step towards patient-centred measures.” Br J Dermatol, December 15, 2020. https://doi.org/10.1111/bjd.19678.
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  - Zigler, Christina K., Heidi Jacobe, Kaveh Ardalan, Theresa M. Coles, Suzane Lane, Kaila L. Schollaert, and Kathryn S. Torok. “The importance of development standards for anchoring vignettes: an illustrative example from pediatric localized scleroderma quality of life.” Qual Life Res 29, no. 12 (December 2020): 3263–72. https://doi.org/10.1007/s11136-020-02575-6.
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  - Zigler, C. K., K. Ardalan, A. Hernandez, A. E. Caliendo, K. E. Magee, M. A. Terry, C. M. Mann, and K. S. Torok. “Exploring the impact of paediatric localized scleroderma on health-related quality of life: focus groups with youth and caregivers.” Br J Dermatol 183, no. 4 (October 2020): 692–701. https://doi.org/10.1111/bjd.18879.
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  - Fridman, Ilona, Nicole Lucas, Debra Henke, and Christina K. Zigler. “Association Between Public Knowledge About COVID-19, Trust in Information Sources, and Adherence to Social Distancing: Cross-Sectional Survey.” Jmir Public Health Surveill 6, no. 3 (September 15, 2020): e22060. https://doi.org/10.2196/22060.
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  - Davis, W Austin, Christina K. Zigler, Theresa M. Crytzer, Sara Izzo, Amy J. Houtrow, and Brad E. Dicianno. “Factors Associated With Ambulation in Myelomeningocele: A Longitudinal Study From the National Spina Bifida Patient Registry.” Am J Phys Med Rehabil 99, no. 7 (July 2020): 586–94. https://doi.org/10.1097/PHM.0000000000001406.
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  - Santa Barbara, Matthew T., Megan Cortazzo, Trent Emerick, Jessica Furnier, Jesse Duff, Steve Shapiro, Christine K. Zigler, Andrea Badway, and Gwendolyn Sowa. “Descriptive Analysis of an Interdisciplinary Musculoskeletal Program.” Pm R 12, no. 7 (July 2020): 639–46. https://doi.org/10.1002/pmrj.12288.
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  - Houtrow, Amy J., David W. Pruitt, and Christina K. Zigler. “Gender-Based Salary Inequities Among Pediatric Rehabilitation Medicine Physicians in the United States.” Arch Phys Med Rehabil 101, no. 5 (May 2020): 741–49. https://doi.org/10.1016/j.apmr.2019.11.007.
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  - Zigler, C. K., K. Ardalan, S. Lane, K. L. Schollaert, and K. S. Torok. “A novel patient-reported outcome for paediatric localized scleroderma: a qualitative assessment of content validity.” Br J Dermatol 182, no. 3 (March 2020): 625–35. https://doi.org/10.1111/bjd.18512.
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  - Houtrow, Amy J., Christina K. Zigler, and David W. Pruitt. “The State of the Field: Results from the 2014 and 2017 Pediatric Rehabilitation Medicine Practice Surveys.” Pm R 12, no. 2 (February 2020): 168–79. https://doi.org/10.1002/pmrj.12235.
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  - Vasquez, Stephanie Gabela, Megan D’Innocenzo, Jon Pearlman, Christy Zigler, Yasmin Garcia Mendez, Perth Rozen, Eviana Hapsari Dewi, and Ignatius Praptoraharjo. “Wheelchair user’s voice: a pilot study in Indonesia,” January 16, 2020. https://doi.org/10.1101/2020.01.16.908772.
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  - Treble-Barna, Amery, Jamie Patronick, Srivatsan Uchani, Noelle C. Marousis, Christina K. Zigler, Ericka L. Fink, Patrick M. Kochanek, Yvette P. Conley, and Keith Owen Yeates. “Epigenetic Effects on Pediatric Traumatic Brain Injury Recovery (EETR): An Observational, Prospective, Longitudinal Concurrent Cohort Study Protocol.” Front Neurol 11 (2020): 460. https://doi.org/10.3389/fneur.2020.00460.
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  - Dicianno, Brad E., James Joseph, Stacy Eckstein, Christina K. Zigler, Eleanor J. Quinby, Mark R. Schmeler, Richard M. Schein, Jon Pearlman, and Rory A. Cooper. “The future of the provision process for mobility assistive technology: a survey of providers.” Disabil Rehabil Assist Technol 14, no. 4 (May 2019): 338–45. https://doi.org/10.1080/17483107.2018.1448470.
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  - Kurzinski, K. L., C. K. Zigler, and K. S. Torok. “Prediction of disease relapse in a cohort of paediatric patients with localized scleroderma.” Br J Dermatol 180, no. 5 (May 2019): 1183–89. https://doi.org/10.1111/bjd.17312.
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  - Zigler, Christina K., and Feifei Ye. “A Comparison of Multilevel Mediation Modeling Methods: Recommendations for Applied Researchers.” Multivariate Behav Res 54, no. 3 (May 2019): 338–59. https://doi.org/10.1080/00273171.2018.1527676.
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  - Paulson, Andrea, Christina K. Zigler, Amy Houtrow, and David Pruitt. “Botulinum Toxin: Techniques Within Pediatric Physiatry.” Pm R 11, no. 1 (January 2019): 38–44. https://doi.org/10.1016/j.pmrj.2018.06.004.
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  - Dicianno, Brad E., Adam Sherman, Christian Roehmer, and Christina K. Zigler. “Co-morbidities Associated With Early Mortality in Adults With Spina Bifida.” Am J Phys Med Rehabil 97, no. 12 (December 2018): 861–65. https://doi.org/10.1097/PHM.0000000000000964.
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  - Dicianno, Brad E., James Joseph, Stacy Eckstein, Christina K. Zigler, Eleanor Quinby, Mark R. Schmeler, Richard M. Schein, Jon Pearlman, and Rory A. Cooper. “The Voice of the Consumer: A Survey of Veterans and Other Users of Assistive Technology.” Mil Med 183, no. 11–12 (November 1, 2018): e518–25. https://doi.org/10.1093/milmed/usy033.
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  - Ardalan, K., G. E. Switzer, C. K. Zigler, N. M. Hershey, and K. S. Torok. “Psychometric properties of the children’s dermatology life quality index in pediatric localized scleroderma.” Journal of Scleroderma and Related Disorders 3, no. 2 (January 1, 2018): 175–81. https://doi.org/10.1177/2397198318760768.
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  - Fisher, M. T., C. K. Zigler, and A. J. Houtrow. “Factors affecting procedural pain in children during and immediately after intramuscular botulinum toxin injections for spasticity.” J Pediatr Rehabil Med 11, no. 3 (2018): 193–97. https://doi.org/10.3233/PRM-170516.
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  - Worobey, Lynn A., Christina K. Zigler, Randall Huzinec, Stephanie K. Rigot, JongHun Sung, and Laura A. Rice. “Reliability and Validity of the Revised Transfer Assessment Instrument.” Top Spinal Cord Inj Rehabil 24, no. 3 (2018): 217–26. https://doi.org/10.1310/sci2403-217.
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  - Ardalan, Kaveh, Christina K. Zigler, and Kathryn S. Torok. “Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma.” Arthritis Care Res (Hoboken) 69, no. 7 (July 2017): 1082–87. https://doi.org/10.1002/acr.23101.
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  - Poff, S., S. C. Li, C. E. Kelsey, I. Foeldvari, and K. S. Torok. “Durometry as an outcome measure in juvenile localized scleroderma.” Br J Dermatol 174, no. 1 (January 2016): 228–30. https://doi.org/10.1111/bjd.14103.
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  - Torok, Kathryn S., Katherine Kurzinski, Christina Kelsey, Jonathan Yabes, Kelsey Magee, Abbe N. Vallejo, Thomas Medsger, and Carol A. Feghali-Bostwick. “Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles.” Semin Arthritis Rheum 45, no. 3 (December 2015): 284–93. https://doi.org/10.1016/j.semarthrit.2015.06.006.
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  - Kelsey, Christina E., and Kathryn S. Torok. “The Localized Scleroderma Cutaneous Assessment Tool: responsiveness to change in a pediatric clinical population.” J Am Acad Dermatol 69, no. 2 (August 2013): 214–20. https://doi.org/10.1016/j.jaad.2013.02.007.
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  - Magee, Kelsey E., Christina E. Kelsey, Katherine L. Kurzinski, Jonhan Ho, Logan R. Mlakar, Carol A. Feghali-Bostwick, and Kathryn S. Torok. “Interferon-gamma inducible protein-10 as a potential biomarker in localized scleroderma.” Arthritis Res Ther 15, no. 6 (2013): R188. https://doi.org/10.1186/ar4378.
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  - Fridman, Ilona, Nicole Lucas, Debra Henke, and Christina K. Zigler. “Association Between Public Knowledge About COVID-19, Trust in Information Sources, and Adherence to Social Distancing: Cross-Sectional Survey (Preprint),” n.d. https://doi.org/10.2196/preprints.22060.
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- Conference Papers
  - Lucas, Nicole, Molly McFatrich, Christina K. Zigler, Allyson Berent, Paula Evans, Kelly Gordon, Harrison N. Jones, Jennifer Panagoulias, and Bryce B. Reeve. “Designing measures of communication ability in individuals with Angelman syndrome.” In Quality of Life Research, 28:S117–S117. SPRINGER, 2019.
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Scholarly, Clinical, & Service Activities
Presentations & Appearances

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Education, Training, & Certifications

Duke Appointment History

Academic Positions Outside Duke

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Presentations & Appearances