Christos Kyriakopoulos

Preprint · April 26, 2026 ABSTRACTBackgroundMechanical ventricular unloading and systemic circulatory support with left ventricular assist devices (LVADs) enab ... Full text Cite

Peroxisome proliferator-activated receptor gamma ( PPARG )-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion.

Preprint · February 15, 2025 Ischemic heart disease and acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Improvements have been made in coronary interventions to restore blood flow, but ischemia/reperfusion (I/R) injury significantly impacts clinical ou ... Full text Link to item Cite

Increased CPT1a expression is a critical cardioprotective response to pathological stress that suppresses gene programs for remodeling and enables rescue by gene transfer

Preprint · October 2, 2024 Text AbstractBackgroundCarnitine palmitoyl transferase 1 (CPT1) is a rate-limiting enzyme for long chain fatty acid oxidation (FAO) i ... Full text Cite

Integrating molecular and clinical variables to predict myocardial recovery.

Preprint · April 20, 2024 Mechanical unloading and circulatory support with left ventricular assist devices (LVADs) mediate significant myocardial improvement in a subset of advanced heart failure (HF) patients. The clinical and biological phenomena associated with cardiac recovery ... Full text Link to item Cite

Mitochondria possess a large, non-selective ionic current that is enhanced during cardiac injury.

Preprint · November 16, 2023 Mitochondrial ion channels are essential for energy production and cell survival. To avoid depleting the electrochemical gradient used for ATP synthesis, channels so far described in the mitochondrial inner membrane open only briefly, are highly ion-select ... Full text Link to item Cite