Clare Smith
Assistant Professor of Molecular Genetics and Microbiology
Current Appointments & Affiliations
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2019
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2019
Contact Information
- 264 Jones, Box 3054, Durham, NC 27710
- 270 Jones Box3054, 207 Research Drive, Durham, NC 27710
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clare.m.smith@duke.edu
(919) 613-6378
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Smith Lab @ Duke
- Background
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Education, Training, & Certifications
- Ph.D., University of Tasmania (Australia) 2012
- Research
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Selected Grants
- Innate Immune Determinants of Granuloma Formation in the Zebrafish awarded by National Institutes of Health 2017 - 2027
- Genetic Dissection of Angiogenesis in the Tuberculous Granuloma awarded by National Institutes of Health 2017 - 2027
- Linking human TB genetic susceptibility loci to granuloma biology awarded by National Institutes of Health 2022 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Dissecting the genetic basis of protective immunity to tuberculosis in diverse hosts awarded by National Institutes of Health 2021 - 2024
- Metabolic determinants of Mtb virulence, vulnerability and variation Animal Core E awarded by Brigham and Women's Hospital 2021 - 2023
- New models to dissect the genetic determinants of disease tolerance awarded by University of North Carolina - Chapel Hill 2020 - 2021
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Adefisayo, Oyindamola O., Erin R. Curtis, and Clare M. Smith. “Mycobacterial Genetic Technologies for Probing the Host-Pathogen Microenvironment.” Infect Immun, May 30, 2023, e0043022. https://doi.org/10.1128/iai.00430-22.Full Text Link to Item
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Wilburn, Kaley M., Rachel K. Meade, Emma M. Heckenberg, Jacob Dockterman, Jörn Coers, Christopher M. Sassetti, Andrew J. Olive, and Clare M. Smith. “Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.” Infection and Immunity 91, no. 2 (February 2023): e0051022. https://doi.org/10.1128/iai.00510-22.Full Text
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Yaron, Tomer M., Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, et al. “Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.” Sci Signal 15, no. 757 (October 25, 2022): eabm0808. https://doi.org/10.1126/scisignal.abm0808.Full Text Link to Item
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Smith, Clare M., Richard E. Baker, Megan K. Proulx, Bibhuti B. Mishra, Jarukit E. Long, Sae Woong Park, Ha-Na Lee, et al. “Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.” Elife 11 (February 3, 2022). https://doi.org/10.7554/eLife.74419.Full Text Link to Item
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Trimarco, Joseph D., Brook E. Heaton, Ryan R. Chaparian, Kaitlyn N. Burke, Raquel A. Binder, Gregory C. Gray, Clare M. Smith, Vineet D. Menachery, and Nicholas S. Heaton. “TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2.” Plos Pathog 17, no. 5 (May 2021): e1009599. https://doi.org/10.1371/journal.ppat.1009599.Full Text Link to Item
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Bourgeois, Jeffrey S., Clare M. Smith, and Dennis C. Ko. “These Are the Genes You're Looking For: Finding Host Resistance Genes.” Trends Microbiol 29, no. 4 (April 2021): 346–62. https://doi.org/10.1016/j.tim.2020.09.006.Full Text Link to Item
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Lovewell, Rustin R., Christina E. Baer, Bibhuti B. Mishra, Clare M. Smith, and Christopher M. Sassetti. “Granulocytes act as a niche for Mycobacterium tuberculosis growth.” Mucosal Immunol 14, no. 1 (January 2021): 229–41. https://doi.org/10.1038/s41385-020-0300-z.Full Text Link to Item
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Yaron, Tomer M., Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, et al. “The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.” Biorxiv, December 16, 2020. https://doi.org/10.1101/2020.08.14.251207.Full Text Link to Item
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Sigmon, John Sebastian, Matthew W. Blanchard, Ralph S. Baric, Timothy A. Bell, Jennifer Brennan, Gudrun A. Brockmann, A Wesley Burks, et al. “Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research.” Genetics 216, no. 4 (December 2020): 905–30. https://doi.org/10.1534/genetics.120.303596.Full Text Link to Item
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Bellerose, Michelle M., Megan K. Proulx, Clare M. Smith, Richard E. Baker, Thomas R. Ioerger, and Christopher M. Sassetti. “Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis.” Msystems 5, no. 4 (August 4, 2020). https://doi.org/10.1128/mSystems.00396-20.Full Text Link to Item
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Olive, Andrew, Clare Smith, Christina Baer, Jörn Coers, and Christopher Sassetti. “Mycobacterium tuberculosis evasion of Guanylate Binding Protein-mediated host defense in mice requires the ESX1 secretion system,” 2020. https://doi.org/10.1101/2020.07.27.223362.Full Text
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Smith, Clare, Richard Baker, Megan Proulx, Bibhuti Mishra, Jarukit Long, Sae Woong Park, Ha-Na Lee, et al. “Host-pathogen genetic interactions underlie tuberculosis susceptibility,” 2020. https://doi.org/10.1101/2020.12.01.405514.Full Text
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Smith, Clare M., Megan K. Proulx, Rocky Lai, Michael C. Kiritsy, Timothy A. Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, et al. “Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.” Mbio 10, no. 6 (November 26, 2019). https://doi.org/10.1128/mBio.02791-19.Full Text Open Access Copy Link to Item
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Subramaniyam, Siddharth, Michael A. DeJesus, Anisha Zaveri, Clare M. Smith, Richard E. Baker, Sabine Ehrt, Dirk Schnappinger, Christopher M. Sassetti, and Thomas R. Ioerger. “Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.” Bmc Bioinformatics 20, no. 1 (November 21, 2019): 603. https://doi.org/10.1186/s12859-019-3156-z.Full Text Open Access Copy Link to Item
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Bellerose, Michelle M., Seung-Hun Baek, Chuan-Chin Huang, Caitlin E. Moss, Eun-Ik Koh, Megan K. Proulx, Clare M. Smith, et al. “Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy.” Mbio 10, no. 4 (July 30, 2019). https://doi.org/10.1128/mBio.00663-19.Full Text Link to Item
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Smith, Clare, Megan Proulx, Rocky Lai, Michael Kiritsy, Timothy Bell, Pablo Hock, Fernando Pardo-Manuel de Villena, et al. “Functionally overlapping variants control TB susceptibility in Collaborative Cross mice,” 2019. https://doi.org/10.1101/785725.Full Text
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Smith, Clare M., and Christopher M. Sassetti. “Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?” Trends Microbiol 26, no. 11 (November 2018): 892–95. https://doi.org/10.1016/j.tim.2018.08.002.Full Text Link to Item
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Olive, Andrew J., Clare M. Smith, Michael C. Kiritsy, and Christopher M. Sassetti. “The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.” J Immunol 201, no. 6 (September 15, 2018): 1705–16. https://doi.org/10.4049/jimmunol.1800202.Full Text Link to Item
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DeJesus, Michael A., Subhalaxmi Nambi, Clare M. Smith, Richard E. Baker, Christopher M. Sassetti, and Thomas R. Ioerger. “Statistical analysis of genetic interactions in Tn-Seq data.” Nucleic Acids Res 45, no. 11 (June 20, 2017): e93. https://doi.org/10.1093/nar/gkx128.Full Text Link to Item
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Mishra, Bibhuti B., Rustin R. Lovewell, Andrew J. Olive, Guoliang Zhang, Wenfei Wang, Eliseo Eugenin, Clare M. Smith, et al. “Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis.” Nat Microbiol 2 (May 15, 2017): 17072. https://doi.org/10.1038/nmicrobiol.2017.72.Full Text Link to Item
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Smith, Clare M., Ante Jerkovic, Thy Thuc Truong, Simon J. Foote, James S. McCarthy, and Brendan J. McMorran. “Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study.” Sci Rep 7 (February 8, 2017): 41975. https://doi.org/10.1038/srep41975.Full Text Link to Item
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Smith, Clare M., Megan K. Proulx, Andrew J. Olive, Dominick Laddy, Bibhuti B. Mishra, Caitlin Moss, Nuria Martinez Gutierrez, et al. “Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.” Mbio 7, no. 5 (September 20, 2016). https://doi.org/10.1128/mBio.01516-16.Full Text Open Access Copy Link to Item
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Smith, Clare, Megan Proulx, Andrew Olive, Dominick Laddy, Bibhuti Mishra, Caitlin Moss, Nuria Martinez Gutierrez, et al. “Tuberculosis susceptibility and vaccine protection are independently controlled by host genotype,” 2016. https://doi.org/10.1101/064253.Full Text
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Smith, Clare M., Ante Jerkovic, Hervé Puy, Ingrid Winship, Jean-Charles Deybach, Laurent Gouya, Giel van Dooren, et al. “Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites.” Blood 125, no. 3 (January 15, 2015): 534–41. https://doi.org/10.1182/blood-2014-04-567149.Full Text Link to Item
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Brizuela, Mariana, Hong Ming Huang, Clare Smith, Gaetan Burgio, Simon J. Foote, and Brendan J. McMorran. “Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine.” Plos One 9, no. 4 (2014): e92411. https://doi.org/10.1371/journal.pone.0092411.Full Text Link to Item
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McMorran, Brendan J., Laura Wieczorski, Karen E. Drysdale, Jo-Anne Chan, Hong Ming Huang, Clare Smith, Chalachew Mitiku, James G. Beeson, Gaetan Burgio, and Simon J. Foote. “Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum.” Science 338, no. 6112 (December 7, 2012): 1348–51. https://doi.org/10.1126/science.1228892.Full Text Link to Item
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Longley, Rhea, Clare Smith, Anny Fortin, Joanne Berghout, Brendan McMorran, Gaétan Burgio, Simon Foote, and Philippe Gros. “Host resistance to malaria: using mouse models to explore the host response.” Mamm Genome 22, no. 1–2 (February 2011): 32–42. https://doi.org/10.1007/s00335-010-9302-6.Full Text Link to Item
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Preprints
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Meade, Rachel K., Jarukit E. Long, Adrian Jinich, Kyu Y. Rhee, David G. Ashbrook, Robert W. Williams, Christopher M. Sassetti, and Clare M. Smith. “Genome-wide screen identifies host loci that modulate M. tuberculosis fitness in immunodivergent mice.,” March 6, 2023. https://doi.org/10.1101/2023.03.05.528534.Full Text Link to Item
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Jinich, Adrian, Sakila Nazia, Andrea Tellez, Amy Wu, Clare Smith, and Kyu Rhee. “Genome-wide co-essentiality analysis inMycobacterium tuberculosisreveals an itaconate defense enzyme module.” BioRxiv, 2022. https://doi.org/10.1101/2022.09.27.509804.Full Text
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Wilburn, Kaley, Rachel Meade, Emma Heckenberg, Jacob Dockterman, Jörn Coers, Christopher Sassetti, Andrew Olive, and Clare Smith. “Differential requirement for IRGM proteins during tuberculosis infection in mice.” BioRxiv, 2022. https://doi.org/10.1101/2022.11.09.515519.Full Text
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- Scholarly, Clinical, & Service Activities
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Service to the Profession
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