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Clare Smith

Assistant Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
264 Jones, Box 3054, Durham, NC 27710
270 Jones BOX3054, 207 Research Drive, Durham, NC 27710


The Smith Lab are interested in host genetic diversity, bacterial variation, and how these host-pathogen genetic interactions drive tuberculosis disease states.

Systems Genetics of Tuberculosis
: We leverage host diversity in mice and macrophages from wild-derived mouse strains and diverse mouse panels, including the Collaborative Cross and BXD mammalian resources. In parallel, we define the bacterial genetic requirements for growth and adaptation across these diverse host environments through cutting-edge mycobacterial genetic approaches. These combined host and bacterial genome-wide approaches allows the interrogation of each host-pathogen interaction underlying tuberculosis disease, drug treatments and vaccine interventions. 

Current Appointments & Affiliations

Assistant Professor of Molecular Genetics and Microbiology · 2019 - Present Molecular Genetics and Microbiology, Basic Science Departments
Assistant Professor of Cell Biology · 2022 - Present Cell Biology, Basic Science Departments
Member of the Duke Human Vaccine Institute · 2019 - Present Duke Human Vaccine Institute, Institutes and Centers

Education, Training & Certifications

University of Tasmania (Australia) · 2012 Ph.D.