Clare Smith

Preprint · August 7, 2025 Abstract Tuberculosis (TB) is a global epidemic that has threatened human health throughout recorded history. TB disease, caused by infection with Mycobacter ... Full text Cite

Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.

Preprint · April 1, 2025 Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB dise ... Full text Link to item Cite

Genome-wide screen identifies host loci that modulate M. tuberculosis fitness in immunodivergent mice.

Preprint · March 6, 2023 Genetic differences among mammalian hosts and Mycobacterium tuberculosis ( Mtb ) strains determine diverse tuberculosis (TB) patient outcomes. The advent of recombinant inbred mouse panels and next-generation transposon mutagenesis and sequencing approache ... Full text Link to item Cite

Genome-wide co-essentiality analysis in Mycobacterium tuberculosis reveals an itaconate defense enzyme module

Preprint · 2022 Genome-wide random mutagenesis screens using transposon sequencing (TnSeq) have been a cornerstone of functional genetics in Mycobacterium tuberculosis ( Mtb ), helping to define gene essentiality across a wide range of experimental conditions. Here, we ... Full text Cite

Differential requirement for IRGM proteins during tuberculosis infection in mice

Preprint · 2022 ABSTRACT Mycobacterium tuberculosis ( Mtb ) is a bacterium that exclusively resides in human hosts and remains a dominant cause of morbidity and mortality among infectious diseases worldwide. Host protection against Mtb infection is dependent o ... Full text Cite