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Journal Article Ann Neurol · February 2026 OBJECTIVE: To establish a framework for validating candidate biomarkers of cerebral small vessel diseases (SVD) associated with cognitive impairment and characterize individuals enrolled by the MarkVCID2 consortium under this framework. METHODS: Participan ... Full text Link to item Cite

Use of Cangrelor for Patients Undergoing Coronary Artery Bypass Grafting: Insights From the CAMEO Registry.

Journal Article JACC Adv · December 2025 BACKGROUND: Little is known about the use of cangrelor in patients with acute myocardial infarction (AMI) undergoing coronary artery bypass grafting (CABG). OBJECTIVES: The purpose of this study was to examine characteristics and patterns of cangrelor util ... Full text Link to item Cite

Circulating prostasin is an independent marker of mortality risk in patients with idiopathic pulmonary fibrosis.

Journal Article ERJ Open Res · May 2025 BACKGROUND: Prostasin is expressed in the lung epithelium where it regulates fluid and electrolyte balance via sodium channel proteolysis. We investigated whether circulating prostasin levels are associated with the presence and severity of idiopathic pulm ... Full text Link to item Cite

Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.

Journal Article Circ Cardiovasc Interv · December 2024 BACKGROUND: The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, ... Full text Link to item Cite

The Use of Cangrelor in Cardiogenic Shock: Insights from the CAMEO Registry.

Journal Article J Card Fail · October 2024 INTRODUCTION: Little is known about the use of cangrelor in patients with myocardial infarction (MI) presenting with cardiogenic shock (CS). METHODS: CAMEO (Cangrelor in Acute MI: Effectiveness and Outcomes) is a multicenter observational registry evaluati ... Full text Link to item Cite

Longitudinal Management of Cardiovascular Risk Factors Among Postpartum Women.

Journal Article J Womens Health (Larchmt) · July 2024 Background: Pregnancy-related cardiovascular (CV) conditions, including hypertensive disorders of pregnancy (HDP) and gestational diabetes (GDM), are associated with increased long-term CV risk. Methods: This retrospective cohort study defined the prevalen ... Full text Link to item Cite

Preliminary analysis of baseline characteristics, patient reported outcomes (PROs), and treatment selection in ODYSSEY

Conference Journal of Clinical Oncology · January 1, 2024 Background: Tyrosine kinase inhibitors (TKI) and immuno-oncology (IO) agents alone or in combination have revolutionized the landscape of management for untreated metastatic renal cell carcinoma (mRCC). Baseline quality of life (QOL) outside of interventio ... Full text Cite

Generalizability of an EHR-network dataset to the United States for cardiovascular disease conditions: Comparison of Cerner real world data with the national inpatient sample.

Journal Article Am Heart J · September 2023 BACKGROUND: Electronic Health Record (EHR) data from health systems are increasingly being combined for clinical research purposes. Yet, it remains unclear whether these large EHR data sources provide a representative assessment of national disease prevale ... Full text Link to item Cite

Bending the Cardiovascular Event Curve by Evaluating the Potential Impact of Achieving Low-Density Lipoprotein Cholesterol Goal Across a Large Health System Among Secondary Prevention Patients.

Journal Article Am J Cardiol · January 1, 2023 Guidelines recommend aggressive low-density lipoprotein cholesterol (LDL-C) lowering in patients with atherosclerotic cardiovascular disease (ASCVD). However, the recommended threshold of LDL-C ≤70 mg/dL is often not achieved. We used data from the Duke Un ... Full text Link to item Cite

Use of Sodium-Glucose Cotransporter 2 Inhibitors and Glucagonlike Peptide-1 Receptor Agonists in Patients With Diabetes and Cardiovascular Disease in Community Practice.

Journal Article JAMA cardiology · January 2023 ImportanceRecent national guidelines recommend sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagonlike peptide-1 receptor agonists (GLP-1 RA) in patients with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD); ye ... Full text Cite

Predictors of Left Main Coronary Artery Disease in the ISCHEMIA Trial.

Journal Article J Am Coll Cardiol · February 22, 2022 BACKGROUND: Detection of ≥50% diameter stenosis left main coronary artery disease (LMD) has prognostic and therapeutic implications. Noninvasive stress imaging or an exercise tolerance test (ETT) are the most common methods to detect obstructive coronary a ... Full text Link to item Cite

Cardiovascular Events and Long-Term Risk of Sudden Death Among Stabilized Patients After Acute Coronary Syndrome: Insights From IMPROVE-IT.

Journal Article J Am Heart Assoc · February 15, 2022 Background Unlike patients with low ejection fraction after an acute coronary syndrome (ACS), little is known about the long-term incidence and influence of cardiovascular events before sudden death among stabilized patients after ACS. Methods and Results ... Full text Link to item Cite

Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.

Journal Article Circulation · September 28, 2021 BACKGROUND: The ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) postulated that patients with stable coronary artery disease (CAD) and moderate or severe ischemia would benefit from revasculariz ... Full text Link to item Cite

Lipoprotein(a) Testing Patterns in a Large Health System.

Journal Article Am J Cardiol · August 15, 2021 Lipoprotein (a) [Lp(a)] is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). As directed therapy for Lp(a) emerges, it is important to understand patterns of Lp(a) testing in routine clinical practice. We set out to characte ... Full text Link to item Cite

Plasma Volume Status and Its Association With In-Hospital and Postdischarge Outcomes in Decompensated Heart Failure.

Journal Article J Card Fail · March 2021 BACKGROUND: Prior analyses suggest an association between formula-based plasma volume (PV) estimates and outcomes in heart failure (HF). We assessed the association between estimated PV status by the Duarte-ePV and Kaplan Hakim (KH-ePVS) formulas, and in-h ... Full text Link to item Cite

Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.

Journal Article Respir Care · September 2020 BACKGROUND: Unanticipated respiratory compromise that lead to unplanned intubations is a known phenomenon in hospitalized patients. Most events occur in patients at high risk in well-monitored units; less is known about the incidence, risk factors, and tra ... Full text Link to item Cite

DIFFERENCES IN ACHIEVING HBA1C GOALS AMONG PATIENTS SEEN BY ENDOCRINOLOGISTS AND PRIMARY CARE PROVIDERS.

Journal Article Endocr Pract · May 2019 Objective: This study evaluated whether there is a difference in the proportion of patients with type 2 diabetes who achieve a hemoglobin A1c (HbA1c) <7% within one year following treatment by an endocrinologist or primary care physician (PCP). Methods: We ... Full text Link to item Cite

Adversarial Time-to-Event Modeling.

Journal Article Proc Mach Learn Res · July 2018 Modern health data science applications leverage abundant molecular and electronic health data, providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called survival analysis, st ... Link to item Cite

Adversarial time-to-event modeling

Journal Article 35th International Conference on Machine Learning Icml 2018 · January 1, 2018 Modern health data science applications leverage abundant molecular and electronic health data; providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called survival analysis, st ... Cite