Scholars@Duke
Darcy Louzao

Darcy Louzao

Clinical Trials Project Leader III
Duke Clinical Research Institute
darcy.louzao@duke.edu
Box 3850 Med Ctr, Durham, NC 27708
200 Morgan St, Durham, NC 27701

Scholarly Works

Lessons Learned From Using PCORnet® to Support the Pathways to Cardiovascular Disease Prevention and Impact of Specialty Referral Among People With HIV From Underrepresented Racial and Ethnic Groups in the Southern United States (PATHWAYS Study).

Journal article Med Care · February 1, 2026 OBJECTIVE: The PATHWAYS Study utilized data from the PCORnet® Common Data Model (CDM) at 4 sites participating in the STAR Clinical Research Network to assess the frequency of cardiology encounters for under-represented racial and ethnic minority group peo ... Full text Open Access Link to item Cite

Investigating the Use of the Fast Health Care Interoperability Resources (FHIR) Standard to Support Data Activities Across the PCORnet® Infrastructure: Lessons Learned From the FHIR Pilots of the Coordinating Center for PCORnet®.

Journal article Med Care · February 1, 2026 BACKGROUND: Institutions that participate in PCORnet® transform their local electronic health record (EHR) data into the PCORnet® Common Data Model (CDM), which is then used to generate data extracts for PCORnet® Studies. PCORnet® Studies can also include ... Full text Open Access Link to item Cite

Assessing and improving research readiness in PCORnet®.

Journal article J Clin Transl Sci · 2025 PURPOSE: We describe the steps taken to assess and improve the research readiness of data within PCORnet®, specifically focusing on the results of the PCORnet data curation process between Cycle 7 (October 2019) and Cycle 16 (October 2024). MATERIAL AND ME ... Full text Open Access Link to item Cite

Cardiology Encounters for Underrepresented Racial and Ethnic Groups with Human Immunodeficiency Virus and Borderline Cardiovascular Disease Risk.

Journal article J Racial Ethn Health Disparities · June 2024 BACKGROUND: Underrepresented racial and ethnic groups (UREGs) with HIV have a higher risk of cardiovascular disease (CVD) compared with the general population. Referral to a cardiovascular specialist improves CVD risk factor management in high-risk individ ... Full text Open Access Link to item Cite

Assessing the impact of privacy-preserving record linkage on record overlap and patient demographic and clinical characteristics in PCORnet®, the National Patient-Centered Clinical Research Network.

Journal article J Am Med Inform Assoc · February 16, 2023 OBJECTIVE: This article describes the implementation of a privacy-preserving record linkage (PPRL) solution across PCORnet®, the National Patient-Centered Clinical Research Network. MATERIAL AND METHODS: Using a PPRL solution from Datavant, we quantified t ... Full text Open Access Link to item Cite

Establishing a framework for privacy-preserving record linkage among electronic health record and administrative claims databases within PCORnet®, the National Patient-Centered Clinical Research Network.

Journal article BMC Res Notes · October 31, 2022 OBJECTIVE: The aim of this study was to determine whether a secure, privacy-preserving record linkage (PPRL) methodology can be implemented in a scalable manner for use in a large national clinical research network. RESULTS: We established the governance a ... Full text Open Access Link to item Cite

Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.

Journal article Pharmacol Res Perspect · October 2020 We used electronic medical record (EMR) data in the National Patient-Centered Clinical Research Network (PCORnet) to characterize "real-world" prescription patterns of Type 2 diabetes (T2D) medications. We identified a retrospective cohort of 613,203 adult ... Full text Open Access Link to item Cite

1643-P: Prevalence of Diabetes Medication Regimens in PCORnet, the National Patient-Centered Clinical Research Network

Journal article Diabetes · June 1, 2019 Background: Understanding the long-term cardiovascular safety of type 2 diabetes (T2D) medications is a high-priority research area. We used electronic medical record (EMR) data in the National Patient Centered Clinical Research Network (PCORnet) t ... Full text Cite

Supporting open access to clinical trial data for researchers: The Duke Clinical Research Institute-Bristol-Myers Squibb Supporting Open Access to Researchers Initiative.

Journal article Am Heart J · February 2016 There are growing calls for sponsors to increase transparency by providing access to clinical trial data. In response, Bristol-Myers Squibb and the Duke Clinical Research Institute have collaborated on a new initiative, Supporting Open Access to Researcher ... Full text Link to item Cite

The ethics and regulatory landscape of including vulnerable populations in pragmatic clinical trials.

Journal article Clinical trials (London, England) · October 2015 Policies have been developed to protect vulnerable populations in clinical research, including the US federal research regulations (45 Code of Federal Regulations 46 Subparts B, C, and D). These policies generally recognize vulnerable populations to includ ... Full text Open Access Cite

Psychometric Characteristics of the Teen Addiction Severity Index-Two (T-ASI-2)

Journal article Substance Abuse · March 2008 The Teen Addiction Severity Index-Two (T-ASI-2) was developed as an extension of the T-ASI to assess the severity of substance abuse and related problems among adolescents (N = 371) 12-19 years of age. The T-ASI-2 consists of 18 domains that assess ... Full text Cite

Adolescent Substance Use Assessment in a Primary Care Setting

Journal article The American Journal of Drug and Alcohol Abuse · January 2007 Full text Cite