David Michael Ashley | Scholars@Duke

David Michael Ashley
Rory David Deutsch Distinguished Professor of Neuro-Oncology

Dr. Ashley's primary research focus is laboratory based, investigating the role of immunotherapy as a novel approach to the treatment of tumors of the central nervous system (CNS). Since beginning his appointment at the faculty level at Duke in August of 1995 his activities have centered on two main areas of investigation. The first involves both in vivo and in vitro studies of the use of molecular therapeutics to target a CNS tumor associated antigen. The second area of interest comprises a detailed analysis of the role of TGF beta, a protein messenger produced by tumors of the CNS, both in the pathogenesis of disease and as a possible target for immunotherapy.

In addition to his laboratory role Dr. Ashley is involved in the design and application of a variety of clinical research protocols in the treatment of children with malignant brain tumors.

Current Appointments & Affiliations

Rory David Deutsch Distinguished Professor of Neuro-Oncology, Neurosurgery, Neurosurgery 2019
Professor of Neurosurgery, Neurosurgery, Neurosurgery 2017
Professor of Medicine, Medicine, Medical Oncology, Medicine 2017
Professor in Pathology, Pathology, Clinical Science Departments 2018
Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017

Contact Information

203 Research Dr Msrb1, Box 2600, Durham, NC 27710
DUMC 2600, Durham, NC 27710
david.ashley@duke.edu (919) 684-4164

Background
Education, Training, & Certifications
- Ph.D., University of Melbourne (Australia) 1998
- M.B.B.S., University of Melbourne (Australia) 1994
- F.R.A.C.P., Royal Australasian College of Physicians (Australia) 1993
Previous Appointments & Affiliations
- Professor in Pediatrics, Pediatrics, Neurology, Pediatrics 2017 - 2020
- Instructor in the Department of Neurosurgery, Neurosurgery, Neurosurgery 2017
- Assistant Consulting Professor in the Department of Neurosurgery, Neurosurgery, Neurosurgery 2017
- Associate in the Department of Pediatrics, Pediatrics, Clinical Science Departments 1995 - 1997
Recognition
In the News
- APR 12, 2023 School of Medicine
  
  Can Scientists Learn to Prevent Brain Tumors?
- JAN 13, 2021 Duke Health News
  
  Recurrent Gliobastoma Brain Tumors with Few Mutations Respond Best to Immunotherapy
Research
Selected Grants
- ATRXmutations,innate immune activation and therapeutic vunerabilityin malignant gliomas awarded by National Institutes of Health 2022 - 2027
- Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM awarded by National Institutes of Health 2022 - 2027
- PNOC 019: A Randomized, Double-Blinded, Pilot Trial of Neoadjuvant Checkpoint Inhibition followed by Combination Adjuvant Checkpoint Inhibition in Children and Young Adults with Recurrent or Progressive High Grade Glioma (HGG) awarded by The Regents of the University of California 2021 - 2026
- 6-thio-2'-deoxyguanosine: A Novel Immunogenic Telomerase-Mediated Therapy in Glioblastoma - A Duke and UTSW Collaboration awarded by National Institutes of Health 2021 - 2026
- CONNECT 1903: Larotrectinib for Children with high-grade glioma with NTRK Fusion awarded by Research Institute at Nationwide Children's Hospital 2021 - 2026
- A Phase II study of Panobinostat in Paediatric, Adolescent and Young Adult Patients with Solid Tumours (ATRT) awarded by Australian and New Zealand Children's Haematology/Oncology Group 2021 - 2026
- Duke Center for Advancement of Child Health (CAtCH). awarded by National Institutes of Health 2021 - 2026
- CONNECT 1702: A Phase 1b STudy of PTC596 in Children with Newly Diagnosed Diffuse Intrinsic Pointine Glioma and High-Grade Glioma awarded by Research Institute at Nationwide Children's Hospital 2021 - 2025
- NEWLY DIAGNOSED CHILDREN (LESS THAN 10 YEARS OLD) WITH MEDULLOBLASTOMA AND OTHER CENTRAL NERVOUS SYSTEMPRIMITIVE NEURO-ECTODERMAL TUMORS:CLINICAL AND MOLECULAR RISK-TAILORED INTENSIVE AND COMPRESSED INDUCTION CHEMOTHERAPY FOLLOWED BY CONSOLIDATION WI awarded by Research Institute at Nationwide Children's Hospital 2019 - 2025
- Phase 2 trial of a novel peptide vaccine targeting CMV antigen for newly diagnosed pediatric high grade glioma and diffuse intrinsic pontine glioma and recurrent medulloblastoma awarded by National Institutes of Health 2021 - 2025
- Genomic and Spatial Expression Analysis of Oligodendroglioma to Identify Novel Therapeutic and Prognostic Targets awarded by Doris Duke Charitable Foundation, Inc. 2022 - 2025
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health 2009 - 2025
- Identifying brainstem glioma subtypes that can be radiosensitized by ATM inhibition awarded by Pediatric Brain Tumor Foundation 2019 - 2023
- Experimental Therapy for Brain Tumors awarded by National Institutes of Health 2018 - 2023
- PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME awarded by Jewish Communal Fund 2022 - 2023
- PRECLINICAL THERAPEUTIC SCREENING FOR NEW THERAPIES FOR GLIOBLASTOMA MULTIFORME awarded by Jewish Communal Fund 2007 - 2023
- PNOC022 A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial D awarded by The Regents of the University of California 2022 - 2023
- ATRX Mutations in Determining Immunity Against Glioma awarded by Brain Tumor Research Charity 2021 - 2023
- Enhancing the efficacy of radiation therapy for brainstem gliomas awarded by St. Baldrick's Foundation 2020 - 2022
- Is Low Tumor Mutational Burden Predictive of Response to Oncolytic Polio Virus Therapy in Recurrent Glioblastoma? awarded by National Institutes of Health 2019 - 2022
- Collaborative Network for Neuroooncology Clinical Trials (CONNECT) awarded by Cincinnati Children's Hospital Medical Center 2020 - 2022
- SJMB12: A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma awarded by St. Jude Children's Research Hospital 2014 - 2021
- LGG-14C03: A Phase III study comparing two carboplatin containing regimens for children and young adults with previously untreated low grade glioma awarded by Ann & Robert H Lurie Children's Hospital of Chicago 2018 - 2021
- Poliovirus-Instigated APC Responses Against BRaf(V600E) for Pediatric Brain Tumor Immunotherapy awarded by V Foundation for Cancer Research 2018 - 2021
- Recombinant Attenuated Poliovirus Immunization Vectors Targeting H3.3(K27M) in DIPG awarded by Michael Mosier Defeat DIPG Foundation 2018 - 2019
External Relationships
- Diverse Bio Pharma
- Immunogenesis
- MAIA Inc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Broom, Alex, Leah Williams Veazey, Katherine Kenny, Imogen Harper, Michelle Peterie, Alexander Page, Nicole Cort, et al. “The Enduring Effects of COVID for Cancer Care: Learning from Real-Life Clinical Practice.” Clin Cancer Res 29, no. 9 (May 1, 2023): 1670–77. https://doi.org/10.1158/1078-0432.CCR-23-0151.
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  - Hanzlik, Emily, Bridget Archambault, Mays El-Dairi, Kristin Schroeder, Mallika P. Patel, Eric S. Lipp, Katherine B. Peters, David M. Ashley, and Daniel Landi. “Use of Trametinib in Children and Young Adults With Progressive Low-grade Glioma and Glioneuronal Tumors.” J Pediatr Hematol Oncol 45, no. 4 (May 1, 2023): e464–70. https://doi.org/10.1097/MPH.0000000000002598.
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  - Brown, Michael C., Georgia M. Beasley, Zachary P. McKay, Yuanfan Yang, Annick Desjardins, Dina M. Randazzo, Daniel Landi, et al. “Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils.” J Immunother Cancer 11, no. 4 (April 2023). https://doi.org/10.1136/jitc-2022-006463.
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  - Thompson, Eric M., Daniel Landi, Michael C. Brown, Henry S. Friedman, Roger McLendon, James E. Herndon, Evan Buckley, et al. “Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial.” Lancet Child Adolesc Health, March 30, 2023. https://doi.org/10.1016/S2352-4642(23)00031-7.
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  - Regal, Joshua A., María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, and Zachary J. Reitman. “Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population.” Acta Neuropathol Commun 11, no. 1 (March 25, 2023): 50. https://doi.org/10.1186/s40478-023-01548-3.
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  - Yang, Yuanfan, Michael C. Brown, Gao Zhang, Kevin Stevenson, Malte Mohme, Reb Kornahrens, Darell D. Bigner, David M. Ashley, Giselle Y. López, and Matthias Gromeier. “Polio Virotherapy Targets the Malignant Glioma Myeloid Infiltrate with Diffuse Microglia Activation Engulfing the CNS.” Neuro Oncol, March 2, 2023. https://doi.org/10.1093/neuonc/noad052.
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  - White, K., K. Connor, M. Meylan, A. Bougoüin, M. Salvucci, F. Bielle, A. C. O’Farrell, et al. “Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy.” Ann Oncol 34, no. 3 (March 2023): 300–314. https://doi.org/10.1016/j.annonc.2022.11.008.
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  - Parker, Scott, Charlotte McDowall, Luis Sanchez-Perez, Cristina Osorio, Patrick C. Duncker, Aaron Briley, Adam M. Swartz, et al. “Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models.” Sci Transl Med 15, no. 682 (February 8, 2023): eabn5649. https://doi.org/10.1126/scitranslmed.abn5649.
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  - Liu, Heng, Cheng Xu, Bill H. Diplas, Alexandrea Brown, Laura M. Strickland, Haipei Yao, Jinjie Ling, et al. “Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells.” Neuro Oncol, January 23, 2023. https://doi.org/10.1093/neuonc/noad022.
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  - Tomaszewski, William H., Jessica Waibl-Polania, Molly Chakraborty, Jonathan Perera, Jeremy Ratiu, Alexandra Miggelbrink, Donald P. McDonnell, et al. “Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma.” Nat Commun 13, no. 1 (October 29, 2022): 6483. https://doi.org/10.1038/s41467-022-34175-y.
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  - Varn, Frederick S., Kevin C. Johnson, Jan Martinek, Jason T. Huse, MacLean P. Nasrallah, Pieter Wesseling, Lee A. D. Cooper, et al. “Glioma progression is shaped by genetic evolution and microenvironment interactions.” Cell 185, no. 12 (June 9, 2022): 2184-2199.e16. https://doi.org/10.1016/j.cell.2022.04.038.
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  - Wei, Shiyou, Delong Yin, Shengnan Yu, Xiang Lin, Milan R. Savani, Kuang Du, Yin Ku, et al. “Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.” Clin Cancer Res 28, no. 10 (May 13, 2022): 2180–95. https://doi.org/10.1158/1078-0432.CCR-21-0833.
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  - Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.
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  - Brown, Michael C., David M. Ashley, and Mustafa Khasraw. “Low tumor mutational burden and immunotherapy in gliomas.” Trends Cancer 8, no. 5 (May 2022): 345–46. https://doi.org/10.1016/j.trecan.2022.01.006.
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  - Abdullah, Kalil G., Cylaina E. Bird, Joseph D. Buehler, Lauren C. Gattie, Milan R. Savani, Alex C. Sternisha, Yi Xiao, et al. “Establishment of patient-derived organoid models of lower-grade glioma.” Neuro Oncol 24, no. 4 (April 1, 2022): 612–23. https://doi.org/10.1093/neuonc/noab273.
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  - Singh, Kirit, Kristen A. Batich, Patrick Y. Wen, Aaron C. Tan, Stephen J. Bagley, Michael Lim, Michael Platten, et al. “Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma.” Clin Cancer Res 28, no. 4 (February 15, 2022): 585–93. https://doi.org/10.1158/1078-0432.CCR-21-2681.
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  - Tripathi, Shashwat, Hinda Najem, Akanksha Sanjay Mahajan, Peng Zhang, Justin T. Low, Alexander H. Stegh, Michael A. Curran, David M. Ashley, Charles David James, and Amy B. Heimberger. “cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.” F1000res 11 (2022): 1010. https://doi.org/10.12688/f1000research.125163.1.
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  - Yu, Shengnan, Shiyou Wei, Milan Savani, Xiang Lin, Kuang Du, Ilgen Mender, Silvia Siteni, et al. “A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.” Clin Cancer Res 27, no. 24 (December 15, 2021): 6800–6814. https://doi.org/10.1158/1078-0432.CCR-21-0374.
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  - Chong, Wai C., W Samantha N. Jayasekara, Vijesh G. Vaghjiani, Sarah Parackal, Claire Sun, Dean Popovski, Elizabeth M. Algar, et al. “Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.” Cancers (Basel) 13, no. 20 (October 14, 2021). https://doi.org/10.3390/cancers13205145.
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  - Kang, Jennifer H., Christa B. Swisher, Evan D. Buckley, James E. Herndon, Eric S. Lipp, John P. Kirkpatrick, Annick Desjardins, et al. “Primary brain tumor patients admitted to a US intensive care unit: a descriptive analysis.” Cns Oncol 10, no. 3 (September 1, 2021): CNS77. https://doi.org/10.2217/cns-2021-0009.
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  - Tan, Aaron C., Stephen J. Bagley, Patrick Y. Wen, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, et al. “Systematic review of combinations of targeted or immunotherapy in advanced solid tumors.” J Immunother Cancer 9, no. 7 (July 2021). https://doi.org/10.1136/jitc-2021-002459.
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  - Randazzo, Dina M., Frances McSherry, James E. Herndon, Mary L. Affronti, Eric S. Lipp, Elizabeth S. Miller, Sarah Woodring, et al. “Spiritual well-being and its association with health-related quality of life in primary brain tumor patients.” Neurooncol Pract 8, no. 3 (June 2021): 299–309. https://doi.org/10.1093/nop/npaa084.
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  - Brown, Michael C., Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, et al. “Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling.” Nat Commun 12, no. 1 (March 25, 2021): 1858. https://doi.org/10.1038/s41467-021-22088-1.
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  - Srinivasan, Ethan S., Aaron C. Tan, Carey K. Anders, Ann Marie Pendergast, Dorothy A. Sipkins, David M. Ashley, Peter E. Fecci, and Mustafa Khasraw. “Salting the Soil: Targeting the Microenvironment of Brain Metastases.” Mol Cancer Ther 20, no. 3 (March 2021): 455–66. https://doi.org/10.1158/1535-7163.MCT-20-0579.
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  - Gromeier, Matthias, Michael C. Brown, Gao Zhang, Xiang Lin, Yeqing Chen, Zhi Wei, Nike Beaubier, et al. “Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.” Nat Commun 12, no. 1 (January 13, 2021): 352. https://doi.org/10.1038/s41467-020-20469-6.
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  - Lee, Jessica W., John P. Kirkpatrick, Frances McSherry, James E. Herndon, Eric S. Lipp, Annick Desjardins, Dina M. Randazzo, et al. “Adjuvant Radiation in Older Patients With Glioblastoma: A Retrospective Single Institution Analysis.” Front Oncol 11 (2021): 631618. https://doi.org/10.3389/fonc.2021.631618.
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  - Khasraw, Mustafa, Kyle M. Walsh, Amy B. Heimberger, and David M. Ashley. “What is the Burden of Proof for Tumor Mutational Burden in gliomas?” Neuro Oncol 23, no. 1 (November 30, 2020): 17–22. https://doi.org/10.1093/neuonc/noaa256.
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  - Broom, Alex, Katherine Kenny, Alexander Page, Nicole Cort, Eric S. Lipp, Aaron C. Tan, David M. Ashley, Kyle M. Walsh, and Mustafa Khasraw. “The Paradoxical Effects of COVID-19 on Cancer Care: Current Context and Potential Lasting Impacts.” Clin Cancer Res 26, no. 22 (November 15, 2020): 5809–13. https://doi.org/10.1158/1078-0432.CCR-20-2989.
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  - Tan, Aaron C., David M. Ashley, Giselle Y. López, Michael Malinzak, Henry S. Friedman, and Mustafa Khasraw. “Management of glioblastoma: State of the art and future directions.” Ca Cancer J Clin 70, no. 4 (July 2020): 299–312. https://doi.org/10.3322/caac.21613.
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  - Tan, Aaron C., David M. Ashley, and Mustafa Khasraw. “Adapting to a Pandemic - Conducting Oncology Trials during the SARS-CoV-2 Pandemic.” Clin Cancer Res 26, no. 13 (July 1, 2020): 3100–3103. https://doi.org/10.1158/1078-0432.CCR-20-1364.
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  - Chen, Lee H., Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, et al. “The integrated genomic and epigenomic landscape of brainstem glioma.” Nat Commun 11, no. 1 (June 17, 2020): 3077. https://doi.org/10.1038/s41467-020-16682-y.
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  - Patel, Mallika P., John P. Kirkpatrick, Margaret O. Johnson, Patrick Healy, James E. Herndon, Eric S. Lipp, Elizabeth S. Miller, et al. “Patterns of relapse after successful completion of initial therapy in primary central nervous system lymphoma: a case series.” J Neurooncol 147, no. 2 (April 2020): 477–83. https://doi.org/10.1007/s11060-020-03446-3.
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  - Thompson, Eric M., David Ashley, and Daniel Landi. “Current medulloblastoma subgroup specific clinical trials.” Transl Pediatr 9, no. 2 (April 2020): 157–62. https://doi.org/10.21037/tp.2020.03.03.
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  - Mosaheb, Mubeen M., Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, and Matthias Gromeier. “Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity.” Nat Commun 11, no. 1 (January 27, 2020): 524. https://doi.org/10.1038/s41467-019-13939-z.
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  - Livingston, Patricia M., Leila Heckel, Liliana Orellana, David Ashley, Anna Ugalde, Mari Botti, Graham Pitson, et al. “Outcomes of a randomized controlled trial assessing a smartphone Application to reduce unmet needs among people diagnosed with CancEr (ACE).” Cancer Med 9, no. 2 (January 2020): 507–16. https://doi.org/10.1002/cam4.2718.
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  - Sampson, John H., Michael D. Gunn, Peter E. Fecci, and David M. Ashley. “Brain immunology and immunotherapy in brain tumours.” Nat Rev Cancer 20, no. 1 (January 2020): 12–25. https://doi.org/10.1038/s41568-019-0224-7.
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  - Barthel, Floris P., Kevin C. Johnson, Frederick S. Varn, Anzhela D. Moskalik, Georgette Tanner, Emre Kocakavuk, Kevin J. Anderson, et al. “Longitudinal molecular trajectories of diffuse glioma in adults.” Nature 576, no. 7785 (December 2019): 112–20. https://doi.org/10.1038/s41586-019-1775-1.
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  - Johnson, Margaret O., John P. Kirkpatrick, Mallika P. Patel, Annick Desjardins, Dina M. Randazzo, Henry S. Friedman, David M. Ashley, and Katherine B. Peters. “The role of chemotherapy in the treatment of central neurocytoma.” Cns Oncol 8, no. 3 (November 1, 2019): CNS41. https://doi.org/10.2217/cns-2019-0012.
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  - Hayley, Amie C., Maja Green, Luke A. Downey, Michael Keane, Michaela Kenneally, Mark Adams, and Yahya Shehabi. “Neurocognitive performance under combined regimens of ketamine-dexmedetomidine and ketamine-fentanyl in healthy adults: A randomised trial.” Prog Neuropsychopharmacol Biol Psychiatry 94 (August 30, 2019): 109647. https://doi.org/10.1016/j.pnpbp.2019.109647.
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  - Randazzo, Dina M., Frances McSherry, James E. Herndon, Mary L. Affronti, Eric S. Lipp, Charlene Flahiff, Elizabeth Miller, et al. “Complementary and integrative health interventions and their association with health-related quality of life in the primary brain tumor population.” Complement Ther Clin Pract 36 (August 2019): 43–48. https://doi.org/10.1016/j.ctcp.2019.05.002.
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  - Murphy, Caitlin, Andrea Muscat, David Ashley, Violet Mukaro, Linda West, Yang Liao, David Chisanga, et al. “Tailored NEOadjuvant epirubicin, cyclophosphamide and Nanoparticle Albumin-Bound paclitaxel for breast cancer: The phase II NEONAB trial-Clinical outcomes and molecular determinants of response.” Plos One 14, no. 2 (2019): e0210891. https://doi.org/10.1371/journal.pone.0210891.
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  - Shen, Erica, Margaret O. Johnson, Jessica W. Lee, Eric S. Lipp, Dina M. Randazzo, Annick Desjardins, Roger E. McLendon, et al. “Performance of a nomogram for IDH-wild-type glioblastoma patient survival in an elderly cohort.” Neurooncol Adv 1, no. 1 (2019): vdz036. https://doi.org/10.1093/noajnl/vdz036.
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  - Thompson, Eric M., Daniel Landi, David Ashley, Stephen T. Keir, and Darell Bigner. “Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.” J Neurooncol 140, no. 2 (November 2018): 261–68. https://doi.org/10.1007/s11060-018-2975-5.
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  - Wood, Paul J., Robyn Strong, Grant A. McArthur, Michael Michael, Elizabeth Algar, Andrea Muscat, Lin Rigby, Melissa Ferguson, and David M. Ashley. “A phase I study of panobinostat in pediatric patients with refractory solid tumors, including CNS tumors.” Cancer Chemother Pharmacol 82, no. 3 (September 2018): 493–503. https://doi.org/10.1007/s00280-018-3634-4.
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  - Sexton-Oates, Alexandra, Andrew Dodgshun, Volker Hovestadt, David T. W. Jones, David M. Ashley, Michael Sullivan, Duncan MacGregor, and Richard Saffery. “Methylation profiling of paediatric pilocytic astrocytoma reveals variants specifically associated with tumour location and predictive of recurrence.” Mol Oncol 12, no. 8 (August 2018): 1219–32. https://doi.org/10.1002/1878-0261.12062.
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  - Desjardins, Annick, Matthias Gromeier, James E. Herndon, Nike Beaubier, Dani P. Bolognesi, Allan H. Friedman, Henry S. Friedman, et al. “Recurrent Glioblastoma Treated with Recombinant Poliovirus.” N Engl J Med 379, no. 2 (July 12, 2018): 150–61. https://doi.org/10.1056/NEJMoa1716435.
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  - GLASS Consortium, Rick A. “Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium.” Neuro Oncol 20, no. 7 (June 18, 2018): 873–84. https://doi.org/10.1093/neuonc/noy020.
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  - Alexander, Brian M., Sujuan Ba, Mitchel S. Berger, Donald A. Berry, Webster K. Cavenee, Susan M. Chang, Timothy F. Cloughesy, et al. “Adaptive Global Innovative Learning Environment for Glioblastoma: GBM AGILE.” Clin Cancer Res 24, no. 4 (February 15, 2018): 737–43. https://doi.org/10.1158/1078-0432.CCR-17-0764.
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  - Muscat, Andrea M., Nicholas C. Wong, Katharine J. Drummond, Elizabeth M. Algar, Mustafa Khasraw, Roel Verhaak, Kathryn Field, Mark A. Rosenthal, and David M. Ashley. “The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection.” Oncotarget 9, no. 8 (January 30, 2018): 7844–58. https://doi.org/10.18632/oncotarget.23541.
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  - Heckel, Leila, Kate M. Fennell, John Reynolds, Anna Boltong, Mari Botti, Richard H. Osborne, Cathrine Mihalopoulos, et al. “Efficacy of a telephone outcall program to reduce caregiver burden among caregivers of cancer patients [PROTECT]: a randomised controlled trial.” Bmc Cancer 18, no. 1 (January 8, 2018): 59. https://doi.org/10.1186/s12885-017-3961-6.
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  - Lorgelly, Paula K., Brett Doble, Donna Rowen, John Brazier, and John Cancer 2015 investigators. “Condition-specific or generic preference-based measures in oncology? A comparison of the EORTC-8D and the EQ-5D-3L.” Qual Life Res 26, no. 5 (May 2017): 1163–76. https://doi.org/10.1007/s11136-016-1443-y.
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  - Rogers, Margaret J., Leigh M. Matheson, Brooke Garrard, Violet Mukaro, Sue Riches, Michael Sheridan, David Ashley, and Graham Pitson. “Cancer diagnosed in the Emergency Department of a Regional Health Service.” Aust J Rural Health 24, no. 6 (December 2016): 409–14. https://doi.org/10.1111/ajr.12280.
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  - Muscat, Andrea, Dean Popovski, W Samantha N. Jayasekara, Fernando J. Rossello, Melissa Ferguson, Kieren D. Marini, Muhammad Alamgeer, et al. “Low-Dose Histone Deacetylase Inhibitor Treatment Leads to Tumor Growth Arrest and Multi-Lineage Differentiation of Malignant Rhabdoid Tumors.” Clin Cancer Res 22, no. 14 (July 15, 2016): 3560–70. https://doi.org/10.1158/1078-0432.CCR-15-2260.
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  - Wann, Alysson, David Ashley, and Mustafa Khasraw. “Use of targeted therapy in cancer patients in the end-of-life period: results from an Australian centre.” Support Care Cancer 24, no. 7 (July 2016): 3023–28. https://doi.org/10.1007/s00520-016-3124-3.
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  - Wong, Shu Fen, Leigh Matheson, Kate Morrissy, Graham Pitson, David M. Ashley, Mustafa Khasraw, Paula K. Lorgelly, and Margaret J. Henry. “Retrospective analysis of cancer survival across South-Western Victoria in Australia.” Aust J Rural Health 24, no. 2 (April 2016): 79–84. https://doi.org/10.1111/ajr.12203.
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  - Wong, Shu Fen, Richard Norman, Trisha Lynette Dunning, David Michael Ashley, Mustafa Khasraw, Theresa Margaret Hayes, Ian Collins, and Paula Kate Lorgelly. “A Discrete Choice Experiment to Examine the Preferences of Patients With Cancer and Their Willingness to Pay for Different Types of Health Care Appointments.” J Natl Compr Canc Netw 14, no. 3 (March 2016): 311–19. https://doi.org/10.6004/jnccn.2016.0036.
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  - Lorgelly, Paula K., Brett Doble, Rachel J. Knott, and Rachel J. Cancer 2015 Investigators. “Realising the Value of Linked Data to Health Economic Analyses of Cancer Care: A Case Study of Cancer 2015.” Pharmacoeconomics 34, no. 2 (February 2016): 139–54. https://doi.org/10.1007/s40273-015-0343-2.
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  - Jefford, Michael, Nicole Kinnane, Paula Howell, Linda Nolte, Spiridoula Galetakis, Gregory Bruce Mann, Lucio Naccarella, et al. “Implementing novel models of posttreatment care for cancer survivors: Enablers, challenges and recommendations.” Asia Pac J Clin Oncol 11, no. 4 (December 2015): 319–27. https://doi.org/10.1111/ajco.12406.
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  - Thomas, David M., Stephen Fox, Paula K. Lorgelly, David Ashley, Gary Richardson, Lara Lipton, John P. Parisot, et al. “Cancer 2015: a longitudinal whole-of-system study of genomic cancer medicine.” Drug Discov Today 20, no. 12 (December 2015): 1429–32. https://doi.org/10.1016/j.drudis.2015.10.009.
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  - Parisot, John P., Heather Thorne, Andrew Fellowes, Ken Doig, Mark Lucas, John J. McNeil, Brett Doble, et al. “"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic.” J Pers Med 5, no. 4 (October 29, 2015): 354–69. https://doi.org/10.3390/jpm5040354.
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  - Heckel, L., K. M. Fennell, J. Reynolds, R. H. Osborne, J. Chirgwin, M. Botti, D. M. Ashley, and P. M. Livingston. “Unmet needs and depression among carers of people newly diagnosed with cancer.” Eur J Cancer 51, no. 14 (September 2015): 2049–57. https://doi.org/10.1016/j.ejca.2015.06.129.
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  - Ashley, David, David Thomas, Lia Gore, Rob Carter, John R. Zalcberg, Renée Otmar, and Julian Savulescu. “Accepting risk in the acceleration of drug development for rare cancers.” Lancet Oncol 16, no. 4 (April 2015): e190–94. https://doi.org/10.1016/S1470-2045(14)71153-2.
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  - Shou, Yaping, Douglas M. Robinson, Dereck D. Amakye, Kristine L. Rose, Yoon-Jae Cho, Keith L. Ligon, Thad Sharp, et al. “A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.” Clin Cancer Res 21, no. 3 (February 1, 2015): 585–93. https://doi.org/10.1158/1078-0432.CCR-13-1711.
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  - Murphy, Caitlin, Sabe Sabesan, Christopher Steer, Patsy Yates, Anne Booms, Victoria Jones, Alison Simpson, et al. “Oncology service initiatives and research in regional Australia.” Aust J Rural Health 23, no. 1 (February 2015): 40–48. https://doi.org/10.1111/ajr.12173.
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  - Wong, Nicholas Cl, Gavin D. Meredith, George Marnellos, Miroslav Dudas, Mandy Parkinson-Bates, Minhee Suh Halemba, Zac Chatterton, et al. “Paediatric leukaemia DNA methylation profiling using MBD enrichment and SOLiD sequencing on archival bone marrow smears.” Gigascience 4 (2015): 11. https://doi.org/10.1186/s13742-015-0050-0.
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  - Wong, Shu Fen, Richard Norman, Trisha L. Dunning, David M. Ashley, and Paula K. Lorgelly. “A protocol for a discrete choice experiment: understanding preferences of patients with cancer towards their cancer care across metropolitan and rural regions in Australia.” Bmj Open 4, no. 10 (October 24, 2014): e006661. https://doi.org/10.1136/bmjopen-2014-006661.
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  - Banks, Patricia, Leigh M. Matheson, Kate Morrissy, Inger Olesen, Graham Pitson, Adam Chapman, David M. Ashley, and Margaret J. Henry. “Characteristics of cancer diagnoses and staging in South Western Victoria: a rural perspective.” Aust J Rural Health 22, no. 5 (October 2014): 257–63. https://doi.org/10.1111/ajr.12112.
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  - Henry, Margaret J., Phil Jones, Kate Morrissy, Leigh M. Matheson, Graham Pitson, Pat Healy, Michael Coory, Rod Lynch, Adam Chapman, and David Ashley. “Radiotherapy in the Barwon South Western Region: a rural perspective.” J Med Imaging Radiat Oncol 58, no. 5 (October 2014): 612–17. https://doi.org/10.1111/1754-9485.12208.
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  - Orme, Lisa M., Franz E. Babl, Chris Barnes, Peter Barnett, Susan Donath, and David M. Ashley. “Outpatient versus inpatient IV antibiotic management for pediatric oncology patients with low risk febrile neutropenia: a randomised trial.” Pediatr Blood Cancer 61, no. 8 (August 2014): 1427–33. https://doi.org/10.1002/pbc.25012.
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  - Chatterton, Zac, Daniel Burke, Kerry R. Emslie, Jeffery M. Craig, Jane Ng, David M. Ashley, Francoise Mechinaud, Richard Saffery, and Nicholas C. Wong. “Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia.” Clin Chem 60, no. 7 (July 2014): 995–1003. https://doi.org/10.1373/clinchem.2013.219956.
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  - Gupta, Sunil, Truyen Tran, Wei Luo, Dinh Phung, Richard Lee Kennedy, Adam Broad, David Campbell, et al. “Machine-learning prediction of cancer survival: a retrospective study using electronic administrative records and a cancer registry.” Bmj Open 4, no. 3 (March 17, 2014): e004007. https://doi.org/10.1136/bmjopen-2013-004007.
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  - Chatterton, Zac, Leah Morenos, Francoise Mechinaud, David M. Ashley, Jeffrey M. Craig, Alexandra Sexton-Oates, Minhee S. Halemba, et al. “Epigenetic deregulation in pediatric acute lymphoblastic leukemia.” Epigenetics 9, no. 3 (March 2014): 459–67. https://doi.org/10.4161/epi.27585.
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  - Livingston, Patricia M., Richard H. Osborne, Mari Botti, Cathy Mihalopoulos, Sean McGuigan, Leila Heckel, Kate Gunn, Jacquie Chirgwin, David M. Ashley, and Melinda Williams. “Efficacy and cost-effectiveness of an outcall program to reduce carer burden and depression among carers of cancer patients [PROTECT]: rationale and design of a randomized controlled trial.” Bmc Health Serv Res 14 (January 6, 2014): 5. https://doi.org/10.1186/1472-6963-14-5.
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  - Bandopadhayay, Pratiti, Anissa M. Jabbour, Christopher Riffkin, Marika Salmanidis, Lavinia Gordon, Dean Popovski, Lin Rigby, et al. “The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.” Bmc Cancer 13 (December 9, 2013): 585. https://doi.org/10.1186/1471-2407-13-585.
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  - Lomax, Anna J., Prue A. Hill, and David M. Ashley. “Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme.” J Oncol Pharm Pract 19, no. 4 (December 2013): 365–68. https://doi.org/10.1177/1078155212466421.
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  - Davis, Justin, Fiona M. Ahlberg, Michael Berk, David M. Ashley, and Mustafa Khasraw. “Emerging pharmacotherapy for cancer patients with cognitive dysfunction.” Bmc Neurol 13 (October 24, 2013): 153. https://doi.org/10.1186/1471-2377-13-153.
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  - Hargrave, Darren, Birgit Geoerger, Didier Frappaz, Torsten Pietsch, Lyle Gesner, Laura Cisar, Aurora Breazna, et al. “A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study.” J Neurooncol 113, no. 1 (May 2013): 127–34. https://doi.org/10.1007/s11060-013-1098-2.
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  - Vassal, Gilles, C Michel Zwaan, David Ashley, Marie Cecile Le Deley, Darren Hargrave, Patricia Blanc, and Peter C. Adamson. “New drugs for children and adolescents with cancer: the need for novel development pathways.” Lancet Oncol 14, no. 3 (March 2013): e117–24. https://doi.org/10.1016/S1470-2045(13)70013-5.
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  - Cain, Jason E., Andrew McCaw, W Samantha N. Jayasekara, Fernando J. Rossello, Kieren D. Marini, Aaron T. Irving, Maya Kansara, David M. Thomas, David M. Ashley, and D Neil Watkins. “Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.” Sarcoma 2013 (2013): 608964. https://doi.org/10.1155/2013/608964.
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  - Clay, Timothy D., and David A. Ashley. “Acute pain associated with oxaliplatin infusion: case report and literature review.” J Oncol Pharm Pract 18, no. 4 (December 2012): 421–24. https://doi.org/10.1177/1078155211428999.
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  - Khasraw, Mustafa, David Ashley, Greg Wheeler, and Michael Berk. “Using lithium as a neuroprotective agent in patients with cancer.” Bmc Med 10 (November 2, 2012): 131. https://doi.org/10.1186/1741-7015-10-131.
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  - McCarthy, Maria C., David M. Ashley, Katherine J. Lee, and Vicki A. Anderson. “Predictors of acute and posttraumatic stress symptoms in parents following their child's cancer diagnosis.” J Trauma Stress 25, no. 5 (October 2012): 558–66. https://doi.org/10.1002/jts.21745.
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  - Ashley, David M., Thomas E. Merchant, Douglas Strother, Tianni Zhou, Patricia Duffner, Peter C. Burger, Douglas C. Miller, et al. “Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children's Oncology Group study P9934.” J Clin Oncol 30, no. 26 (September 10, 2012): 3181–86. https://doi.org/10.1200/JCO.2010.34.4341.
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  - Pejnovic, Laura P., Cinzia R. De Luca, Ellen Gentle, Katie Anson, David M. Ashley, Vicki A. Anderson, and Maria C. McCarthy. “Feasibility of neurobehavioral screening following diagnosis of pediatric cancer.” Pediatr Blood Cancer 59, no. 2 (August 2012): 295–300. https://doi.org/10.1002/pbc.24056.
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  - Rigby, Lin, Andrea Muscat, David Ashley, and Elizabeth Algar. “Methods for the analysis of histone H3 and H4 acetylation in blood.” Epigenetics 7, no. 8 (August 2012): 875–82. https://doi.org/10.4161/epi.20983.
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  - Wong, Nicholas C., David Ashley, Zac Chatterton, Mandy Parkinson-Bates, Hong Kiat Ng, Minhee S. Halemba, Adam Kowalczyk, et al. “A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia.” Epigenetics 7, no. 6 (June 1, 2012): 535–41. https://doi.org/10.4161/epi.20193.
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  - Malaterre, Jordane, Cameron S. McPherson, Delphine Denoyer, Emily Lai, Jim Hagekyriakou, Sally Lightowler, Koishi Shudo, et al. “Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.” Stem Cells Transl Med 1, no. 6 (June 2012): 469–79. https://doi.org/10.5966/sctm.2011-0046.
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  - Morenos, Leah, Richard Saffery, Francoise Mechinaud, David Ashley, Ngaire Elwood, Jeffrey M. Craig, and Nicholas C. Wong. “Evaluation of microRNA expression in patient bone marrow aspirate slides.” Plos One 7, no. 8 (2012): e42951. https://doi.org/10.1371/journal.pone.0042951.
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  - Birks, Diane K., Andrew M. Donson, Purvi R. Patel, Christopher Dunham, Andrea Muscat, Elizabeth M. Algar, David M. Ashley, et al. “High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survival.” Neuro Oncol 13, no. 12 (December 2011): 1296–1307. https://doi.org/10.1093/neuonc/nor140.
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  - Bandopadhayay, Pratiti, Timothy E. Hassall, Jeffrey V. Rosenfeld, Greg C. Wheeler, Peter A. Downie, Maria L. Kirby, Richard J. Cohn, Michael J. Sullivan, and David M. Ashley. “ANZCCSG BabyBrain99; intensified systemic chemotherapy, second look surgery and involved field radiation in young children with central nervous system malignancy.” Pediatr Blood Cancer 56, no. 7 (July 1, 2011): 1055–61. https://doi.org/10.1002/pbc.22942.
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  - Wang, L., H. Long, D. Ashley, M. Roberts, and P. White. “Effects of the roller feed ratio on wrinkling failure in conventional spinning of a cylindrical cup.” Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture 225, no. 11 (January 1, 2011): 1991–2006. https://doi.org/10.1177/0954405410396024.
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  - Wu, Xiangru, Pratiti Bandopadhayay, Jessica Ng, David Ashley, and C. W. Chow. “The evolution of the histology in pleomorphic xanthoastrocytomas in children: a study of 15 cases.” Pathology 43, no. 1 (January 2011): 9–16. https://doi.org/10.1097/PAT.0b013e328340bb98.
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  - Chatterton, Zac, Leah Morenos, Richard Saffery, Jeffrey M. Craig, David Ashley, and Nicholas C. Wong. “DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.” Epigenomics 2, no. 5 (October 2010): 697–708. https://doi.org/10.2217/epi.10.39.
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  - Crawford, Nigel W., John A. Heath, David Ashley, Peter Downie, and Jim P. Buttery. “Survivors of childhood cancer: an Australian audit of vaccination status after treatment.” Pediatr Blood Cancer 54, no. 1 (January 2010): 128–33. https://doi.org/10.1002/pbc.22256.
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  - Dagar, Vinod, Chung-Wo Chow, David M. Ashley, and Elizabeth M. Algar. “Rapid detection of SMARCB1 sequence variation using high resolution melting.” Bmc Cancer 9 (December 13, 2009): 437. https://doi.org/10.1186/1471-2407-9-437.
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  - Clarke, Naomi E., Maria C. McCarthy, Peter Downie, David M. Ashley, and Vicki A. Anderson. “Gender differences in the psychosocial experience of parents of children with cancer: a review of the literature.” Psychooncology 18, no. 9 (September 2009): 907–15. https://doi.org/10.1002/pon.1515.
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  - McCarthy, Maria C., Naomi E. Clarke, Alasdair Vance, David M. Ashley, John A. Heath, and Vicki A. Anderson. “Measuring psychosocial risk in families caring for a child with cancer: the Psychosocial Assessment Tool (PAT2.0).” Pediatr Blood Cancer 53, no. 1 (July 2009): 78–83. https://doi.org/10.1002/pbc.22007.
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  - Dally, M., M. Rosenthal, K. Drummond, M. Murphy, L. Cher, D. Ashley, V. Thursfield, and G. Giles. “Radiotherapy management of patients diagnosed with glioma in Victoria (1998-2000): a retrospective cohort study.” J Med Imaging Radiat Oncol 53, no. 3 (June 2009): 318–24. https://doi.org/10.1111/j.1754-9485.2009.02072.x.
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  - Ashley, D. M., C. D. Riffkin, M. M. Lovric, T. Mikeska, A. Dobrovic, J. A. Maxwell, H. S. Friedman, et al. “In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs (British Journal of Cancer (2008) 99, (294-304) DOI: 10.1038/sj.bjc.6604459).” British Journal of Cancer 100, no. 6 (March 24, 2009): 1012. https://doi.org/10.1038/sj.bjc.6604990.
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  - Chintagumpala, Murali, Tim Hassall, Shawna Palmer, David Ashley, Dana Wallace, Kimberly Kasow, Thomas E. Merchant, et al. “A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET.” Neuro Oncol 11, no. 1 (February 2009): 33–40. https://doi.org/10.1215/15228517-2008-079.
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  - Algar, Elizabeth M., Andrea Muscat, Vinod Dagar, Christian Rickert, C. W. Chow, Jaclyn A. Biegel, Paul G. Ekert, et al. “Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors.” Plos One 4, no. 2 (2009): e4482. https://doi.org/10.1371/journal.pone.0004482.
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  - De Luca, Cinzia R., Rowena Conroy, Maria C. McCarthy, Vicki A. Anderson, and David M. Ashley. “Neuropsychological impact of treatment of brain tumors.” Cancer Treat Res 150 (2009): 277–96. https://doi.org/10.1007/b109924_17.
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  - Jackson, Alun C., Kate Enderby, Maree O’Toole, Shane A. Thomas, David Ashley, Jeffrey V. Rosenfeld, Emma Simos, Nicole Tokatlian, and Ranee Gedye. “The role of social support in families coping with childhood brain tumor.” J Psychosoc Oncol 27, no. 1 (2009): 1–24. https://doi.org/10.1080/07347330802614634.
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  - Caruso, Denise A., Sarah Fraser, Kellie Hardy, Gerlinda Amor, Jorinde J. Helmich, and David M. Ashley. “Costimulation molecule expression and subset distribution of blood dendritic cells in normal children and newly diagnosed pediatric leukemia and lymphoma patients.” Exp Hematol 36, no. 12 (December 2008): 1691–1703. https://doi.org/10.1016/j.exphem.2008.07.003.
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  - Wu, Xiangru, Vinod Dagar, Elizabeth Algar, Andrea Muscat, Pratiti Bandopadhayay, David Ashley, and Chung Wo Chow. “Rhabdoid tumour: a malignancy of early childhood with variable primary site, histology and clinical behaviour.” Pathology 40, no. 7 (December 2008): 664–70. https://doi.org/10.1080/00313020802436451.
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  - Fouladi, Maryam, Murali Chintagumpala, David Ashley, Stewart Kellie, Sridharan Gururangan, Tim Hassall, Lindsey Gronewold, et al. “Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastoma.” J Clin Oncol 26, no. 22 (August 1, 2008): 3749–55. https://doi.org/10.1200/JCO.2007.14.3974.
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  - Ashley, D. M., C. D. Riffkin, M. M. Lovric, T. Mikeska, A. Dobrovic, J. A. Maxwell, H. S. Friedman, et al. “In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.” Br J Cancer 99, no. 2 (July 22, 2008): 294–304. https://doi.org/10.1038/sj.bjc.6604459.
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  - Rosenthal, M. A., D. M. Ashley, K. Drummond, M. Dally, M. Murphy, L. Cher, V. Thursfield, and G. G. Giles. “Intramedullary spinal cord tumors: Patterns of care in Victoria from 1998-2000.” Asia Pacific Journal of Clinical Oncology 4, no. 2 (June 1, 2008): 77–80. https://doi.org/10.1111/j.1743-7563.2008.00151.x.
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  - Cher, Lawrence, Mark A. Rosenthal, Katharine J. Drummond, Michael Dally, Michael Murphy, David Ashley, Vicky Thursfield, and Graham G. Giles. “The use of chemotherapy in patients with gliomas: patterns of care in Victoria from 1998-2000.” J Clin Neurosci 15, no. 4 (April 2008): 398–401. https://doi.org/10.1016/j.jocn.2007.04.001.
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  - Rosenthal, Mark A., David M. Ashley, Katharine J. Drummond, Michael Dally, Michael Murphy, Lawrence Cher, Vicky Thursfield, and Graham G. Giles. “Brain stem gliomas: patterns of care in Victoria from 1998-2000.” J Clin Neurosci 15, no. 3 (March 2008): 237–40. https://doi.org/10.1016/j.jocn.2007.04.008.
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  - Merchant, Thomas E., Larry E. Kun, Matthew J. Krasin, Dana Wallace, Murali M. Chintagumpala, Shiao Y. Woo, David M. Ashley, et al. “Multi-institution prospective trial of reduced-dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma.” Int J Radiat Oncol Biol Phys 70, no. 3 (March 1, 2008): 782–87. https://doi.org/10.1016/j.ijrobp.2007.07.2342.
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  - Khaw, Seong L., Lee T. Coleman, Peter A. Downie, John A. Heath, and David M. Ashley. “Temozolomide in pediatric low-grade glioma.” Pediatr Blood Cancer 49, no. 6 (November 2007): 808–11. https://doi.org/10.1002/pbc.21270.
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  - Ashton, Lesley J., Jayne E. Murray, Michelle Haber, Glenn M. Marshall, David M. Ashley, and Murray D. Norris. “Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma.” Pharmacogenet Genomics 17, no. 9 (September 2007): 709–17. https://doi.org/10.1097/FPC.0b013e3280e1cc92.
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  - Khaw, Seong L., Peter A. Downie, Keith D. Waters, David M. Ashley, and John A. Heath. “Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide.” Pediatr Blood Cancer 49, no. 3 (September 2007): 341–43. https://doi.org/10.1002/pbc.20617.
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  - Stargatt, Robyn, Jeffrey V. Rosenfeld, Wirginia Maixner, and David Ashley. “Multiple factors contribute to neuropsychological outcome in children with posterior fossa tumors.” Dev Neuropsychol 32, no. 2 (2007): 729–48. https://doi.org/10.1080/87565640701376151.
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  - Jackson, Alun C., Helen Stewart, Maree O’Toole, Nicole Tokatlian, Kate Enderby, Jane Miller, and David Ashley. “Pediatric brain tumor patients: their parents' perceptions of the hospital experience.” J Pediatr Oncol Nurs 24, no. 2 (2007): 95–105. https://doi.org/10.1177/1043454206296030.
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  - Stargatt, Robyn, Jeffrey V. Rosenfeld, Vicki Anderson, Timothy Hassall, Wirginia Maixner, and David Ashley. “Intelligence and adaptive function in children diagnosed with brain tumour during infancy.” J Neurooncol 80, no. 3 (December 2006): 295–303. https://doi.org/10.1007/s11060-006-9187-0.
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  - Gajjar, Amar, Murali Chintagumpala, David Ashley, Stewart Kellie, Larry E. Kun, Thomas E. Merchant, Shaio Woo, et al. “Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.” Lancet Oncol 7, no. 10 (October 2006): 813–20. https://doi.org/10.1016/S1470-2045(06)70867-1.
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  - Muscat, Andrea, Christine Hawkins, and David M. Ashley. “Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.” Cancer 107, no. 4 (August 15, 2006): 824–31. https://doi.org/10.1002/cncr.22052.
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  - Jabbour, Anissa M., Michelle A. Puryer, Jai Y. Yu, Trevor Lithgow, Christopher D. Riffkin, David M. Ashley, David L. Vaux, Paul G. Ekert, and Christine J. Hawkins. “Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1.” J Cell Sci 119, no. Pt 12 (June 15, 2006): 2572–82. https://doi.org/10.1242/jcs.02985.
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  - Thomas, D. M., J. F. Seymour, T. O’Brien, S. M. Sawyer, and D. M. Ashley. “Adolescent and young adult cancer: a revolution in evolution?” Intern Med J 36, no. 5 (May 2006): 302–7. https://doi.org/10.1111/j.1445-5994.2006.01062.x.
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  - Rosenthal, Mark A., Katharine J. Drummond, Michael Dally, Michael Murphy, Lawrence Cher, David Ashley, Vicky Thursfield, and Graham G. Giles. “Management of glioma in Victoria (1998-2000): retrospective cohort study.” Med J Aust 184, no. 6 (March 20, 2006): 270–73. https://doi.org/10.5694/j.1326-5377.2006.tb00235.x.
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  - Wong, Shirley, Mark A. Rosenthal, Anthony Dowling, Ross Jennens, Anne-Marie Woods, David Ashley, and Lawrence Cher. “Phase II study of two-weekly temozolomide in patients with high-grade gliomas.” J Clin Neurosci 13, no. 1 (January 2006): 18–22. https://doi.org/10.1016/j.jocn.2004.10.018.
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  - Ashley, David M., Christopher D. Riffkin, Andrea M. Muscat, Melissa J. Knight, Andrew H. Kaye, Ulrike Novak, and Christine J. Hawkins. “Caspase 8 is absent or low in many ex vivo gliomas.” Cancer 104, no. 7 (October 1, 2005): 1487–96. https://doi.org/10.1002/cncr.21323.
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  - Mulhern, Raymond K., Shawna L. Palmer, Thomas E. Merchant, Dana Wallace, Mehmet Kocak, Pim Brouwers, Kevin Krull, et al. “Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma.” J Clin Oncol 23, no. 24 (August 20, 2005): 5511–19. https://doi.org/10.1200/JCO.2005.00.703.
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  - Caruso, Denise A., Lisa M. Orme, Gerlinda M. Amor, Alana M. Neale, Fiona J. Radcliff, Peter Downie, Mimi L. K. Tang, and David M. Ashley. “Results of a Phase I study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children with Stage 4 neuroblastoma.” Cancer 103, no. 6 (March 15, 2005): 1280–91. https://doi.org/10.1002/cncr.20911.
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  - Jabbour, A. M., P. -. K. Ho, M. A. Puryer, D. M. Ashley, P. G. Ekert, and C. J. Hawkins. “The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast.” Cell Death Differ 11, no. 12 (December 2004): 1309–16. https://doi.org/10.1038/sj.cdd.4401501.
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  - Meir, D Ben, M. Inoue, U. Gur, P. M. Livne, Y. Yaniv, K. Tiedeman, D. M. Ashley, and J. M. Hutson. “Urinary diversion in children with pelvic tumors.” J Pediatr Surg 39, no. 12 (December 2004): 1787–90. https://doi.org/10.1016/j.jpedsurg.2004.08.003.
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  - Fouladi, Maryam, Murali Chintagumpala, Fred H. Laningham, David Ashley, Stewart J. Kellie, James W. Langston, Charles W. McCluggage, et al. “White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor.” J Clin Oncol 22, no. 22 (November 15, 2004): 4551–60. https://doi.org/10.1200/JCO.2004.03.058.
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  - Richards, Amanda L., Jeffrey V. Rosenfeld, Michael F. Gonzales, David Ashley, and Catriona Mc Lean. “Supratentorial tanycytic ependymoma.” J Clin Neurosci 11, no. 8 (November 2004): 928–30. https://doi.org/10.1016/j.jocn.2004.03.022.
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  - Stewart, Clinton F., Lisa C. Iacono, Murali Chintagumpala, Stewart J. Kellie, David Ashley, W. C. Zamboni, M. N. Kirstein, et al. “Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor.” J Clin Oncol 22, no. 16 (August 15, 2004): 3357–65. https://doi.org/10.1200/JCO.2004.10.103.
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  - Caruso, Denise A., Lisa M. Orme, Alana M. Neale, Fiona J. Radcliff, Gerlinda M. Amor, Wirginia Maixner, Peter Downie, Timothy E. Hassall, Mimi L. K. Tang, and David M. Ashley. “Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer.” Neuro Oncol 6, no. 3 (July 2004): 236–46. https://doi.org/10.1215/S1152851703000668.
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  - Mitchell, A. E., D. L. Scarcella, G. L. Rigutto, D. M. Ashley, V. J. Thursfield, G. G. Giles, and M. Sexton. “Cancer in adolescents and young adults: treatment and outcome in Victoria - In reply.” Medical Journal of Australia 180, no. 12 (June 21, 2004): 654–654.
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  - Rosenthal, Mark A., David L. Ashley, and Lawrence Cher. “BCNU as second line therapy for recurrent high-grade glioma previously treated with Temozolomide.” J Clin Neurosci 11, no. 4 (May 2004): 374–75. https://doi.org/10.1016/j.jocn.2003.01.002.
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  - Gajjar, Amar, Roberto Hernan, Mehmet Kocak, Christine Fuller, Youngsoo Lee, Peter J. McKinnon, Dana Wallace, et al. “Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma.” J Clin Oncol 22, no. 6 (March 15, 2004): 984–93. https://doi.org/10.1200/JCO.2004.06.032.
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  - Knight, Melissa J., Christopher D. Riffkin, Paul G. Ekert, David M. Ashley, and Christine J. Hawkins. “Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis.” Mol Carcinog 39, no. 3 (March 2004): 173–82. https://doi.org/10.1002/mc.20011.
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  - Mitchell, Anne E., Deborah L. Scarcella, Gemma L. Rigutto, Vicky J. Thursfield, Graham G. Giles, Maree Sexton, and David M. Ashley. “Cancer in adolescents and young adults: treatment and outcome in Victoria.” Med J Aust 180, no. 2 (January 19, 2004): 59–62. https://doi.org/10.5694/j.1326-5377.2004.tb05799.x.
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  - Chua, Susan L., Mark A. Rosenthal, Shirley S. Wong, David M. Ashley, Anne-Marie Woods, Anthony Dowling, and Lawrence M. Cher. “Phase 2 study of temozolomide and Caelyx in patients with recurrent glioblastoma multiforme.” Neuro Oncol 6, no. 1 (January 2004): 38–43. https://doi.org/10.1215/S1152851703000188.
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  - Orme, Lisa M., Jodie D. Bond, Maureen S. Humphrey, Margaret R. Zacharin, Peter A. Downie, Kris M. Jamsen, Susan L. Mitchell, Jacqueline M. Robinson, Natalie A. Grapsas, and David M. Ashley. “Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression.” Cancer 98, no. 2 (July 15, 2003): 397–405. https://doi.org/10.1002/cncr.11502.
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  - Ekert, H., and D. Ashley. “To the editor [3].” Journal of Clinical Oncology 21, no. 6 (March 15, 2003): 1192. https://doi.org/10.1200/JCO.2003.99.211.
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  - Crock, C., C. Olsson, R. Phillips, G. Chalkiadis, S. Sawyer, D. Ashley, S. Camilleri, J. Carlin, and P. Monagle. “General anaesthesia or conscious sedation for painful procedures in childhood cancer: the family's perspective.” Arch Dis Child 88, no. 3 (March 2003): 253–57. https://doi.org/10.1136/adc.88.3.253.
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  - Waters, Elizabeth B., Melissa A. Wake, Kylie D. Hesketh, David M. Ashley, and Elizabeth Smibert. “Health-related quality of life of children with acute lymphoblastic leukaemia: comparisons and correlations between parent and clinician reports.” Int J Cancer 103, no. 4 (February 10, 2003): 514–18. https://doi.org/10.1002/ijc.10815.
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  - Jabbour, A. M., P. G. Ekert, E. J. Coulson, M. J. Knight, D. M. Ashley, and C. J. Hawkins. “The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.” Cell Death Differ 9, no. 12 (December 2002): 1311–20. https://doi.org/10.1038/sj.cdd.4401135.
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  - Radcliff, Fiona J., Denise A. Caruso, Craig Koina, Marcia J. Riordan, Andrew W. Roberts, Mimi L. K. Tang, Charles M. Baum, Susan L. Woulfe, and David M. Ashley. “Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy.” Br J Haematol 119, no. 1 (October 2002): 204–11. https://doi.org/10.1046/j.1365-2141.2002.03717.x.
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  - Barnes, Chris, Vera Ignjatovic, Fiona Newall, John Carlin, Felicia Ng, Simone Hamilton, David Ashley, Keith Waters, and Paul Monagle. “Change in serum procalcitonin (deltaPCT) predicts the clinical outcome of children admitted with febrile neutropenia.” Br J Haematol 118, no. 4 (September 2002): 1197–98. https://doi.org/10.1046/j.1365-2141.2002.37029.x.
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  - Gururangan, Sridharan, Christina M. Cavazos, David Ashley, James E. Herndon, Carol S. Bruggers, Albert Moghrabi, Deborah L. Scarcella, et al. “Phase II study of carboplatin in children with progressive low-grade gliomas.” J Clin Oncol 20, no. 13 (July 1, 2002): 2951–58. https://doi.org/10.1200/JCO.2002.12.008.
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  - Rosenthal, M. A., D. L. Ashley, and L. Cher. “Temozolomide-induced flare in high-grade gliomas: a new clinical entity.” Intern Med J 32, no. 7 (July 2002): 346–48. https://doi.org/10.1046/j.1445-5994.2002.00242.x.
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  - Rosenthal, Mark A., David L. Ashley, and Lawrence Cher. “Treatment of high risk or recurrent meningiomas with hydroxyurea.” J Clin Neurosci 9, no. 2 (March 2002): 156–58. https://doi.org/10.1054/jocn.2001.1019.
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  - Dennis, Sally L., Shehnaaz S. M. Manji, Darryl P. Carrington, Deborah L. Scarcella, David M. Ashley, Peter J. Smith, and Elizabeth M. Algar. “Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors.” Int J Cancer 97, no. 5 (February 10, 2002): 713–15. https://doi.org/10.1002/ijc.10106.
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  - Caruso, D. A., and D. M. Ashley. “Current and future directions for cancer immunotherapy.” Cancer Forum 26, no. 2 (January 1, 2002): 102–4.
  - Mitchell, A. E., J. E. Elder, D. A. Mackey, K. D. Waters, and D. M. Ashley. “Visual improvement despite radiologically stable disease after treatment with carboplatin in children with progressive low-grade optic/thalamic gliomas.” J Pediatr Hematol Oncol 23, no. 9 (December 2001): 572–77. https://doi.org/10.1097/00043426-200112000-00004.
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  - Hassall, T. E., A. E. Mitchell, and D. M. Ashley. “Carboplatin chemotherapy for progressive intramedullary spinal cord low-grade gliomas in children: three case studies and a review of the literature.” Neuro Oncol 3, no. 4 (October 2001): 251–57. https://doi.org/10.1093/neuonc/3.4.251.
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  - Hawkins, C. J., J. Silke, A. M. Verhagen, R. Foster, P. G. Ekert, and D. M. Ashley. “Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism.” Apoptosis 6, no. 5 (October 2001): 331–38. https://doi.org/10.1023/a:1011329917895.
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  - Riffkin, C. D., A. Z. Gray, C. J. Hawkins, C. W. Chow, and D. M. Ashley. “Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction.” Neuro Oncol 3, no. 4 (October 2001): 229–40. https://doi.org/10.1093/neuonc/3.4.229.
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  - Knight, M. J., C. D. Riffkin, A. M. Muscat, D. M. Ashley, and C. J. Hawkins. “Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.” Oncogene 20, no. 41 (September 13, 2001): 5789–98. https://doi.org/10.1038/sj.onc.1204810.
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  - Ekert, H., S. Vivekanandan, C. W. Chow, G. Marshall, M. Haber, M. Norris, and D. M. Ashley. “Expression of GAGE genes in neuroblastoma by reverse transcription - Polymerase chain reaction.” Cancer Research, Therapy and Control 11, no. 2 (July 14, 2001): 197–203.
  - Harris, M. T., M. A. Rosenthal, D. L. Ashley, and L. Cher. “An Australian experience with temozolomide for the treatment of recurrent high grade gliomas.” J Clin Neurosci 8, no. 4 (July 2001): 325–27. https://doi.org/10.1054/jocn.2000.0809.
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  - Strother, D., D. Ashley, S. J. Kellie, A. Patel, D. Jones-Wallace, S. Thompson, R. Heideman, et al. “Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study.” J Clin Oncol 19, no. 10 (May 15, 2001): 2696–2704. https://doi.org/10.1200/JCO.2001.19.10.2696.
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  - Friedman, H. S., J. Pluda, J. A. Quinn, R. B. Ewesuedo, L. Long, A. H. Friedman, I. Cokgor, et al. “Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.” J Clin Oncol 18, no. 20 (October 15, 2000): 3522–28. https://doi.org/10.1200/JCO.2000.18.20.3522.
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  - Ashley, D. M. “Chemotherapy is useful in the treatment of gliomas. Discussant.” J Clin Neurosci 7, no. 5 (September 2000): 467–68. https://doi.org/10.1054/jocn.2000.0689.
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  - Sampson, J. H., L. E. Crotty, S. Lee, G. E. Archer, D. M. Ashley, C. J. Wikstrand, L. P. Hale, et al. “Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.” Proc Natl Acad Sci U S A 97, no. 13 (June 20, 2000): 7503–8. https://doi.org/10.1073/pnas.130166597.
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  - Ashley, D. “Cosa, Melbourne 1999.” Cancer Forum 24, no. 1 (January 1, 2000): 38–40.
  - Ng, S., M. A. Rosenthal, D. Ashley, and L. Cher. “High-dose methotrexate for primary CNS lymphoma in the elderly.” Neuro Oncol 2, no. 1 (January 2000): 40–44. https://doi.org/10.1093/neuonc/2.1.40.
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  - Bottom, K. S., D. M. Ashley, H. S. Friedman, and D. C. Longee. “Evaluation of pre-radiotherapy cyclophosphamide in patients with newly diagnosed glioblastoma multiforme. Writing Committee for The Brain Tumor Center at Duke.” J Neurooncol 46, no. 2 (2000): 151–56. https://doi.org/10.1023/a:1006258026274.
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  - Friedman, H. S., W. P. Petros, A. H. Friedman, L. J. Schaaf, T. Kerby, J. Lawyer, M. Parry, et al. “Irinotecan therapy in adults with recurrent or progressive malignant glioma.” J Clin Oncol 17, no. 5 (May 1999): 1516–25. https://doi.org/10.1200/JCO.1999.17.5.1516.
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  - Scarcella, D. L., C. W. Chow, M. F. Gonzales, C. Economou, F. Brasseur, and D. M. Ashley. “Expression of MAGE and GAGE in high-grade brain tumors: a potential target for specific immunotherapy and diagnostic markers.” Clin Cancer Res 5, no. 2 (February 1999): 335–41.
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  - Ashley, D. “Laboratory advances in central nervous system tumours.” Cancer Forum 22, no. 2 (December 1, 1998): 142–48.
  - Friedman, H. S., R. E. McLendon, T. Kerby, M. Dugan, S. H. Bigner, A. J. Henry, D. M. Ashley, et al. “DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.” J Clin Oncol 16, no. 12 (December 1998): 3851–57. https://doi.org/10.1200/JCO.1998.16.12.3851.
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  - Friedman, H. S., D. M. Kokkinakis, J. Pluda, A. H. Friedman, I. Cokgor, M. M. Haglund, D. M. Ashley, et al. “Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.” J Clin Oncol 16, no. 11 (November 1998): 3570–75. https://doi.org/10.1200/JCO.1998.16.11.3570.
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  - Ashley, D. M., J. H. Sampson, G. E. Archer, L. P. Hale, and D. D. Bigner. “Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model.” J Neuroimmunol 86, no. 1 (June 1, 1998): 46–52. https://doi.org/10.1016/s0165-5728(98)00017-4.
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  - Moghrabi, A., H. S. Friedman, D. M. Ashley, K. S. Bottom, T. Kerby, E. Stewart, C. Bruggers, et al. “Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas.” Neurosurg Focus 4, no. 4 (April 15, 1998): e3. https://doi.org/10.3171/foc.1998.4.4.6.
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  - McCowage, G. B., H. S. Friedman, A. Moghrabi, T. Kerby, L. Ferrell, E. Stewart, M. Duncan-Brown, et al. “Activity of high-dose cyclophosphamide in the treatment of childhood malignant gliomas.” Med Pediatr Oncol 30, no. 2 (February 1998): 75–80. https://doi.org/10.1002/(sici)1096-911x(199802)30:2<75::aid-mpo1>3.0.co;2-x.
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  - Ashley, D. M., F. M. Kong, D. D. Bigner, and L. P. Hale. “Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model.” Cancer Res 58, no. 2 (January 15, 1998): 302–9.
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  - Ashley, D. M., and D. D. Bigner. “Recent advances in the biology of central nervous system tumors.” Curr Opin Neurol 10, no. 6 (December 1997): 445–51. https://doi.org/10.1097/00019052-199712000-00002.
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  - Sampson, J. H., D. M. Ashley, G. E. Archer, H. E. Fuchs, G. Dranoff, L. P. Hale, and D. D. Bigner. “Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion.” Neurosurgery 41, no. 6 (December 1997): 1365–72. https://doi.org/10.1097/00006123-199712000-00024.
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  - Ashley, D. M., S. K. Batra, and D. D. Bigner. “Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors.” J Neurooncol 35, no. 3 (December 1997): 259–73. https://doi.org/10.1023/a:1005812417638.
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  - Ashley, D. M., B. Faiola, S. Nair, L. P. Hale, D. D. Bigner, and E. Gilboa. “Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors.” J Exp Med 186, no. 7 (October 6, 1997): 1177–82. https://doi.org/10.1084/jem.186.7.1177.
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  - Ashley, D. M., J. H. Sampson, G. E. Archer, S. K. Batra, D. D. Bigner, and L. P. Hale. “A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo.” J Neuroimmunol 78, no. 1–2 (September 1997): 34–46. https://doi.org/10.1016/s0165-5728(97)00080-5.
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  - Ashley, D. M., R. E. Coleman, H. Fuchs, G. Dear, B. Ginsberg, F. M. Zalduondo, H. S. Friedman, and D. Longee. “Chronic CSF leak into the peritoneal cavity shown by radionuclide cisternography. Successful treatment with an epidural blood patch.” Clin Nucl Med 22, no. 6 (June 1997): 390–92. https://doi.org/10.1097/00003072-199706000-00010.
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  - Sampson, J. H., G. E. Archer, D. M. Ashley, H. E. Fuchs, L. P. Hale, G. Dranoff, and D. D. Bigner. “Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.” Proc Natl Acad Sci U S A 93, no. 19 (September 17, 1996): 10399–404. https://doi.org/10.1073/pnas.93.19.10399.
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  - Ashley, D. M., D. Longee, R. Tien, H. Fuchs, M. L. Graham, J. Kurtzberg, J. Casey, et al. “Treatment of patients with pineoblastoma with high dose cyclophosphamide.” Med Pediatr Oncol 26, no. 6 (June 1996): 387–92. https://doi.org/10.1002/(SICI)1096-911X(199606)26:6<387::AID-MPO3>3.0.CO;2-D.
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  - Ashley, D. M., L. Meier, T. Kerby, F. M. Zalduondo, H. S. Friedman, A. Gajjar, L. Kun, P. K. Duffner, S. Smith, and D. Longee. “Response of recurrent medulloblastoma to low-dose oral etoposide.” J Clin Oncol 14, no. 6 (June 1996): 1922–27. https://doi.org/10.1200/JCO.1996.14.6.1922.
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  - Ashley, D. M., S. J. Bol, and G. Kannourakis. “Viable bone marrow stromal cells are required for the in vitro survival of B-cell precursor acute lymphoblastic leukemic cells.” Leuk Res 19, no. 2 (February 1995): 113–20. https://doi.org/10.1016/0145-2126(94)00136-x.
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  - Ashley, D. M., S. J. Bol, D. P. Tucker, C. M. Waugh, and G. Kannourakis. “Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells.” Leukemia 9, no. 1 (January 1995): 58–67.
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  - Ashley, D. M., S. J. Bol, and G. Kannourakis. “Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts.” Leuk Res 18, no. 5 (May 1994): 337–46. https://doi.org/10.1016/0145-2126(94)90017-5.
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  - Ashley, D. M., S. J. Bol, and G. Kannourakis. “Measurement of the growth parameters of precursor B-acute lymphoblastic leukaemic cells in co-culture with bone marrow stromal cells; detection of two cd10 positive populations with different proliferative capacities and survival.” Leuk Res 18, no. 1 (January 1994): 37–48. https://doi.org/10.1016/0145-2126(94)90007-8.
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  - Ashley, D. M., S. J. Bol, C. Waugh, and G. Kannourakis. “A novel approach to the measurement of different in vitro leukaemic cell growth parameters: the use of PKH GL fluorescent probes.” Leuk Res 17, no. 10 (October 1993): 873–82. https://doi.org/10.1016/0145-2126(93)90153-c.
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- Book Sections
  - Wong, N. C., and D. M. Ashley. “Genome-scale DNA methylation analyses of cancer in children.” In Epigenomics: From Chromatin Biology to Therapeutics, 338–46, 2012. https://doi.org/10.1017/CBO9780511777271.030.
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- Conference Papers
  - Aulakh, Sonikpreet, Joanne Xiu, Pavel Brodskiy, Ekokobe Fonkem, Sourat Darabi, Michael J. Demeure, Soma Sengupta, et al. “Biological and prognostic relevance of epigenetic regulatory genes in high-grade gliomas (HGGs).” In Journal of Clinical Oncology, Vol. 40, 2022.
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  - Brown, Michael, Yuanfan Yang, Zachary Mckay, Darell Bigner, David Ashley, Matthias Gromeier, and Smita Nair. “CXCR3 SIGNALING ENGAGES GLIOMA INFILTRATING T CELLS AND IS REQUIRED FOR THE ANTITUMOR EFFICACY OF INNATE STIMULATING IMMUNOTHERAPY.” In Neuro Oncology, 24:140–41, 2022.
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  - Desjardins, Annick, Vidya Chandramohan, Daniel Landi, Katherine B. Peters, Margaret Johnson, Mustafa Khasraw, Justin Low, et al. “DOSE ESCALATION TRIAL OF FC-ENGINEERED ANTI-CD40 MONOCLONAL ANTIBODY (2141-V11) ADMINISTERED INTRATUMORALLY WITH D2C7-IT VIA CONVECTION-ENHANCED DELIVERY (CED) FOR RECURRENT MALIGNANT GLIOMAS (RMGS).” In Neuro Oncology, 24:65–65, 2022.
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  - Desjardins, Annick, Vidyalakshmi Chandramohan, Daniel B. Landi, Margaret O. Johnson, Mustafa Khasraw, Katherine B. Peters, Justin Low, et al. “A phase 1 trial of D2C7-it in combination with an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convectionenhanced delivery for adult patients with recurrent malignant glioma (MG).” In Journal of Clinical Oncology, Vol. 40, 2022.
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  - Johnson, Margaret, April Bell, Yajas Shah, Kayla Viets-Layng, Elizabeth Mauer, Joanne Xiu, Olivier Elemento, et al. “THE GENOMIC, TRANSCRIPTOMIC, AND EPIGENOMIC LANDSCAPE OF ISOCITRATE DEHYDROGENASE WILD TYPE GLIOBLASTOMA ACROSS THE AGE CONTINUUM.” In Neuro Oncology, 24:13–14, 2022.
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  - Jomaa, Danny, Prasidda Khadka, Dana Novikov, Alexandra L. Condurat, Jessica W. Tsai, Frank Dubois, Shu Zhang, et al. “CHARACTERIZING THE LANDSCAPE OF STRUCTURAL VARIANTS IN ADAMANTINOMATOUS CRANIOPHARYNGIOMA.” In Neuro Oncology, 24:14–14, 2022.
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  - Lazow, Margot A., Patricia Baxter, Joseph Stanek, Adam Lane, Diana P. Rodriguez, Shiva Senthil Kumar, James L. Leach, et al. “PHASE IB STUDY OF UNESBULIN (PTC596) IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND HIGH-GRADE GLIOMA (HGG): A REPORT FROM THE COLLABORATIVE NETWORK FOR NEURO-ONCOLOGY CLINICAL TRIALS (CONNECT).” In Neuro Oncology, 24:36–36, 2022.
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  - Mangoli, Avani, Seetha Hariharan, David Ashley, Rebecca Fuller, Michelle Bowie, Aaron Briley, Michael Brown, and Janell Hostettler. “RECONSTITUTION OF CGAS/STING PATHWAY VIA EPIGENETIC REPROGRAMMING LEADS TO ANTI-VIRAL INFLAMMATORY SIGNALING IN ATYPICAL TERATOID RHABDOID TUMORS (ATRTS).” In Neuro Oncology, 24:1–1, 2022.
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  - Shoaf, Madison, Frances Chow, Joanne Xiu, Michael Glantz, Sonikpreet Aulakh, David Ashley, Eric S. Lipp, et al. “CLINICAL FEATURES AND MOLECULAR CHARACTERIZATION OF LEPTOMENINGEAL DISEASE IN PATIENTS WITH HIGH GRADE GLIOMA.” In Neuro Oncology, 24:154–55, 2022.
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  - Sim, Hao-Wen, Zarnie Lwin, Elizabeth Barnes, Kerrie McDonald, Eng-Siew Koh, Mark Rosenthal, Matthew Foote, et al. “GENOME-WIDE DNA METHYLATION PATTERNS IN VERTU: A RANDOMIZED PHASE II TRIAL OF VELIPARIB, RADIOTHERAPY AND TEMOZOLOMIDE IN PATIENTS WITH MGMT-UNMETHYLATED GLIOBLASTOMA.” In Neuro Oncology, 24:81–81, 2022.
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  - Sim, Hao-Wen, Zarnie Lwin, Elizabeth Barnes, Kerrie McDonald, Sonia Yip, Roel Verhaak, Amy Heimberger, et al. “NUTMEG: A RANDOMIZED PHASE II STUDY OF NIVOLUMAB AND TEMOZOLOMIDE VERSUS TEMOZOLOMIDE ALONE IN NEWLY DIAGNOSED ELDERLY PATIENTS WITH GLIOBLASTOMA.” In Neuro Oncology, 24:65–65, 2022.
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  - Singh, Kirit, Matthew Foster, Elizabeth S. Miller, Simon Gregory, Kent J. Weinhold, David M. Ashley, Annick Desjardins, et al. “A phase 0/surgical window-of-opportunity study in progress, evaluating evolocumab in patients with high-grade glioma or glioblastoma.” In Journal of Clinical Oncology, Vol. 40, 2022.
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  - Sun, Michael, Rui Yang, Heng Liu, Wenzhe Wang, Xiao Song, Bo Hu, Nathan Reynolds, et al. “REPURPOSING CLEMASTINE TO SUPPRESS GLIOBLASTOMA STEM CELLS.” In Neuro Oncology, 24:35–35, 2022.
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  - Thompson, Eric, Daniel Landi, Michael Brown, Henry S. Friedman, Roger McLendon, Dani Bolognesi, Kristin Schroeder, et al. “RESULTS OF A PHASE IB TRIAL OF RECOMBINANT POLIO:RHINOVIRUS IMMUNOTHERAPY FOR RECURRENT PEDIATRIC HIGH GRADE GLIOMA.” In Neuro Oncology, 24:62–63, 2022.
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  - Waitkus, Matthew, Heng Liu, Alexandrea Brown, Laura Strickland, Taher Khambati, Casey Fraley, Bill Diplas, Stephen Keir, and David Ashley. “THE ROLE OF SMARCAL1 AS A SYNTHETIC LETHAL VULNERABILITY IN ATRX-DEFICIENT GLIOMAS.” In Neuro Oncology, 24:91–92, 2022.
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  - Wood, Paul, Jayesh Desai, Kelly Waldeck, Jason Cain, Nicholas Gottardo, Robyn Strong, Kathryn Kinross, et al. “A PHASE II STUDY OF CONTINUOUS LOW DOSE PANOBINOSTAT IN PAEDIATRIC PATIENTS WITH MALIGNANT RHABDOID TUMOURS AND ATYPICAL TERATOID RHABDOID TUMOURS.” In Neuro Oncology, 24:6–7, 2022.
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  - Batich, Kristen, Duane Mitchell, Patrick Healy, James Herndon, Gloria Broadwater, Gunn Michael, Min-Nung Huang, et al. “CTIM-10. REPRODUCIBILITY OF CLINICAL TRIALS USING CMV-TARGETED DENDRITIC CELL VACCINES IN PATIENTS WITH GLIOBLASTOMA.” In Neuro Oncology, 23:vi51–vi51. Oxford University Press (OUP), 2021. https://doi.org/10.1093/neuonc/noab196.202.
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  - Peters, Katherine, John Kirkpatrick, Ines Batinic-Haberle, Mary Affronti, Sarah Woodring, Deborah Iden, Sujata Panta, et al. “PHASE 1 DOSE ESCALATION TRIAL OF THE SAFETY OF BMX-001 CONCURRENT WITH RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED PATIENTS WITH HIGH-GRADE GLIOMAS.” In Neuro Oncology, 20:1vi7-vi17. OXFORD UNIV PRESS INC, 2018. https://doi.org/10.1093/neuonc/noy148.061.
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  - Vaslow, Zachary, John Kirkpatrick, Mary Affronti, Patrick Healy, James Herndon, Eric Lipp, Leslie Thomas, et al. “CLINICAL AND HISTOPATHOLOGICAL CHARACTERISTICS OF YOUNG ADULTS WITH GLIOBLASTOMA AT DIAGNOSIS.” In Neuro Oncology, 20:vi239–vi239. OXFORD UNIV PRESS INC, 2018. https://doi.org/10.1093/neuonc/noy148.990.
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  - Ashley, David, Annick Desjardins, Matthias Gromeier, Andrea Muscat, James Herndon, Allan Friedman, Henry Friedman, et al. “INTRATUMORAL ADMINISTRATION OF AN ONCOLYTIC POLIO/RHINOVIRUS RECOMBINANT (PVSRIPO) IN MALIGNANT GLIOMA PATIENTS: ASSESSMENT OF MUTATIONAL RESPONSE CORRELATES.” In Neuro Oncology, 20:7–7. OXFORD UNIV PRESS INC, 2018.
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  - Batich, Kristen, David Ashley, Gary Archer, Luis Sanchez-Perez, Pam Norberg, Kendra Congdon, James Herndon, et al. “ENHANCING VACCINE RESPONSES WITH DOSE-INTENSIFIED TEMOZOLOMIDE IN GLIOBLASTOMA: INITIATION OF THE I-ATTAC TRIAL.” In Neuro Oncology, 20:234–234. OXFORD UNIV PRESS INC, 2018.
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  - Bowie, Michelle, David Ashley, Janell Hostettler, Michael Brown, Jeffrey Bryant, Darell Bigner, Matthias Gromeier, and Smita Nair. “DYSFUNCTIONAL STING PATHWAY SIGNALING COMPROMISES INNATE IMMUNITY IN GLIOBLASTOMA.” In Neuro Oncology, 20:127–28. OXFORD UNIV PRESS INC, 2018.
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  - Keir, Stephen, Matthew Waitkus, Martin Roskoski, Henry Friedman, Darell Bigner, Hai Yan, and David Ashley. “ESTABLISHMENT AND PRELIMINARY EVALUATION OF BEVACIZUMAB-RESISTANT GLIOMA XENOGRAFT MODELS.” In Neuro Oncology, 20:275–275. OXFORD UNIV PRESS INC, 2018.
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  - Thompson, Eric, Daniel Landi, David Ashley, Steve Keir, and Darell Bigner. “BEVACIZUMAB, IRINOTECAN, TEMOZOLOMIDE, TYROSINE KINASE INHIBITION, AND MEK INHIBITION ARE EFFECTIVE AGAINST PLEOMORPHIC XANTHOASTROCYTOMA REGARDLESS OF V600E STATUS.” In Neuro Oncology, 20:102–102. OXFORD UNIV PRESS INC, 2018.
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  - Verhaak, Roel, Kenneth Aldape, Samirkumar Amin, David Ashley, Jill Barnholtz-Sloan, Amanda Bates, Rameen Beroukhim, et al. “MOLECULAR EVOLUTION OF DIFFUSE GLIOMAS AND THE GLIOMA LONGITUDINAL ANALYSIS CONSORTIUM.” In Neuro Oncology, 20:76–76. OXFORD UNIV PRESS INC, 2018.
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  - Ashley, David M., Eric M. Thompson, Daniel Landi, Annick Desjardins, Allan H. Friedman, Stevie Threatt, James E. Herndon, et al. “PHASE 1B STUDY POLIO VACCINE SABIN-RHINOVIRUS POLIOVIRUS (PVSRIPO) FOR RECURRENT MALIGNANT GLIOMA IN CHILDREN.” In Neuro Oncology, 20:93–93. OXFORD UNIV PRESS INC, 2018.
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  - Landi, Daniel, Eric Thompson, James Herndon, John Sampson, and David Ashley. “CMV PP65 RNA-PULSED DENDRITIC CELL VACCINES FOR PEDIATRIC GLIOBLASTOMA AND MEDULLOBLASTOMA: A PHASE I TRIAL.” In Neuro Oncology, 20:103–103. OXFORD UNIV PRESS INC, 2018.
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  - Landi, Daniel, Eric Thompson, Roger McLendon, Annick Desjardins, Vidya Chandramohan, David Ashley, and Darell Bigner. “TARGETING EGFR IN HYPOMUTATED PEDIATRIC BRAIN TUMORS USING THE D2C7 IMMUNOTOXIN.” In Neuro Oncology, 20:103–103. OXFORD UNIV PRESS INC, 2018.
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  - Wood, Paul, Jayesh Desai, Nick Gottardo, Jason Cain, and David Ashley. “A PHASE II STUDY OF PANOBINOSTAT IN PAEDIATRIC PATIENTS WITH SOLID TUMORS INCLUDING MALIGNANT RHABDOID TUMOR/ATYPICAL TERATOID RHABDOID TUMOURS.” In Neuro Oncology, 20:33–33. OXFORD UNIV PRESS INC, 2018.
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  - Khasraw, Mustafa, Kerrie Leanne McDonald, Mark Rosenthal, Zarnie Lwin, David M. Ashley, Helen Wheeler, Elizabeth Barnes, et al. “A randomized phase 2 trial of veliparib (V), radiotherapy (RT) and temozolomide (TMZ) in patients (pts) with unmethylated MGMT (uMGMT) glioblastoma (GBM): Feasibility and safety outcomes (the VERTU study).” In Journal of Clinical Oncology, 36:2045–2045. American Society of Clinical Oncology (ASCO), 2018. https://doi.org/10.1200/jco.2018.36.15_suppl.2045.
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  - Vaslow, Zachary, Katherine Peters, John Kirkpatrick, Frances McSherry, James Herndon, Eric Lipp, Margaret O. Johnson, et al. “Long-term outcomes of adult patients with ependymoma.” In Neurology, 90:P6–P6. American Academy of Neurology, 2018.
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  - Inamullah, O., John Kirkpatrick, Patrick Healy, Eric Lipp, Margaret Johnson, David Ashley, Dina Randazzo, Henry Friedman, and Katherine Peters. “Adult pilocytic astrocytoma: clinical management and prognostic factors.” In Neurology, 90:P6.158-P6.158. American Academy of Neurology, 2018.
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  - Popovski, Dean, Catherine R. Cochrane, Elizabeth M. Algar, Anette Szczepny, W Samantha Jayasekara, David M. Ashley, Peter Downie, D Neil Watkins, and Jason E. Cain. “TARGETED CATALYTIC INHIBITION OF EZH2 SYNERGIZES WITH LOW-DOSE PANOBINOSTAT IN MALIGNANT RHABDOID TUMOR.” In Neuro Oncology, 19:190–91. OXFORD UNIV PRESS INC, 2017.
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  - Rogers, M. J., L. Matheson, B. Garrard, B. Maher, S. Cowdery, W. Luo, M. Reed, S. Riches, G. Pitson, and D. M. Ashley. “Comparison of outcomes for cancer patients discussed and not discussed at a multidisciplinary meeting.” In Public Health, 149:74–80, 2017. https://doi.org/10.1016/j.puhe.2017.04.022.
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  - Popovski, Dean, Catherine Cochrane, Elizabeth Algar, Anette Szczepny, Samantha Jayasekara, David Ashley, Peter Downie, Neil Watkins, and Jason Cain. “TARGETED CATALYTIC INHIBITION OF EZH2 SYNERGIZES WITH LOW-DOSE PANOBINOSTAT IN MALIGNANT RHABDOID TUMOR.” In Neuro Oncology, 19:1–1. OXFORD UNIV PRESS INC, 2017.
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  - Livingston, P. M., D. Ashley, S. Chambers, V. Whites, L. Heckel, B. Lavelle, P. Parente, et al. “M-HEALTH: THE IMPACT OF SMARTPHONE TECHNOLOGY TO IMPROVE QUALITY OF LIFE OUTCOMES AMONG PEOPLE WITH CANCER: A RANDOMISED CONTROLLED TRIAL.” In International Journal of Behavioral Medicine, 23:S168–S168. SPRINGER, 2016.
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  - Pitson, Graham, Leigh Matheson, Brooke Garrard, Bianca Maher, Stephanie Cowdery, W. Luo, Marita Reed, Sue Riches, David Ashley, and Margaret J. Rogers. “MULTIDISCIPLINARY MEETINGS IN THE TREATMENT OF BREAST CANCER.” In Asia Pacific Journal of Clinical Oncology, 12:144–144. WILEY-BLACKWELL, 2016.
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  - Pitson, Graham, Leigh Matheson, David Campbell, Brooke Garrard, Ian M. Collins, Violet Mukaro, Greg Mitchell, Sue Riches, David Ashley, and Margaret J. Rogers. “BREAST CANCER CLINICAL QUALITY INDICATORS.” In Asia Pacific Journal of Clinical Oncology, 12:143–143. WILEY-BLACKWELL, 2016.
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  - Khasraw, M., C. Murphy, V. Mukaro, L. West, K. White, C. Brandt, S. E. Baron-Hay, et al. “TAILORED NEOADJUVANT EPIRUBICIN AND CYCLOPHOSPHAMIDE (EC) AND NANOPARTICLE ALBUMIN- BOUND PACLITAXEL (NAB-P) IN BREAST CANCER.” In Asia Pacific Journal of Clinical Oncology, 12:44–44. WILEY-BLACKWELL, 2016.
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  - Khasraw, Mustafa, Violet Rudo Mukaro, Linda West, Karen White, Elisabeth Rippy, Conrad Brandt, Robert Tobler, et al. “Tailored neoadjuvant epirubicin and cyclophosphamide (EC) and nanoparticle albumin-bound paclitaxel (nab-P) in breast cancer.” In Journal of Clinical Oncology, 34:e12515–e12515. American Society of Clinical Oncology (ASCO), 2016. https://doi.org/10.1200/jco.2016.34.15_suppl.e12515.
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  - Li, C., S. Gupta, S. Rana, V. Nguyen, S. Venkatesh, D. Ashley, and T. Livingston. “Multiple adverse effects prediction in longitudinal cancer treatment.” In Proceedings International Conference on Pattern Recognition, 0:3156–61, 2016. https://doi.org/10.1109/ICPR.2016.7900120.
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  - Heckel, Leila, Kate M. Fennell, John Reynolds, David M. Ashley, Mari Botti, Jacquie Chirgwin, Richard H. Osborne, Melinda Williams, and Patricia M. Livingston. “RECRUITMENT OF CARER/PERSON WITH CANCER DYADS INTO A RANDOMISED CONTROLLED TRIAL: FACTORS ASSOCIATED WITH NON-PARTICIPATION AND REASONS FOR DECLINE.” In Asia Pacific Journal of Clinical Oncology, 11:157–157. WILEY-BLACKWELL, 2015.
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  - Heckel, Leila, Kate M. Fennell, Mari Botti, John Reynolds, Jacquie Chirgwin, David M. Ashley, Richard H. Osborne, Anna Boltong, Katherine Simons, and Patricia M. Livingston. “ACCEPTABILITY AND UTILITY OF A TELEPHONE OUTCALL PROGRAM FOR CARERS OF PERSONS DIAGNOSED WITH CANCER.” In Asia Pacific Journal of Clinical Oncology, 11:156–156. WILEY-BLACKWELL, 2015.
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  - Livingston, Patricia, David Ashley, Suzanne Chambers, Victoria White, Leila Heckel, Barbara Lavelle, Philip Parente, et al. “M-HEALTH: THE IMPACT OF SMARTPHONE TECHNOLOGY TO IMPROVE QUALITY OF LIFE OUTCOMES AMONG PEOPLE WITH CANCER: A RANDOMISED CONTROLLED TRIAL.” In Asia Pacific Journal of Clinical Oncology, 11:161–161. WILEY-BLACKWELL, 2015.
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  - Khasraw, Mustafa, Violet Rudo Mukaro, Linda West, Conrad Brandt, Anne Maree Woollett, Michelle Edwards, Robert Spokes, et al. “Tailored neoadjuvant epirubicin and cyclophosphamide (EC) and nanoparticle albumin bound (nab)-paclitaxel for newly diagnosed breast cancer (BC).” In Journal of Clinical Oncology, Vol. 33. AMER SOC CLINICAL ONCOLOGY, 2015.
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  - Ashley, David M., Andrea Muscat, Julia Yin, Elizabeth Algar, Kate Drummond, Mustafa Khasraw, Kathryn Maree Field, Nicholas Wong, Mark Rosenthal, and Kerrie Leanne McDonald. “Mutational analysis of matched initial and recurrent TP53 WT primary GBM.” In Journal of Clinical Oncology, 33:2043–2043. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.2043.
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  - Ashley, David M., Sunil Gupta, Truyen Tran, Luo Wei, Paula K. Lorgelly, David Morgan Thomas, Stephen B. Fox, and Svetha Venkatesh. “Machine-learning prediction of cancer survival: A prospective study examining the impact of combining clinical and genomic data.” In Journal of Clinical Oncology, 33:6521–6521. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.6521.
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  - McDonald, Kerrie Leanne, Mustafa Khasraw, and David M. Ashley. “Identification of glioblastoma patients who stand to benefit from PARP inhibitor therapy.” In Journal of Clinical Oncology, 33:2071–2071. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.2071.
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  - Wong, Shu Fen, Richard Norman, Trisha L. Dunning, David M. Ashley, Mustafa Khasraw, and Paula K. Lorgelly. “A discrete choice experiment to examine the preferences of patients with cancer and their willingness to pay for different types of health care appointments.” In Journal of Clinical Oncology, 33:6527–6527. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.6527.
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  - Heckel, Leila, Kate Gunn, John Reynolds, Richard Osborne, Jacquie Chirgwin, David Ashley, Mari Botti, and Patricia Livingston. “CARER BURDEN, DEPRESSION AND UNMET NEEDS AMONG CARERS OF PEOPLE NEWLY DIAGNOSED WITH CANCER.” In Asia Pacific Journal of Clinical Oncology, 10:230–230. WILEY-BLACKWELL, 2014.
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  - Jefford, Michael, Linda Nolte, Spiri Galetakis, Sharon Avery, Lucio Naccarella, Kate Thompson, Bruce Mann, et al. “KEY LEARNINGS FROM AN EVALUATION OF STATEWIDE MODELS OF POST-TREATMENT CARE.” In Asia Pacific Journal of Clinical Oncology, 10:184–184. WILEY-BLACKWELL, 2014.
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  - Shih, Sophy T. F., Trish M. Livingston, Kate Schofield, Kate Morrissy, David Ashley, and Cathrine Mihalopoulos. “ECONOMIC ASSESSMENT ON A TRIAL INTERVENTION OF CANCER SURVIVORSHIP SERVICE.” In Asia Pacific Journal of Clinical Oncology, 10:252–252. WILEY-BLACKWELL, 2014.
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  - Williams, C., A. Shelly, J. Williamson, P. Downie, F. Mechinaud, G. Wheeler, D. Ashley, and K. Whitfield. “DEVELOPING A SERVICE CAPABILITY FRAMEWORK: A GUIDE FOR HEALTH SERVICES PROVIDING CARE TO CHILDREN AND ADOLESCENTS WITH CANCER.” In Pediatric Blood & Cancer, 61:S356–S356. WILEY-BLACKWELL, 2014.
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  - Williams, Chris, Jane Williamson, Francoise Mechinaud, Peter Downie, Greg Wheeler, and David Ashley. “DEVELOPING A SERVICE CAPABILITY FRAMEWORK: A GUIDE FOR HEALTH SERVICES PROVIDING CARE TO CHILDREN AND ADOLESCENTS WITH CANCER.” In Asia Pacific Journal of Clinical Oncology, 10:75–75. WILEY-BLACKWELL, 2014.
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  - Heckel, Leila, Kate Gunn, John Reynolds, Richard Osborne, Jacquie Chirgwin, David Ashley, Mari Botti, and Patricia Livingston. “Carer Burden, Depression and Unmet Needs among Carers of People Newly Diagnosed with Cancer.” In Psycho Oncology, 23:79–80. WILEY-BLACKWELL, 2014.
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  - Muscat, Andrea, Jason Cain, Melissa Ferguson, Dean Popovski, Elizabeth Algar, Fernando J. Rossello, Samantha Jayasekara, D Neil Watkins, Jason Hodge, and David Ashley. “LOW DOSE HISTONE DEACETYLASE INHIBITOR TREATMENT HALTS RHABDOID TUMOUR GROWTH AND INDUCES OSTEOGENESIS AND NEURONAL DIFFERENTIATION.” In Neuro Oncology, 16:1–1. OXFORD UNIV PRESS INC, 2014.
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  - Khasraw, Mustafa, Linda West, Wei Duan, Violet Mukaro, Sandra Harvey, Robert Spokes, Conrad Brandt, et al. “Tailored neoadjuvant epirubicin and cyclophosphamide and nanoparticle albumin bound (nab)-paclitaxel for newly diagnosed breast cancer.” In Journal of Clinical Oncology, 32:TPS1135–TPS1135. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.tps1135.
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  - Khasraw, Mustafa, Malaka Ameratunga, Andrew B. Lassman, David M. Ashley, Helen Wheeler, and Nick Pavlakis. “A meta-analysis of antiangiogenic therapy for glioblastoma (GBM).” In Journal of Clinical Oncology, 32:2047–2047. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.2047.
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  - Wood, Paul James, Robyn Strong, Grant A. McArthur, Michael Michael, Elizabeth Algar, Andrea Muscat, Lin Rigby, and David M. Ashley. “A phase I study of panobinostat in pediatric patients with refractory solid tumors, including CNS tumors.” In Journal of Clinical Oncology, 32:10061–10061. American Society of Clinical Oncology (ASCO), 2014. https://doi.org/10.1200/jco.2014.32.15_suppl.10061.
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  - Gottardo, Nicholas G., Jordan R. Hansford, Jacqueline P. McGlade, Frank Alvaro, David M. Ashley, Simon Bailey, David L. Baker, et al. “Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group.” In Acta Neuropathol, 127:189–201, 2014. https://doi.org/10.1007/s00401-013-1213-7.
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  - Khasraw, Mustafa, Violet R. Mukaro, Michael Berk, Greg Wheeler, Madhu Singh, Chris Brown, Michael Francis, et al. “LITHIUM AS A NEUROPROTECTIVE AGENT IN PATIENTS UNDERGOING PROPHYLACTIC CRANIAL IRRADIATION (PCI) FOR SMALL CELL LUNG CANCER (SCLC): THE TULIP STUDY.” In Journal of Thoracic Oncology, 8:S932–S932. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Livingston, Trish, Richard Osborne, Mari Botti, Jacquie Chirgwin, Cathy Mihalopoulos, Sean McGuigan, Leila Heckel, et al. “EFFICACY AND COST-EFFECTIVENESS OF A TELEPHONE OUTCALL PROGRAM TO REDUCE CARER BURDEN AND DEPRESSION AMONG CARERS OF CANCER PATIENTS [PROTECT]. RATIONALE AND DESIGN OF A MULTI-STATE, MULTI-CENTRE RANDOMISED CONTROLLED TRIAL.” In Asia Pacific Journal of Clinical Oncology, 9:159–159. WILEY-BLACKWELL, 2013.
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  - Bandopadhayay, P., A. Jabbour, C. Riffkin, M. Salmanidis, L. Gordon, D. Popovski, L. Rigby, et al. “THE ONCOGENIC PROPERTIES OF THE EWS/WT1 FUSION PROTEIN OF DESMOPLASTIC SMALL ROUND CELL TUMOUR.” In Pediatric Blood & Cancer, 60:8–8. WILEY-BLACKWELL, 2013.
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  - Green, Daniel M., Thomas E. Merchant, Catherine A. Billups, Dennis C. Stokes, Alberto Broniscer, Ashok Srinivasan, Murali M. Chintagumpala, et al. “Pulmonary function after treatment for embryonal brain tumors on SJMB03 that included craniospinal irradiation.” In Journal of Clinical Oncology, Vol. 31. AMER SOC CLINICAL ONCOLOGY, 2013.
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  - Amakye, Dereck, Douglas Robinson, Kristine Rose, Yoon-Jae Cho, Keith L. Ligon, Thad Sharp, Yuichi Ando, et al. “DEVELOPMENT OF A FIVE-GENE HEDGEHOG SIGNATURE AS A PATIENT PRESELECTION TOOL FOR HEDGEHOG PATHWAY-TARGETED THERAPY IN MEDULLOBLASTOMA.” In Neuro Oncology, 15:33–34. OXFORD UNIV PRESS INC, 2013.
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  - Geoerger, Birgit, Isabelle Aerts, Michela Casanova, Julia Chisholm, Darren Hargrave, Sarah E. S. Leary, David Ashley, et al. “UPDATED RESULTS FROM A PHASE I STUDY OF LDE225, A SMOOTHENED ANTAGONIST, IN PEDIATRIC PATIENTS WITH RECURRENT MEDULLOBLASTOMA OR OTHER SOLID TUMORS.” In Pediatric Blood & Cancer, 59:980–980. WILEY PERIODICALS, INC, 2012.
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  - Algar, Elizabeth, Dean Popovski, Andrea Muscat, and David Ashley. “RHABDOID TUMOUR SUPPRESSOR SMARCB1: EVIDENCE FOR A ROLE IN THE POST-TRANSCRIPTIONAL REGULATION OF NF2.” In Neuro Oncology, 14:5–5. OXFORD UNIV PRESS INC, 2012.
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  - Geoerger, Birgit, Isabelle Aerts, Michela Casanova, Julia C. Chisholm, Darren R. Hargrave, Sarah Leary, David M. Ashley, et al. “A phase I/II study of LDE225, a smoothened (Smo) antagonist, in pediatric patients with recurrent medulloblastoma (MB) or other solid tumors.” In Journal of Clinical Oncology, Vol. 30. AMER SOC CLINICAL ONCOLOGY, 2012.
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  - Amakye, Dereck, Douglas Robinson, Kristine Rose, Jae Cho, Keith L. Ligon, Thad Sharp, Asifa Haider, et al. “The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor therapy.” In Cancer Research, Vol. 72. AMER ASSOC CANCER RESEARCH, 2012. https://doi.org/10.1158/1538-7445.AM2011-4818.
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  - Ashley, David M., Andrea Muscat, Lavinia Gordon, Lin Rigby, Diane Birks, Nicholas Foreman, and Elizabeth Algar. “SMARCB1 MANIPULATION AND EPIGENETIC PROFILING IN ATYPICAL TERATOID RHABDOID TUMORS (ATRTs) PROVIDES NOVEL INSIGHTS INTO TUMOR ETIOLOGY.” In Neuro Oncology, 13:102–102. OXFORD UNIV PRESS INC, 2011.
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  - Hutchinson, Esther, Maria McCarthy, David Ashley, Sarah Knight, Ellen Gentle, and Cinzia de Luca. “VISUO-MOTOR INTEGRATION AND MOTOR CO-ORDINATION IN SURVIVORS OF CHILDHOOD CANCER.” In Pediatric Blood & Cancer, 57:710–710. WILEY PERIODICALS, INC, 2011.
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  - Khasraw, Mustafa, Chris Brown, David M. Ashley, and Mark A. Rosenthal. “A METANALYSIS OF ALTERNATIVE SCHEDULE OF TEMOZOLOMIDE (TMZ) IN RECURRENT MALIGNANT GLIOMA (MG).” In Neuro Oncology, 13:50–50. OXFORD UNIV PRESS INC, 2011.
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  - McCarthy, Maria C., Cinzia DeLuca, Naomi E. Clarke, Sarah Knight, David M. Ashley, and Vicki E. Anderson. “WHAT'S BEHIND THE SCREEN? IMPLICATIONS FOR CLINICAL PRACTICE.” In Pediatric Blood & Cancer, 56:1155–1155. WILEY PERIODICALS, INC, 2011.
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  - De Luca, Cinzia, Maria McCarthy, Sarah Knight, Amanda Wood, Vicki Anderson, and David Ashley. “PAY ATTENTION! THE INTEGRITY OF ATTENTION SKILLS IN SURVIVORS OF CHILDHOOD BRAIN TUMOURS AND THE RELATIONSHIP WITH WHITE MATTER VOLUME.” In Pediatric Blood & Cancer, 55:921–921. WILEY-LISS, 2010.
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  - De Luca, Cinzia, Maria McCarthy, Sarah Knight, David Ashley, Aleksandra Tarnawski, and Vicki Anderson. “TRACKWELL: A NEUROCOGNITIVE SCREEN TO MONITOR COGNITIVE DEVELOPMENT IN SURVIVORS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA.” In Pediatric Blood & Cancer, 55:840–41. WILEY-LISS, 2010.
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  - Orme, Lisa, Franz Babl, Chris Barnes, Peter Barnett, Susan Donath, and David Ashley. “QUALITY OF LIFE: A RANDOMIZED TRIAL OF OUTPATIENT VERSUS INPATIENT IV ANTIBIOTICS FOR PAEDIATRIC ONCOLOGY PATIENTS WITH LOW RISK FEBRILE NEUTROPAENIA.” In Pediatric Blood & Cancer, 55:823–24. WILEY-LISS, 2010.
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  - Ashley, D. M., A. Muscat, L. Rigby, and E. Algar. “EXPLORING THE FEASIBILITY OF EPIGENETIC THERAPIES FOR RHABDOID TUMOR.” In Neuro Oncology, 12:II36–II36. OXFORD UNIV PRESS INC, 2010.
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  - Ashley, D. M., N. Lyon, M. Bonner, M. Msall, Z. Tianni, D. Strother, T. Merchant, et al. “DEVELOPMENTAL AND FUNCTIONAL OUTCOME FOLLOWING POST-OPERATIVE CHEMOTHERAPY AND LOCAL CONFORMAL RADIATION IN INFANTS WITH MEDULLOBLASTOMA USING A CENTRALLY ADMINISTERED PHONE BASED INTERVIEW TECHNIQUE, FOLLOW UP REPORT: A CHILDRENS ONCOLOGY GROUP STUDY.” In Neuro Oncology, 12:II8–II8. OXFORD UNIV PRESS INC, 2010.
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  - Bandopadhayay, P., X. Wu, J. Ng, D. M. Ashley, and C. W. Chow. “PLEOMORPHIC XANTHOASTROCYTOMA IN CHILDHOOD.” In Neuro Oncology, 12:II94–II94. OXFORD UNIV PRESS INC, 2010.
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  - McCarthy, M. C., C. R. DeLuca, D. Papachristos, V. A. Anderson, and D. M. Ashley. “FATIGUE SYMPTOMS IN SURVIVORS OF CHILDHOOD CANCER: A COMPARISON OF PATIENT AND PARENT REPORT.” In Neuro Oncology, 12:II29–30. OXFORD UNIV PRESS INC, 2010.
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  - Partap, S., T. V. Hoc, T. T. Ha, and D. Ashley. “IDENTIFYING OBSTACLES IN TREATING CHILDREN WITH PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS IN DEVELOPING COUNTRIES.” In Neuro Oncology, 12:II18–II18. OXFORD UNIV PRESS INC, 2010.
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  - Wright, K. D., M. Chintagumpala, T. Hassall, D. M. Ashley, E. Bouffet, S. J. Kellie, S. Gururangan, et al. “RISK-ADAPTED CRANIOSPINAL RADIOTHERAPY FOLLOWED BY HIGH DOSE CHEMOTHERAPY WITH AUTOLOGOUS STEM CELL RESCUE IN CHILDREN WITH LARGE CELL/ANAPLASTIC MEDULLOBLASTOMA: RESULTS FROM ST. JUDE MEDULLOBLASTOMA 96 (SJMB96) AND ST. JUDE MEDULLOBLASTOMA 03 (SJMB03).” In Neuro Oncology, 12:II5–6. OXFORD UNIV PRESS INC, 2010.
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  - Ashley, David, Andrea Muscat, Vinod Dagar, Christian H. Rickert, C. W. Chow, J. A. Biegel, Paul Ekert, et al. “Insights into the epigenetics of atypical teratoid rhabdoid tumors: The potential for treatment with histone deacetylase inhibitors.” In Neuro Oncology, 10:372–372. DUKE UNIV PRESS, 2008.
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  - Ashley, David, Lyon Nancy, Bonner Melanie, Msall Michael, Tianni Zhou, Douglas Strother, Thomas Merchant, Russell Geyer, Ian Pollack, and Patricia Duffner. “Developmental and functional outcome following postoperative chemotherapy and local conformal radiation in infants with medulloblastoma using a centrally administered phone-based interview technique, initial report: A children's oncology group study.” In Neuro Oncology, 10:434–434. DUKE UNIV PRESS, 2008.
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  - Ashley, David, Pratiti Bandopadhayay, Maria Kirby, Michael Sullivan, Jennifer Houlihan, Richard Cohn, and Timothy Hassall. “ANZCCSG babybrain 99: Intensified systemic chemotherapy, second look surgery, and involved field radiation in young children with CNS malignancy.” In Neuro Oncology, 10:421–22. OXFORD UNIV PRESS INC, 2008.
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  - Ashley, David, Thomas Merchant, Tianni Zhou, Lee Coleman, Ian Pollack, Patricia Duffner, Peter Burger, Douglas Miller, Allen Buxton, and Strother Douglas. “P9934: Systemic chemotherapy, secondlook surgery and conformal radiation therapy limited to the posterior fossa and primary site for children > 8 months and < 3 years with nonmetastatic medulloblastoma: A children's oncology group phase III study.” In Neuro Oncology, 10:436–37. DUKE UNIV PRESS, 2008.
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  - Ashley, D. M., C. D. Riffkin, A. M. Muscat, and C. Hawkins. “Low caspase-8 expression levels will preclude meaningful death ligand therapy in malignant glioma.” In Neuro Oncology, 9:185–185. DUKE UNIV PRESS, 2007.
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  - Ashley, D. M., K. E. Enderby, A. C. Jackson, J. Miller, M. O’Toole, N. Tokatlian, M. Tsantefski, S. L. Khaw, and S. A. Thomas. “The impact of childhood brain tumors on families: A longitudinal study.” In Neuro Oncology, 9:174–174. DUKE UNIV PRESS, 2007.
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  - Ashley, D. M., and S. L. Khaw. “Temozolomide as second-line chemotherapy for progressive low-grade glioma in children.” In Neuro Oncology, 9:190–190. DUKE UNIV PRESS, 2007.
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  - Gajjar, A., M. Chintagumpala, D. Ashley, A. Broniscer, M. Fouladi, D. Wallace, T. Merchant, L. Kun, R. Gilbertson, and C. Fuller. “Tumor histology is an important independent prognostic factor of event-free survival in average-risk and high-risk medulloblastoma: Results from a prospective collaborative trial (SJMB 96).” In Neuro Oncology, 9:192–192. DUKE UNIV PRESS, 2007.
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  - Elwood, N. J., M. J. Ferguson, S. Li, K. Tiedemann, and D. M. Ashley. “Telomere length of donor cord blood cells predicts survival following a cord blood transplant.” In Experimental Hematology, 34:86–86. ELSEVIER SCIENCE INC, 2006.
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  - Fouladi, M., M. Chintagumpala, D. Ashley, S. Kellie, A. Broniscer, T. E. Merchant, L. E. Kun, C. Stewart, D. Wallace, and A. Gajjar. “Role of amifostine as a cytoprotectant in children >= 3 years with average risk (AR) medulloblastoma (MB) treated with craniospinal irradiation (CSI) and 4 courses of cisplatin (CDDP)-based high dose chemotherapy.” In Journal of Clinical Oncology, 24:517S-517S. AMER SOC CLINICAL ONCOLOGY, 2006.
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  - Thompson, Margaret C., Christine Fuller, Twala L. Hogg, James Dalton, David Finkelstein, Ching C. Lau, Murali Chintagumpala, et al. “Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.” In J Clin Oncol, 24:1924–31, 2006. https://doi.org/10.1200/JCO.2005.04.4974.
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  - Ashton, Lesley J., Jayne E. Murray, Glenn M. Marshall, Michelle Haber, David M. Ashley, and Murray D. Norris. “Polymorphisms of glutathione-S-transferase and N-acetyltransferase genes and response to treatment in childhood neuroblastoma.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.
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  - Ashley, D., C. Riffkin, A. Muscat, and C. Hawkins. “Caspase-8 status of ex vivo gliomas.” In Neuro Oncology, 7:301–301. DUKE UNIV PRESS, 2005.
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  - Chintagumpala, M., D. Ashley, T. Hassall, D. Wallace, T. E. Merchant, S. Woo, M. Sexton, R. Cheuk, and A. Gajjar. “Excellent event-free survival (EFS) in newly diagnosed patients with supratentorial primitive neurectodermal tumors (SPNET) treated with risk-adapted craniospinal (CSI) radiation (RT) therapy followed by 4 cycles of high-dose chemotherapy and stem cell rescue.” In Journal of Clinical Oncology, 23:813S-813S. AMER SOC CLINICAL ONCOLOGY, 2005.
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  - Hassall, T. V., M. Sexton, J. Houlihan, L. Chow, Y. Hastings, and D. Ashley. “Anzccsg baby B99: Systemic chemotherapy, second-look surgery and involved field radiation for children less than four years of age with malignant central nervous system tumours.” In Neuro Oncology, 6:458–458. DUKE UNIV PRESS, 2004.
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  - Heath, J. A., W. H. Ng, W. Maixner, C. W. Chow, J. Laidlaw, M. Gonzales, and D. M. Ashley. “Oligoastrocytoma/oligodendroglioma in association with dysembryoplastic neuroepithelial tumor (DNET).” In Neuro Oncology, 6:408–408. DUKE UNIV PRESS, 2004.
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  - Desjardins, Annick, Dina Randazzo, V. Chandramohan, Katherine B. Peters, Margaret O. Johnson, Steve Threatt, James E. Herndon, et al. “Dose escalation study of D2C7-IT administered intratumorally via convection-enhanced delivery for recurrent malignant glioma.,” n.d.
  - Desjardins, Annick, Dina Randazzo, V. Chandramohan, Katherine Peters, Margaret O. Johnson, Stevie Threatt, James Herndon, et al. “Dose escalation study of D2C7-IT administered intratumorally via convection-enhanced delivery for recurrent malignant glioma.,” n.d.

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