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Dequing Wu

Research Scientist, Senior
Center for Population Health & Aging
Box 90088, Durham, NC 27708-0088
A104 Erwin Mill Building, 2024 W. Main St., Durham, NC 27705

Current Appointments & Affiliations


Recent Publications


Basic Science and Pathogenesis

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous system. Polymor ... Full text Cite

Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

Journal Article J Alzheimers Dis · 2024 Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and ... Full text Link to item Cite

How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.

Journal Article Frontiers in aging · January 2024 The ε4 allele of the APOE gene (APOE4) is known for its negative association with human longevity; however, the mechanism is unclear. APOE4 is also linked to changes in body weight, and the latter changes were associated with survival in some ... Full text Cite
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Recent Grants


Understanding Alzheimer's Disease in the Context of the Aging

ResearchInvestigator · Awarded by National Institutes of Health · 2019 - 2025

Project 1: The Long Life Family Study

ResearchSenior Research Scientist · Awarded by Washington University in St. Louis · 2019 - 2025

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