Scholars@Duke

• Research
• 

  Selected Grants

  • Understanding Alzheimer's Disease in the Context of the Aging awarded by National Institutes of Health 2019 - 2024
  • Genetics of aging, health and longevity: focus on regulatory mechanisms and functional variants connecting aging and Alzheimer's disease" awarded by National Institutes of Health 2020 - 2024
  • Analysis: The Long Life Family Study awarded by Washington University in St. Louis 2019 - 2024
  • Project 1: The Long Life Family Study awarded by Washington University in St. Louis 2019 - 2024
  • Genetics of changes in population pyramids: Implications for health forecasting with a focus on Alzheimer's Disease and related dementias awarded by National Institute on Aging 2014 - 2023
  • Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center awarded by National Institutes of Health 2004 - 2019
  • The Future of Major Geriatric Disorders in the US Elderly awarded by National Institutes of Health 2008 - 2013
  • Evaluating New Genetic Effects on Health and Aging from Longitudinal Data awarded by National Institutes of Health 2007 - 2013
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yashin, Anatoliy I., Deqing Wu, Konstantin Arbeev, Olivia Bagley, Igor Akushevich, Matt Duan, Arseniy Yashkin, and Svetlana Ukraintseva. “Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.” Mechanisms of Ageing and Development 196 (June 2021): 111477. https://doi.org/10.1016/j.mad.2021.111477.
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    • Ukraintseva, Svetlana, Matt Duan, Konstantin Arbeev, Deqing Wu, Olivia Bagley, Arseniy P. Yashkin, Galina Gorbunova, Igor Akushevich, Alexander Kulminski, and Anatoliy Yashin. “Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.” Frontiers in Cell and Developmental Biology 9 (January 2021): 692020. https://doi.org/10.3389/fcell.2021.692020.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin Arbeev, Arseniy P. Yashkin, Igor Akushevich, Olivia Bagley, Matt Duan, and Svetlana Ukraintseva. “Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.” Journal of Translational Genetics and Genomics 5, no. 4 (January 2021): 357–79.
    • Arbeev, Konstantin G., Olivia Bagley, Svetlana V. Ukraintseva, Deqing Wu, Hongzhe Duan, Alexander M. Kulminski, Eric Stallard, et al. “Genetics of physiological dysregulation: findings from the long life family study using joint models.” Aging 12, no. 7 (April 2020): 5920–47. https://doi.org/10.18632/aging.102987.
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    • Arbeev, Konstantin G., Olivia Bagley, Svetlana V. Ukraintseva, Hongzhe Duan, Alexander M. Kulminski, Eric Stallard, Deqing Wu, et al. “Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.” Frontiers in Public Health 8 (January 2020): 56. https://doi.org/10.3389/fpubh.2020.00056.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Olivia Bagley, Eric Stallard, Alexander M. Kulminski, et al. “Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 73, no. 11 (October 2018): 1472–81. https://doi.org/10.1093/gerona/gly057.
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    • Yashin, Anatoliy I., Fang Fang, Mikhail Kovtun, Deqing Wu, Matt Duan, Konstantin Arbeev, Igor Akushevich, et al. “Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.” Experimental Gerontology 107 (July 2018): 148–60. https://doi.org/10.1016/j.exger.2017.10.020.
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    • Arbeeva, Liubov S., Heidi A. Hanson, Konstantin G. Arbeev, Alexander M. Kulminski, Eric Stallard, Svetlana V. Ukraintseva, Deqing Wu, et al. “How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database.” Frontiers in Public Health 6 (January 2018): 277. https://doi.org/10.3389/fpubh.2018.00277.
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    • Kulminski, Alexander M., Yelena Kernogitski, Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, et al. “Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.” Aging Cell 16, no. 1 (February 2017): 61–72. https://doi.org/10.1111/acel.12526.
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    • Bhattacharyya, Onil, Diane Wu, Kathryn Mossman, Leigh Hayden, Pavan Gill, Yu-Ling Cheng, Abdallah Daar, et al. “Criteria to assess potential reverse innovations: opportunities for shared learning between high- and low-income countries.” Global Health 13, no. 1 (January 25, 2017): 4. https://doi.org/10.1186/s12992-016-0225-1.
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    • Kulminski, Alexander M., Nalini Raghavachari, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Deqing Wu, Svetlana V. Ukraintseva, Kaare Christensen, and Anatoliy I. Yashin. “Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.” Biogerontology 17, no. 5–6 (November 2016): 893–905. https://doi.org/10.1007/s10522-016-9659-3.
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    • Kulminski, Alexander M., Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G. Arbeev, Elena Loiko, et al. “Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.” Plos Genetics 12, no. 11 (November 2016): e1006314. https://doi.org/10.1371/journal.pgen.1006314.
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    • Ukraintseva, Svetlana, Anatoliy Yashin, Konstantin Arbeev, Alexander Kulminski, Igor Akushevich, Deqing Wu, Gaurang Joshi, Kenneth C. Land, and Eric Stallard. “Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.” Biogerontology 17, no. 1 (February 2016): 109–27. https://doi.org/10.1007/s10522-015-9600-1.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Liubov S. Arbeeva, Deqing Wu, Igor Akushevich, Mikhail Kovtun, Arseniy Yashkin, et al. “How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.” Biogerontology 17, no. 1 (February 2016): 89–107. https://doi.org/10.1007/s10522-015-9594-8.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov Arbeeva, Alexander Kulminski, Irina Kulminskaya, Igor Akushevich, and Svetlana V. Ukraintseva. “How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.” North American Actuarial Journal : Naaj 20, no. 3 (January 2016): 201–32. https://doi.org/10.1080/10920277.2016.1178588.
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    • Yashin, Anatoliy I., Ilya Zhbannikov, Liubov Arbeeva, Konstantin G. Arbeev, Deqing Wu, Igor Akushevich, Arseniy Yashkin, et al. “Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.” Frontiers in Genetics 7 (January 2016): 188. https://doi.org/10.3389/fgene.2016.00188.
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    • Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Deqing Wu, and Anatoliy I. Yashin. “Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.” Plos One 10, no. 8 (January 2015): e0136319. https://doi.org/10.1371/journal.pone.0136319.
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    • Yashin, Anatoliy I., Deqing Wu, Liubov S. Arbeeva, Konstantin G. Arbeev, Alexander M. Kulminski, Igor Akushevich, Mikhail Kovtun, et al. “Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.” Frontiers in Genetics 6 (January 2015): 122. https://doi.org/10.3389/fgene.2015.00122.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, Liubov S. Arbeeva, Igor Akushevich, Alexander Kulminski, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span.” Annals of Gerontology and Geriatric Research 1, no. 4 (January 2014): 1020.
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    • Cypser, James R., Deqing Wu, Sang-Kyu Park, Takamasa Ishii, Patricia M. Tedesco, Alexander R. Mendenhall, and Thomas E. Johnson. “Predicting longevity in C. elegans: fertility, mobility and gene expression.” Mechanisms of Ageing and Development 134, no. 7–8 (July 2013): 291–97. https://doi.org/10.1016/j.mad.2013.02.003.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, Alexander M. Kulminski, Eric Stallard, and Svetlana V. Ukraintseva. “Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key.” Frontiers in Genetics 4 (January 2013): 75. https://doi.org/10.3389/fgene.2013.00075.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander M. Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How the quality of GWAS of human lifespan and health span can be improved.” Frontiers in Genetics 4 (January 2013): 125. https://doi.org/10.3389/fgene.2013.00125.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.” Frontiers in Genetics 4 (January 2013): 3. https://doi.org/10.3389/fgene.2013.00003.
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    • Wu, Deqing, Patricia M. Tedesco, Patrick C. Phillips, and Thomas E. Johnson. “Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans.” Experimental Gerontology 47, no. 10 (October 2012): 759–63. https://doi.org/10.1016/j.exger.2012.06.010.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, Eric Stallard, Kenneth C. Land, and Svetlana V. Ukraintseva. “How genes influence life span: the biodemography of human survival.” Rejuvenation Research 15, no. 4 (August 2012): 374–80. https://doi.org/10.1089/rej.2011.1290.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, and Svetlana V. Ukraintseva. “Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.” Rejuvenation Research 15, no. 4 (August 2012): 381–94. https://doi.org/10.1089/rej.2011.1257.
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    • Mendenhall, Alexander R., Deqing Wu, Sang-Kyu Park, James R. Cypser, Patricia M. Tedesco, Christopher D. Link, Patrick C. Phillips, and Thomas E. Johnson. “Genetic dissection of late-life fertility in Caenorhabditis elegans.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 66, no. 8 (August 2011): 842–54. https://doi.org/10.1093/gerona/glr089.
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    • Kulminski, Alexander M., Irina Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Liubov Arbeeva, Deqing Wu, Igor Akushevich, Kenneth C. Land, and Anatoli I. Yashin. “Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.” Aging Cell 10, no. 3 (June 2011): 533–41. https://doi.org/10.1111/j.1474-9726.2011.00689.x.
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    • Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, and Svetlana V. Ukraintseva. “Joint influence of small-effect genetic variants on human longevity.” Aging 2, no. 9 (September 2010): 612–20. https://doi.org/10.18632/aging.100191.
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    • Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Liubov Arbeeva, Julia Kravchenko, Dora Il’yasova, Alexander Kulminski, et al. “Dynamic determinants of longevity and exceptional health.” Curr Gerontol Geriatr Res 2010 (2010). https://doi.org/10.1155/2010/381637.
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    • Wu, Deqing, Shane L. Rea, James R. Cypser, and Thomas E. Johnson. “Mortality shifts in Caenorhabditis elegans: remembrance of conditions past.” Aging Cell 8, no. 6 (December 2009): 666–75. https://doi.org/10.1111/j.1474-9726.2009.00523.x.
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    • Wu, Deqing, James R. Cypser, Anatoli I. Yashin, and Thomas E. Johnson. “Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.” Experimental Gerontology 44, no. 9 (September 2009): 607–12. https://doi.org/10.1016/j.exger.2009.06.007.
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    • Wu, Deqing, James R. Cypser, Anatoli I. Yashin, and Thomas E. Johnson. “The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality?” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 63, no. 7 (July 2008): 660–68. https://doi.org/10.1093/gerona/63.7.660.
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    • Wu, Deqing, Shane L. Rea, Anatoli I. Yashin, and Thomas E. Johnson. “Visualizing hidden heterogeneity in isogenic populations of C. elegans.” Experimental Gerontology 41, no. 3 (March 2006): 261–70. https://doi.org/10.1016/j.exger.2006.01.003.
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    • Rea, Shane L., Deqing Wu, James R. Cypser, James W. Vaupel, and Thomas E. Johnson. “A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans.” Nature Genetics 37, no. 8 (August 2005): 894–98. https://doi.org/10.1038/ng1608.
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    • Johnson, T. E., D. Wu, P. Tedesco, S. Dames, and J. W. Vaupel. “Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56, no. 8 (August 2001): B331–39. https://doi.org/10.1093/gerona/56.8.b331.
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    • Müller, H. G., J. R. Carey, D. Wu, P. Liedo, and J. W. Vaupel. “Reproductive potential predicts longevity of female Mediterranean fruitflies.” Proceedings. Biological Sciences 268, no. 1466 (March 2001): 445–50. https://doi.org/10.1098/rspb.2000.1370.
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    • Zeng, Y., and D. Wu. “Regional analysis of divorce in China since 1980.” Demography 37, no. 2 (May 2000): 215–19.
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  • Book Sections

    • Yashin, A. I., K. G. Arbeev, S. V. Ukraintseva, L. S. Arbeeva, I. Akushevich, J. Kravchenko, A. M. Kulminski, I. Culminskaya, D. Wu, and K. C. Land. “Dynamic Characteristics of Aging-Related Changes as Predictors of Longevity and Healthy Lifespan.” In Springer Series on Demographic Methods and Population Analysis, 40:187–210, 2016. https://doi.org/10.1007/978-94-017-7587-8_8.
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  • Other Articles

    • Klionsky, Daniel J., Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, et al. “Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).” Autophagy, 2016. https://doi.org/10.1080/15548627.2015.1100356.
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  • Conference Papers

    • Yashin, A. I., K. G. Arbeev, L. S. Arbeeva, D. Wu, I. Akushevich, A. Kulminski, M. Kovtun, I. Zhbannikov, and S. V. Ukraintseva. “Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity.” In Proceedings  2nd International Symposium on Stochastic Models in Reliability Engineering, Life Science, and Operations Management, Smrlo 2016, 403–9, 2016. https://doi.org/10.1109/SMRLO.2016.70.
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    • Arbeev, Konstantin G., Liubov S. Arbeeva, Olivia Bagley, Hongzhe Duan, Igor Akushevich, Alexander M. Kulminski, Mikhail Kovtun, et al. “On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies.” In Genetic Epidemiology, 39:530–530. WILEY-BLACKWELL, 2015.
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    • Arbeev, Konstantin G., Svetlana V. Ukraintseva, Alexander M. Kulminski, Liubov S. Arbeeva, Igor Akushevich, Irina V. Culminskaya, Deqing Wu, and Anatoliy I. Yashin. “Relationship Between the APOE Polymorphism and Risks of Cancer and Alzheimer's Disease: Application of the Genetic Stochastic Process Model.” In Genetic Epidemiology, 36:747–747. WILEY-BLACKWELL, 2012.
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    • Arbeev, Konstantin G., AlexanderM Kulminski, Svetlana V. Ukraintseva, Liubov S. Arbeeva, Igor Akushevich, Irina V. Culminskaya, Deqing Wu, and Anatoliy I. Yashin. “Trade-Off In The Effects Of The APOE Polymorphism On The Ages At Onset Of CVD And Cancer: Insights From The Genetic Stochastic Process Model.” In Genetic Epidemiology, 36:157–157. WILEY-BLACKWELL, 2012.
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