Overview
Physician scientist and accredited specialist in clinical pharmacology, therapeutics and internal medicine. Extensive experience of early phase drug development.
Current Appointments & Affiliations
Adjunct Professor in the Department of Medicine
·
2016 - Present
Medicine, Endocrinology, Metabolism, and Nutrition,
Medicine
Recent Publications
GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells.
Journal Article Sci Adv · March 2021 Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP receptor (GIPR) on β cells. The GIPR is also expressed in α cells, and GIP stimulates glucagon ... Full text Link to item CiteFactors influencing longitudinal changes of circulating liver enzyme concentrations in subjects randomized to placebo in four clinical trials.
Journal Article Am J Physiol Gastrointest Liver Physiol · March 1, 2019 Liver enzyme concentrations are measured as safety end points in clinical trials to detect drug-related hepatotoxicity, but little is known about the epidemiology of these biomarkers in subjects without hepatic dysfunction who are enrolled in drug trials. ... Full text Open Access Link to item CiteGlucagon receptor as a drug target: A witches' brew of eye of newt (peptides) and toe of frog (receptors).
Journal Article Diabetes Obes Metab · February 2018 Full text Open Access Link to item CiteEducation, Training & Certifications
University of Cambridge (United Kingdom) ·
1993
M.D.