Scholars@Duke
Edward Bealmear Breitschwerdt

Edward Bealmear Breitschwerdt

Adjunct Professor in the Department of Medicine
Medicine, Infectious Diseases
Duke Box 102359, Durham, NC 27710
4445 Oak Manor Lane, Fuquay Varina, NC 27526

Scholarly Works

Wildlife fleas and ticks in Wisconsin, USA: unrecognized vectors of bacterial pathogens.

Journal article Int J Parasitol · February 2026 Small wildlife species host flea and tick species that can also infest or transmit pathogens to domestic animals and humans, including Anaplasma, Babesia, Bartonella, Borrelia, Ehrlichia, and Rickettsia species. Despite their zoonotic potential, little is ... Full text Link to item Cite

Babesia and Bartonella Species DNA in Blood and Enrichment Blood Cultures from People with Chronic Fatigue and Concurrent Neurological Symptoms.

Journal article Pathogens · December 19, 2025 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a medical condition characterized by extreme fatigue lasting at least 6 months. Based upon case reports, patients infected with Babesia or Bartonella spp. have reported a history of chronic fat ... Full text Link to item Cite

Development and validation of enzyme-linked immunosorbent assays for the serodiagnosis of canine bartonelloses.

Journal article J Clin Microbiol · December 17, 2025 Bartonella species, emerging vector-borne pathogens of dogs, are increasingly associated with severe, chronic sequelae, as well as potentially life-threatening diseases, such as endocarditis and myocarditis. Diagnosis of bartonelloses is mainly based on PC ... Full text Link to item Cite

Vector-Borne Pathogens and Immune-Mediated Disease

Book section · December 9, 2025 Immune-mediated hemolytic anemia (IMHA), immune thrombocytopenia (ITP), immune-mediated polyarthritis (IMPA), and immune-complex glomerulonephritis (ICGN) are common primary (idiopathic; non-associative) immune-mediated diseases in dogs. These diseases als ... Full text Cite

Resolution of pancytopenia in a dog infected with Bartonella rochalimae in association with antibiotic therapy

Journal article Veterinary Record Case Reports · December 1, 2025 Fever, non-regenerative anaemia and leukopenia were documented in a 7-year-old, entire, male Akita Inu dog. The serum biochemistry and urinalysis were unremarkable. Tests for infectious agents were negative, except for SNAP 4Dx seropositive for Anaplasma p ... Full text Cite

Isolation and Characterization of Rickettsia finnyi, Novel Pathogenic Spotted Fever Group Rickettsia in Dogs, United States.

Journal article Emerg Infect Dis · November 2025 In 2020, a novel spotted fever group Rickettsia was described in 3 clinically ill dogs in the United States. Using naturally infected canine blood, the novel Rickettsia sp. was isolated in epithelial (Vero E6) and mononuclear (DH82 and 030D) cell lines. Th ... Full text Link to item Cite

Development of a multiplex serological assay to detect immunoreactivity against a novel Bartonella species in military working dogs.

Journal article Microbiol Spectr · October 7, 2025 Bartonella pose a significant health risk to military working dogs (MWDs), and these zoonotic organisms may also cause disease in humans. According to the U.S. Army zoonotic disease surveillance program, there was a 47.4% seroprevalence for Bartonella spp. ... Full text Link to item Cite

Repeated Detection of Bartonella DNA in Feline Placenta: Potential Implications for Placental and Fetal Development.

Journal article Animals (Basel) · July 11, 2025 The domestic cat is the primary reservoir host of three flea-borne Bartonella species, one of which (Bartonella henselae) causes reduced fertility and reproductive failure in experimentally infected cats. Vertical transmission of Bartonella has been docume ... Full text Link to item Cite

Using Digital PCR to Unravel the Occurrence of Piroplasmids, Bartonella spp., and Borrelia spp. in Wild Animals from Brazil.

Journal article Pathogens · June 6, 2025 Piroplasmids (Babesia spp., Rangelia spp., Theileria spp., Cytauxzoon spp.) are tick-borne apicomplexan protozoa that infect, depending on the species, erythrocytes and leucocytes in a wide variety of mammals and birds. The genera Bartonella and Borrelia i ... Full text Link to item Cite

Experimental Infection of Ferrets with Bartonella henselae: In Search of a Novel Animal Model for Zoonotic Bartonellosis.

Journal article Pathogens · April 26, 2025 Bartonella henselae is an important zoonotic pathogen with a wide range of clinical manifestations in humans. Despite advances in understanding its pathogenesis, there is no broadly applicable laboratory animal model for bartonellosis. This study aimed to ... Full text Link to item Cite

Peliosis hepatis and hepatic fibrosis in a dog infected with multiple Bartonella species.

Journal article J Vet Diagn Invest · March 2025 A 13-y-old, spayed female dog had regenerative anemia, lymphopenia, hypoalbuminemia, and elevated hepatic biochemical parameters. Liver biopsy revealed hepatic peliosis (hepatic sinusoidal angiectasis), frequently associated with perisinusoidal fibrosis. T ... Full text Link to item Cite

Diversity of Cytauxzoon spp. (Piroplasmida: Theileriidae) in Wild Felids from Brazil and Argentina.

Journal article Pathogens · February 4, 2025 Domestic and wild felids are frequently parasitized by apicomplexan protozoa in the genus Cytauxzoon. Expanding species diversity has recently been described within this genus, with potential implications for epidemiology and pathogenesis. In light of thes ... Full text Link to item Cite

Comparison of transcriptomic profiles between intracellular and extracellular Bartonella henselae.

Journal article Commun Biol · January 29, 2025 The Bartonella genus of bacteria encompasses ubiquitous species, some of which are pathogenic in humans and animals. Bartonella henselae, the causative agent of Cat Scratch disease, is responsible for a large portion of human Bartonella infections. These b ... Full text Link to item Cite

A One Health Zoonotic Vector Borne Infectious Disease Family Outbreak Investigation.

Journal article Pathogens · January 23, 2025 This study reinforces the value of a One Health approach to infectious disease outbreak investigations. After the onset of neuropsychiatric symptoms in their son, our investigation focused on a family composed of a mother, father, two daughters, the son, t ... Full text Link to item Cite

Bottom-Up Proteomics Workflow for Studying Multi-organism Systems.

Journal article Methods Mol Biol · 2025 In recent years, discovery proteomics has emerged as a pivotal tool in biological research, especially when studying the intricate relationships among multiple organisms. To delve deeper into these interactions, we pioneered a bottom-up proteomics workflow ... Full text Link to item Cite

Bartonella henselae, Babesia odocoilei and Babesia divergens-like MO-1 infection in the brain of a child with seizures, mycotoxin exposure and suspected Rasmussen's encephalitis.

Journal article J Cent Nerv Syst Dis · 2025 BACKGROUND: In conjunction with more sensitive culture and molecular diagnostic testing modalities, simultaneous or sequential infection with more than 1 vector borne zoonotic pathogen is being increasingly documented in human patients. On a frequent basis ... Full text Link to item Cite

Molecular detection of Bartonella spp. DNA in dogs with hemangiosarcoma.

Journal article PLoS One · 2025 INTRODUCTION: The potential role of pathogens, particularly vector-transmitted infectious agents, as a cofactor or cause of neoplasia has not been intensively investigated. We previously reported a potential link between Bartonella spp. bacteremia and sple ... Full text Link to item Cite

Detection of Dirofilaria repens and Mansonella llewellyni in the United States by Wolbachia Surveillance.

Journal article Transbound Emerg Dis · 2025 In mammals, detection of Wolbachia bacteria can be used to diagnose filarial infection, while antibiotic treatment to eliminate Wolbachia can assist in eliminating filarial infections. Because Wolbachia are necessary for survival of several filarioids and ... Full text Link to item Cite

Development of Multiplex Assays for the Identification of Zoonotic Babesia Species.

Journal article Pathogens · December 11, 2024 More than one-hundred Babesia species that affect animals and humans have been described, eight of which have been associated with emerging and underdiagnosed zoonoses. Most diagnostic studies in humans have used serology or molecular assays based on the 1 ... Full text Link to item Cite

The role of vector-borne pathogens and cardiac Striatin genotype on survival in boxer dogs with arrhythmogenic right ventricular cardiomyopathy.

Journal article J Vet Cardiol · December 2024 INTRODUCTION/OBJECTIVES: Risk factors for severe disease in boxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC) are not well understood. This study's objective was to determine whether Striatin genotype or canine vector-borne pathogen (C ... Full text Link to item Cite

Evaluation of the Veterinary IDEXX SNAP 4Dx Plus Test for the Diagnosis of Lyme Disease in Humans.

Journal article Vector Borne Zoonotic Dis · November 2024 Background: Lyme disease, caused by infection with Borrelia burgdorferi, is the most common vector-borne disease in the United States. The standard two-tier testing (STTT) algorithm suffers from low sensitivity, misinterpretation, and long turnaround time, ... Full text Link to item Cite

Neurobartonelloses: emerging from obscurity!

Journal article Parasit Vectors · October 5, 2024 BACKGROUND: Bartonella species are fastidious, intracellular bacteria responsible for an expanding array of human pathologies. Most are considered to be transmitted by direct inoculation with infected bodily fluids from a mammalian reservoir species or vec ... Full text Link to item Cite

Bartonella spp. in Phlebotominae Sand Flies, Brazil.

Journal article Emerg Infect Dis · October 2024 Bartonella spp. are opportunistic, vectorborne bacteria that can cause disease in both animals and humans. We investigated the molecular occurrence of Bartonella spp. in 634 phlebotomine sand fly specimens, belonging to 44 different sand fly species, sampl ... Full text Link to item Cite

Sequence typing of Bartonella henselae in small Indian mongooses (Urva auropunctata).

Journal article Sci Rep · August 12, 2024 This study aimed to determine the sequence type (ST) of Bartonella henselae infecting small Indian mongooses from Saint Kitts via multi-locus sequence typing (MLST). This investigation used stored EDTA blood (n = 22) samples from mongooses previously ident ... Full text Link to item Cite

Human Babesia odocoilei and Bartonella spp. co-infections in the Americas.

Journal article Parasit Vectors · July 11, 2024 BACKGROUND: In recent years, Babesia and Bartonella species co-infections in patients with chronic, nonspecific illnesses have continued to challenge and change the collective medical understanding of "individual pathogen" vector-borne infectious disease d ... Full text Link to item Cite

A case of mistaken identity: a systematic review, meta-analysis, and reinvestigation of hemotropic Mycoplasma spp. infection in Ctenocephalides felis (cat flea).

Journal article Parasit Vectors · May 9, 2024 BACKGROUND: Feline-associated hemotropic Mycoplasma (hemoplasmas) are believed to be transmitted by two primary mechanisms: (1) direct transmission via fighting and (2) vector-borne transmission by the cat flea (Ctenocephalides felis). While the efficiency ... Full text Link to item Cite

Assessment of the effect of long-term serum storage for retrospective serologic diagnosis of canine monocytic ehrlichiosis (Ehrlichia canis).

Journal article Comp Immunol Microbiol Infect Dis · May 2024 There is currently sparse information on the possible effect of long-term storage of serum specimens for the retrospective serodiagnosis of canine monocytic ehrlichiosis (CME). The aim of this study was to assess the agreement between the original serologi ... Full text Link to item Cite

Antibodies to Borrelia burgdorferi and Bartonella species in serum and synovial fluid from people with rheumatic diseases.

Journal article Microbiol Spectr · April 2, 2024 UNLABELLED: Vector-borne infections may underlie some rheumatic diseases, particularly in people with joint effusions. This study aimed to compare serum and synovial fluid antibodies to B. burgdorferi and Bartonella spp. in patients with rheumatic diseases ... Full text Link to item Cite

Vector biology of the cat flea Ctenocephalides felis.

Journal article Trends Parasitol · April 2024 Ctenocephalides felis, the cat flea, is among the most prevalent and widely dispersed vectors worldwide. Unfortunately, research on C. felis and associated pathogens (Bartonella and Rickettsia spp.) lags behind that of other vectors and vector-borne pathog ... Full text Link to item Cite

Dilated cardiomyopathy of possible dietary origin in a cat.

Journal article J Vet Cardiol · February 2024 An 11-year-old spayed female domestic shorthaired cat was diagnosed with severe dilated cardiomyopathy (DCM) and congestive heart failure. The cat had been eating cat foods that were high in pulses (e.g. peas, lentils, chickpeas). Neither plasma nor whole ... Full text Link to item Cite

A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice.

Journal article PLoS One · 2024 Bartonellosis refers to disease caused by the Bartonella genus of bacteria. The breadth of disease manifestations associated with Bartonella is currently expanding and includes regional lymphadenopathy, rheumatic, ocular, and neurological disorders. The de ... Full text Link to item Cite

Bartonella species bacteremia in association with adult psychosis.

Journal article Front Psychiatry · 2024 INTRODUCTION: The potential role of pathogens, particularly vector-transmitted infectious agents, as a cause of psychosis has not been intensively investigated. We have reported a potential link between Bartonella spp. bacteremia and neuropsychiatric sympt ... Full text Link to item Cite

Bartonella spp. infection in people with Mild Cognitive Impairment: A pilot study.

Journal article PLoS One · 2024 Mild Cognitive Impairment (MCI) is a neurological disorder at the transition between normal cognitive decline and dementia. Despite the potential role of neuroinflammation in the pathogenesis of MCI, infectious triggers remain mostly unknown. Infection wit ... Full text Link to item Cite

Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.

Journal article Alzheimers Dement · November 2023 Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detec ... Full text Link to item Cite

Viability and Desiccation Resistance of Bartonella henselae in Biological and Non-Biological Fluids: Evidence for Pathogen Environmental Stability.

Journal article Pathogens · July 18, 2023 Pathogen environmental stability is an often-neglected research priority for pathogens that are known to be vector-transmitted. Bartonella henselae, the etiologic agent of Cat Scratch Disease, has become a "pathogen of interest" in several serious human il ... Full text Link to item Cite

A second-generation, point-of-care immunoassay provided improved detection of Anaplasma and Ehrlichia antibodies in PCR-positive dogs naturally infected with Anaplasma or Ehrlichia species.

Journal article J Vet Diagn Invest · July 2023 A validated second-generation SNAP 4Dx Plus (Idexx) incorporates new peptides for improved detection of antibodies against Anaplasma and Ehrlichia tick-borne pathogens in dogs. We compared the first- and second-generation SNAP 4Dx Plus using dogs naturally ... Full text Link to item Cite

Risk Factors for Bartonella Seroreactivity Among Veterinary Workers in the Pacific Northwest.

Journal article Vector Borne Zoonotic Dis · July 2023 Background: Exposure to zoonotic diseases is a significant occupational risk in veterinary medicine. In this study, we characterized personal protective equipment use, injury frequency, and Bartonella seroreactivity in Washington State veterinary workers. ... Full text Link to item Cite

Blood Supplementation Enhances Bartonella henselae Growth and Molecular Detection of Bacterial DNA in Liquid Culture.

Journal article Microbiol Spectr · June 15, 2023 Bacteria of the genus Bartonella, a member of the Alphaproteobacteria, are fastidious, Gram-negative, aerobic bacilli that comprise numerous species, subspecies, and genotypes. Bartonella henselae, with a worldwide distribution, infects cats, dogs, horses, ... Full text Link to item Cite

Feeding on a Bartonella henselae Infected Host Triggers Temporary Changes in the Ctenocephalides felis Microbiome.

Journal article Pathogens · February 22, 2023 The effect of Bartonella henselae on the microbiome of its vector, Ctenocephalides felis (the cat flea) is largely unknown, as the majority of C. felis microbiome studies have utilized wild-caught pooled fleas. We surveyed the microbiome of laboratory-orig ... Full text Link to item Cite

A bottom-up proteomics workflow for a system containing multiple organisms.

Journal article Rapid Commun Mass Spectrom · February 2023 RATIONALE: Discovery proteomics has been popularized to be essential in the investigator's biological toolbox. Many biological problems involve the interplay of multiple organisms. Herein, a bottom-up proteomics workflow was developed to study a system con ... Full text Link to item Cite

The association of host and vector characteristics with Ctenocephalides felis pathogen and endosymbiont infection.

Journal article Front Microbiol · 2023 Surveillance of the fleas and flea-borne pathogens infecting cats is important for both human and animal health. Multiple zoonotic Bartonella and Rickettsia species are known to infect the most common flea infesting cats and dogs worldwide: Ctenocephalides ... Full text Link to item Cite

Case report: Substantial improvement of autism spectrum disorder in a child with learning disabilities in conjunction with treatment for poly-microbial vector borne infections.

Journal article Front Psychiatry · 2023 Poly-microbial vector-borne infections may have contributed to neuropsychiatric symptoms in a boy diagnosed with autism spectrum disorder. Targeted antimicrobial treatment resulted in substantial improvement in cognitive (such as learning disabilities, foc ... Full text Link to item Cite

Eosinophilic pericardial effusion and pericarditis in a cat.

Journal article JFMS Open Rep · 2023 CASE SUMMARY: A 10-year-old domestic shorthair cat presented for lethargy, anorexia and labored breathing. Significant pleural and pericardial effusions prompted thoracocentesis and pericardiocentesis. Cytologic evaluation of the pericardial effusion revea ... Full text Link to item Cite

Cat scratch disease: What to do with the cat?

Journal article Am J Ophthalmol Case Rep · December 2022 PURPOSE: Cat scratch disease (CSD) frequently has ophthalmologic manifestations. The ophthalmologist's approach to treating neuroretinitis is familiar, but few eye care providers are comfortable answering the next question of "what do I do with my cat?" Pu ... Full text Link to item Cite

Vector-borne and other pathogens of potential relevance disseminated by relocated cats.

Journal article Parasit Vectors · November 8, 2022 Large populations of unowned cats constitute an animal welfare, ecological, societal and public health issue worldwide. Their relocation and homing are currently carried out in many parts of the world with the intention of relieving suffering and social pr ... Full text Link to item Cite

Identification of microbial taxa present in Ctenocephalides felis (cat flea) reveals widespread co-infection and associations with vector phylogeny.

Journal article Parasit Vectors · October 31, 2022 BACKGROUND: Ctenocephalides felis, the cat flea, is the most common ectoparasite of cats and dogs worldwide. As a cause of flea allergy dermatitis and a vector for two genera of zoonotic pathogens (Bartonella and Rickettsia spp.), the effect of the C. feli ... Full text Link to item Cite

FtlA and FtlB Are Candidates for Inclusion in a Next-Generation Multiantigen Subunit Vaccine for Lyme Disease.

Journal article Infect Immun · October 20, 2022 Lyme disease (LD) is a tick-transmitted bacterial infection caused by Borreliella burgdorferi and other closely related species collectively referred to as the LD spirochetes. The LD spirochetes encode an uncharacterized family of proteins originally desig ... Full text Link to item Cite

Rickettsia typhi infection in a clinically-ill dog from Houston, Texas.

Journal article Vet Parasitol Reg Stud Reports · October 2022 In 2020, Rickettsia typhi was diagnosed in a dog from Houston, Texas, USA based upon R. typhi IFA seroreactivity in both acute and convalescent sera, and PCR with DNA sequencing of 4 different gene regions, all of which were 100% identical to R. typhi. The ... Full text Link to item Cite

Vector-borne disease and its relationship to hematologic abnormalities and microalbuminuria in retired racing and show-bred greyhounds.

Journal article J Vet Intern Med · July 2022 BACKGROUND: Reference intervals for platelets and white blood cell (WBCs) counts are lower in greyhounds than other breeds. Proteinuria is common. Vector-borne diseases (VBD) cause thrombocytopenia, leukopenia, and proteinuria. Racing greyhounds are common ... Full text Link to item Cite

Bartonella

Book section · June 3, 2022 Bartonella species are members of the alpha-2 subgroup of the class Alphaproteobacteria , within the Rhizobiales order. There are now more than 22 species or subspecies described, and DNA sequences from numerous other species or strains have been deposited ... Full text Cite

Bartonella henselae Recombinant Pap31 for the Diagnosis of Canine and Human Bartonelloses.

Journal article Pathogens · January 28, 2022 Bartonella spp. comprise a genus of Gram-negative alphaproteobacteria that are slow growing, fastidious, and facultative intracellular pathogens with zoonotic potential. Immunofluorescent antibody assays (IFAs), Western blot (WB), and enzyme-linked immunos ... Full text Link to item Cite

Prospective serological and molecular cross-sectional study focusing on Bartonella and other blood-borne organisms in cats from Catalonia (Spain).

Journal article Parasit Vectors · January 4, 2022 BACKGROUND: There is limited clinical or epidemiological knowledge regarding Bartonella infection in cats, and no serological studies have compared the presence of antibodies against different Bartonella species. Moreover, there are limited feline Bartonel ... Full text Link to item Cite

Bartonella spp. seroepidemiology and associations with clinicopathologic findings in dogs in the United States.

Journal article J Vet Intern Med · January 2022 BACKGROUND: Improved understanding of Bartonella spp. serology in dogs may aid clinical decision making. OBJECTIVE: Describe demographic and geographic patterns of Bartonella spp. seroreactivity in dogs, and describe hematologic and serum biochemical abnor ... Full text Link to item Cite

Using Proteomic Approaches to Unravel the Response of Ctenocephalides felis felis to Blood Feeding and Infection With Bartonella henselae.

Journal article Front Cell Infect Microbiol · 2022 Among the Ctenocephalides felis felis-borne pathogens, Bartonella henselae, the main aetiological agent of cat scratch disease (CSD), is of increasing comparative biomedical importance. Despite the importance of B. henselae as an emergent pathogen, prevent ... Full text Link to item Cite

Osteomyelitis associated with Bartonella henselae infection in a young cat.

Journal article JFMS Open Rep · 2022 CASE SUMMARY: A 1-year-old male intact domestic shorthair cat was evaluated for acute onset non-weightbearing left forelimb lameness and generalized peripheral lymphadenopathy. CT identified a monostotic aggressive bone lesion with an incomplete fracture o ... Full text Link to item Cite

An Improved Point-of-Care ELISA for the Diagnosis of Anaplasmosis and Ehrlichiosis During the Acute Phase of Tick-Borne Infections in Dogs.

Journal article Top Companion Anim Med · 2022 Veterinarians often test for serologic evidence of vector-borne infections in sick dogs presenting with clinical signs or to screen for subclinical chronic infections. Additional peptide targets for the detection of antibodies to Anaplasma phagocytophilum, ... Full text Link to item Cite

Spotted Fever Rickettsioses, Flea-Borne Rickettsioses, and Typhus

Book section · January 1, 2022 • First Described: Rickettsia rickettsii was first described in Montana, United States, 19091 (Ricketts). • Cause: Rickettsia rickettsii, a gram-negative, obligately intracellular bacteria. Other Spotted Fever group (SFG) Rickettsia spp., typhus group (TG) ... Full text Cite

Bartonellosis

Book section · January 1, 2022 • Bartonellosis is an emerging, zoonotic, vector-borne infectious disease of cats, dogs, other animals, and humans. • Causes: The most common species reported in cats are Bartonella henselae, Bartonella clarridgeiae, and Bartonella koehlerae, whereas dogs ... Full text Cite

Development of a Multiplex Droplet Digital PCR Assay for the Detection of Babesia, Bartonella, and Borrelia Species.

Journal article Pathogens · November 11, 2021 We describe the development, optimization, and validation of a multiplex droplet digital PCR (ddPCR) assay for the simultaneous detection of Babesia, Bartonella, and Borrelia spp. DNA from several sample matrices, including clinical blood samples from anim ... Full text Link to item Cite

Prevalence of Vector-Borne Pathogens in Reproductive and Non-Reproductive Tissue Samples from Free-Roaming Domestic Cats in the South Atlantic USA.

Journal article Pathogens · September 21, 2021 Reservoir to multiple species of zoonotic pathogens, free-roaming cats (FRCs) interact with domestic and wild animals, vectors, and humans. To assess the potential for feline vector-borne pathogens to be vertically transmitted, this study surveyed ear tip ... Full text Link to item Cite

Bartonellosis: A zoonosis hidden in plain sight

Journal article American Journal of Veterinary Research · July 1, 2021 Full text Cite

Comparison of Serological and Molecular Assays for Bartonella Species in Dogs with Hemangiosarcoma.

Journal article Pathogens · June 23, 2021 Currently, a gold standard diagnostic test for Bartonella infection in dogs is lacking. This represents a critical limitation for the development and evaluation of new diagnostic tests, as well as for the diagnosis of, and research on, bartonellosis in dog ... Full text Link to item Cite

Haematological and biochemical abnormalities in hunting dogs infected with Acanthocheilonema reconditum, associated risk factors, and a European overview.

Journal article Parasitol Res · June 2021 Acanthocheilonema reconditum is a filarial parasite transmitted by arthropods (fleas, lice, and ticks) that infect dogs. There is minimal published data available to date on potential haematological and biochemical changes associated with this parasitic in ... Full text Link to item Cite

Schizophrenia and Bartonella spp. Infection: A Pilot Case-Control Study.

Journal article Vector Borne Zoonotic Dis · June 2021 Recently, infections with emerging zoonotic bacteria of the genus Bartonella have been reported in association with a range of central nervous system (CNS) symptoms. Currently, it remains unknown if Bartonella spp. infection is associated with symptoms of ... Full text Link to item Cite

Exposure of Domestic Cats to Three Zoonotic Bartonella Species in the United States.

Journal article Pathogens · March 17, 2021 Cat-associated Bartonella species, which include B. henselae, B. koehlerae, and B. clarridgeiae, can cause mild to severe illness in humans. In the present study, we evaluated 1362 serum samples obtained from domestic cats across the U.S. for seroreactivit ... Full text Link to item Cite

Bartonella henselae Antibodies in Serum and Oral Fluid Specimens from Cats.

Journal article Pathogens · March 11, 2021 Cats are the primary reservoir host for Bartonella henselae(B. henselae), an etiological agent of human bartonellosis, including cat scratch disease. Although Bartonella DNA has been amplified from salivary swabs from cats, dogs and humans, we are not awar ... Full text Link to item Cite

Bartonella henselae Detected in Malignant Melanoma, a Preliminary Study.

Journal article Pathogens · March 10, 2021 Bartonella bacilliformis (B. bacilliformis), Bartonella henselae (B. henselae), and Bartonella quintana (B. quintana) are bacteria known to cause verruga peruana or bacillary angiomatosis, vascular endothelial growth factor (VEGF)-dependent cutaneous lesio ... Full text Link to item Cite

Demographics and travel history of imported and autochthonous cases of leishmaniosis in dogs in the United States and Canada, 2006 to 2019.

Journal article J Vet Intern Med · March 2021 BACKGROUND: Leishmania infantum infections are reported in foxhounds throughout the United States (US) and Canada, but only rarely in other dog breeds. A seroprevalence report from 2006 documented leishmaniosis in foxhounds (8.9%) tested in the US between ... Full text Link to item Cite

Comparison of Anaplasma and Ehrlichia species-specific peptide ELISAs with whole organism-based immunofluorescent assays for serologic diagnosis of anaplasmosis and ehrlichiosis in dogs.

Journal article Am J Vet Res · January 2021 OBJECTIVE: To compare the performance of 5 synthetic peptide-based ELISAs with that of 3 commercially available immunofluorescent assays (IFAs) for serologic diagnosis of anaplasmosis and ehrlichiosis in dogs. SAMPLE: A convenience set of 109 serum samples ... Full text Link to item Cite

Recent Progress in Lyme Disease and Remaining Challenges.

Journal article Front Med (Lausanne) · 2021 Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in the United States with an estimated 476,000 cases per year. While historically, the long-term impact of Lyme disease on patients has been controversial, mounting evide ... Full text Link to item Cite

Bartonella Associated Cutaneous Lesions (BACL) in People with Neuropsychiatric Symptoms.

Journal article Pathogens · December 4, 2020 Bartonella species are globally important emerging pathogens that were not known to infect animals or humans in North America prior to the human immunodeficiency virus (HIV) epidemic. Ongoing improvements in diagnostic testing modalities have allowed for t ... Full text Link to item Cite

Novel Rickettsia Species Infecting Dogs, United States.

Journal article Emerg Infect Dis · December 2020 In 2018 and 2019, spotted fever was suspected in 3 dogs in 3 US states. The dogs had fever and hematological abnormalities; blood samples were Rickettsia seroreactive. Identical Rickettsia DNA sequences were amplified from the samples. Multilocus phylogene ... Full text Link to item Cite

Distribution and risk factors of canine haemotropic mycoplasmas in hunting dogs from southern Italy.

Journal article Vet Microbiol · December 2020 Mycoplasma haemocanis (Mhc) and "Candidatus Mycoplasma haematoparvum" (CMhp) are the main haemoplasma species known to infect dogs. The aim of this study was to determine the prevalence of haemoplasma species infections in hunting dogs from southern Italy ... Full text Link to item Cite

Parasites and vector-borne diseases disseminated by rehomed dogs.

Journal article Parasit Vectors · November 10, 2020 The Companion Vector-Borne Diseases (CVBD) World Forum is a working group of leading international experts who meet annually to evaluate current scientific findings and future trends concerning the distribution, pathogenesis, clinical presentation, diagnos ... Full text Link to item Cite

Development and validation of a droplet digital PCR assay for the detection and quantification of Bartonella species within human clinical samples.

Journal article J Microbiol Methods · September 2020 This report describes the development, optimization, and validation of a ddPCR assay for the detection of Bartonella spp. DNA within several sample matrices, including clinical blood samples from patients with or without documented Bartonella spp. bacterem ... Full text Link to item Cite

Hepatozoon canis in hunting dogs from Southern Italy: distribution and risk factors.

Journal article Parasitol Res · September 2020 Hepatozoon canis is a hemoprotozoan organism that infects domestic and wild carnivores throughout much of Europe. The parasite is mainly transmitted through the ingestion of infected ticks containing mature oocysts. The aims of the present survey were to d ... Full text Link to item Cite

Imaging analysis of Bartonella species in the skin using single-photon and multi-photon (second harmonic generation) laser scanning microscopy.

Journal article Clin Case Rep · August 2020 We demonstrate Bartonella spp are abundant in skin lesions resembling striae distensae. These striae distensae-like lesions, coincidental with sudden onset of neuropsychiatric symptoms, indicate testing for suspected Bartonella spp. infection. ... Full text Link to item Cite

Bartonella rochalimae, a newly recognized pathogen in dogs.

Journal article J Vet Intern Med · July 2020 BACKGROUND: Bartonella spp. comprise a genus of bacteria that frequently cause persistent, often subclinical infection. Although many Bartonella spp. have been implicated in a variety of clinical presentations, Bartonella rochalimae has yet to be documente ... Full text Link to item Cite

Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs.

Journal article J Clin Microbiol · March 25, 2020 Bartonella spp. are etiological agents of life-threatening zoonotic diseases in dogs worldwide. Due to the poor sensitivity of immunofluorescent-antibody assays (IFAs), a reliable serodiagnostic test for canine bartonelloses is of clinical importance. The ... Full text Link to item Cite

Bartonella spp. Prevalence (Serology, Culture, and PCR) in Sanitary Workers in La Rioja Spain.

Journal article Pathogens · March 4, 2020 Bartonella spp. are increasingly implicated in association with a spectrum of zoonotic infectious diseases. One hundred sanitary workers in La Rioja, Spain completed a questionnaire and provided blood specimens for Bartonella spp. serology and Bartonella a ... Full text Link to item Cite

A retrospective study of vector-borne disease prevalence in dogs with proteinuria: Southeastern United States.

Journal article J Vet Intern Med · March 2020 BACKGROUND: Proteinuria is a risk factor for progressive kidney injury in dogs. Enhanced understanding of potential associations between canine vector-borne diseases (CVBD) and proteinuria is needed. OBJECTIVES: To determine the proportion of evaluated pro ... Full text Link to item Cite

Detection of Bartonella spp. in dogs after infection with Rickettsia rickettsii.

Journal article J Vet Intern Med · January 2020 BACKGROUND: Dynamics of infection by Bartonella and Rickettsia species, which are epidemiologically associated in dogs, have not been explored in a controlled setting. OBJECTIVES: Describe an outbreak investigation of occult Bartonella spp. infection among ... Full text Link to item Cite

Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States.

Journal article PLoS One · 2020 Hemangiosarcoma (HSA), a locally invasive and highly metastatic endothelial cell neoplasm, accounts for two-thirds of all cardiac and splenic neoplasms in dogs. Bartonella spp. infection has been reported in association with neoplastic and non-neoplastic v ... Full text Link to item Cite

Ehrlichia chaffeensis EplA Interaction With Host Cell Protein Disulfide Isomerase Promotes Infection.

Journal article Front Cell Infect Microbiol · 2020 Ehrlichia chaffeensis is an obligate intracellular bacterium that invades monocytes to cause the emerging and potentially severe disease, monocytic ehrlichiosis. Ehrlichial invasion of host cells, a process that is essential for the bacterium's survival an ... Full text Link to item Cite

Molecular identification of vector-borne organisms in Ehrlichia seropositive Nicaraguan horses and first report of Rickettsia felis infection in the horse.

Journal article Acta Trop · December 2019 Certain vector-borne organisms serve as etiological agents of equine disease. After previously identifying a new Ehrlichia species in horses from Mérida, we aimed to determine the infection frequency and screen for a wide range of vector-borne organisms fr ... Full text Link to item Cite

Canine Leishmaniasis Control in the Context of One Health.

Journal article Emerg Infect Dis · December 2019 Dogs are the main reservoir of Leishmania infantum and in some countries have been regularly culled as part of government policy to control visceral leishmaniasis. At the 13th Symposium of the Companion Vector-Borne Diseases World Forum in Windsor, UK, Mar ... Full text Link to item Cite

Prevalence of Babesia spp. and clinical characteristics of Babesia vulpes infections in North American dogs.

Journal article J Vet Intern Med · September 2019 BACKGROUND: Babesiosis is an important cause of thrombocytopenia and hemolytic anemia in dogs. Babesia vulpes, reported in European dogs and North American foxes, rarely has been reported in domestic North American dogs. Newly optimized polymerase chain re ... Full text Link to item Cite

Ecological and Socioeconomic Factors Associated with Bartonella henselae Exposure in Dogs Tested for Vector-Borne Diseases in North Carolina.

Journal article Vector Borne Zoonotic Dis · August 2019 Bartonella henselae is a zoonotic vector-borne pathogen affecting both humans and dogs. Little is known about the epidemiology of B. henselae in dogs, including risk factors associated with exposure. The objectives of this study were to map the current dis ... Full text Link to item Cite

Evidence for vertical transmission of Mycoplasma haemocanis, but not Ehrlichia ewingii, in a dog.

Journal article J Vet Intern Med · July 2019 A 2-year-old female intact pregnant Beagle was evaluated after the owner surrendered her to a shelter. Prepartum and 2 months postpartum at the time of routine spay, the dam was whole-blood polymerase chain reaction (PCR) positive for Ehrlichia ewingii. Sh ... Full text Link to item Cite

Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Journal article Vaccine · April 17, 2019 As Ixodes ticks spread to new regions, the incidence of Lyme disease (LD) in companion animals and humans will increase. Preventive strategies for LD in canines center on vaccination and tick control (acaricides). Both subunit and bacterin based LD veterin ... Full text Link to item Cite

Bartonella spp. Bloodstream Infection in a Canadian Family.

Journal article Vector Borne Zoonotic Dis · April 2019 Historically, Bartonella spp. have been associated with febrile illness (Oroya fever, trench fever, and cat scratch disease), endocarditis (numerous Bartonella spp.), and vasoproliferative lesions (Bartonella bacilliformis, Bartonella quintana, Bartonella ... Full text Link to item Cite

An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis).

Journal article Vet J · April 2019 Canine monocytic ehrlichiosis (CME), caused by Ehrlichia canis, a gram-negative, obligate intracellular bacterium, is a tick-borne disease of worldwide distribution. Experimentally, the course of E. canis infection can be sequentially divided into acute, s ... Full text Link to item Cite

Clinicopathological findings in 41 dogs (2008-2018) naturally infected with Ehrlichia ewingii.

Journal article J Vet Intern Med · March 2019 BACKGROUND: Ehrlichia ewingii is the most seroprevalent Ehrlichia-infecting dogs in the southern and mid-western United States. Fever, lameness, and polyarthritis are commonly reported findings in dogs naturally infected with E. ewingii. OBJECTIVES: To eva ... Full text Link to item Cite

Bartonella quintana and Bartonella vinsonii subsp. vinsonii bloodstream co-infection in a girl from North Carolina, USA.

Journal article Med Microbiol Immunol · February 2019 The genus Bartonella consists of globally distributed and highly diverse alpha-proteobacteria that infect a wide-range of mammals. Medically, Bartonella spp. constitute emerging, vector-borne, zoonotic, intravascular organisms that induce long-lasting bact ... Full text Link to item Cite

Regional prevalences of Borrelia burgdorferi, Borrelia bissettiae, and Bartonella henselae in Ixodes affinis, Ixodes pacificus and Ixodes scapularis in the USA.

Journal article Ticks Tick Borne Dis · February 2019 The objective of this work was to determine the prevalence of Borrelia and Bartonella species in Ixodes spp. ticks collected from 16 USA states. Genus PCR amplification and sequence analysis of Bartonella and Borrelia 16SsRNA-23SsRNA intergenic regions wer ... Full text Link to item Cite

Pasteurella canis infective endocarditis in a dog.

Journal article Vet Microbiol · February 2019 Infective endocarditis, an infrequent clinical syndrome in dogs, is typically associated with nondescript clinical signs such as fever, malaise and loss of appetite. Although an uncommonly reported infection in dogs, Pasteurella canis is an emerging pathog ... Full text Link to item Cite

Bartonella henselae Bloodstream Infection in a Boy With Pediatric Acute-Onset Neuropsychiatric Syndrome.

Journal article J Cent Nerv Syst Dis · 2019 BACKGROUND: With the advent of more sensitive culture and molecular diagnostic testing modalities, Bartonella spp. infections have been documented in blood and/or cerebrospinal fluid specimens from patients with diverse neurological symptoms. Pediatric acu ... Full text Link to item Cite

Pyogranulomatous myocarditis and diaphragmatic myositis associated with bartonella henselae in a cat from Turkey

Journal article Ankara Universitesi Veteriner Fakultesi Dergisi · January 1, 2019 A case of pyogranulomatous myocarditis and diaphragmatic myositis caused by Bartonella henselae in an 18 months old tricolor female cat in Turkey was reported in this study. The cat had flea infestation before clinical disease onset. The cat showed clinica ... Full text Cite

Bartonella infections in cats and dogs including zoonotic aspects.

Journal article Parasit Vectors · December 4, 2018 Bartonellosis is a vector-borne zoonotic disease with worldwide distribution that can infect humans and a large number of mammals including small companion animals (cats and dogs). In recent years, an increasing number of studies from around the world have ... Full text Link to item Cite

Bartonella henselae in a dog with ear tip vasculitis.

Journal article Vet Dermatol · December 2018 BACKGROUND: Bartonella henselae, a Gram-negative, zoonotic, alpha-proteobacteria has been previously implicated in association with cutaneous vasoproliferative lesions (bacillary angiomatosis), nodular panniculitis and multifocal erythema (erythema multifo ... Full text Link to item Cite

Molecular and Serological Prevalence of Anaplasma phagocytophilum, A. platys, Ehrlichia canis, E. chaffeenses, E. ewingii, Borrelia burgdorferi, Babesia canis, B. gibsoni and B. vogeli among Clinically Healthy Outdoor Dogs in Serbia.

Journal article Vet Parasitol Reg Stud Reports · December 2018 Data concerning combined molecular and serological prevalence of emerging canine tick-borne pathogens in Serbia are lacking. A large population of outdoor living dogs in Belgrade, Serbia's' capital, present an excellent population for epidemiology study. B ... Full text Link to item Cite

Comparative Evaluation of 2 In-Clinic Assays for Vector-Borne Disease Testing in Dogs.

Journal article Top Companion Anim Med · December 2018 Vector-borne agents comprise medically important infections affecting dogs throughout much of the world. Sensitive detection of antibodies directed at tick-borne disease-causing organisms in dogs is diagnostically important for veterinarians, pets and thei ... Full text Link to item Cite

Babesia gibsoni cytochrome b mutations in canine blood samples submitted to a US veterinary diagnostic laboratory.

Journal article J Vet Intern Med · November 2018 BACKGROUND: Babesiosis caused by Babesia gibsoni is recognized throughout the world and can be difficult to treat. Resistance to atovaquone is associated with mutations in the B. gibsoni mitochondrial genome, specifically the M128 position of cytochrome b ... Full text Link to item Cite

Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs.

Journal article J Vet Intern Med · November 2018 BACKGROUND: Because of poor sensitivity and questionable specificity of immunofluorescent antibody assays (IFAs), serological diagnosis of Bartonella species infections in dogs remains challenging. Despite limitations, IFA testing is the historical "gold s ... Full text Link to item Cite

Distribution and risk factors associated with Babesia spp. infection in hunting dogs from Southern Italy.

Journal article Ticks Tick Borne Dis · September 2018 Canine babesiosis is caused by haemoprotozoan organisms of the genus Babesia which are transmitted by the bite of a hard tick. The aim of this survey was to determine the prevalence and risk factors associated with Babesia species infections in hunting dog ... Full text Link to item Cite

Bartonella spp. as a Possible Cause or Cofactor of Feline Endomyocarditis-Left Ventricular Endocardial Fibrosis Complex.

Journal article J Comp Pathol · July 2018 Endomyocarditis is a commonly detected post-mortem finding in domestic cats presenting for sudden onset cardiovascular death, yet the aetiology remains unresolved. Cats are documented reservoir hosts for Bartonella henselae, the infectious cause of cat scr ... Full text Link to item Cite

Improvement of Bartonella henselae DNA Detection in Cat Blood Samples by Combining Molecular and Culture Methods.

Journal article J Clin Microbiol · May 2018 Bartonella spp. are bacteria of worldwide distribution that cause asymptomatic to fatal infections in animals and humans. The most common zoonotic species is Bartonella henselae, for which cats are the major natural reservoir host. To better understand Bar ... Full text Link to item Cite

Doxycycline treatment efficacy in dogs with naturally occurring Anaplasma phagocytophilum infection.

Journal article J Small Anim Pract · May 2018 OBJECTIVES: To evaluate doxycycline treatment efficacy and post-treatment pathogen persistence in dogs naturally infected with Anaplasma phagocytophilum in endemic regions of the USA. MATERIALS AND METHODS: Symptomatic dogs in four US states (MN, WI, CT an ... Full text Link to item Cite

Identification of Hemotropic Mycoplasmas in an Eastern Box Turtle ( Terrapene carolina carolina) and a Yellow-bellied Slider ( Trachemys scripta scripta) from North Carolina, USA.

Journal article J Wildl Dis · April 2018 Mycoplasma spp. are known from several chelonian and other reptilian species. We determined if turtles obtained by the Turtle Rescue Team at North Carolina State University are carriers of hemotropic Mycoplasma or Bartonella spp. Spleen samples were collec ... Full text Link to item Cite

Rheumatological presentation of Bartonella koehlerae and Bartonella henselae bacteremias: A case report.

Journal article Medicine (Baltimore) · April 2018 INTRODUCTION: Systemic Bartonella spp. infections are being increasingly reported in association with complex medical presentations. Individuals with frequent arthropod exposures or animal contact appear to be at risk for acquiring long standing infections ... Full text Link to item Cite

Sensitivity and specificity levels of two rapid assays for antibodies to Anaplasma spp. in dogs.

Journal article J Vet Diagn Invest · March 2018 Canine anaplasmosis is a tick-borne disease of dogs that results following infection with Anaplasma phagocytophilum or Anaplasma platys. The SNAP 4Dx Plus test (IDEXX Laboratories) and the VetScan Canine Anaplasma Rapid test (Abaxis) are commercial in-hous ... Full text Link to item Cite

Bartonella henselae infection in a dog with recalcitrant ineffective erythropoiesis.

Journal article Vet Clin Pathol · March 2018 Ineffective erythropoiesis was diagnosed in an 8-year-old male castrated Labrador Retriever. Despite treatment with immunosuppressive therapy for suspected immune-mediated erythrocyte maturation arrest, resolution of the nonregenerative anemia was not achi ... Full text Link to item Cite

Molecular surveillance of novel tick-borne organisms in Madagascar's lemurs.

Journal article Ticks Tick Borne Dis · March 2018 The discovery and characterization of emerging tick-borne organisms are critical for global health initiatives to improve animal and human welfare (One Health). It is possible that unknown tick-borne organisms underlie a subset of undiagnosed illness in wi ... Full text Link to item Cite

Bartonella henselae in small Indian mongooses (Herpestes auropunctatus) from Grenada, West Indies.

Journal article Vet Microbiol · March 2018 Many mammals are established hosts for the vector borne bacterial genus, Bartonella. Small Indian mongooses (Herpestes auropunctatus) have only been reported as a possible host for Bartonella henselae in southern Japan. Confirming Bartonella presence in mo ... Full text Link to item Cite

Bartonella Seroepidemiology in Dogs from North America, 2008-2014.

Journal article J Vet Intern Med · January 2018 BACKGROUND: Improved understanding of Bartonella species seroepidemiology in dogs may aid clinical decision making and enhance current understanding of naturally occurring arthropod vector transmission of this pathogen. OBJECTIVES: To identify demographic ... Full text Link to item Cite

Prevalence of Bartonella spp. by culture, PCR and serology, in veterinary personnel from Spain.

Journal article Parasit Vectors · November 7, 2017 BACKGROUND: The genus Bartonella includes fastidious, facultative intracellular bacteria mainly transmitted by arthropods and distributed among mammalian reservoirs. Bartonella spp. implicated as etiological agents of zoonoses are increasing. Apart from th ... Full text Link to item Cite

Seroprevalence and risk factors associated with Ehrlichia canis, Anaplasma spp., Borrelia burgdorferi sensu lato, and D. immitis in hunting dogs from southern Italy.

Journal article Parasitol Res · October 2017 Canine vector-borne diseases (CVBDs) are caused by a range of pathogens transmitted to dogs by arthropods. The present study investigates Ehrlichia canis, Anaplasma spp., Borrelia burgdorferi sensu lato, and Dirofilaria immitis seroprevalences in hunting d ... Full text Link to item Cite

Seroprevalence of Bartonella species, Coxiella burnetii and Toxoplasma gondii among patients with hematological malignancies: A pilot study in Romania.

Journal article Zoonoses Public Health · September 2017 Patients receiving immunosuppressive cancer treatments in settings where there is a high degree of human-animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. We sought to determine the sero ... Full text Link to item Cite

Vector-borne and zoonotic diseases of dogs in North-west New South Wales and the Northern Territory, Australia.

Journal article BMC Vet Res · August 15, 2017 BACKGROUND: Vector-borne diseases of dogs in Australian Aboriginal communities are relatively unexplored. These dogs represent a unique group with variable ecto- and endo-parasitic burdens, nutritional stresses and a general lack of veterinary intervention ... Full text Link to item Cite

Prevalence of Vector-Borne Pathogens in Southern California Dogs With Clinical and Laboratory Abnormalities Consistent With Immune-Mediated Disease.

Journal article J Vet Intern Med · July 2017 BACKGROUND: Studies investigating the prevalence of vector-borne pathogens in southern California dogs are limited. Occult infections might be misdiagnosed as idiopathic immune-mediated disease. HYPOTHESIS/OBJECTIVES: (1) To determine the prevalence of vec ... Full text Link to item Cite

Bartonella henselae in canine cavitary effusions: prevalence, identification, and clinical associations.

Journal article Vet Clin Pathol · June 2017 BACKGROUND: Previous reports suggest an association between Bartonella infection and effusions in dogs and human beings. OBJECTIVES: The aims of this study were to determine the prevalence of Bartonella infection in canine effusions and to investigate hist ... Full text Link to item Cite

Neurological and immunological dysfunction in two patients with Bartonella henselae bacteremia.

Journal article Clin Case Rep · June 2017 Recently, BAPGM enrichment culture has documented Bartonella bacteremia in previously healthy, "nonimmunocompromised" patients following arthropod exposures. Neurobartonellosis should be among the differential diagnoses for patients with persistent or recu ... Full text Link to item Cite

Improved molecular detection of Babesia infections in animals using a novel quantitative real-time PCR diagnostic assay targeting mitochondrial DNA.

Journal article Parasit Vectors · March 7, 2017 BACKGROUND: Babesiosis is a protozoal, tick transmitted disease found worldwide in humans, wildlife and domesticated animals. Commonly used approaches to diagnose babesiosis include microscopic examination of peripheral blood smears, detection of circulati ... Full text Link to item Cite

Death of Military Working Dogs Due to Bartonella vinsonii Subspecies berkhoffii Genotype III Endocarditis and Myocarditis.

Journal article Mil Med · March 2017 OBJECTIVES: As a result of extensive field-related activities, military working dogs (MWDs) have an increased occupational risk for acquiring vector-borne infectious diseases. METHODS: Indirect fluorescent antibody, Bartonella alpha-proteobacteria growth m ... Full text Link to item Cite

Antimicrobial use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases.

Journal article J Vet Intern Med · March 2017 Respiratory tract disease can be associated with primary or secondary bacterial infections in dogs and cats and is a common reason for use and potential misuse, improper use, and overuse of antimicrobials. There is a lack of comprehensive treatment guideli ... Full text Link to item Cite

Bartonellosis, One Health and all creatures great and small.

Journal article Vet Dermatol · February 2017 BACKGROUND: Bartonellosis is a zoonotic infectious disease of worldwide distribution, caused by an expanding number of recently discovered Bartonella spp. OBJECTIVES: This review serves as an update on comparative medical aspects of this disease, including ... Full text Link to item Cite

Bartonella henselae, Bartonella koehlerae and Rickettsia rickettsii seroconversion and seroreversion in a dog with acute-onset fever, lameness, and lymphadenopathy followed by a protracted disease course.

Journal article Vet Parasitol Reg Stud Reports · January 2017 Following recent tick exposure in Arkansas, a 2-year-old, female spayed Labradoodle was examined because of a one-week history of lethargy and shifting-leg lameness. The dog was febrile, had prominent lymph nodes, dull mentation, a stiff gait, and left for ... Full text Link to item Cite

Infective endocarditis in 13 cats.

Journal article J Vet Cardiol · September 2016 INTRODUCTION: To describe the clinical presentation, clinicopathological abnormalities and outcomes of a series of cats diagnosed with infective endocarditis (IE) at two tertiary care referral institutions. ANIMALS: Thirteen client-owned cats presenting to ... Full text Link to item Cite

Successful treatment of mitral valve endocarditis in a dog associated with 'Actinomyces canis-like' infection.

Journal article J Vet Cardiol · September 2016 Infective endocarditis, an inflammation of the endocardial surface due to invasion by an infectious agent, is more common in middle sized to large breed dogs. We herein report a case of mitral valve endocarditis in a 9-year-old male-castrated Weimaraner ca ... Full text Link to item Cite

Vasculitis, cerebral infarction and persistent Bartonella henselae infection in a child.

Journal article Parasit Vectors · May 10, 2016 BACKGROUND: The genus Bartonella is comprised of a rapidly increasing number of pathogenic species that induce a seemingly diverse spectrum of neurological symptoms. During the 12 year period that followed the initial onset of neurological and gastrointest ... Full text Link to item Cite

Vertical transmission of Anaplasma platys and Leishmania infantum in dogs during the first half of gestation.

Journal article Parasit Vectors · May 10, 2016 BACKGROUND: Leishmania infantum is a canine zoonotic vector-borne protozoan pathogen transmitted by phlebotomine sand flies, whereas Anaplasma platys is a bacterium most likely transmitted by ticks. While vertical transmission of L. infantum from pregnant ... Full text Link to item Cite

A putative marker for human pathogenic strains of Anaplasma phagocytophilum correlates with geography and host, but not human tropism.

Journal article Ticks Tick Borne Dis · March 2016 Anaplasma phagocytophilum is an Ixodes species tick-transmitted bacterium that is capable of infecting a variety of host species, although there is a diversity of bacterial strains with differing host tropism. Recent analysis of A. phagocytophilum strains ... Full text Link to item Cite

Risk Factors for Bartonella species Infection in Blood Donors from Southeast Brazil.

Journal article PLoS Negl Trop Dis · March 2016 Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection with ... Full text Link to item Cite

Bartonella Species and Vascular Pathology

Book section · January 1, 2016 In recent years, an increasing number of Bartonella species have been identified as zoonotic pathogens that are transmitted by animal bites or scratches, needle sticks, blood transfusions, or by arthropods. Potentially, because Bartonella spp. can infect e ... Full text Cite

Prevalence of Bartonella spp. in Canine Cutaneous Histiocytoma.

Journal article J Comp Pathol · July 2015 Canine cutaneous histiocytoma (CCH) is a common, benign neoplastic proliferation of histiocytes of Langerhans cell origin that often ulcerate, become secondarily infected and regress spontaneously. Bartonella is a fastidious genus of facultative intracellu ... Full text Link to item Cite

Serological and molecular analysis of feline vector-borne anaplasmosis and ehrlichiosis using species-specific peptides and PCR.

Journal article Parasit Vectors · June 12, 2015 BACKGROUND: With the exception of Bartonella spp. or Cytauxzoon felis, feline vector-borne pathogens (FVBP) have been less frequently studied in North America and are generally under-appreciated as a clinical entity in cats, as compared to dogs or people. ... Full text Link to item Cite

Did Bartonella henselae contribute to the deaths of two veterinarians?

Journal article Parasit Vectors · June 12, 2015 Bartonella henselae, a flea-transmitted bacterium, causes chronic, zoonotic, blood stream infections in immunocompetent and immunocompromised patients throughout the world. As an intra-erythrocytic and endotheliotropic bacterium, B. henselae causes a spect ... Full text Link to item Cite

Infection with Bartonella henselae in a Danish family.

Journal article J Clin Microbiol · May 2015 Bartonella species constitute emerging, vector-borne, intravascular pathogens that produce long-lasting bacteremia in reservoir-adapted (natural host or passive carrier of a microorganism) and opportunistic hosts. With the advent of more sensitive and spec ... Full text Link to item Cite

Vector-borne pathogens in arctic foxes, Vulpes lagopus, from Canada.

Journal article Res Vet Sci · April 2015 Because of the relatively low biodiversity within arctic ecosystems, arctic foxes, Vulpes lagopus, could serve as sentinels for the study of changes in the ecology of vector-borne zoonotic pathogens. The objective of this study was to determine the molecul ... Full text Link to item Cite

Concurrent Bartonella henselae infection in a dog with panniculitis and owner with ulcerated nodular skin lesions.

Journal article Vet Dermatol · February 2015 BACKGROUND: Bartonella henselae, a Gram-negative, zoonotic Alphaproteobacteria that infects erythrocytes, endothelial cells and dendritic cells, has previously been implicated as a cause of panniculitis in dogs and a human. ANIMAL AND OWNER: An 8-year-old, ... Full text Link to item Cite

Potentially novel Ehrlichia species in horses, Nicaragua.

Journal article Emerg Infect Dis · February 2015 Ehrlichia sp. DNA was amplified from 4 Ehrlichia-seroreactive horses from Mérida, Nicaragua. Sequencing of 16S rDNA, sodB, and groEL genes indicated that the bacterium is most likely a novel Ehrlichia species. The tick vector and the potential for canine a ... Full text Link to item Cite

Bartonella clarridgeiae bacteremia detected in an asymptomatic blood donor.

Journal article J Clin Microbiol · January 2015 Human exposure to Bartonella clarridgeiae has been reported only on the basis of antibody detection. We report for the first time an asymptomatic human blood donor infected with B. clarridgeiae, as documented by enrichment blood culture, PCR, and DNA seque ... Full text Link to item Cite

Bartonella spp. bacteremia in blood donors from Campinas, Brazil.

Journal article PLoS Negl Trop Dis · January 2015 Bartonella species are blood-borne, re-emerging organisms, capable of causing prolonged infection with diverse disease manifestations, from asymptomatic bacteremia to chronic debilitating disease and death. This pathogen can survive for over a month in sto ... Full text Link to item Cite

Splenic vasculitis, thrombosis, and infarction in a febrile dog infected with Bartonella henselae.

Journal article J Vet Emerg Crit Care (San Antonio) · 2015 OBJECTIVE: To describe the clinical course and successful management of a febrile dog with polyarthritis, splenic vasculitis, thrombosis, and infarction that was infected with Bartonella henselae. CASE SUMMARY: An 8-year-old female spayed Labrador Retrieve ... Full text Link to item Cite

Bartonella henselae as a cause of acute-onset febrile illness in cats.

Journal article JFMS Open Rep · 2015 CASE SERIES SUMMARY: At different time points spanning 6 months, three adopted feral flea-infested cats, residing in the household of a veterinary technician, became acutely anorexic, lethargic and febrile. Enrichment blood culture/PCR using Bartonella alp ... Full text Link to item Cite

Relationship between degenerative joint disease, pain, and Bartonella spp. seroreactivity in domesticated cats.

Journal article J Vet Intern Med · January 2015 BACKGROUND: Recently, a potential association was identified between Bartonella exposure and arthritides in mammalian species other than cats. HYPOTHESIS/OBJECTIVES: We hypothesized that Bartonella exposure is associated with more severe degenerative joint ... Full text Link to item Cite

Evaluation of blood and bone marrow in selected canine vector-borne diseases.

Journal article Parasit Vectors · December 2, 2014 BACKGROUND: Bone marrow (BM) is a major hematopoietic organ that can harbour a variety of vector-borne pathogens; however, knowledge of BM pathological changes in dogs infected with vector-borne pathogens is limited. Thus, the aim of the present study was ... Full text Link to item Cite

Case report: Molecular evidence of Anaplasma platys infection in two women from Venezuela.

Journal article Am J Trop Med Hyg · December 2014 This article presents two case reports of Anaplasma platys detection in two women from Venezuela. Both patients were exposed to Rhipicephalus sanguineus, the presumed tick vector, and experienced chronic, nonspecific clinical signs including headaches and ... Full text Link to item Cite

Zoonotic Bartonella species in cardiac valves of healthy coyotes, California, USA.

Journal article Emerg Infect Dis · December 2014 We investigated whether Bartonella spp. could cause endocarditis in coyotes or localize to cardiac valves before lesions develop. Bartonella DNA was amplified more often from coyote cardiac valves than spleen. Bartonella infection apparently leads to cardi ... Full text Link to item Cite

Molecular identification of Bartonella species in dogs with leishmaniosis (leishmania infantum) with or without cytological evidence of arthritis.

Journal article Vet Microbiol · November 7, 2014 Recent evidence suggest that Bartonella species may cause polyarthritis and lameness in dogs. Canine leishmaniosis (CanL) due to Leishmania infantum is a multi-systemic disease often occurring in association with arthritis. We hypothesized that concurrent ... Full text Link to item Cite

Development and validation of a sensitive and specific sodB-based quantitative PCR assay for molecular detection of Ehrlichia species.

Journal article J Clin Microbiol · November 2014 We developed a sensitive and specific sodB-based quantitative PCR assay to detect Ehrlichia spp. The assay's limit of detection was 5 copies/reaction, and it did not amplify nonspecific DNA. Compared with a 16S rRNA gene PCR target, the sodB target may off ... Full text Link to item Cite

Regional seroreactivity and vector-borne disease co-exposures in dogs in the United States from 2004-2010: utility of canine surveillance.

Journal article Vector Borne Zoonotic Dis · October 2014 Vector-borne disease (VBD) pathogens remain an emerging health concern for animals and humans throughout the world. Surveillance studies of ticks and humans have made substantial contributions to our knowledge of VBD epidemiology trends, but long-term VBD ... Full text Link to item Cite

Bartonella henselae infections in an owner and two Papillon dogs exposed to tropical rat mites (Ornithonyssus bacoti).

Journal article Vector Borne Zoonotic Dis · October 2014 After raccoons were trapped and removed from under a house in New York, the owner and her two Papillon dogs became infested with numerous rat mites (Ornithonyssus bacoti). Two weeks later, both dogs developed pruritus, progressively severe vesicular lesion ... Full text Link to item Cite

Bilateral mandibular pyogranulomatous lymphadenitis and pulmonary nodules in a dog with Bartonella henselae bacteremia.

Journal article Can Vet J · October 2014 This report describes a 2-year-old collie dog with pulmonary nodules, visualized by computed tomographic (CT) scan, with evidence of Bartonella henselae bacteremia and pyogranulomatous lymphadenitis. Clinical signs resolved with antimicrobial therapy. ... Link to item Cite

Prostatitis, steatitis, and diarrhea in a dog following presumptive flea-borne transmission of Bartonella henselae.

Journal article J Clin Microbiol · September 2014 Bartonella henselae is increasingly associated with a variety of pathological entities, which are often similar in dogs and human patients. Following an acute flea infestation, a dog developed an unusual clinical presentation for canine bartonellosis. Comp ... Full text Link to item Cite

Experimental infection of cats with Afipia felis and various Bartonella species or subspecies.

Journal article Vet Microbiol · August 27, 2014 Based upon prior studies, domestic cats have been shown to be the natural reservoir for Bartonella henselae, Bartonella clarridgeiae and Bartonella koehlerae. However, other Bartonella species, such as Bartonella vinsonii subsp. berkhoffii, Bartonella quin ... Full text Link to item Cite

Co-infection with Anaplasma platys, Bartonella henselae, Bartonella koehlerae and 'Candidatus Mycoplasma haemominutum' in a cat diagnosed with splenic plasmacytosis and multiple myeloma.

Journal article J Feline Med Surg · August 2014 Anaplasma platys (Apl), 'Candidatus Mycoplasma haemominutum' (CMh), Bartonella henselae (Bh) and Bartonella koehlerae (Bk) were confirmed by polymerase chain reaction (PCR) amplification and DNA sequencing in a cat diagnosed with multiple myeloma. Other in ... Full text Link to item Cite

Detection of Bartonella species in the blood of veterinarians and veterinary technicians: a newly recognized occupational hazard?

Journal article Vector Borne Zoonotic Dis · August 2014 BACKGROUND: Bartonella species are important emerging pathogens in human and veterinary medicine. In the context of their daily activities, veterinary professionals have frequent animal contact and arthropod exposures. Detection of Bartonella spp. using tr ... Full text Open Access Link to item Cite

Performance of a commercially available in-clinic ELISA for detection of antibodies against Anaplasma phagocytophilum, Anaplasma platys, Borrelia burgdorferi, Ehrlichia canis, and Ehrlichia ewingii and Dirofilaria immitis antigen in dogs.

Journal article J Am Vet Med Assoc · July 1, 2014 OBJECTIVE: To evaluate the performance of an in-clinic ELISA designed for detection of heartworm antigen and antibodies against 5 tick-borne pathogens. DESIGN: Validation study. SAMPLE: 1,601 serum or matched serum, plasma, and blood samples from dogs. PRO ... Full text Link to item Cite

Intravascular persistence of Anaplasma platys, Ehrlichia chaffeensis, and Ehrlichia ewingii DNA in the blood of a dog and two family members.

Journal article Parasit Vectors · July 1, 2014 BACKGROUND: Anaplasmosis, caused by Anaplasma phagocytophilum and Anaplasma platys, and ehrlichiosis, caused by Ehrlichia chaffeensis, Ehrlichia ewingii, the "Panola Mountain Ehrlichia" and Ehrlichia muris-like pathogens have been identified as emerging ti ... Full text Link to item Cite

Novel Bartonella infection in northern and southern sea otters (Enhydra lutris kenyoni and Enhydra lutris nereis).

Journal article Vet Microbiol · June 4, 2014 Since 2002, vegetative valvular endocarditis (VVE), septicemia and meningoencephalitis have contributed to an Unusual Mortality Event (UME) of northern sea otters in southcentral Alaska. Streptococcal organisms were commonly isolated from vegetative lesion ... Full text Link to item Cite

Anaplasma platys in bone marrow megakaryocytes of young dogs.

Journal article J Clin Microbiol · June 2014 Anaplasma platys is an obligate intracellular rickettsial pathogen that infects platelets of dogs, forming basophilic intracellular morulae. In the present report, cellular inclusions were documented in bone marrow thrombocyte precursors of two young natur ... Full text Link to item Cite

Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases).

Journal article Vet Dermatol · June 2014 BACKGROUND: Superficial bacterial folliculitis (SBF) is usually caused by Staphylococcus pseudintermedius and routinely treated with systemic antimicrobial agents. Infection is a consequence of reduced immunity associated with alterations of the skin barri ... Full text Link to item Cite

Bartonellosis: A one health perspective

Book section · June 1, 2014 Recently, Bartonella, a genus comprised of fastidious, Gram-negative, intracellular bacteria, has rapidly expanded from approximately 4-5 species in the 1990s to 30-40 named or proposed species that are currently described in the literature. While Bartonel ... Full text Cite

Comparative microbiological features of Bartonella henselae infection in a dog with fever of unknown origin and granulomatous lymphadenitis.

Journal article Med Microbiol Immunol · April 2014 We report the first documented case of Bartonella henselae infection in a dog from France and the first isolation of B. henselae from a dog with fever of unknown origin. This observation contributes to the "One Health" concept focusing on zoonotic pathogen ... Full text Link to item Cite

Spontaneous onset of complex regional pain syndrome Type I in a woman infected with Bartonella koehlerae.

Journal article Med Microbiol Immunol · April 2014 After a short-term fever, complex regional pain syndrome, characterized by hyperalgesia, intermittent swelling, erythema and cyanosis of both feet, was diagnosed in a female veterinarian. The woman was infected with Bartonella koehlerae and she was also Ba ... Full text Link to item Cite

Comparison of serological and molecular panels for diagnosis of vector-borne diseases in dogs.

Journal article Parasit Vectors · March 26, 2014 BACKGROUND: Canine vector-borne diseases (CVBD) are caused by a diverse array of pathogens with varying biological behaviors that result in a wide spectrum of clinical presentations and laboratory abnormalities. For many reasons, the diagnosis of canine ve ... Full text Link to item Cite

Hemotropic mycoplasmas in little brown bats (Myotis lucifugus).

Journal article Parasit Vectors · March 24, 2014 BACKGROUND: Hemotropic mycoplasmas are epicellular erythrocytic bacteria that can cause infectious anemia in some mammalian species. Worldwide, hemotropic mycoplasmas are emerging or re-emerging zoonotic pathogens potentially causing serious and significan ... Full text Link to item Cite

Serological and molecular prevalence of selected canine vector borne pathogens in blood donor candidates, clinically healthy volunteers, and stray dogs in North Carolina.

Journal article Parasit Vectors · March 24, 2014 BACKGROUND: Canine vector borne diseases (CVBDs) comprise illnesses caused by a spectrum of pathogens that are transmitted by arthropod vectors. Some dogs have persistent infections without apparent clinical, hematological or biochemical abnormalities, whe ... Full text Link to item Cite

Survey of veterinarians' perceptions of borreliosis in North Carolina.

Journal article J Am Vet Med Assoc · March 1, 2014 OBJECTIVE--To evaluate the practices and perceptions of veterinarians in North Carolina regarding borreliosis in dogs in various geographic regions of the state. DESIGN--Cross-sectional survey. SAMPLE--Data from 208 completed surveys. PROCEDURES--Surveys w ... Full text Link to item Cite

Bartonella henselae and B. koehlerae DNA in birds.

Journal article Emerg Infect Dis · March 2014 Full text Link to item Cite

In Pursuit of a Stealth Pathogen: Laboratory Diagnosis of Bartonellosis

Journal article Clinical Microbiology Newsletter · March 1, 2014 Members of the genus Bartonella cause illnesses in humans and animals. Bartonella spp. are gram-negative, fastidious, facultative, intracellular pathogens transmitted by the bites of certain arthropods or by bites and scratches from infected animals. While ... Full text Cite

Flea species infesting dogs in Florida and Bartonella spp. prevalence rates.

Journal article Vet Parasitol · January 31, 2014 Several Bartonella spp. associated with fleas can induce a variety of clinical syndromes in both dogs and humans. However, few studies have investigated the prevalence of Bartonella in the blood of dogs and their fleas. The objectives of this study were to ... Full text Link to item Cite

A serological survey of tick-borne pathogens in dogs in North America and the Caribbean as assessed by Anaplasma phagocytophilum, A. platys, Ehrlichia canis, E. chaffeensis, E. ewingii, and Borrelia burgdorferi species-specific peptides.

Journal article Infect Ecol Epidemiol · 2014 INTRODUCTION: Tick-borne pathogens cause a spectrum of disease manifestations in both dogs and humans. Recognizing regional and temporal shifts in exposure are important as tick distributions change. To better delineate regional exposure to canine tick-bor ... Full text Link to item Cite

Bartonellosis: one health perspectives for an emerging infectious disease.

Journal article ILAR J · 2014 In recent years, an increasing number of Bartonella species have been identified as zoonotic pathogens, transmitted by animal bites, scratches, arthropods and even by needle sticks. Considering the diversity of newly discovered Bartonella species and subsp ... Full text Link to item Cite

Intraoperative bleeding in dogs from Grenada seroreactive to Anaplasma platys and Ehrlichia canis.

Journal article J Vet Intern Med · 2014 BACKGROUND: Frequent exposure of Grenadian dogs to Rhipicephalus sanguineus results in Anaplasma platys, and Ehrlichia canis seroreactivity. During elective surgeries, substantial intraoperative hemorrhage occurs in some seroreactive dogs. OBJECTIVES: To a ... Full text Link to item Cite

Analysis of seroreactivity against cell culture-derived Bartonella spp. antigens in dogs.

Journal article J Vet Intern Med · 2014 BACKGROUND: Little is known about the specificity of Bartonella spp. immunofluorescent antibody (IFA) assays in dogs. Bacteremia in sick dogs most often has been associated with Bartonella henselae (Bh), Bartonella vinsonii subspecies berkhoffii (Bvb), and ... Full text Link to item Cite

Experimental infection of dogs with Bartonella henselae and Bartonella vinsonii subsp. berkhoffii.

Journal article Vet Immunol Immunopathol · November 15, 2013 The lack of a suitable infection model remains an important obstacle for the pathophysiological understanding of Bartonella spp. The following pilot study was designed to determine whether cell culture-grown Bartonella henselae SA2 and Bartonella vinsonii ... Full text Link to item Cite

Infection with hemotropic Mycoplasma species in patients with or without extensive arthropod or animal contact.

Journal article J Clin Microbiol · October 2013 PCR amplification targeting the 16S rRNA gene was used to test individuals with and without extensive arthropod and animal contact for the possibility of hemotropic mycoplasma infection. The prevalence of hemotropic mycoplasma infection (4.7%) was signific ... Full text Link to item Cite

An unmatched case controlled study of clinicopathologic abnormalities in dogs with Bartonella infection.

Journal article Comp Immunol Microbiol Infect Dis · September 2013 We compared clinicopathologic findings in dogs with Bartonella infection to Bartonella spp. negative dogs suspected of a vector-borne disease. Cases (n=47) and controls (n=93) were selected on the basis of positive or negative enrichment culture PCR result ... Full text Link to item Cite

Efficacy of an imidacloprid/flumethrin collar against fleas, ticks and tick-borne pathogens in dogs.

Journal article Parasit Vectors · August 23, 2013 BACKGROUND: Tick-borne diseases comprise a group of maladies that are of substantial medical and veterinary significance. A range of tick-borne pathogens, including diverse species of bacteria and protozoa, can infect both dogs and humans. Hence, the contr ... Full text Link to item Cite

Serial testing from a 3-day collection period by use of the Bartonella Alphaproteobacteria growth medium platform may enhance the sensitivity of Bartonella species detection in bacteremic human patients.

Journal article J Clin Microbiol · June 2013 Patients with infection from bacteremic Bartonella spp., tested using Bartonella Alphaproteobacteria growth medium (BAPGM), were retrospectively categorized into one of two groups that included those whose blood was collected once (group 1; n = 55) or thre ... Full text Link to item Cite

"Candidatus Mycoplasma haemomacaque" and Bartonella quintana bacteremia in cynomolgus monkeys.

Journal article J Clin Microbiol · May 2013 Here, we report latent infections with Bartonella quintana and a hemotropic Mycoplasma sp. in a research colony of cynomolgus monkeys (Macaca fascicularis). Sequence alignments, evolutionary analysis, and signature nucleotide sequence motifs of the hemotro ... Full text Link to item Cite

Bartonella henselae infection in a family experiencing neurological and neurocognitive abnormalities after woodlouse hunter spider bites.

Journal article Parasit Vectors · April 15, 2013 BACKGROUND: Bartonella species comprise a group of zoonotic pathogens that are usually acquired by vector transmission or by animal bites or scratches. METHODS: PCR targeting the Bartonella 16S-23S intergenic spacer (ITS) region was used in conjunction wit ... Full text Link to item Cite

Are vector-borne pathogen co-infections complicating the clinical presentation in dogs?

Journal article Parasit Vectors · April 15, 2013 BACKGROUND: Infection by two or more canine vector-borne disease (CVBD)-causing pathogens is common in subtropical and tropical regions where vectors are plentiful. Co-infections may potentiate disease pathogenesis, thereby altering clinical manifestations ... Full text Link to item Cite

Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian.

Journal article Parasit Vectors · April 15, 2013 BACKGROUND: During a two year period, a 27-year-old female veterinarian experienced migraine headaches, seizures, including status epilepticus, and other neurological and neurocognitive abnormalities. Prior to and during her illness, she had been actively ... Full text Link to item Cite

Bartonella henselae bacteremia in a mother and son potentially associated with tick exposure.

Journal article Parasit Vectors · April 15, 2013 BACKGROUND: Bartonella henselae is a zoonotic, alpha Proteobacterium, historically associated with cat scratch disease (CSD), but more recently associated with persistent bacteremia, fever of unknown origin, arthritic and neurological disorders, and bacill ... Full text Link to item Cite

Infection of human brain vascular pericytes (HBVPs) by Bartonella henselae.

Journal article Med Microbiol Immunol · April 2013 Angiogenesis is an important physiological and pathological process. Bartonella is the only genus of bacteria known to induce pathological angiogenesis in the mammalian host. Bartonella-induced angiogenesis leads to the formation of vascular tumors includi ... Full text Link to item Cite

Koch's postulates and the pathogenesis of comparative infectious disease causation associated with Bartonella species.

Journal article J Comp Pathol · February 2013 In his homage to Lucretius ('Georgica'), Vergil is credited with stating: 'Felix qui potuit rerum cognoscere causas' ('Fortunate is he who knows the causes of things'). Based on numerous commentaries and publications it is obvious that clinicians, diagnost ... Full text Link to item Cite

Isolation of a novel strain of Mycobacterium iranicum from a woman in the United States.

Journal article J Clin Microbiol · February 2013 A novel strain of Mycobacterium iranicum, a recently described nontuberculous Mycobacterium species, was isolated from the sputum of a woman. The source of infection was not determined; however, fomite transmission of inhaled aerosolized secretions from he ... Full text Link to item Cite

Bartonella henselae infection in a man with hypergammaglobulinaemia, splenomegaly and polyclonal plasmacytosis.

Journal article J Med Microbiol · February 2013 Bartonella henselae is an infrequently reported cause of polyclonal plasmacytosis and hypergammaglobulinaemia. We herein document B. henselae infection in a 66-year-old patient who presented with hypergammaglobulinaemia, splenomegaly with polyclonal plasma ... Full text Link to item Cite

Phylogenetic diversity of bacteria isolated from sick dogs using the BAPGM enrichment culture platform.

Journal article J Vet Intern Med · 2013 BACKGROUND: Bartonella alpha-Proteobacteria growth medium (BAPGM) enrichment culture has proven useful for documenting Bartonella species infection and has facilitated growth of other fastidious bacteria from human samples. PURPOSE: To report non-Bartonell ... Full text Link to item Cite

Rocky mountain spotted fever

Book section · January 1, 2013 Full text Cite

Survey of Bartonella spp. in U.S. bed bugs detects Burkholderia multivorans but not Bartonella.

Journal article PLoS One · 2013 Bed bugs (Cimex lectularius L.) have resurged in the United States and globally. Bed bugs are hematophagous ectoparasites of humans and other animals, including domestic pets, chickens, and bats, and their blood feeding habits contribute to their potential ... Full text Link to item Cite

Candidatus Mycoplasma haematoparvum and Mycoplasma haemocanis infections in dogs from the United States.

Journal article Comp Immunol Microbiol Infect Dis · December 2012 Mycoplasma haemocanis (Mhc) and Candidatus Mycoplasma haematoparvum (CMhp) have been described in dogs. Historically, microscopic visualization of hemotropic Mycoplasma spp. has occurred most often in immunocompromised or splenectomized dogs. The aim of th ... Full text Link to item Cite

Surveillance of zoonotic infectious disease transmitted by small companion animals

Journal article Emerging Infectious Diseases · December 1, 2012 The One Health paradigm for global health recognizes that most new human infectious diseases will emerge from animal reservoirs. Little consideration has been given to the known and potential zoonotic infectious diseases of small companion animals. Cats an ... Full text Cite

Serum cardiac troponin I concentrations in naturally occurring myelosuppressive and non-myelosuppressive canine monocytic ehrlichiosis.

Journal article Vet J · November 2012 The aim of this study was to determine whether serum cardiac troponin I (cTnI) concentration measured on admission was associated with the clinical severity of canine monocytic ehrlichiosis and was predictive of clinical outcome (death or survival) in dogs ... Full text Link to item Cite

Feline bartonellosis: we're just scratching the surface.

Journal article J Feline Med Surg · September 2012 Full text Link to item Cite

Perinuclear antineutrophil cytoplasmic autoantibodies in dogs infected with various vector-borne pathogens and in dogs with immune-mediated hemolytic anemia.

Journal article Am J Vet Res · September 2012 OBJECTIVE: To determine the prevalence of perinuclear antineutrophil cytoplasmic autoantibodies (pANCA) in dogs with confirmed or suspected immune-mediated hemolytic anemia (IMHA) or dogs infected with various vector-borne pathogens, including Rickettsia r ... Full text Link to item Cite

Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue.

Journal article J Vet Diagn Invest · September 2012 Canine granulomatous hepatitis is an uncommon morphologic diagnosis that has been associated with a variety of diseases, including a number of systemic infectious etiologies. Formalin-fixed, paraffin-embedded (FFPE) tissues are typically the only source of ... Full text Link to item Cite

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae as potential causes of proliferative vascular diseases in animals.

Journal article Med Microbiol Immunol · August 2012 Bartonella species are highly fastidious, vector borne, zoonotic bacteria that cause persistent intraerythrocytic bacteremia and endotheliotropic infection in reservoir and incidental hosts. Based upon prior in vitro research, three Bartonella sp., B. baci ... Full text Link to item Cite

Uropathogenic E. coli promote a paracellular urothelial barrier defect characterized by altered tight junction integrity, epithelial cell sloughing and cytokine release.

Journal article J Comp Pathol · July 2012 The urinary bladder is a common site of bacterial infection with a majority of cases attributed to uropathogenic Escherichia coli. Sequelae of urinary tract infections (UTIs) include the loss of urothelial barrier function and subsequent clinical morbidity ... Full text Link to item Cite

Identification of Bartonella henselae in 2 cats with pyogranulomatous myocarditis and diaphragmatic myositis.

Journal article Vet Pathol · July 2012 Most cats infected with Bartonella henselae remain outwardly healthy carriers for years; however, self-limiting fever, transient anemia, neurologic dysfunction, lymphadenopathy, reproductive disorders, aortic valvular endocarditis, and neutrophilic myocard ... Full text Link to item Cite

Bartonella spp. bacteremia and rheumatic symptoms in patients from Lyme disease-endemic region.

Journal article Emerg Infect Dis · May 2012 Bartonella spp. infection has been reported in association with an expanding spectrum of symptoms and lesions. Among 296 patients examined by a rheumatologist, prevalence of antibodies against Bartonella henselae, B. koehlerae, or B. vinsonii subsp. berkho ... Full text Link to item Cite

Invasion of canine erythrocytes by Bartonella vinsonii subsp. berkhoffii.

Journal article Vet Microbiol · April 23, 2012 Bartonella vinsonii subsp. berkhoffii is a recognized cause of endocarditis in dogs and human patients and has been associated with cardiac arrhythmias, myocarditis, granulomatous lymphadenitis, polyarthritis, and granulomatous rhinitis in dogs. Little is ... Full text Link to item Cite

Vector-borne diseases--constant challenge for practicing veterinarians: recommendations from the CVBD World Forum.

Journal article Parasit Vectors · March 20, 2012 The human-animal bond has been a fundamental feature of mankind's history for millennia. The first, and strongest of these, man's relationship with the dog, is believed to pre-date even agriculture, going back as far as 30,000 years. It remains at least as ... Full text Link to item Cite

Seroprevalence of Ehrlichia canis, Ehrlichia chaffeensis and Ehrlichia ewingii in dogs in North America.

Journal article Parasit Vectors · February 8, 2012 BACKGROUND: This study evaluated the exposure of dogs to three different Ehrlichia spp. in the south and central regions of the United States where vector-borne disease prevalence has been previously difficult to ascertain, particularly beyond the metropol ... Full text Link to item Cite

Vector-borne diseases in client-owned and stray cats from Madrid, Spain.

Journal article Vector Borne Zoonotic Dis · February 2012 The role of various vector-borne pathogens as a cause of disease in cats has not been clearly determined. The current study evaluated risk factors, clinical and laboratory abnormalities associated with Ehrlichia spp., Anaplasma spp., Neorickettsia spp., Le ... Full text Link to item Cite

Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient.

Journal article BMC Infect Dis · January 23, 2012 BACKGROUND: Bartonella henselae (B. henselae) is considered a rare cause of granulomatous hepatitis. Due to the fastidious growth characteristics of the bacteria, the limited sensitivity of histopathological stains, and the non-specific histological findin ... Full text Link to item Cite

Bartonella spp. infection in healthy and sick horses and foals from the southeastern United States.

Journal article J Vet Intern Med · 2012 BACKGROUND: Bartonella species bacteremia has been identified in numerous animal species. These bacteria cause, or have been associated with, a spectrum of clinical manifestations in dogs and human patients. The frequency of exposure to or infection with B ... Full text Link to item Cite

Experimental infection of horses with Bartonella henselae and Bartonella bovis.

Journal article J Vet Intern Med · 2012 BACKGROUND: Experimental infection of horses with Bartonella species is not documented. OBJECTIVES: Determine clinical signs, hematologic changes, duration of bacteremia, and pattern of seroconversion in Bartonella henselae or Bartonella bovis-inoculated h ... Full text Link to item Cite

Candidatus Bartonella merieuxii, a potential new zoonotic Bartonella species in canids from Iraq.

Journal article PLoS Negl Trop Dis · 2012 Bartonellae are emerging vector-borne pathogens infecting erythrocytes and endothelial cells of various domestic and wild mammals. Blood samples were collected from domestic and wild canids in Iraq under the United States Army zoonotic disease surveillance ... Full text Link to item Cite

Experimental infection by capillary tube feeding of Rhipicephalus sanguineus with Bartonella vinsonii subspecies berkhoffii.

Journal article Comp Immunol Microbiol Infect Dis · January 2012 It has been speculated that ticks may serve as vectors of Bartonella species. Circumstantial, clinical, epidemiological and serological evidence suggest that B. vinsonii subspecies berkhoffii (B. v. berkhoffii) might be transmitted by Rhipicephalus sanguin ... Full text Link to item Cite

Bartonella spp. bacteremia in high-risk immunocompetent patients.

Journal article Diagn Microbiol Infect Dis · December 2011 Serum and blood samples from 192 patients, who reported animal exposure (100.0%) and recent animal bites or scratches (88.0%), were screened for antibodies by indirect immunofluorescence assays and for bacteremia using the BAPGM (Bartonella alpha Proteobac ... Full text Link to item Cite

Bartonella species bacteremia in two patients with epithelioid hemangioendothelioma.

Journal article J Clin Microbiol · November 2011 Bartonella henselae and B. koehlerae bacteremia was documented in two epithelioid hemangioendothelioma patients and B. koehlerae bacteremia in an asymptomatic partner of one of the patients. Considering the biology and clinically variable natural history o ... Full text Link to item Cite

Ecological diversity of Bartonella species infection among dogs and their owner in Virginia.

Journal article Vector Borne Zoonotic Dis · November 2011 Bartonella species comprise a genus of gram-negative, fastidious, intracellular bacteria that have been implicated in association with an increasing spectrum of disease manifestations in dogs and human patients. In this study, chronic canine and human dise ... Full text Link to item Cite

Hallucinations, sensory neuropathy, and peripheral visual deficits in a young woman infected with Bartonella koehlerae.

Journal article J Clin Microbiol · September 2011 A young woman experiencing depression, anxiety, mood swings, severe headaches, muscle spasms, interphalangeal joint stiffness, decreased peripheral vision, diminished tactile sensation, and hallucinations was persistently Bartonella koehlerae seroreactive ... Full text Link to item Cite

Rickettsia rickettsii transmission by a lone star tick, North Carolina.

Journal article Emerg Infect Dis · May 2011 Only indirect or circumstantial evidence has been published to support transmission of Rickettsia rickettsii by Amblyomma americanum (lone star) ticks in North America. This study provides molecular evidence that A. americanum ticks can function, although ... Full text Open Access Link to item Cite

Bartonella spp. in feral pigs, southeastern United States.

Journal article Emerg Infect Dis · May 2011 In conjunction with efforts to assess pathogen exposure in feral pigs from the southeastern United States, we amplified Bartonella henselae, B. koehlerae, and B. vinsonii subsp. berkhoffii from blood samples. Feral pigs may represent a zoonotic risk for hu ... Full text Link to item Cite

"Candidatus Neoehrlichia mikurensis" infection in a dog from Germany.

Journal article J Clin Microbiol · May 2011 "Candidatus Neoehrlichia mikurensis" is a new intracellular pathogen associated with human infection and death. "Candidatus Neoehrlichia mikurensis" infection in a chronically neutropenic dog from Germany was confirmed by DNA sequencing. The same organism ... Full text Link to item Cite

Evolution of clinical, haematological and biochemical findings in young dogs naturally infected by vector-borne pathogens.

Journal article Vet Microbiol · April 21, 2011 Longitudinal studies evaluating the evolution of clinical, haematological, biochemical findings in young dogs exposed for the first time to multiple vector-borne pathogens have not been reported. With the objective of assessing the evolution of clinical, h ... Full text Link to item Cite

Assessment of urine solute and matrix effects on the performance of an enzyme-linked immunosorbent assay for measurement of interleukin-6 in dog urine.

Journal article J Vet Diagn Invest · March 2011 Measurement of cytokine concentrations within body fluids is a means of recognizing subclinical and/or unresolved, infectious and inflammatory states in patients. In the urinary tract, such information may be useful for identifying patients with pyelonephr ... Full text Link to item Cite

Autocrine effects of interleukin-6 mediate acute-phase proinflammatory and tissue-reparative transcriptional responses of canine bladder mucosa.

Journal article Infect Immun · February 2011 During early urinary tract infection (UTI) the interplay between invading bacteria and the urothelium elicits a mucosal response aimed at clearing infection. Unfortunately, the resultant inflammation and associated local tissue injury are responsible for p ... Full text Link to item Cite

Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: antimicrobial guidelines working group of the international society for companion animal infectious diseases.

Journal article Vet Med Int · 2011 Urinary tract disease is a common reason for use (and likely misuse, improper use, and overuse) of antimicrobials in dogs and cats. There is a lack of comprehensive treatment guidelines such as those that are available for human medicine. Accordingly, guid ... Full text Link to item Cite

Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma sp. in dogs with splenic disease.

Journal article J Vet Intern Med · 2011 BACKGROUND: Among diseases that cause splenomegaly in dogs, lymphoid nodular hyperplasia (LNH), splenic hemangiosarcoma (HSA), and fibrohistiocytic nodules (FHN) are common diagnoses. The spleen plays an important role in the immunologic control or elimina ... Full text Link to item Cite

Molecular and serological diagnosis of Bartonella infection in 61 dogs from the United States.

Journal article J Vet Intern Med · 2011 BACKGROUND: Molecular diagnosis of canine bartonellosis can be extremely challenging and often requires the use of an enrichment culture approach followed by PCR amplification of bacterial DNA. HYPOTHESES: (1) The use of enrichment culture with PCR will in ... Full text Link to item Cite

Magnetic resonance imaging lesions in the central nervous system of a dog with caninemonocytic ehrlichiosis

Journal article Case Reports in Veterinary Medicine · January 1, 2011 A ten-year-old neutered male dog was examined for tetraparesis, vestibular dysfunction, ataxia, and vertebral column hyperesthesia of 10 days duration. On magnetic resonance imaging (MRI), there were multifocal, punctate, T2-hyperintense lesions in the bra ... Full text Cite

Fatal aortic endocarditis associated with community-acquired Serratia marcescens infection in a dog.

Journal article J Am Anim Hosp Assoc · 2011 A 12 yr old Dalmatian was referred for evaluation of acute lethargy, fever, neurologic signs, and a recently ausculted heart murmur. Echocardiography in combination with blood cultures resulted in a diagnosis of nonhospital-acquired Serratia marcescens bac ... Full text Link to item Cite

Bartonella spp. DNA in cardiac tissues from dogs in Colorado and Wyoming.

Journal article J Vet Intern Med · 2011 BACKGROUND: Several Bartonella species (spp.) have been identified in dogs diagnosed with infectious endocarditis (IE) or myocarditis. OBJECTIVE: To interrogate cardiac tissues of dogs with suspected IE for the presence of Bartonella spp. DNA of dogs in th ... Full text Link to item Cite

Typical and atypical manifestations of Anaplasma phagocytophilum infection in dogs.

Journal article J Am Anim Hosp Assoc · 2011 Eighteen clinically ill dogs, naturally infected with Anaplasma phagocytophilum, were examined at a veterinary practice in Baxter, Minnesota. A clinical examination, complete blood cell count, enzyme- linked immunosorbent assay (ELISA) for A phagocytophilu ... Full text Link to item Cite

Leishmaniasis in a dog native to Colorado.

Journal article J Am Vet Med Assoc · December 1, 2010 CASE DESCRIPTION: A 1-year-old 32.5-kg (71.5-lb) sexually intact male foxhound-Treeing Walker Coonhound cross was evaluated because of a 2.5-month history of dermatologic lesions, weight loss, and diarrhea. CLINICAL FINDINGS: Physical examination revealed ... Full text Link to item Cite

Performance of a commercially available in-clinic ELISA for the detection of antibodies against Anaplasma phagocytophilum, Ehrlichia canis, and Borrelia burgdorferi and Dirofilaria immitis antigen in dogs.

Journal article Am J Vet Res · December 2010 OBJECTIVE: To evaluate the sensitivity and specificity of a commercially available in-clinic ELISA for detection of heartworm infection and tick-borne diseases in dogs. SAMPLE POPULATION: 846 serum, plasma, or blood samples obtained from dogs. PROCEDURES: ... Full text Link to item Cite

Human coinfection with Bartonella henselae and two hemotropic mycoplasma variants resembling Mycoplasma ovis.

Journal article J Clin Microbiol · October 2010 Two variants of an organism resembling the ovine hemoplasma, Mycoplasma ovis, were detected by PCR in blood samples from a veterinarian in Texas. Coinfection with similar variants has been described in sheep. This represents the first report of human infec ... Full text Link to item Cite

Evaluation of peptide- and recombinant protein-based assays for detection of anti-Ehrlichia ewingii antibodies in experimentally and naturally infected dogs. [corrected].

Journal article Am J Vet Res · October 2010 OBJECTIVE: To evaluate microtiter-plate format ELISAs constructed by use of different diagnostic targets derived from the Ehrlichia ewingii p28 outer membrane protein for detection of E ewingii antibodies in experimentally and naturally infected dogs. SAMP ... Full text Link to item Cite

Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field study.

Journal article Vet Parasitol · September 20, 2010 Canine vector-borne diseases (CVBDs) are highly prevalent and increasing in distribution worldwide. A longitudinal study was conducted in southern Italy to determine the incidence of and protection against CVBD-causing pathogens in dogs treated with a comb ... Full text Link to item Cite

Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study.

Journal article J Clin Microbiol · September 2010 Canine vector-borne diseases (CVBDs) pose a diagnostic challenge, particularly when a dog is coinfected with more than one pathogen. The purpose of this study was to generate information about the diagnosis of CVBDs in young dogs following their first expo ... Full text Link to item Cite

PCR amplification of Bartonella koehlerae from human blood and enrichment blood cultures.

Journal article Parasit Vectors · August 24, 2010 BACKGROUND: Cats appear to be the primary reservoir host for Bartonella koehlerae, an alpha Proteobacteria that is most likely transmitted among cat populations by fleas (Ctenocephalides felis). Bartonella koehlerae has caused endocarditis in a dog and in ... Full text Link to item Cite

Bacillary angiomatosis in an immunosuppressed dog.

Journal article Vet Dermatol · August 2010 A dog being treated with immunosuppressive doses of prednisone and azathioprine for pancytopenia of unknown origin, developed, over a 2-week period, multiple erythematous nodular lesions in the skin including footpads. Skin samples revealed lesions identic ... Full text Link to item Cite

Prevalence of selected vector-borne organisms and identification of Bartonella species DNA in North American river otters (Lontra canadensis).

Journal article J Wildl Dis · July 2010 Trapper-killed North American river otters (Lontra canadensis) in North Carolina, USA, were screened for multiple vector-borne bacteria known to be pathogenic to mammals. Blood was collected from 30 carcasses in 2006, from 35 in 2007, and from one live ott ... Full text Link to item Cite

Feline immunodeficiency virus, feline leukemia virus and Bartonella species in stray cats on St Kitts, West Indies.

Journal article J Feline Med Surg · June 2010 Stray cats trapped in various areas of Basseterre, the capital of St Kitts in the West Indies, were tested for infection with feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) using commercial kits. Of 99 (51 male and 48 female) cats tra ... Full text Link to item Cite

Molecular evidence of perinatal transmission of Bartonella vinsonii subsp. berkhoffii and Bartonella henselae to a child.

Journal article J Clin Microbiol · June 2010 Bartonella vinsonii subsp. berkhoffii, Bartonella henselae, or DNA of both organisms was amplified and sequenced from blood, enrichment blood cultures, or autopsy tissues from four family members. Historical and microbiological results support perinatal tr ... Full text Link to item Cite

Successful treatment of Bartonella henselae endocarditis in a cat.

Journal article J Feline Med Surg · June 2010 This report describes the clinical presentation, diagnosis and treatment of a cat with vegetative valvular endocarditis temporally associated with natural infection with Bartonella henselae. Lethargy, abnormal gait and weakness were the main clinical signs ... Full text Link to item Cite

Experimental infection and co-infection of dogs with Anaplasma platys and Ehrlichia canis: hematologic, serologic and molecular findings.

Journal article Parasit Vectors · April 8, 2010 BACKGROUND: Rhipicephalus sanguineus is a ubiquitous tick responsible for transmitting Ehrlichia canis and most likely Anaplasma platys to dogs, as either single or co-infections. The objective of this study was to assess the effects of either simultaneous ... Full text Link to item Cite

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease.

Journal article Parasit Vectors · April 8, 2010 BACKGROUND: Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. ... Full text Open Access Link to item Cite

Bartonellosis: Clinical and diagnostic challenges

Journal article Veterinary Medicine · April 1, 2010 Cite

The increasing recognition of rickettsial pathogens in dogs and people.

Journal article Trends Parasitol · April 2010 Dogs and people are exposed to and susceptible to infection by many of the same tick-borne bacterial pathogens in the order Rickettsiales, including Anaplasma phagocytophilum, Ehrlichia canis, E. chaffeensis, E. ewingii, Rickettsia rickettsii, R. conorii, ... Full text Link to item Cite

Flea-associated zoonotic diseases of cats in the USA: bartonellosis, flea-borne rickettsioses, and plague.

Journal article Trends Parasitol · April 2010 Cat-scratch disease, flea-borne typhus, and plague are three flea-associated zoonoses of cats of concern in the USA. Although flea concentrations may be heaviest in coastal and temperate climates, fleas and flea-borne disease agents can occur almost anywhe ... Full text Link to item Cite

Bartonellosis: An emerging and potentially hidden epidemic?

Journal article Veterinary Medicine · March 1, 2010 Cite

Prevalence of Bartonella henselae and Borrelia burgdorferi sensu lato DNA in ixodes ricinus ticks in Europe.

Journal article Appl Environ Microbiol · March 2010 Bartonella spp. can cause persistent bloodstream infections in humans and animals. To determine whether Bartonella henselae is present in questing Ixodes ricinus ticks, we analyzed the prevalence of B. henselae DNA among tick stages compared to the prevale ... Full text Link to item Cite

High prevalence of tick-borne pathogens in dogs from an Indian reservation in northeastern Arizona.

Journal article Vector Borne Zoonotic Dis · March 2010 We evaluated the serological and molecular prevalence of selected organisms in 145 dogs during late spring (May/June) of 2005 and in 88 dogs during winter (February) of 2007 from the Hopi Indian reservation. Additionally, in 2005, 442 ticks attached to dog ... Full text Link to item Cite

Potential for tick-borne bartonelloses.

Journal article Emerg Infect Dis · March 2010 As worldwide vectors of human infectious diseases, ticks are considered to be second only to mosquitoes. Each tick species has preferred environmental conditions and biotopes that determine its geographic distribution, the pathogens it vectors, and the are ... Full text Link to item Cite

Bartonellosis: an emerging infectious disease of zoonotic importance to animals and human beings.

Journal article J Vet Emerg Crit Care (San Antonio) · February 2010 OBJECTIVE: To provide a review of clinically relevant observations related to Bartonella species as emerging pathogens in veterinary and human medicine. DATA SOURCES: Literature as cited in PubMed and as generated by each of the authors who have contribute ... Full text Link to item Cite

Comparative activity of pradofloxacin, enrofloxacin, and azithromycin against Bartonella henselae isolates collected from cats and a human.

Journal article J Clin Microbiol · February 2010 Using Bartonella henselae isolates from cats and a human, the activity of pradofloxacin was compared with those of enrofloxacin and azithromycin. By Etest and disc diffusion assay, pradofloxacin showed greater antimicrobial activity than did other antibiot ... Full text Link to item Cite

Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases).

Journal article J Vet Intern Med · 2010 BACKGROUND: Vector-transmitted microorganisms in the genera Ehrlichia, Anaplasma, Rickettsia, Bartonella, and Borrelia are commonly suspected in dogs with meningoencephalomyelitis (MEM), but the prevalence of these pathogens in brain tissue and cerebrospin ... Full text Link to item Cite

Infection and replication of Bartonella species within a tick cell line.

Journal article Exp Appl Acarol · November 2009 Bartonella species are fastidious, gram negative bacteria, some of which are transmitted by arthropod vectors, including fleas, sandflies, and lice. There is very little information regarding the interaction and/or transmission capabilities of Bartonella s ... Full text Link to item Cite

Co-isolation of Bartonella henselae and Bartonella vinsonii subsp. berkhoffii from blood, joint and subcutaneous seroma fluids from two naturally infected dogs.

Journal article Vet Microbiol · September 18, 2009 This report describes the clinical presentation, isolation and treatment of two dogs naturally infected with Bartonella henselae and Bartonella vinsonii subsp. berkhoffii. Chronic and progressive polyarthritis was the primary complaint for dog #1, from whi ... Full text Link to item Cite

Cross-contamination in the molecular detection of Bartonella from paraffin-embedded tissues.

Journal article Vet Pathol · September 2009 The genus Bartonella comprises a group of gram-negative, fastidious bacteria. Because of diagnostic limitations of culture and serologic testing, polymerase chain reaction (PCR) has become a powerful tool for the detection of Bartonella spp. in blood and t ... Full text Link to item Cite

Prevention of transmission of ehrlichia spp

Journal article Compendium Continuing Education for Veterinarians · August 1, 2009 Cite

Isolation of Bartonella vinsonii subsp. berkhoffii genotype II from a boy with epithelioid hemangioendothelioma and a dog with hemangiopericytoma.

Journal article J Clin Microbiol · June 2009 In this report, we describe isolation of Bartonella vinsonii subsp. berkhoffii genotype II from a boy with epithelioid hemangioendothelioma and a dog with hemangiopericytoma. These results suggest that B. vinsonii subsp. berkhoffii may cause vasoproliferat ... Full text Link to item Cite

Bartonella endocarditis: a pathology shared by animal reservoirs and patients.

Journal article Ann N Y Acad Sci · May 2009 Bartonellae were first recognized to cause endocarditis in humans in 1993 when cases caused by Bartonella quintana, B. elizabethae, and B. henselae were reported. Since the first isolation of Bartonella vinsonii subspecies berkhoffii from a dog with endoca ... Full text Link to item Cite

Molecular documentation of Bartonella infection in dogs in Greece and Italy.

Journal article J Clin Microbiol · May 2009 This study reports the occurrence of "Bartonella rochalimae" in Europe and the presence of Bartonella vinsonii subsp. berkhoffii genotypes II and III in dogs in southern Italy and provides DNA sequencing evidence of a potentially new Bartonella sp. infecti ... Full text Link to item Cite

Molecular epidemiology of feline and human Bartonella henselae isolates.

Journal article Emerg Infect Dis · May 2009 Multiple locus variable number tandem repeat analysis was performed on 178 Bartonella henselae isolates from 9 countries; 99 profiles were distributed into 2 groups. Human isolates/strains were placed into the second group. Genotype I and II isolates share ... Full text Link to item Cite

Managing canine vector-borne diseases of zoonotic concern: part two.

Journal article Trends Parasitol · May 2009 Despite recent achievements in scientific knowledge related to canine vector-borne diseases (CVBDs) of zoonotic concern, their management is still impaired by several neglected issues related to accurate diagnosis and effective treatment of both single and ... Full text Link to item Cite

Managing canine vector-borne diseases of zoonotic concern: part one.

Journal article Trends Parasitol · April 2009 Canine vector-borne diseases (CVBDs) comprise a group of globally distributed and rapidly spreading illnesses that are caused by a range of pathogens transmitted by arthropods including ticks, fleas, mosquitoes and phlebotomine sandflies. In addition to th ... Full text Link to item Cite

PCR detection of Bartonella bovis and Bartonella henselae in the blood of beef cattle.

Journal article Vet Microbiol · March 30, 2009 Although an organism primarily associated with non-clinical bacteremia in domestic cattle and wild ruminants, Bartonella bovis was recently defined as a cause of bovine endocarditis. The purpose of this study was to develop a B. bovis species-specific PCR ... Full text Link to item Cite

A confusing case of canine vector-borne disease: clinical signs and progression in a dog co-infected with Ehrlichia canis and Bartonella vinsonii ssp. berkhoffii.

Journal article Parasit Vectors · March 26, 2009 Bartonella spp. are important pathogens in human and veterinary medicine, and bartonellosis is considered as an emerging zoonosis that is being reported with increasing frequency. Of 22 known species and subspecies of Bartonella, seven have been isolated f ... Full text Link to item Cite

Use of broad range16S rDNA PCR in clinical microbiology.

Journal article J Microbiol Methods · March 2009 Broad range 16S rDNA PCR can be used to facilitate the diagnosis of infectious diseases of bacterial origin by detecting 16S rDNA sequences in patient samples. Post amplification sequencing facilitates identification of the infecting organism, but may not ... Full text Link to item Cite

Prevalence of Bartonella species antibodies and Bartonella species DNA in the blood of cats with and without fever.

Journal article J Feline Med Surg · February 2009 The purpose of this study was to determine whether there are associations between Bartonella species antibody (enzyme-linked immunosorbent assay (ELISA) and Western blot (WB)) and polymerase chain reaction assay results in cats with and without fever. Afeb ... Full text Link to item Cite

Clinical relevance of annual screening using a commercial enzyme-linked immunosorbent assay (SNAP 3Dx) for canine ehrlichiosis.

Journal article J Am Anim Hosp Assoc · 2009 Eighty-six dogs were selected based upon Ehrlichia (E.) canis SNAP 3Dx positive results to determine clinical relevance of annual E. canis screening. Immunofluorescence assay showed 72 (84%) of 86 dogs were seroreactive for E. canis. Polymerase chain react ... Full text Link to item Cite

Lack of evidence for perinatal transmission of canine granulocytic anaplasmosis from a bitch to her offspring.

Journal article J Am Anim Hosp Assoc · 2009 Granulocytic anaplasmosis is an emerging infectious disease affecting dogs and humans in the United States and other regions of the world. Relatively few cases have been described in pregnant women, and perinatal transmission appears to occur infrequently ... Full text Link to item Cite

Ecological fitness and strategies of adaptation of Bartonella species to their hosts and vectors.

Journal article Vet Res · 2009 Bartonella spp. are facultative intracellular bacteria that cause characteristic hostrestricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. In the mammalian reservoir, these bacteria initially infect a yet un ... Full text Link to item Cite

Isolation of Candidatus Bartonella melophagi from human blood.

Journal article Emerg Infect Dis · January 2009 Candidatus Bartonella melophagi was isolated by blood culture from 2 women, 1 of whom was co-infected with B. henselae. Partial 16S rRNA, RNA polymerase B, and citrate synthase genes and 16S-23S internal transcribed spacer sequences indicated that human is ... Full text Link to item Cite

Bartonella henselae in captive and hunter-harvested beluga (Delphinapterus leucas).

Journal article J Wildl Dis · October 2008 Previously, we reported the isolation of Bartonella henselae from the blood of harbor porpoises (Phocoena phocoena) and loggerhead sea turtles (Caretta caretta) from the North Carolina coast. Hematologic, pathologic, and microbiologic findings surrounding ... Full text Link to item Cite

Coxiella-like infection in psittacines and a toucan.

Journal article Avian Dis · September 2008 Seven psittacine birds and a toucan (Ramphastos toco) were diagnosed as infected with Coxiella-like bacteria, based on polymerase chain reaction and bacterial 16S rRNA gene sequence obtained from each bird's liver tissue. Most of the birds exhibited lethar ... Full text Link to item Cite

Bartonella sp. bacteremia in patients with neurological and neurocognitive dysfunction.

Journal article J Clin Microbiol · September 2008 We detected infection with a Bartonella species (B. henselae or B. vinsonii subsp. berkhoffii) in blood samples from six immunocompetent patients who presented with a chronic neurological or neurocognitive syndrome including seizures, ataxia, memory loss, ... Full text Link to item Cite

Failure to identify an association between serologic or molecular evidence of Bartonella infection and idiopathic rhinitis in dogs.

Journal article J Am Vet Med Assoc · August 15, 2008 OBJECTIVE: To determine whether infection with or exposure to Bartonella spp was associated with idiopathic rhinitis in dogs. DESIGN: Case-control study. ANIMALS: 44 dogs with idiopathic nasal discharge and 63 age- and weight-matched control dogs without n ... Full text Link to item Cite

Serological and molecular prevalence of Borrelia burgdorferi, Anaplasma phagocytophilum, and Ehrlichia species in dogs from Minnesota.

Journal article Vector Borne Zoonotic Dis · August 2008 A population of 731 naturally exposed pet dogs examined at a private practice in Baxter, Minnesota, an area endemic for Lyme disease and anaplasmosis, was tested by serological and molecular methods for evidence of exposure to or infection with selected ve ... Full text Link to item Cite

Evaluation of conventional and real-time PCR assays for detection and differentiation of Spotted Fever Group Rickettsia in dog blood.

Journal article Vet Microbiol · June 22, 2008 Spotted Fever Group Rickettsia is important cause of emerging and re-emerging infectious disease in people and dogs. Importantly, dogs can serve as sentinels for disease in people. Sensitive and specific diagnostic tests that differentiate among species of ... Full text Link to item Cite

Feline bartonellosis and cat scratch disease.

Journal article Vet Immunol Immunopathol · May 15, 2008 Bartonella species are important emerging zoonotic pathogens. Transmission of these organisms in nature may be much more complex than is currently appreciated. Cats can be infected with five Bartonella species, including, Bartonella henselae, Bartonella cl ... Full text Link to item Cite

Molecular characterization of Bartonella vinsonii subsp. berkhoffii genotype III.

Journal article J Clin Microbiol · May 2008 The molecular characterization of a Bartonella vinsonii subsp. berkhoffii genotype III strain (NCSU strain 06-CO1) isolated from the blood of a military working dog diagnosed with endocarditis is reported in this study. Several genes were amplified and seq ... Full text Link to item Cite

Vector transmission of Bartonella species with emphasis on the potential for tick transmission.

Journal article Med Vet Entomol · March 2008 Bartonella species are gram-negative bacteria that infect erythrocytes, endothelial cells and macrophages, often leading to persistent blood-borne infections. Because of the ability of various Bartonella species to reside within erythrocytes of a diverse n ... Full text Link to item Cite

Prevalence of Ehrlichia canis, Anaplasma platys, Babesia canis vogeli, Hepatozoon canis, Bartonella vinsonii berkhoffii, and Rickettsia spp. in dogs from Grenada.

Journal article Vet Parasitol · February 14, 2008 To identify the tick-borne pathogens in dogs from Grenada, we conducted a serologic survey for Ehrlichia canis in 2004 (104 dogs) and a comprehensive serologic and molecular survey for a variety of tick-borne pathogens in 2006 (73 dogs). In 2004 and 2006, ... Full text Link to item Cite

Bartonella DNA in the blood and lymph nodes of Golden Retrievers with lymphoma and in healthy controls.

Journal article J Vet Intern Med · 2008 BACKGROUND: Although lymphoma is the most common neoplastic process reported in dogs, its precise etiology is unknown. Golden Retrievers are more likely to develop lymphoma, suggesting a breed predisposition; however, other factors, including environment, ... Full text Link to item Cite

Serum cardiac troponin I concentration in dogs with ehrlichiosis.

Journal article J Vet Intern Med · 2008 BACKGROUND: Ehrlichiosis is a multisystemic disease with the potential to cause cardiomyocyte injury in naturally infected dogs. HYPOTHESIS: Myocardial injury occurs in dogs infected with Ehrlichia canis. ANIMALS: One-hundred and ninety-four dogs from Braz ... Full text Link to item Cite

Factors associated with the occurrence of epistaxis in natural canine leishmaniasis (Leishmania infantum).

Journal article J Vet Intern Med · 2008 BACKGROUND: Canine leishmaniasis (CanL) is a common cause of epistaxis in dogs residing in endemic areas. The pathogenesis of CanL-associated epistaxis has not been fully explored because of the limited number of cases reported so far. HYPOTHESIS: Epistaxi ... Full text Link to item Cite

Detection of Bartonella henselae in the blood of 2 adult horses.

Journal article J Vet Intern Med · 2008 BACKGROUND: Bartonella spp. are emerging zoonotic agents that have been found in a wide variety of domestic animals and wildlife and cause a number of clinical syndromes. Bartonella sp. infection has been identified in a growing number of animal species, i ... Full text Link to item Cite

Bartonella species detection in captive, stranded and free-ranging cetaceans.

Journal article Vet Res · 2008 We present prevalence of Bartonella spp. for multiple cohorts of wild and captive cetaceans. One hundred and six cetaceans including 86 bottlenose dolphins (71 free-ranging, 14 captive in a facility with a dolphin experiencing debility of unknown origin, 1 ... Full text Link to item Cite

Detection of two Bartonella tamiae-like sequences in Amblyomma americanum (Acari: Ixodidae) using 16S-23S intergenic spacer region-specific primers.

Journal article J Med Entomol · January 2008 Four hundred and sixty-six questing Amblyomma americanum (L.) (Acari: Ixodidae) from Carolina County, VA, and 98 questing A. americanum from Chatham County, NC, were screened by polymerase chain reaction (PCR) for the Bartonella 16S-23S intergenic spacer r ... Full text Link to item Cite

Bartonella DNA in dog saliva.

Journal article Emerg Infect Dis · December 2007 Bartonella species, transmitted by arthropods or animal bites and scratches, are emerging pathogens in human and veterinary medicine. PCR and DNA sequencing were used to test oral swabs collected from dogs. Results indicated the presence of 4 Bartonella sp ... Full text Link to item Cite

Bartonella vinsonii subsp. berkhoffii endocarditis in a dog from Saskatchewan.

Journal article Can Vet J · August 2007 A dog referred for lameness was diagnosed with culture-negative endocarditis. Antibodies to Bartonella spp. were detected. Antibiotic treatment resulted in transient clinical improvement, but the dog developed cardiac failure and was euthanized. Bartonella ... Link to item Cite

Bartonella species in blood of immunocompetent persons with animal and arthropod contact.

Journal article Emerg Infect Dis · June 2007 Using PCR in conjunction with pre-enrichment culture, we detected Bartonella henselae and B. vinsonii subspecies berkhoffii in the blood of 14 immunocompetent persons who had frequent animal contact and arthropod exposure. ... Full text Link to item Cite

Bartonella DNA in loggerhead sea turtles.

Journal article Emerg Infect Dis · June 2007 Full text Link to item Cite

A combined approach for the enhanced detection and isolation of Bartonella species in dog blood samples: pre-enrichment liquid culture followed by PCR and subculture onto agar plates.

Journal article J Microbiol Methods · May 2007 Historically, direct plating, lysis centrifugation, or freeze-thaw approaches have proven to be highly insensitive methods for confirming Bartonella species infection in dogs. A prospective study was designed to compare diagnostic methods for the detection ... Full text Link to item Cite

Use of an insect cell culture growth medium to isolate bacteria from horses with effusive, fibrinous pericarditis: a preliminary study.

Journal article Vet Microbiol · March 31, 2007 Effusive, fibrinous pericarditis is an uncommon disease entity in horses. In 2001, pericarditis occurred in conjunction with an epizootic in central Kentucky that was associated with exposure to eastern tent caterpillars (ETCs). Bacterial isolation from eq ... Full text Link to item Cite

Detection of Bartonella henselae DNA in two dogs with pyogranulomatous lymphadenitis.

Journal article J Am Vet Med Assoc · March 1, 2007 CASE DESCRIPTION: 1 dog evaluated because of inappetence and lameness of the left hind limb of 1 day's duration and 1 dog evaluated because of inappetence, fever, and lymphadenopathy of 2 weeks' duration. CLINICAL FINDINGS: Histologic examination of excisi ... Full text Link to item Cite

Severe anemia, panserositis, and cryptogenic hepatitis in an HIV patient infected with Bartonella henselae.

Journal article Ultrastruct Pathol · 2007 Bartonella spp. constitute emerging pathogens of worldwide distribution. Bacillary angiomatosis is the most frequent skin manifestation of bartonelloses; nevertheless, B. henselae infection should always be considered systemic, especially in immunodeficien ... Full text Link to item Cite

Surveillance for zoonotic vector-borne infections using sick dogs from southeastern Brazil.

Journal article Vector Borne Zoonotic Dis · 2007 For many vector-borne organisms, dogs can be used as sentinels to estimate the risk of human infection. The objective of this study was to use dogs as sentinels for multiple vector-borne organisms in order to evaluate the potential for human infection with ... Full text Link to item Cite

Canine bartonellosis: serological and molecular prevalence in Brazil and evidence of co-infection with Bartonella henselae and Bartonella vinsonii subsp. berkhoffii.

Journal article Vet Res · 2007 The purpose of this study was to determine the serological and molecular prevalence of Bartonella spp. infection in a sick dog population from Brazil. At the São Paulo State University Veterinary Teaching Hospital in Botucatu, 198 consecutive dogs with cli ... Full text Link to item Cite

Doxycycline clearance of experimentally induced chronic Ehrlichia canis infection in dogs.

Journal article J Vet Intern Med · 2007 BACKGROUND: Ineffective clearance of Ehrlichia canis after doxycycline administration has been reported despite the fact that the recommended treatment for canine ehrlichiosis is doxycycline. The effectiveness of doxycycline in clearing E canis infection f ... Full text Link to item Cite

Detection of Rickettsia amblyommii in association with a tick bite rash.

Journal article Vector Borne Zoonotic Dis · 2007 In the summer of 2006, an Amblyomma americanum tick was removed from a woman in central North Carolina, who subsequently developed a rash at the site of tick attachment. When examined by polymerase chain reaction (PCR) for Borrelia, Anaplasma, Ehrlichia, B ... Full text Link to item Cite

Isolation of Bartonella quintana from a woman and a cat following putative bite transmission.

Journal article J Clin Microbiol · January 2007 We report here the detection of Bartonella quintana, after putative bite transmission, in pre-enrichment blood cultures from a woman and from two feral barn cats. Prospective molecular epidemiological studies are necessary to characterize the risk of human ... Full text Link to item Cite

Serological and molecular evidence of exposure to arthropod-borne organisms in cats from northeastern Spain.

Journal article Vet Microbiol · December 20, 2006 One hundred sixty-eight cat sera from Spain were tested for IgG antibodies to Rickettsia conorii (Rc), Ehrlichia canis (Ec), Anaplasma phagocytophilum (Ap) and Bartonella henselae (Bh) antigens using IFA and for FeLV antigen and FIV antibody by ELISA. For ... Full text Link to item Cite

Febrile illness associated with Rickettsia conorii infection in dogs from Sicily.

Journal article Emerg Infect Dis · December 2006 We report serologic and molecular evidence of acute, febrile illness associated with Rickettsia conorii in 3 male Yorkshire terriers from Sicily (Italy). ... Full text Link to item Cite

Bartonella quintana endocarditis in dogs.

Journal article Emerg Infect Dis · December 2006 We provide the first evidence that Bartonella quintana can infect dogs and cause typical signs of endocarditis. Using PCR and sequencing, we identified B. quintana in the blood of a dog from the United States with aortic valve endocarditis and probably als ... Full text Link to item Cite

The low seroprevalence of tick-transmitted agents of disease in dogs from southern Ontario and Quebec.

Journal article Can Vet J · December 2006 Infectious diseases caused by pathogens transmitted by ticks and other insect vectors are an important cause of morbidity and mortality in both dogs and humans throughout North America. The purpose of this study was to determine the seroprevalence of selec ... Link to item Cite

Molecular characterization of Rickettsia rickettsii infecting dogs and people in North Carolina.

Journal article Ann N Y Acad Sci · October 2006 Rocky Mountain spotted fever (RMST) is an important cause of morbidity and mortality in people and dogs in the United States. Disease manifestations are strikingly similar in both species, and illness in dogs can precede illness in people. R. rickettsii ha ... Full text Link to item Cite

Development and evaluation of a PCR assay for the detection of Cytauxzoon felis DNA in feline blood samples.

Journal article Vet Parasitol · April 15, 2006 Cytauxzoonosis is an emerging tick borne infectious disease of domestic cats in the United States, caused by the organism Cytauxzoon felis (C. felis). In naturally infected domestic cats the disease is almost always fatal. Currently there are no commercial ... Full text Link to item Cite

A Bartonella vinsonii berkhoffii typing scheme based upon 16S-23S ITS and Pap31 sequences from dog, coyote, gray fox, and human isolates.

Journal article Mol Cell Probes · April 2006 Since the isolation of Bartonella vinsonii subspecies berkhoffii from a dog with endocarditis in 1993, this organism has emerged as an important pathogen in dogs and as an emerging pathogen in people. Current evidence indicates that coyotes, dogs and gray ... Full text Link to item Cite

Molecular characterization of a Babesia species identified in a North American raccoon.

Journal article J Wildl Dis · April 2006 Piroplasmosis was first described in raccoons (Procyon lotor) in 1926, and the official description of a small piroplasm as Babesia lotori was done in 1981. Babesia microti-like gene sequences have been characterized in raccoons in both North American and ... Full text Link to item Cite

Bartonella spp. in pets and effect on human health.

Journal article Emerg Infect Dis · March 2006 Among the many mammals infected with Bartonella spp., pets represent a large reservoir for human infection because most Bartonella spp. infecting them are zoonotic. Cats are the main reservoir for Bartonella henselae, B. clarridgeiae, and B. koehlerae. Dog ... Full text Link to item Cite

Vector-borne diseases: What you don't know can kill you, your clients, or your patients

Journal article Compendium on Continuing Education for the Practicing Veterinarian · March 1, 2006 Cite

Cytauxzoon felis infection in cats in the mid-Atlantic states: 34 cases (1998-2004).

Journal article J Am Vet Med Assoc · February 15, 2006 OBJECTIVE: To describe the demographic and clinical characteristics of feline cytauxzoonosis in the mid-Atlantic states and compare the Cytauxzoon felis 18S rRNA gene sequences from affected cats with sequences reported from affected cats in other regions. ... Full text Link to item Cite

Comparison of an indirect immunofluorescence assay, western blot analysis, and a commercially available ELISA for detection of Ehrlichia canis antibodies in canine sera.

Journal article Am J Vet Res · February 2006 OBJECTIVE: To examine the correlation between results for an indirect immunofluorescence assay (IFA) that uses Ehrlichia canis antigen as a substrate (ie, E canis-IFA), 2 western blot (WB) analyses, and a commercially available ELISA in the detection of E ... Full text Link to item Cite

Experimental Ehrlichia canis infection in the dog does not cause immunosuppression.

Journal article Vet Immunol Immunopathol · January 15, 2006 A carrier state develops in some Ehrlichia canis-infected dogs due to ineffective host defenses. The subsequent development of immune-mediated diseases or opportunistic infections in chronic ehrlichiosis suggests dysregulation of immunity; however, the imm ... Full text Link to item Cite

Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs.

Journal article J Vet Intern Med · 2006 The recommended treatment for canine ehrlichiosis is tetracycline or its analog doxycycline, although recent reports have documented ineffective clearing of Erchlichia canis after doxycycline administration. Imidocarb dipropionate is used as an alternative ... Full text Link to item Cite

A serological study of exposure to arthropod-borne pathogens in dogs from northeastern Spain.

Journal article Vet Res · 2006 There is limited information regarding the prevalence of many vector borne pathogens in Europe and especially in Spanish dogs. We investigated 206 sick and 260 clinically healthy dogs from three different regions in northeastern Spain for antibodies to Ric ... Full text Link to item Cite

Bartonella quintana in cynomolgus monkey (Macaca fascicularis).

Journal article Emerg Infect Dis · December 2005 We identified a Bartonella quintana strain by polymerase chain reaction amplification, cloning, and sequencing of DNA extracted from lysed erythrocytes and cultured colonies grown from peripheral blood collected from a captive-bred cynomolgus monkey (Macac ... Full text Link to item Cite

Bartonella henselae in porpoise blood.

Journal article Emerg Infect Dis · December 2005 We report detection of Bartonella henselae DNA in blood samples from 2 harbor porpoises (Phocoena phocoena). By using real-time polymerase chain reaction, we directly amplified Bartonella species DNA from blood of a harbor porpoise stranded along the north ... Full text Link to item Cite

Clinicopathologic findings in dogs seroreactive to Bartonella henselae antigens.

Journal article Am J Vet Res · December 2005 OBJECTIVE: To assess the potential clinical relevance of seroreactivity to Bartonella henselae antigens in dogs. ANIMALS: 40 dogs seroreactive to B henselae and 45 dogs that did not seroreact to B henselae. PROCEDURE: A case-control study was conducted. Cl ... Full text Link to item Cite

Detection of medically important Ehrlichia by quantitative multicolor TaqMan real-time polymerase chain reaction of the dsb gene.

Journal article J Mol Diagn · October 2005 Ehrlichia species are the etiological agents of emerging and life-threatening tick-borne human zoonoses, in addition to causing serious and fatal infections in companion animals and livestock. We developed the first tricolor TaqMan real-time polymerase cha ... Full text Link to item Cite

Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000-2003).

Journal article J Am Vet Med Assoc · September 15, 2005 OBJECTIVE: To identify the geographic distribution of babesiosis among dogs in the United States and determine, for dogs other than American Pit Bull Terriers (APBTs), whether infection was associated with a recent dog bite. DESIGN: Retrospective study. AN ... Full text Link to item Cite

Anaplasma phagocytophilum infection (granulocytic anaplasmosis) in a dog from Vancouver Island.

Journal article Can Vet J · September 2005 A 7-year-old Labrador retriever had nonspecific clinical signs that included lethargy, malaise, and difficult ambulation. The dog was native to Vancouver Island, British Columbia, and had never left this area. Morulae were identified in polymorphonuclear c ... Link to item Cite

Phylogenetic analysis of the spirochetes Borrelia parkeri and Borrelia turicatae and the potential for tick-borne relapsing fever in Florida.

Journal article J Clin Microbiol · August 2005 Isolates of Borrelia turicatae, Borrelia parkeri, and the Florida canine borrelia (FCB) were examined to further phylogenetically characterize the identities of these spirochetes in the United States. DNA sequences of four chromosomal loci (the 16S rRNA ge ... Full text Link to item Cite

Isolation of necrotoxigenic Escherichia coli from a dog with hemorrhagic pneumonia.

Journal article J Am Vet Med Assoc · June 15, 2005 A 7-month-old sexually intact male Cocker Spaniel was admitted to the North Carolina State University Veterinary Teaching Hospital for evaluation of lethargy, panting, and excessive salivation that had become progressively severe during a 5-hour period. De ... Full text Link to item Cite

Novel chemically modified liquid medium that will support the growth of seven bartonella species.

Journal article J Clin Microbiol · June 2005 Bacteria of the genus Bartonella, a member of the Alphaproteobacteria, are fastidious, gram-negative, aerobic bacilli that comprise numerous species, subspecies, and subtypes. In human and veterinary medicine, species isolation remains a vital component of ... Full text Link to item Cite

Bartonella species as a potential cause of epistaxis in dogs.

Journal article J Clin Microbiol · May 2005 Infection with a Bartonella species was implicated in three cases of epistaxis in dogs, based upon isolation, serology, or PCR amplification. These cases, in conjunction with previously published reports, support a potential role for Bartonella spp. as a c ... Full text Link to item Cite

Potential limitations of the 16S-23S rRNA intergenic region for molecular detection of Bartonella species.

Journal article J Clin Microbiol · March 2005 PCR targeting the 16S-23S rRNA gene intergenic transcribed spacer (ITS) region has been proposed as a rapid and reliable method for the detection of Bartonella species DNA in clinical samples. Because of variation in ITS sequences among Bartonella species, ... Full text Link to item Cite

Isolation of bacteriophages from Bartonella vinsonii subsp. berkhoffii and the characterization of Pap31 gene sequences from bacterial and phage DNA.

Journal article J Mol Microbiol Biotechnol · 2005 Bacteriophages enhance bacterial survival, facilitate bacterial adaptation to new environmental conditions, assist in the adaptation to a new host species, and enhance bacterial evasion or inactivation of host defense mechanisms. We describe the detection ... Full text Link to item Cite

The dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic States.

Journal article Vector Borne Zoonotic Dis · 2005 Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs after the bite of an Ixodid tick that is infected with Borrelia burgdorferi. Dogs have often been reported to serve as effective sentinel an ... Full text Link to item Cite

Seroprevalences of antibodies against Bartonella henselae and Toxoplasma gondii and fecal shedding of Cryptosporidium spp, Giardia spp, and Toxocara cati in feral and pet domestic cats.

Journal article J Am Vet Med Assoc · November 1, 2004 OBJECTIVE: To compare seroprevalences of antibodies against Bartonella henselae and Toxoplasma gondii and fecal shedding of Cryptosporidium spp, Giardia spp, and Toxocara cati in feral and pet domestic cats. DESIGN: Prospective cross-sectional serologic an ... Full text Link to item Cite

Detection and molecular characterization of a novel large Babesia species in a dog.

Journal article Vet Parasitol · October 5, 2004 Babesia canis has generally been considered the only large Babesia to infect dogs. Here we describe the molecular characterization of a large Babesia species that was detected in the blood and bone marrow of a dog with clinical and hematological abnormalit ... Full text Link to item Cite

Prevalence of infectious diseases in feral cats in Northern Florida.

Journal article J Feline Med Surg · October 2004 Objectives of this study were to determine prevalence of infection in feral cats in Northern Florida with a select group of infectious organisms and to determine risk factors for infection. Blood samples or sera from 553 cats were tested with a panel of an ... Full text Link to item Cite

Molecular and serologic evidence of Anaplasma phagocytophilum infection in cats in North America.

Journal article J Am Vet Med Assoc · September 15, 2004 Anaplasma phagocytophilum DNA was detected in blood of clinically ill cats from Massachusetts (n = 4) and Connecticut (1) by use of polymerase chain reaction assay and DNA sequencing. All 5 cats were allowed outdoors, and Ixodes scapularis were found on 3 ... Full text Link to item Cite

Comparison of results for serologic testing and a polymerase chain reaction assay to determine the prevalence of stray dogs in eastern Tennessee seropositive to Ehrlichia canis.

Journal article Am J Vet Res · September 2004 OBJECTIVE: To determine the prevalence of stray dogs in eastern Tennessee seropositive to Ehrlichia canis and examine the correlation between results for an ELISA, indirect immunofluorescent antibody (IFA) test, and polymerase chain reaction (PCR) assay. S ... Full text Link to item Cite

The dog as a sentinel for human infection: prevalence of Borrelia burgdorferi C6 antibodies in dogs from southeastern and mid-Atlantic states.

Journal article Vector Borne Zoonotic Dis · 2004 Lyme disease is the most frequently reported human vector-associated disease in the United States. Infection occurs after the bite of an Ixodid tick that is infected with Borrelia burgdorferi. Dogs have often been reported to serve as effective sentinel an ... Full text Link to item Cite

The Clinician Investigator program in companion animal internal medicine at north Carolina State University.

Journal article J Vet Med Educ · 2004 A retrospective study was conducted to describe the development and evolution of the combined internal medicine/PhD program, the Clinician Investigator (CI) Program, at North Carolina State University. Separate survey instruments were developed for individ ... Full text Link to item Cite

Orchitis in two dogs with Rocky Mountain spotted fever.

Journal article Vet Radiol Ultrasound · 2004 Two dogs with testicular swelling were sonographically diagnosed with orchitis and were subsequently diagnosed with Rocky Mountain spotted fever (RMSF). Use of both gray scale and color Doppler sonography allowed for differentiation of orchitis from neopla ... Full text Link to item Cite

Chronic canine ehrlichiosis (Ehrlichia canis): a retrospective study of 19 natural cases.

Journal article J Am Anim Hosp Assoc · 2004 Nineteen dogs from Greece with chronic ehrlichiosis were studied. The dogs exhibited bicytopenia or pancytopenia, bone marrow hypoplasia, seroreactivity to Ehrlichia canis (E. canis) antigens, and had no history of drug or radiation exposure. Anorexia, dep ... Full text Link to item Cite

Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs.

Journal article J Vet Intern Med · 2004 Babesiosis caused by Babesia gibsoni (Asian genotype) is an emerging disease in dogs in the United States. To date, no drugs have been shown to eliminate B. gibsoni (Asian genotype) infections from dogs. Twenty-two dogs that remained persistently infected ... Full text Link to item Cite

Clinicopathological abnormalities and treatment response in 24 dogs seroreactive to Bartonella vinsonii (berkhoffii) antigens.

Journal article J Am Anim Hosp Assoc · 2004 Bartonella vinsonii (B. vinsonii) subspecies berkhoffii is a recently recognized cause of endocarditis, myocarditis, and granulomatous disease in dogs. In an effort to elucidate other potential disease manifestations, the case records of 24 dogs that were ... Full text Link to item Cite

Antinuclear antibodies can be detected in dog sera reactive to Bartonella vinsonii subsp. berkhoffii, Ehrlichia canis, or Leishmania infantum antigens.

Journal article J Vet Intern Med · 2004 The presence of antinuclear antibodies (ANAs) is used to support a clinical diagnosis of systemic lupus erythematosus (SLE) in dogs. However, clinicians must interpret the detection of ANAs with caution, particularly in light of increasing evidence that do ... Full text Link to item Cite

Bartonella henselae IgG antibodies are prevalent in dogs from southeastern USA.

Journal article Vet Res · 2004 In contrast to the large body of literature regarding Bartonella henselae in humans and cats, there is little information about B. henselae as an infectious agent in dogs. Due to the paucity of information regarding the B. henselae serology in dogs, we per ... Full text Link to item Cite

Bartonella vinsonii subspecies berkhoffi as a possible cause of anterior uveitis and choroiditis in a dog.

Journal article Vet Ophthalmol · December 2003 A 2-year old, neutered, female spaniel mixed breed was referred to the North Carolina State University Veterinary Teaching Hospital for evaluation of bilateral anterior uveitis. The dog was febrile and, in addition to anterior uveitis, multifocal hyporefle ... Full text Link to item Cite

Concurrent bartonellosis and babesiosis in a dog with persistent thrombocytopenia.

Journal article J Am Vet Med Assoc · November 1, 2003 A 12-year-old castrated male West Highland White Terrier was referred because of recurrent episodes of collapsing. The dog was mildly anemic and severely thrombocytopenic and had high serum alanine aminotransferase activity. Infection with Bartonella vinso ... Full text Link to item Cite

Capnocytophaga sp. isolated from a cat with chronic sinusitis and rhinitis.

Journal article J Clin Microbiol · November 2003 A Capnocytophaga sp. was inadvertently isolated from a cat with chronic sinusitis and rhinitis when cytopathic effects were observed in Crandall-Reese feline kidney cells that had been inoculated with oropharyngeal swab samples. Although Capnocytophaga spp ... Full text Link to item Cite

Transmission Times and Prevention of Tick-Borne Diseases in Dogs

Journal article Compendium on Continuing Education for the Practicing Veterinarian · October 1, 2003 Increasing evidence indicates that tick infestation can result in the transmission of a broad spectrum of bacterial and protozoal organisms to dogs. Anaplasma, Babesia, Bartonella, Borrelia, Coxiella, Ehrlichia, Hepatozoon, and Rickettsia species are the m ... Cite

Development and evaluation of a seminested PCR for detection and differentiation of Babesia gibsoni (Asian genotype) and B. canis DNA in canine blood samples.

Journal article J Clin Microbiol · September 2003 Canine babesiosis has recently been recognized as an emerging infectious disease of dogs in North America. We sought to develop a seminested PCR to detect and differentiate Babesia gibsoni (Asian genotype), B. canis subsp. vogeli, B. canis subsp. canis, an ... Full text Link to item Cite

The immunologic response of dogs to Bartonella vinsonii subspecies berkhoffii antigens: as assessed by Western immunoblot analysis.

Journal article J Vet Diagn Invest · July 2003 Bartonella vinsonii subspecies berkhoffii is a recently recognized zoonotic pathogen that causes endocarditis, granulomatous rhinitis, and granulomatous lymphadenitis in dogs. Isolation of B. vinsonii (berkhoffii) from blood or tissue samples is frequently ... Full text Link to item Cite

Characterization of the major antigenic protein 2 of Ehrlichia canis and Ehrlichia chaffeensis and its application for serodiagnosis of ehrlichiosis.

Journal article Clin Diagn Lab Immunol · July 2003 Canine monocytic ehrlichiosis, caused by Ehrlichia canis or Ehrlichia chaffeensis, can result in clinical disease in naturally infected animals. Coinfections with these agents may be common in certain areas of endemicity. Currently, a species-specific meth ... Full text Link to item Cite

Clinical impact of persistent Bartonella bacteremia in humans and animals.

Journal article Ann N Y Acad Sci · June 2003 Bartonella spp. are emerging vector-borne pathogens that cause persistent, often asymptomatic bacteremia in their natural hosts. As our knowledge progresses, it appears that chronic infection may actually predispose the host to mild, insidious nonspecific ... Full text Link to item Cite

Molecular identification of Ehrlichia ewingii infection in dogs: 15 cases (1997-2001).

Journal article J Am Vet Med Assoc · April 15, 2003 OBJECTIVE: To determine historical, physical examination, hematologic, and serologic findings in dogs with Ehrlichia ewingii infection. DESIGN: Retrospective study. ANIMALS: 15 dogs. PROCEDURE: In all dogs, infection with E ewingii was confirmed with a pol ... Full text Link to item Cite

Transfusion-associated Babesia gibsoni infection in a dog.

Journal article J Am Vet Med Assoc · April 1, 2003 A 2.5-year-old spayed female German Shepherd Dog was referred for evaluation of progressive anemia, lethargy, and weight loss. Seventeen days earlier, the dog had received a whole blood transfusion to manage hemorrhage after ovariohysterectomy. Mild fever, ... Full text Link to item Cite

Acute nontraumatic hemoabdomen in the dog: a retrospective analysis of 39 cases (1987-2001).

Journal article J Am Anim Hosp Assoc · 2003 The medical records of 39 dogs with acute nontraumatic hemoabdomen were identified and reviewed. Anemia and hypoalbuminemia were identified in 36/37 (97%) and 25/33 (76%) dogs, respectively. Coagulopathies were identified in 26/31 (84%) dogs. When a defini ... Full text Link to item Cite

Detection of Bartonella henselae and Bartonella clarridgeiae DNA in hepatic specimens from two dogs with hepatic disease.

Journal article J Am Vet Med Assoc · January 1, 2003 A 4-year-old Basset Hound and a 6-year-old Doberman Pinscher were referred for diagnostic evaluation following documentation of persistently increased hepatic enzyme activities and hepatic dysfunction. Histologic evaluation of hepatic biopsy specimens from ... Full text Link to item Cite

Emerging and re-emerging infectious diseases

Journal article Veterinary Clinics of North America Small Animal Practice · January 1, 2003 Full text Cite

Serosurvey of antiBabesia antibodies in stray dogs and American pit bull terriers and American staffordshire terriers from North Carolina.

Journal article J Am Anim Hosp Assoc · 2003 Stray dogs (n=359) and kennel dogs (n=149) from North Carolina were tested for evidence of antiBabesia antibodies. AntiBabesia antibodies were detected in 21/359 and 22/149 of the stray and kennel dogs, respectively. A total of 57 dogs from both groups wer ... Full text Link to item Cite

Naturally occurring Ehrlichia chaffeensis infection in two prosimian primate species: ring-tailed lemurs (Lemur catta) and ruffed lemurs (Varecia variegata).

Journal article Emerg Infect Dis · December 2002 A naturally occurring infection of Ehrlichia chaffeensis in lemurs is described. DNA of Ehrlichia chaffeensis was identified by polymerase chain reaction in peripheral blood from six of eight clinically ill lemurs. Organisms were cultured from the blood of ... Full text Link to item Cite

Bartonella henselae and Bartonella elizabethae as potential canine pathogens.

Journal article J Clin Microbiol · December 2002 Bartonella henselae or Bartonella elizabethae DNA from EDTA-anticoagulated blood samples obtained from four dogs was amplified and sequenced. The results showed that B. elizabethae should be added to the list of Bartonella species (i.e., B. vinsonii subsp. ... Full text Link to item Cite

Investigation of the phylogenetic relationships within the genus Bartonella based on comparative sequence analysis of the rnpB gene, 16S rDNA and 23S rDNA.

Journal article Int J Syst Evol Microbiol · November 2002 A variety of genes and analytical methods have been applied to the study of phylogenetic relationships within the genus Bartonella, but so far the results have been inconsistent. While previous studies analysed single protein-encoding genes, we have analys ... Full text Link to item Cite

Single-tube nested PCR for detection of tritrichomonas foetus in feline feces.

Journal article J Clin Microbiol · November 2002 Tritrichomonas foetus, a venereal pathogen of cattle, was recently identified as an inhabitant of the large intestine in young domestic cats with chronic diarrhea. Recognition of the infection in cats has been mired by unfamiliarity with T. foetus in cats ... Full text Link to item Cite

Differentiation of Haemobartonella canis and Mycoplasma haemofelis on the basis of comparative analysis of gene sequences.

Journal article Am J Vet Res · October 2002 OBJECTIVE: To determine whether Haemobartonella canis and Mycoplasma haemofelis (formerly known as H felis [large form]) can be differentiated by use of comparative analysis of gene sequences. SAMPLE POPULATION: Blood samples obtained from 3 dogs infected ... Full text Link to item Cite

Comparison of serological detection methods for diagnosis of Ehrlichia canis infections in dogs.

Journal article J Clin Microbiol · September 2002 We determined the value of four serological assays for the diagnosis of canine monocytic ehrlichiosis by comparing them to the indirect fluorescent-antibody assay "gold standard." The specificity of Dip-S-Ticks was significantly lower than that of all of t ... Full text Link to item Cite

Isolation and identification of Mycobacterium kansasii from pleural fluid of a dog with persistent pleural effusion.

Journal article J Am Vet Med Assoc · May 1, 2002 A 3-year-old spayed female Whippet was examined for cough and respiratory distress. Lung lobe torsion with pleural effusion was diagnosed, and lung lobectomy was performed. Pleural effusion recurred during the following 27 months; conventional bacteriologi ... Full text Link to item Cite

Feline Ehrlichiosis. The genetic identification of the agent in two cats

Conference Pratique Medicale Et Chirurgicale De L Animal De Compagnie · May 1, 2002 An infection resembling ehrlichiosis was diagnosed in 24 cats living about Sommières, (Gard, southern France), between 1994 and 2000. These cats presented evocative clinical and laboratory signs, were seropositive for Ehrlichia canis (IFA test), and respon ... Cite

Molecular evidence supporting Ehrlichia canis-like infection in cats.

Journal article J Vet Intern Med · 2002 Currently, the pathogenic role of Ehrlichia canis in cats has been proposed predominantly on the basis of the serologic evidence of natural infection and the infrequent detection of morulae-like structures within the cytoplasm of leukocytes in cats. The pu ... Full text Link to item Cite

Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM. American College of Veterinary Internal Medicine.

Journal article J Vet Intern Med · 2002 Within the past several decades, the number of Ehrlichia spp. recognized to infect cats, dogs, and human beings has expanded substantially. The recent application of advanced techniques in molecular biology has changed how ehrlichiosis is diagnosed and has ... Full text Link to item Cite

Visceral leishmaniasis in a New York foxhound kennel.

Journal article J Vet Intern Med · 2002 Although endemic throughout much of the world, autochthonous visceral leishmaniasis has been reported on only 3 previous occasions in North America. After diagnosis of visceral leishmaniasis in 4 foxhounds from a kennel in Dutchess County, New York (index ... Full text Link to item Cite

Imaging of pheochromocytoma in 2 dogs using p-[18F] fluorobenzylguanidine.

Journal article Vet Radiol Ultrasound · 2002 p-[18F]Fluorobenzylguanidine ([18F]PFBG) is a norepinephrine analog that has been developed as a positron emission tomography (PET) imaging radiopharmaceutical. Myocardial sympathetic innervation, neuroendocrine structures, and tumors can be noninvasively ... Full text Link to item Cite

Immunopathology of Bartonella vinsonii (berkhoffii) in experimentally infected dogs.

Journal article Vet Immunol Immunopathol · December 2001 Following natural infection with Bartonella, dogs and humans develop comparable disease manifestations including endocarditis, peliosis hepatis, and granulomatous disease. As the immunologic response to infection in these hosts has not been clearly establi ... Full text Link to item Cite

Differentiation of Ehrlichia platys and E. equi infections in dogs by using 16S ribosomal DNA-based PCR.

Journal article J Clin Microbiol · December 2001 We have encountered a previously unrecognized specificity problem when using the small-subunit ribosomal DNA (16S rDNA)-based PCR primers recommended for use in the identification of Ehrlichia equi in clinical samples. These PCR primers annealed to E. plat ... Full text Link to item Cite

Experimental infection of cats with Tritrichomonas foetus.

Journal article Am J Vet Res · November 2001 OBJECTIVE: To determine whether infection with Tritrichomonas foetus causes diarrhea in specific-pathogen-free or Cryptosporidium coinfected cats. ANIMALS: 4 cats with subclinical cryptosporidiosis (group 1) and 4 specific-pathogen-free cats (group 2). PRO ... Full text Link to item Cite

Recombinant major antigenic protein 2 of Ehrlichia canis: a potential diagnostic tool.

Journal article J Clin Microbiol · July 2001 The major antigenic protein 2 (MAP2) of Ehrlichia canis was cloned and expressed. The recombinant protein was characterized and tested in an enzyme-linked immunosorbent assay (ELISA) format for potential application in the serodiagnosis of canine monocytic ... Full text Link to item Cite

Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs.

Journal article J Am Vet Med Assoc · April 1, 2001 OBJECTIVE: To determine whether the geographic distribution of deer ticks (Ixodes scapularis) was associated with the distribution of dogs seropositive for various tick-transmitted disease organisms (ie, Borrelia burgdorferi, Rickettsia rickettsii, the hum ... Full text Link to item Cite

Testing for Tick-Borne Diseases in Dogs: A Roundtable Discussion

Journal article Veterinary Technician · April 1, 2001 Tick-borne diseases pose an increasing threat to companion animals, and two of these diseases - canine ehrlichiosis and Lyme disease - have the focus of various research projects. When a decision is made to test a dog for exposure to the agents of ehrlichi ... Cite

Infection with Bartonella weissii and detection of Nanobacterium antigens in a North Carolina beef herd.

Journal article J Clin Microbiol · March 2001 Very recently, Bartonella organisms have been isolated from large ruminants (deer, elk, and dairy and beef cattle) located in the United States and in France. In this study, we report the serologic, microbiologic, and molecular findings related to the isol ... Full text Link to item Cite

Tick-borne infectious diseases of dogs.

Journal article Trends Parasitol · February 2001 Tick-transmitted infections are an emerging problem in dogs. In addition to causing serious disease in traditional tropical and semi-tropical regions, they are now increasingly recognized as a cause of disease in dogs in temperate climates and urban enviro ... Full text Link to item Cite

Serologic and molecular evidence of coinfection with multiple vector-borne pathogens in dogs from Thailand.

Journal article J Vet Intern Med · 2001 Forty-nine dogs from Thailand were evaluated for serologic evidence of exposure or polymerase chain reaction (PCR) evidence of infection with vectorborne pathogens, including Ehrlichia sp. (Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, and Ehrlic ... Full text Link to item Cite

Immunodiagnosis of Ehrlichia canis infection with recombinant proteins.

Journal article J Clin Microbiol · January 2001 Ehrlichia canis causes a potentially fatal rickettsial disease of dogs that requires rapid and accurate diagnosis in order to initiate appropriate therapy leading to a favorable prognosis. We recently reported the cloning of two immunoreactive E. canis pro ... Full text Link to item Cite

Coinfection with three Ehrlichia species in dogs from Thailand and Venezuela with emphasis on consideration of 16S ribosomal DNA secondary structure.

Journal article J Clin Microbiol · January 2001 As part of a larger study to investigate tick-borne infections in dogs from Thailand and Venezuela, documentation of coinfection with three Ehrlichia species in two dogs, one from each country, became the focus of the present study. Although neither dog ha ... Full text Link to item Cite

Infection of fetal feline brain cells in culture with Bartonella henselae.

Journal article Infect Immun · January 2001 Bartonella henselae is known to cause central nervous system (CNS) disease in humans, and neurological signs have been observed in experimentally infected cats. However, the pathogenesis of CNS disease remains unclear. This study was undertaken to determin ... Full text Link to item Cite

Canine Rocky Mountain Spotted fever: a retrospective study of 30 cases.

Journal article J Am Anim Hosp Assoc · 2001 Rocky Mountain spotted fever (RMSF) was diagnosed in 30 dogs examined at North Carolina State University, Veterinary Teaching Hospital between 1984 and 1997. Historical, physical examination, and laboratory abnormalities were reviewed. Diagnostic criteria ... Full text Link to item Cite

Coyotes (Canis latrans) as the reservoir for a human pathogenic Bartonella sp.: molecular epidemiology of Bartonella vinsonii subsp. berkhoffii infection in coyotes from central coastal California.

Journal article J Clin Microbiol · November 2000 Bartonella vinsonii subsp. berkhoffii was originally isolated from a dog suffering infectious endocarditis and was recently identified as a zoonotic agent causing human endocarditis. Following the coyote bite of a child who developed clinical signs compati ... Full text Link to item Cite

Bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection.

Journal article Clin Microbiol Rev · July 2000 Recent observations have begun to support a role for Bartonella spp. as animal as well as human pathogens. Bartonella spp. are vector-transmitted, blood-borne, intracellular, gram-negative bacteria that can induce prolonged infection in the host. Persisten ... Full text Link to item Cite

Cyclic CD8+ lymphopenia in dogs experimentally infected with Bartonella vinsonii subsp. berkhoffii.

Journal article Vet Immunol Immunopathol · June 30, 2000 Until recently, it was presumed that Bartonella vinsonii only infected voles, a species of North American rodents. In April of 1993, however, our laboratory isolated a novel subspecies of B. vinsonii (B. vinsonii subsp. berkhoffii) from the blood of a dog ... Full text Link to item Cite

Rapid identification and differentiation of Bartonella species using a single-step PCR assay.

Journal article J Clin Microbiol · May 2000 Five species of Bartonella have been reported to infect humans and cause a variety of diseases that can be difficult to diagnose. Four species of Bartonella have been reported to infect cats and dogs, and two of these species are considered to be zoonotic ... Full text Link to item Cite

Bartonella spp antibodies and DNA in aqueous humour of cats.

Journal article J Feline Med Surg · March 2000 Bartonella spp antibodies were measured in the serum and aqueous humour of cats with and without uveitis and polymerase chain reaction (PCR) for Bartonella spp DNA was performed on aqueous humour from most of the cats. Serum and aqueous humour were assayed ... Full text Link to item Cite

Peliosis hepatis in a dog infected with Bartonella henselae.

Journal article J Am Vet Med Assoc · February 15, 2000 A 6-year-old spayed female Golden Retriever was examined because of generalized weakness and abdominal distention. Abdominal ultrasonography revealed a large quantity of peritoneal fluid. In addition, the liver appeared larger than normal and contained mul ... Full text Link to item Cite

Seroprevalence of Ehrlichia canis, Ehrlichia equi, and Ehrlichia risticii in sick dogs from North Carolina and Virginia.

Journal article J Vet Intern Med · 2000 Ehrlichia canis, E. equi, and E. risticii seroprevalence was determined by microimmunofluorescent antibody testing (IFA) in a sequential population of 1,845 sick dogs admitted during a 1-year period to the North Carolina State University Veterinary Teachin ... Full text Link to item Cite

Granulomatous disease associated with Bartonella infection in 2 dogs.

Journal article J Vet Intern Med · 2000 Shortly after removal of an engorged tick from the left ear, a 4-year-old Greyhound was referred for evaluation of fever and a rapidly enlarging mass in the region of the left submandibular lymph node. Histopathologic evaluation of the lymph node resulted ... Full text Link to item Cite

Prevalence of Bartonella henselae antibody in Florida panthers.

Journal article J Wildl Dis · January 2000 Serum samples from 28 free-ranging Florida panthers (Puma concolor coryi) and seven mountain lions from Texas (P. concolor stanleyana) living in south Florida (USA) between 1997 to 1998 were tested for antibodies to Bartonella henselae. Twenty percent (7/3 ... Full text Link to item Cite

Familial glomerulonephropathy in a litter of beagles.

Journal article J Am Vet Med Assoc · January 1, 2000 Membranoproliferative glomerulonephropathy was diagnosed in 5 of 7 adult Beagles from the same litter. Dogs were raised in more than 1 area of the United States. One died without evidence of renal disease when it was 3 years old. At 8 years of age, 2 dogs ... Full text Link to item Cite

Diarrhea associated with trichomonosis in cats.

Journal article J Am Vet Med Assoc · November 15, 1999 OBJECTIVE: To establish clinical features, course of illness, and treatment outcome of cats with diarrhea and concurrent infection with Trichomonas organisms. Prevalence of fecal trichomonads in a geographically comparable population of healthy indoor and ... Link to item Cite

Bartonella vinsonii subsp. berkhoffii and related members of the alpha subdivision of the Proteobacteria in dogs with cardiac arrhythmias, endocarditis, or myocarditis.

Journal article J Clin Microbiol · November 1999 Cardiac arrhythmias, endocarditis, or myocarditis was identified in 12 dogs, of which 11 were seroreactive to Bartonella vinsonii subspecies berkhoffii antigens. Historical abnormalities were highly variable but frequently included substantial weight loss, ... Full text Link to item Cite

The incidence of ehrlichial and rickettsial infection in patients with unexplained fever and recent history of tick bite in central North Carolina.

Journal article J Infect Dis · September 1999 We examined the clinical and laboratory findings of a consecutive series of patients from central North Carolina presenting with fever and a history of tick bite within the preceding 14 days. Evidence of a tick-transmitted pathogen was detected in 16 of 35 ... Full text Link to item Cite

Coinfection with multiple tick-borne pathogens in a Walker Hound kennel in North Carolina.

Journal article J Clin Microbiol · August 1999 Both dogs and humans can be coinfected with various Ehrlichia, Bartonella, Rickettsia, and Babesia species. We investigated a kennel of sick Walker Hounds and their owners in southeastern North Carolina for evidence of tick-borne infections and associated ... Full text Link to item Cite

Clinical and pathologic evaluation of chronic Bartonella henselae or Bartonella clarridgeiae infection in cats.

Journal article J Clin Microbiol · May 1999 Human Bartonella infections result in diverse medical presentations, whereas many cats appear to tolerate chronic bacteremia without obvious clinical abnormalities. Eighteen specific-pathogen-free cats were inoculated with Bartonella henselae- and/or Barto ... Full text Link to item Cite

Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain spotted fever in dogs.

Journal article Antimicrob Agents Chemother · April 1999 Dogs were experimentally inoculated with Rickettsia rickettsii (canine origin) in order to compare the efficacies of azithromycin and trovafloxacin to that of the current antibiotic standard, doxycycline, for the treatment of Rocky Mountain spotted fever. ... Full text Link to item Cite

A retrospective study of ehrlichiosis in 62 dogs from North Carolina and Virginia.

Journal article J Vet Intern Med · 1999 The purpose of this retrospective study is to report the clinical signs, clinicopathological findings, and response to therapy of 62 dogs from North Carolina and Virginia. Ehrlichiosis was diagnosed in all of these dogs, and previous retrospective studies ... Full text Link to item Cite

Babesia gibsoni infections in dogs from North Carolina.

Journal article J Am Anim Hosp Assoc · 1999 The recognition of canine babesiosis in North Carolina caused by Babesia gibsoni documents the expansion of the previously reported endemic area of this disease. Clinical signs ranged from severe hemolytic anemia and thrombocytopenia to subclinical infecti ... Full text Link to item Cite

Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky Mountain spotted fever and ehrlichiosis.

Journal article J Am Anim Hosp Assoc · 1999 Antiplatelet antibodies were detected in the sera of dogs with naturally occurring and experimentally induced Rickettsia rickettsii and Ehrlichia canis infections. This is the first known report documenting elevated platelet-associated immunoglobulin (PAIg ... Full text Link to item Cite

Sequential evaluation of dogs naturally infected with Ehrlichia canis, Ehrlichia chaffeensis, Ehrlichia equi, Ehrlichia ewingii, or Bartonella vinsonii.

Journal article J Clin Microbiol · September 1998 Historically, disease manifestations in dogs seroreactive to Ehrlichia canis antigens by indirect immunofluorescent antibody testing have been attributed to infection with either E. canis or Ehrlichia ewingii. A 1996 study by Dawson and colleagues provided ... Full text Link to item Cite

Doxycycline hyclate treatment of experimental canine ehrlichiosis followed by challenge inoculation with two Ehrlichia canis strains.

Journal article Antimicrob Agents Chemother · February 1998 Dogs were experimentally inoculated with Ehrlichia canis Florida to assess the efficacy of doxycycline hyclate for the treatment of acute ehrlichiosis. Treatment with doxycycline eliminated infection in eight of eight dogs. Untreated infected control dogs ... Full text Link to item Cite

A survey of tick-borne bacteria and protozoa in naturally exposed dogs from Israel.

Journal article Vet Parasitol · January 31, 1998 Antibody reactivity against seven bacterial or protozoal pathogens was measured in sera derived from 40 dogs suspected of a tick-borne disease. Sera from 73% (29/40) of the dogs reacted with three or more test antigens. Seroreactivity was most prevalent to ... Full text Link to item Cite

Immunophenotypic comparison of blood and lymph node from dogs with lymphoma.

Journal article Vet Clin Pathol · 1998 Peripheral blood and lymph node tissue from 12 dogs with lymphoma was immunophenotyped. Additionally, the bone marrow was immunophenotyped in 6 dogs. The lymphomas were characterized as B-cell in 11 dogs and T-cell in 1 dog. Immunophenotypic patterns in th ... Full text Link to item Cite

Persistent infection of pets within a household with three Bartonella species.

Journal article Emerg Infect Dis · 1998 We monitored by blood culture and immunofluorescence assay (IFA) bartonella infection in one dog and eight cats in a household to determine the prevalence and persistence of the infection as well as its transmissibility to humans. Ectoparasite control was ... Full text Link to item Cite

Granulocytic ehrlichiosis in dogs from North Carolina and Virginia.

Journal article J Vet Intern Med · 1998 Medical records of 3 dogs from North Carolina and 3 dogs from Virginia with ehrlichial morulae in circulating neutrophils were studied retrospectively. Two clinically distinct disease syndromes, including chronic, moderate to severe anemia (n = 3) and poly ... Full text Link to item Cite

Dual infection with Ehrlichia chaffeensis and a spotted fever group rickettsia: a case report.

Journal article Emerg Infect Dis · 1998 Well-documented cases of simultaneous human infection with more than one tick-borne pathogen are rare. To our knowledge only two dual infections have been reported: simultaneous human infection with the agent of human granulocytic ehrlichiosis and Borrelia ... Full text Open Access Link to item Cite

Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats.

Journal article Antimicrob Agents Chemother · November 1997 Enrofloxacin and doxycycline are antimicrobial agents used to treat bacterial diseases of cats. In vitro susceptibility data indicate that either drug should be effective against Bartonella species. In vivo efficacies of these drugs for eradication of chro ... Full text Link to item Cite

Bartonella clarridgeiae, a newly recognized zoonotic pathogen causing inoculation papules, fever, and lymphadenopathy (cat scratch disease).

Journal article J Clin Microbiol · July 1997 Shortly after adopting a 6-week-old cat, a veterinarian was bitten on the left index finger. Within 3 weeks, he developed headache, fever, and left axillary lymphadenopathy. Initial blood cultures from the cat and veterinarian were sterile. Repeat cultures ... Full text Link to item Cite

Epidemiologic evaluation of the risk factors associated with exposure and seroreactivity to Bartonella vinsonii in dogs.

Journal article Am J Vet Res · May 1997 OBJECTIVES: To determine seroprevalence to Bartonella vinsonii subsp berkhoffii in a population of sick dogs from North Carolina and Virginia and to evaluate potential risk factors associated with increased likelihood of exposure to the organism. SAMPLE PO ... Link to item Cite

Relapsing bacteremia after blood transmission of Bartonella henselae to cats.

Journal article Am J Vet Res · May 1997 OBJECTIVES: To determine persistence of bacteremia, pathogenicity, and immunoglobulin kinetics after blood transmission of Bartonella henselae in cats. ANIMALS: 18 specific-pathogen-free (SPF) cats (16 weeks old) received blood or urine from 4 adult cats ( ... Link to item Cite

Life-threatening Cache Valley virus infection.

Journal article N Engl J Med · February 20, 1997 Full text Link to item Cite

Thoracic radiographic findings in dogs infected with Rickettsia rickettsii.

Journal article Vet Radiol Ultrasound · 1997 Sixteen beagle dogs were injected intradermally with Rickettsia rickettsii. The dogs were divided into four groups (n = 4): 1) infected, non-treated control; 2) infected, treated with doxycycline; 3) infected, treated with doxycycline and an anti-inflammat ... Full text Link to item Cite

A retrospective case-control of acute renal failure in 99 dogs.

Journal article J Vet Intern Med · 1997 The objective of this study was to evaluate retrospectively demographic and clinicopathologic factors that may be associated with the diagnosis and outcome of acute renal failure (ARF) in dogs presented to a large referral hospital. Medical records of dogs ... Full text Link to item Cite

Immunoblot analysis of the immunoglobulin G response to Ehrlichia canis in dogs: an international survey.

Journal article J Vet Diagn Invest · January 1997 Historically, considerable variation has been reported in the type and severity of clinical and hematologic abnormalities associated with canine ehrlichiosis. Because of difficulties associated with the isolation of intracellular monocytic Ehrlichia specie ... Full text Link to item Cite

Prednisolone at anti-inflammatory or immunosuppressive dosages in conjunction with doxycycline does not potentiate the severity of Rickettsia rickettsii infection in dogs.

Journal article Antimicrob Agents Chemother · January 1997 Dogs were experimentally inoculated with Rickettsia rickettsii to determine if anti-inflammatory or immunosuppressive dosages of prednisolone, when administered in conjunction with an antirickettsial antibiotic (doxycycline), induced therapeutically releva ... Full text Link to item Cite

Bartonella vinsonii subsp. berkhoffii subsp. nov., isolated from dogs; Bartonella vinsonii subsp. vinsonii; and emended description of Bartonella vinsonii.

Journal article Int J Syst Bacteriol · July 1996 Two bacterial strains, one isolated from the blood of a dog with valvular endocarditis and one isolated from the blood of a healthy dog, were similar to Bartonella species, as determined by a number of phenotypic criteria, including growth characteristics, ... Full text Link to item Cite

Comparative seroreactivity to Bartonella henselae and Bartonella quintana among cats from Israel and North Carolina.

Journal article Vet Microbiol · May 1996 Bartonella henselae, the predominant cause of cat scratch disease, and Bartonella quintana, the cause of trench fever, are closely related Bartonella species that induce cross-reactivity when cat or human sera are tested using an indirect immunofluorescenc ... Full text Link to item Cite

Myocarditis in mice and guinea pigs experimentally infected with a canine-origin Borrelia isolate from Florida.

Journal article Am J Vet Res · April 1996 OBJECTIVE: To characterize the pathogenic potential of a unique Borrelia isolate obtained from a dog from Florida (FCB isolate). DESIGN: Prospective experimental infection. ANIMALS: 32 preweanling Swiss Webster mice and 12 adult male Hartley guinea pigs we ... Link to item Cite

Prolonged Bartonella bacteremia in cats associated with cat-scratch disease patients.

Journal article J Clin Microbiol · December 1995 Recent evidence supports a causal relationship between Bartonella (Rochalimaea) henselae, cat-scratch disease (CSD), and bacillary angiomatosis. Cats appear to be the primary reservoir. Blood from 19 cats owned by 14 patients diagnosed with CSD was culture ... Full text Link to item Cite

Evaluation of the pathogenic potential of Rickettsia canada and Rickettsia prowazekii organisms in dogs.

Journal article J Am Vet Med Assoc · July 1, 1995 An unusual pattern of seroreactivity to antigens of rickettsial organisms (Rickettsia rickettsii, R rhipicephali, R montana, and R bellii), particularly to R bellii antigen, was detected in 3 dogs during a 2-month period. Thus, studies were initiated to cl ... Link to item Cite

Bartonellosis.

Journal article J Am Vet Med Assoc · June 15, 1995 Link to item Cite

Intraerythrocytic presence of Bartonella henselae.

Journal article J Clin Microbiol · June 1995 Recent reports in the medical literature emphasize the risk of zoonotic disease and the high degree of prevalence of asymptomatic feline infection with Bartonella (Rochalimaea) henselae. While investigating Bartonella bacteremia in cats, we used transmissi ... Full text Link to item Cite

Erythrocyte fragility and chronic intermittent pigmenturia in a dog.

Journal article J Am Vet Med Assoc · April 1, 1995 A 2-year-old spayed female Shetland Sheepdog had recurrent episodes of discolored urine. Treatments administered for presumed urinary tract infection did not prevent recurrence. Episodes of pigmenturia appeared to correlate with stressful situations or exc ... Link to item Cite

The effects of cyclosporine versus standard care in dogs with naturally occurring glomerulonephritis.

Journal article J Vet Intern Med · 1995 Glomerulonephritis (GN) is a leading cause of chronic renal failure in dogs. However, little is known about the efficacy of available treatment options for GN in this species. The purpose of this study was to determine the effects of cyclosporine (Cy) admi ... Full text Link to item Cite

Diagnostic and therapeutic considerations in a hypercalcemic dog with multiple endocrine neoplasia.

Journal article J Am Anim Hosp Assoc · 1995 Hypercalcemia was found in a dog examined for episodic weakness and disorientation. A right adrenal mass identified on abdominal ultrasonographic examination was diagnosed as a pheochromocytoma based on increased 1231-metaiodobenzylguanidine uptake and cha ... Full text Link to item Cite

Endocarditis in a dog due to infection with a novel Bartonella subspecies.

Journal article J Clin Microbiol · January 1995 Vegetative valvular endocarditis involving the aortic and, to a lesser extent, mitral valves was diagnosed echocardiographically in a 3-year-old spayed female Labrador retriever. Historically, the dog had been treated with tetracycline hydrochloride and pr ... Full text Link to item Cite

Canine mitochondrial myopathy associated with reduced mitochondrial mRNA and altered cytochrome c oxidase activities in fibroblasts and skeletal muscle.

Journal article Comp Biochem Physiol A Physiol · December 1994 Skeletal muscle and fibroblast biopsies obtained from a normal dog and an old English sheep dog with exertional myopathy and lactic acidosis were examined for mitochondrial enzyme activities and mitochondrially coded mRNAs. The fibroblast cultures of the a ... Full text Link to item Cite

Natural infections with Borrelia spirochetes in two dogs from Florida.

Journal article J Clin Microbiol · February 1994 Spirochetemia is a rarely reported observation in dogs. We describe the clinical, hematologic, and immunodiagnostic features of two spirochetemic dogs from northern Florida and the subsequent isolation and preliminary characterization of a Borrelia species ... Full text Link to item Cite

Fanconi's syndrome in a dog with primary hypoparathyroidism.

Journal article J Vet Intern Med · 1994 An 11-year-old castrated male mixed breed dog was referred for evaluation of muscle twitching, polyuria, polydipsia, anorexia, and periocular alopecia. Primary hypoparathyroidism was diagnosed by documenting decreased serum concentrations of parathyroid ho ... Full text Link to item Cite

Thrombocytopenia associated with neoplasia in dogs.

Journal article J Vet Intern Med · 1994 Ten percent (214/2,059) of all dogs with cancer at North Carolina State University Veterinary Teaching Hospital had thrombocytopenia. The thrombocytopenia was associated with infectious/inflammatory etiologies in 4%, miscellaneous disorders (therapy, bone ... Full text Link to item Cite

The use of a polymerase chain reaction as a diagnostic test for Rocky Mountain spotted fever.

Journal article Am J Trop Med Hyg · January 1994 A polymerase chain reaction (PCR) for amplifying ribosomal DNA of Rickettsia rickettsii was performed on blood clots and urine samples from 10 patients with suspected Rocky Mountain spotted fever (RMSF) and five controls with nonrickettsial diseases. The r ... Link to item Cite

Acute membranous glomerulopathy in a dog with retrobulbar cellulitis

Journal article Journal of the American Animal Hospital Association · December 1, 1993 Acute renal failure secondary to membranous glomerulopathy was diagnosed in a dog with retrobulbar cellulitis. Renal function deteriorated rapidly during a period of approximately 72 hours. The historical progression of illness, laboratory findings, and li ... Cite

Risk factors associated with acute pancreatitis in dogs: 101 cases (1985-1990).

Journal article J Am Vet Med Assoc · September 1, 1993 The medical records of 101 dogs with acute pancreatitis, diagnosed on the basis of medical histories of acute vomiting, with serum lipase or amylase activity greater than the reference range, or with gross signs of pancreatitis at surgery or histopathologi ... Link to item Cite

Brazilian spotted fever in Espirito Santo, Brazil: description of a focus of infection in a new endemic region.

Journal article Am J Trop Med Hyg · August 1993 Although Brazilian spotted fever is known to occur in several adjacent states, infection with spotted fever group (SFG) rickettsiae has not previously been documented in the Brazilian state of Espirito Santo. We report a cluster of two proven and four susp ... Full text Link to item Cite

USE OF 123IODINE METAIODOBENZYLGUANIDINE SCINTIGRAPHY FOR THE DIAGNOSIS OF A PHEOCHROMOCYTOMA IN A DOG

Journal article Veterinary Radiology Ultrasound · January 1, 1993 A 13‐year‐old neutered female Yorkshire terrier presented with a history of progressive episodic weakness and disorientation of 4 months duration. Physical and neurologic examinations were normal at presentation. Abdominal ultrasound revealed a mass involv ... Full text Cite

Thrombocytopenia in cats: a retrospective study of 41 cases.

Journal article J Vet Intern Med · 1993 The prevalence of feline thrombocytopenia (< 200,000 platelets/microL) at North Carolina State University, College of Veterinary Medicine Teaching Hospital, from January 1985 to March 1990, was 1.2% (41/3300). Cats were divided into six categories based on ... Full text Link to item Cite

Endemic visceral leishmaniasis in a dog from Texas.

Journal article J Vet Intern Med · 1993 Visceral leishmaniasis was diagnosed by cytology and positive indirect immunofluorescent antibody titers to Leishmania donovani in a 7-month-old female Basenji dog from Texas. Clinical and laboratory findings included weight loss, hematochezia, hyperglobul ... Full text Link to item Cite

Comparison of latex agglutination, indirect immunofluorescent antibody, and enzyme immunoassay methods for serodiagnosis of Rocky Mountain spotted fever in dogs.

Journal article Am J Vet Res · January 1993 Indirect immunofluorescent antibody (IFA), latex agglutination (LA), and enzyme immunoassay (EIA) methods were compared for evaluation of the serum antibody responses of dogs experimentally and naturally exposed to spotted fever-group rickettsiae. Selected ... Link to item Cite

Episodic weakness associated with exertional lactic acidosis and myopathy in Old English sheepdog littermates.

Journal article J Am Vet Med Assoc · September 1, 1992 Two Old English Sheepdog littermates were evaluated for weakness that developed during periods of minimally intense exercise. Lactic acidosis accompanied by increased muscle enzyme activity, an increased lactate/pyruvate ratio, and increased venous PO2 sup ... Link to item Cite

Immunoproliferative enteropathy of basenjis.

Journal article Semin Vet Med Surg Small Anim · May 1992 Link to item Cite

Effects of dietary protein source on Basenjis with immunoproliferative enteropathy.

Journal article Am J Vet Res · February 1992 The effects of 3 experimental diets that varied only in the source of dietary protein (ie, poultry, cereal, red meat) were compared in Basenjis (n = 8) with immunoproliferative enteropathy and healthy Beagles (n = 8). Significant differences in fecal chara ... Link to item Cite

Seroprevalence of babesiosis in Greyhounds in Florida.

Journal article J Am Vet Med Assoc · January 1, 1992 An indirect fluorescent antibody test was used to serologically survey Greyhounds from 10 kennels that are part of the racing Greyhound industry in Florida. Age of dogs ranged from 11 months to 11 years. Additionally, 50 adult non-Greyhound pet dogs were c ... Link to item Cite

Postsurgical mortality secondary to zinc toxicity in dogs.

Journal article Vet Hum Toxicol · December 1991 Zinc may be extremely toxic when absorbed from a metallic foreign body retained in the stomach. The most common cause of zinc toxicosis in dogs appears associated with accidental ingestion of copper-coated zinc pennies minted after 1982. In a retrospective ... Link to item Cite

Efficacy of chloramphenicol, enrofloxacin, and tetracycline for treatment of experimental Rocky Mountain spotted fever in dogs.

Journal article Antimicrob Agents Chemother · November 1991 Dogs were experimentally inoculated with Rickettsia rickettsii to characterize the comparative efficacies of chloramphenicol, enrofloxacin, and tetracycline for the treatment of Rocky Mountain spotted fever (RMSF). All three antibiotics were equally effect ... Full text Link to item Cite

Acute blindness associated with intracranial tumors in dogs and cats: eight cases (1984-1989).

Journal article J Am Vet Med Assoc · September 15, 1991 Rostral and middle cranial fossa tumors affecting the optic chiasm and resulting in acute visual deficits were diagnosed in 7 dogs and 1 cat. Blindness and dilated nonresponsive pupils were the primary signs in all animals. Other concurrent neurologic defi ... Link to item Cite

Bone marrow hypoplasia in a cat treated with griseofulvin.

Journal article J Am Vet Med Assoc · February 1, 1991 Three weeks after initiation of griseofulvin treatment for dermatophytosis (40 mg/kg of body weight, q 12 h), an 8-yr-old domestic shorthair cat developed depression, vomiting, and pyrexia. Abnormalities found during physical examination included bilateral ... Link to item Cite

Intrahepatic postsinusoidal venous obstruction in a dog.

Journal article J Vet Intern Med · 1991 Intrahepatic postsinusoidal obstruction, similar to congenital Budd-Chiari syndrome in human patients, was diagnosed in a young Basenji dog. Sonographic, radiographic, and manometric studies were used in antemortem localization of this unusual functional l ... Full text Link to item Cite

Epidemiologic survey of thrombocytopenia in dogs: a report on 987 cases.

Journal article Vet Clin Pathol · 1991 Thrombocytopenia was documented in 987 of 18,910 (5.2%) dogs admitted to North Carolina State University, College of Veterinary Medicine, Veterinary Teaching Hospital, between 1983 and 1989. Classifying thrombocytopenic dogs by etiologic groups revealed th ... Full text Link to item Cite

Gastric acid secretion in Basenji dogs with immunoproliferative enteropathy.

Journal article J Vet Intern Med · 1991 Gastric acid secretion was studied in 13 Basenji dogs with immunoproliferative enteropathy. Considerable variation in the severity of gastritis and enteritis existed among dogs. Basenji dogs were categorized into two groups on the basis of postmortem gastr ... Full text Link to item Cite

Acute renal failure after methylene blue infusion in a dog

Journal article Journal of the American Animal Hospital Association · August 22, 1990 Cite

An epizootic of peroneal and tibial neuropathy in Walker Hound pups.

Journal article J Am Vet Med Assoc · August 15, 1990 Early in life, Walker Hound pups from several litters, later determined to have peroneal and tibial neuropathy, had been given supplements of either evaporated milk and corn syrup mixed with well water or powdered bitch milk formula mixed with well water. ... Link to item Cite

Kinetics of IgM and IgG responses to experimental and naturally acquired Rickettsia rickettsii infection in dogs.

Journal article Am J Vet Res · August 1990 The kinetics of specific IgM and IgG antibody response was characterized in four 9-month-old Beagles after inoculation of 2 x 10(2) plaque-forming units (PFU) of Sheila Smith strain of Rickettsia rickettsii. Immunoglobulin M antibodies were first detected ... Link to item Cite

Platelet aggregation in dogs experimentally infected with Rickettsia rickettsii.

Journal article Vet Clin Pathol · 1990 Platelet aggregation studies were performed on nine Beagle dogs experimentally infected with Rickettsia rickettsia. Platelets from dogs with Rocky Mountain spotted fever tended to be more aggregable than controls. ... Full text Link to item Cite

Vascular permeability and coagulation during Rickettsia rickettsii infection in dogs.

Journal article Am J Vet Res · January 1990 The vascular permeability of the ocular fundus, alterations in the coagulation system, and plasma concentrations of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were studied in dogs following intradermal inoculation with 5 x ... Link to item Cite

Taking a second hard look at Borrelia burgdorferi.

Journal article J Am Vet Med Assoc · September 1, 1989 Link to item Cite

Ocular manifestations of Rocky Mountain spotted fever in dogs.

Journal article J Am Vet Med Assoc · March 15, 1989 Dogs were examined ophthalmoscopically to determine the prevalence and type of ocular lesions associated with naturally acquired Rocky Mountain spotted fever (RMSF). In a consecutive series of 11 dogs with serologically confirmed RMSF, 9 had ocular involve ... Link to item Cite

Identification of rickettsiae in cutaneous biopsy specimens from dogs with experimental Rocky Mountain spotted fever.

Journal article J Vet Intern Med · 1989 Direct immunofluorescence reaction for Rickettsia rickettsii was performed on formalin-fixed, paraffin-embedded cutaneous biopsy specimens collected from dogs with experimental Rocky Mountain spotted fever (RMSF). A technique of trypsin digestion of depara ... Link to item Cite

Elevated serum IgA associated with immunoproliferative enteropathy of Basenji dogs: lack of evidence for alpha heavy-chain disease or enhanced intestinal IgA secretion.

Journal article Vet Immunol Immunopathol · December 1988 Immunoglobulin isotypes in serum and intestinal secretions of Basenji dogs with chronic diarrhea, asymptomatic Basenji dogs, and healthy control dogs were quantitated and their molecular sizes characterized to detect alpha-chain, gamma-chain, or mu-chain f ... Full text Link to item Cite

Clinical and serologic evaluations of induced Borrelia burgdorferi infection in dogs.

Journal article Am J Vet Res · June 1988 Adult Beagles were used to evaluate clinical signs and serologic response after inoculation with, or exposure to, Borrelia burgdorferi. An indirect immunofluorescent assay (IFA) and 2 ELISA were used to monitor the serologic response to B burgdorferi. Feed ... Link to item Cite

Zollinger-Ellison syndrome and myelofibrosis in a dog.

Journal article J Am Vet Med Assoc · May 15, 1988 Zollinger-Ellison syndrome and myelofibrosis were diagnosed concurrently in a 10-year-old neutered female Brittany Spaniel. Documentation of gastric ulceration, hypergastrinemia, and gastrin-secreting islet cell tumor with splenic metastases facilitated th ... Link to item Cite

Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs.

Journal article J Clin Microbiol · April 1988 Immunoblots were used to study the immunoglobulin G response to Borrelia burgdorferi in experimentally and naturally exposed dogs. Adsorption studies confirmed that the antibodies were specific for B. burgdorferi. Experimentally exposed dogs were asymptoma ... Full text Link to item Cite

Antibodies to Borrelia burgdorferi in dogs in North Carolina.

Journal article Am J Vet Res · April 1988 An indirect immunofluorescence assay was used to detect antibodies against Borrelia burgdorferi in sera from 600 dogs in 1983 and 402 dogs in 1985. In 1983, the overall prevalence rate of dogs with B burgdorferi titers greater than or equal to 1:64 was 3.6 ... Link to item Cite

Antibodies to Ehrlichia canis, Ehrlichia platys, and spotted fever group rickettsiae in Louisiana dogs.

Journal article J Vet Intern Med · 1988 Antibodies to Ehrlichia canis, Ehrlichia platys, and spotted fever group (SFG) rickettsiae were detected by indirect immunofluorescence in sera from 27 ill individually owned thrombocytopenic dogs (platelet concentrations less than 200,000 platelets/microl ... Full text Link to item Cite

Clinical, hematologic, and humoral immune response in female dogs inoculated with Rickettsia rickettsii and Rickettsia montana.

Journal article Am J Vet Res · January 1988 Female Beagles were inoculated intradermally with a sublethal dose of Rickettsia rickettsii and R montana. Three dogs (group 1) were inoculated with 2 X 10(2) plaque-forming units (PFU) of R rickettsia and were treated with tetracycline beginning on postin ... Link to item Cite

Gastroenteritis of basenji dogs.

Journal article Vet Pathol · January 1988 Intestinal digestive and absorptive function and the gross and histologic appearance of the gastrointestinal tract were evaluated in Basenji dogs with chronic diarrhea, asymptomatic Basenji dogs, and healthy control dogs. Gastric rugal hypertrophy, lymphoc ... Full text Link to item Cite

Antibodies to spotted fever-group rickettsiae in dogs in North Carolina.

Journal article Am J Vet Res · October 1987 A seroepidemiologic survey was conducted to determine the prevalence of antibodies reactive with 4 spotted fever-group (SFG) rickettsiae in sera of dogs from various geographic regions in North Carolina. Serum specimens were obtained from 600 dogs, and ant ... Link to item Cite

Rhinitis, pneumonia, and defective neutrophil function in the Doberman pinscher.

Journal article Am J Vet Res · July 1987 Eight closely related Doberman Pinschers with chronic rhinitis and pneumonia had normal or increased numbers of structurally normal leukocytes. Serum concentrations of immunoglobulins and complement were above or within normal ranges. Lymphocyte transforma ... Link to item Cite

Antibody activity to Babesia canis in dogs in North Carolina.

Journal article Am J Vet Res · March 1987 Sera from 600 dogs from 6 geographic regions of North Carolina were analyzed for antibody activity to Babesia canis, using an indirect fluorescent antibody test. Overall, 3.8% of the dogs had an antibody titer greater than or equal to 1:80, which was consi ... Link to item Cite

Monoclonal gammopathy associated with naturally occurring canine ehrlichiosis.

Journal article J Vet Intern Med · 1987 Clinical, hematologic, and immunologic findings for 14 dogs with Ehrlichia canis monoclonal gammopathy were studied retrospectively. Epistaxis, anemia, thrombocytopenia, hypoalbuminemia, hypergammaglobulinemia, and proteinuria were documented in the majori ... Full text Link to item Cite

Cultivation of Rhinosporidium seeberi in vitro: interaction with epithelial cells.

Journal article Science · October 24, 1986 Rhinosporidium seeberi, a fungus that is associated with polyp-like tumors in animals and man, was successfully cultivated. This organism stimulated proliferation of epithelial cells in vitro, producing polyp-like structures. Spores produced in culture req ... Full text Link to item Cite

Three cases of acute zinc toxicosis in dogs.

Journal article Vet Hum Toxicol · April 1986 Link to item Cite

Nasal rhinosporidiosis in the dog.

Journal article Vet Pathol · January 1986 Rhinosporidiosis was diagnosed in six dogs from the southeastern United States. All six dogs had unilateral nasal polyps with multiple small white sporangia visible beneath the surface. Microscopically, the polyps consisted of organisms and fibrovascular t ... Full text Link to item Cite

Idiopathic hyperaldosteronism in a dog.

Journal article J Am Vet Med Assoc · October 15, 1985 Idiopathic hyperaldosteronism was diagnosed in an 8-year-old castrated male Yorkshire Terrier, based on increased concentration of plasma aldosterone, hypertension, hypernatremia, decreased natriuresis, hypokalemia, and hyperkaluria. Unilateral adrenalecto ... Link to item Cite

Canine Rocky Mountain spotted fever: a kennel epizootic.

Journal article Am J Vet Res · October 1985 Within a period of 5 consecutive days after the initial observation of illness was made, 7 of 12 Siberian Husky dogs developed clinical signs of Rickettsia rickettsii infection. One dog died and was necropsied. Clinical signs of infection consisted of leth ... Link to item Cite

Mycotic keratitis in a dog: concurrent Aspergillus sp and Curvularia sp infections.

Journal article J Am Vet Med Assoc · May 1, 1985 A dog with exposure keratopathy developed secondary bilateral keratitis from which Aspergillus sp and Curvularia sp were identified. Mycotic keratitis, while rare in the dog, should be considered in the differential diagnosis of keratitis. ... Link to item Cite

Serologic pattern of canine heartworm (Dirofilaria immitis) infection.

Journal article Am J Vet Res · June 1984 A total of 602 dogs at the Louisiana State University Veterinary Teaching Hospital were tested for antibodies to Dirofilaria immitis by enzyme-linked immunosorbent assay (ELISA), using a purified adult dirofilaria-derived antigen. Most dogs also were evalu ... Link to item Cite

Immunoproliferative small intestinal disease in Basenji dogs: morphologic observations.

Journal article Am J Vet Res · March 1984 Eleven Basenjis with chronic diarrhea were evaluated for pathologic changes. Light microscopic and ultrastructural changes were characterized by lymphoplasmacytic infiltration of the lamina propria of the intestine and stomach and by evidence of degranulat ... Link to item Cite

Clinical and laboratory characterization of Basenjis with immunoproliferative small intestinal disease.

Journal article Am J Vet Res · February 1984 Eleven adult Basenji dogs with immunoproliferative small intestinal disease (IPSID) were studied. Two items of history related to the digestive tract were characteristic: (i) chronic intractable diarrhea in most dogs, and (ii) progressive emaciation. Anore ... Link to item Cite

Lymphocyte transformation and humoral immune factors in Basenji dogs with immunoproliferative small intestinal disease.

Journal article Am J Vet Res · October 1983 Serum protein concentrations and 4 immunologic factors were determined in 5 Basenji dogs with immunoproliferative small intestinal disease. There was no correlation between the total serum proteins, immunoglobulin G and immunoglobulin M concentrations, and ... Link to item Cite

Multiple endocrine abnormalities in Basenji dogs with renal tubular dysfunction.

Journal article J Am Vet Med Assoc · June 15, 1983 Three Basenji dogs with renal tubular dysfunction were studied. Hyposthenuria and diminished urine concentrating ability, indicative of nephrogenic diabetes insipidus, were documented. Metabolic acidosis, hyperchloremia, and reduction in glomerular filtrat ... Link to item Cite

Babesiosis in the Greyhound.

Journal article J Am Vet Med Assoc · May 1, 1983 Babesiosis was diagnosed in five 11- to 18-day old Greyhound pups. In 3 pups, Babesia canis organisms were identified by examination of a Wright's-Giemsa-stained smear of blood. In 2 pups, the diagnosis was established by examination of a splenic impressio ... Link to item Cite

Serum proteins in healthy Basenjis and Basenjis with chronic diarrhea.

Journal article Am J Vet Res · February 1983 A serologic survey was conducted to characterize the electrophoretic patterns of serum proteins in healthy Basenji dogs (n = 137) and Basenjis with chronic diarrhea (n = 32). Serum protein electrophoresis values for Basenjis were similar to previously repo ... Link to item Cite

PULMONARY ACTINOMYCOSIS IN A DOG

Journal article Veterinary Radiology · January 1, 1983 A six‐year‐old spayed female mixed‐breed dog was evaluated for coughing, dyspnea, exercise intolerance, and intermittent fever of four month's duration. Extensive alveolar, interstitial, and peribroncial infiltration was observed throughout the lung fields ... Full text Cite

Nephrogenic diabetes insipidus in three dogs.

Journal article J Am Vet Med Assoc · August 1, 1981 Link to item Cite

Hypoglycemia in four dogs with sepsis.

Journal article J Am Vet Med Assoc · May 15, 1981 Link to item Cite

Strongyloides stercoralis-like infection in a dog.

Journal article J Am Vet Med Assoc · January 15, 1980 Helminths similar to Strongyloides stercoralis were recovered from the jejunum and ileum of a 6-month-old Boston Terrier that was shedding unusually large eggs, both unembryonated and embryonated, as well as first-stage larvae in fresh feces. Clinical sign ... Link to item Cite

Inappropriate secretion of antidiuretic hormone in a dog.

Journal article J Am Vet Med Assoc · July 15, 1979 Hyponatremia with simultaneous renal sodium loss was associated with the inappropriate secretion of antidiuretic hormone in a dog with heartworm disease. Antidiuresis caused expansion of extracellular fluid volume, which induced renal salt wasting and a ne ... Link to item Cite

Clinical and electroencephalographic findings associated with ten cases of suspected limbic epilepsy in the dog

Journal article Journal of the American Animal Hospital Association · January 1, 1979 Ten dogs were evaluated clinically and electroencephalographically for various behavioral, psychomotor, and autonomic abnormalities. Rapid diffuse spindles (20 to 30 Hz) were recorded on the electroencephalogram in all cases. The correlation of this electr ... Cite

Feline histoplasmosis

Journal article Journal of the American Animal Hospital Association · December 1, 1977 Cite

Canine hemangioma of the scrotum with fatal bleeding: a case report

Journal article Journal of the American Animal Hospital Association · January 1, 1976 Cite