Scholars@Duke
Eric S Richardson

Eric S Richardson

Professor of the Practice in the Department of Biomedical Engineering
Biomedical Engineering
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Selected Publications

Animal Models for Cardiac Valve Research

Chapter · January 1, 2023 The modern era of cardiac valve repair and replacement has its foundations rooted in the pioneering research completed by surgeons, scientists, and engineers in animal research laboratories. Today, animal models are required for the preclinical assessment ... Full text Cite

One Small Step for a Patient, One Giant Leap for Orthostatic Hypotension.

Journal Article Cureus · November 2022 A 52-year-old man with ischemic cardiomyopathy presented with progressive, severe orthostatic hypotension refractory to medical therapy. Standard abdominal and leg compression devices were used without success. A novel, inflatable abdominal compression dev ... Full text Open Access Link to item Cite

A Portable Negative Pressure Isolation System as a Solution to Minimize Exposure of Health Care Providers to Infectious Pathogens.

Journal Article Am Surg · August 2022 The COVID-19 pandemic has resulted in the exposure of many surgeons and healthcare providers (HCPs) to disease given high patient loads and limited availability of negative pressure rooms. For these reasons we pursued the development of a portable patient ... Full text Link to item Cite

Quantifying the forces needed for ureteral stent removal: Initial evaluation of magnetic stent removal devices on benchtop and porcine models.

Journal Article Journal of pediatric urology · October 2020 BackgroundIndwelling ureteral stents are commonly used in pediatric surgeries for kidney stones and urinary tract obstruction, but often require instrumentation or anesthesia for removal. We evaluated the use of novel magnet devices to remove indw ... Full text Cite

Helmet Modification to PPE With 3D Printing During the COVID-19 Pandemic at Duke University Medical Center: A Novel Technique.

Journal Article J Arthroplasty · July 2020 Care for patients during COVID-19 poses challenges that require the protection of staff with recommendations that health care workers wear at minimum, an N95 mask or equivalent while performing an aerosol-generating procedure with a face shield. The United ... Full text Open Access Link to item Cite

Pediatric medical device development by surgeons via capstone engineering design programs.

Journal Article Journal of pediatric surgery · March 2018 BackgroundThere is a need for pediatric medical devices that accommodate the unique physiology and anatomy of pediatric patients that is increasingly receiving more attention. However, there is limited literature on the programs within children's ... Full text Cite

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine.

Journal Article Journal of visualized experiments : JoVE · July 2016 To date, many pharmacological agents used to treat or prevent arrhythmias in open-heart cases create undesired systemic side effects. For example, antiarrhythmic drugs administered intravenously can produce drops in systemic pressure in the already comprom ... Full text Cite

The pericardium

Chapter · January 1, 2015 The pericardium is a unique structure that surrounds the heart and serves several important physiological roles. The removal of the pericardium, certain pericardial disorders, or the buildup of fluids within this space will ultimately alter hemodynamic per ... Full text Cite

Cardiac responses to the intrapericardial delivery of metoprolol: targeted delivery compared to intravenous administration.

Journal Article Journal of cardiovascular translational research · August 2012 Anti-arrhythmic drugs have narrow therapeutic ranges and typically can engender harmful side effects. The intrapericardial (IP) delivery of anti-arrhythmic agents proposes to achieve higher myocardial levels while minimizing plasma concentrations, thus dim ... Full text Cite

Electrophysiological mechanisms of the anti-arrhythmic effects of omega-3 fatty acids.

Journal Article Journal of cardiovascular translational research · February 2011 Heart rhythm disorders, or arrhythmias, are a leading cause of morbidity and mortality worldwide. Omega-3 polyunsaturated fatty acids (ω3PUFAs), commonly found in fish oils and plant seeds, have recently emerged as potential anti-arrhythmic agents. The pur ... Full text Cite

Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking.

Journal Article Sheng li xue bao : [Acta physiologica Sinica] · February 2010 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels modulate and regulate cardiac rhythm and rate. It has been suggested that, unlike the HCN1 and HCN2 channels, the slower HCN4 channel may not exhibit voltage-dependent hysteresis. We st ... Cite

Not every bulb is a rose: a functional comparison of bulb suction devices.

Journal Article The Journal of surgical research · October 2009 BackgroundNot all closed drainage suction bulbs are equivalent, and there may be a discrepancy between purported and observed clinical efficacy. We evaluated four popular bulb suction apparati to directly compare their maximum attainable suction, ... Full text Cite

Over-pressure suppresses ultrasonic-induced drug uptake.

Journal Article Ultrasound in medicine & biology · March 2009 Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent drug or gene uptake by the cell. ... Full text Cite

A novel combination therapy for post-operative arrhythmias

Journal Article Journal of Medical Devices, Transactions of the ASME · January 1, 2009 Full text Cite

Design of a novel perfusion system to perform mr imaging of an isolated beating heart

Journal Article Journal of Medical Devices, Transactions of the ASME · January 1, 2009 Full text Cite

Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias.

Journal Article American journal of physiology. Heart and circulatory physiology · May 2008 Basic and clinical evidence suggests that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) decrease fatal arrhythmias and infarct sizes. This study investigated if pericardial delivery of n-3 PUFAs would protect the myocardium from ischemic damages and ar ... Full text Cite

The role of cavitation in liposome formation.

Journal Article Biophysical journal · December 2007 Liposome size is a vital parameter of many quantitative biophysical studies. Sonication, or exposure to ultrasound, is used widely to manufacture artificial liposomes, yet little is known about the mechanism by which liposomes are affected by ultrasound. C ... Full text Cite

Reducing liposome size with ultrasound: bimodal size distributions.

Journal Article Journal of liposome research · January 2006 Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when s ... Full text Cite

The pericardium

Chapter · December 1, 2005 The pericardium is a unique structure that surrounds the heart and serves several important physiological roles; the removal of the pericardium, certain pericardial disorders, or the build-up of fluids within this space will ultimately alter hemodynamic pe ... Full text Cite

Animal Models for Cardiac Valve Research

Chapter · January 1, 2023 The modern era of cardiac valve repair and replacement has its foundations rooted in the pioneering research completed by surgeons, scientists, and engineers in animal research laboratories. Today, animal models are required for the preclinical assessment ... Full text Cite

One Small Step for a Patient, One Giant Leap for Orthostatic Hypotension.

Journal Article Cureus · November 2022 A 52-year-old man with ischemic cardiomyopathy presented with progressive, severe orthostatic hypotension refractory to medical therapy. Standard abdominal and leg compression devices were used without success. A novel, inflatable abdominal compression dev ... Full text Open Access Link to item Cite

A Portable Negative Pressure Isolation System as a Solution to Minimize Exposure of Health Care Providers to Infectious Pathogens.

Journal Article Am Surg · August 2022 The COVID-19 pandemic has resulted in the exposure of many surgeons and healthcare providers (HCPs) to disease given high patient loads and limited availability of negative pressure rooms. For these reasons we pursued the development of a portable patient ... Full text Link to item Cite

Quantifying the forces needed for ureteral stent removal: Initial evaluation of magnetic stent removal devices on benchtop and porcine models.

Journal Article Journal of pediatric urology · October 2020 BackgroundIndwelling ureteral stents are commonly used in pediatric surgeries for kidney stones and urinary tract obstruction, but often require instrumentation or anesthesia for removal. We evaluated the use of novel magnet devices to remove indw ... Full text Cite

Helmet Modification to PPE With 3D Printing During the COVID-19 Pandemic at Duke University Medical Center: A Novel Technique.

Journal Article J Arthroplasty · July 2020 Care for patients during COVID-19 poses challenges that require the protection of staff with recommendations that health care workers wear at minimum, an N95 mask or equivalent while performing an aerosol-generating procedure with a face shield. The United ... Full text Open Access Link to item Cite

Pediatric medical device development by surgeons via capstone engineering design programs.

Journal Article Journal of pediatric surgery · March 2018 BackgroundThere is a need for pediatric medical devices that accommodate the unique physiology and anatomy of pediatric patients that is increasingly receiving more attention. However, there is limited literature on the programs within children's ... Full text Cite

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine.

Journal Article Journal of visualized experiments : JoVE · July 2016 To date, many pharmacological agents used to treat or prevent arrhythmias in open-heart cases create undesired systemic side effects. For example, antiarrhythmic drugs administered intravenously can produce drops in systemic pressure in the already comprom ... Full text Cite

The pericardium

Chapter · January 1, 2015 The pericardium is a unique structure that surrounds the heart and serves several important physiological roles. The removal of the pericardium, certain pericardial disorders, or the buildup of fluids within this space will ultimately alter hemodynamic per ... Full text Cite

Cardiac responses to the intrapericardial delivery of metoprolol: targeted delivery compared to intravenous administration.

Journal Article Journal of cardiovascular translational research · August 2012 Anti-arrhythmic drugs have narrow therapeutic ranges and typically can engender harmful side effects. The intrapericardial (IP) delivery of anti-arrhythmic agents proposes to achieve higher myocardial levels while minimizing plasma concentrations, thus dim ... Full text Cite

Electrophysiological mechanisms of the anti-arrhythmic effects of omega-3 fatty acids.

Journal Article Journal of cardiovascular translational research · February 2011 Heart rhythm disorders, or arrhythmias, are a leading cause of morbidity and mortality worldwide. Omega-3 polyunsaturated fatty acids (ω3PUFAs), commonly found in fish oils and plant seeds, have recently emerged as potential anti-arrhythmic agents. The pur ... Full text Cite

Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking.

Journal Article Sheng li xue bao : [Acta physiologica Sinica] · February 2010 The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels modulate and regulate cardiac rhythm and rate. It has been suggested that, unlike the HCN1 and HCN2 channels, the slower HCN4 channel may not exhibit voltage-dependent hysteresis. We st ... Cite

Not every bulb is a rose: a functional comparison of bulb suction devices.

Journal Article The Journal of surgical research · October 2009 BackgroundNot all closed drainage suction bulbs are equivalent, and there may be a discrepancy between purported and observed clinical efficacy. We evaluated four popular bulb suction apparati to directly compare their maximum attainable suction, ... Full text Cite

Over-pressure suppresses ultrasonic-induced drug uptake.

Journal Article Ultrasound in medicine & biology · March 2009 Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent drug or gene uptake by the cell. ... Full text Cite

A novel combination therapy for post-operative arrhythmias

Journal Article Journal of Medical Devices, Transactions of the ASME · January 1, 2009 Full text Cite

Design of a novel perfusion system to perform mr imaging of an isolated beating heart

Journal Article Journal of Medical Devices, Transactions of the ASME · January 1, 2009 Full text Cite

Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias.

Journal Article American journal of physiology. Heart and circulatory physiology · May 2008 Basic and clinical evidence suggests that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) decrease fatal arrhythmias and infarct sizes. This study investigated if pericardial delivery of n-3 PUFAs would protect the myocardium from ischemic damages and ar ... Full text Cite

The role of cavitation in liposome formation.

Journal Article Biophysical journal · December 2007 Liposome size is a vital parameter of many quantitative biophysical studies. Sonication, or exposure to ultrasound, is used widely to manufacture artificial liposomes, yet little is known about the mechanism by which liposomes are affected by ultrasound. C ... Full text Cite

Reducing liposome size with ultrasound: bimodal size distributions.

Journal Article Journal of liposome research · January 2006 Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when s ... Full text Cite

The pericardium

Chapter · December 1, 2005 The pericardium is a unique structure that surrounds the heart and serves several important physiological roles; the removal of the pericardium, certain pericardial disorders, or the build-up of fluids within this space will ultimately alter hemodynamic pe ... Full text Cite

Ultrasonic drug release from micelles correlates with subharmonic emission

Conference AIChE Annual Meeting, Conference Proceedings · December 1, 2005 Cite

The role of cavitation in acoustically activated drug delivery.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · October 2005 Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this st ... Full text Cite