Scholars@Duke
Erin O'Kane

Scholarly Works

Spectroscopic correlation tomography (SpCT) for visualization of spatial correlations in volumetric OCT scans.

Journal article Biomed Opt Express · July 1, 2026 Spectroscopic optical coherence tomography (SOCT) allows for the targeted analysis of cell nuclei due to their spectrally distinct scattering properties. SOCT has been explored for optical biopsy based on its ability to extract structural and spectroscopic ... Full text Link to item Cite

Spectroscopic analysis of volumetric OCT data for the automated measurement of scatterer size.

Journal article Journal of the Optical Society of America. A, Optics, image science, and vision · September 2025 Spectroscopic optical coherence tomography enables an accurate estimation of scatterer size by computing the correlation distance (CD) function. For calibration and accuracy verification, polystyrene spheres are commonly used as size standards. However, an ... Full text Cite

Development of next generation low-cost OCT towards improved point-of-care retinal imaging.

Journal article Biomedical optics express · February 2025 Low-cost optical coherence tomography (OCT) has shown promise in increasing access to noninvasive retinal imaging at the point of care, especially in low-resource environments. A next-generation low-cost OCT system is presented which improves performance o ... Full text Cite

Correlation Tomography of Volumetric OCT Images Using HSV Color Space

Conference Clinical and Translational Biophotonics Translational 2025 in Proceedings Optica Biophotonics Congress 2025 Part of Optica Biophotonics Congress Optics in the Life Sciences · January 1, 2025 We propose a method for correlation tomography of scatterer signatures using spectroscopic OCT. We visualize spatial correlations of 5.3μm and 7.7μm polystyrene beads, and cell nuclei of A431 cells using HSV color space. ... Full text Cite

Deep learning classification of ex vivo human colon tissues using spectroscopic optical coherence tomography.

Journal article J Biophotonics · September 2024 Screening for colorectal cancer (CRC) with colonoscopy has improved patient outcomes; however, it remains the third leading cause of cancer-related mortality, novel strategies to improve screening are needed. Here, we propose an optical biopsy technique ba ... Full text Link to item Cite

Developing Methods for Characterizing Nuclear Signatures of Colon Polyps via Spectroscopic Optical Coherence Tomography

Conference Optical Coherence Tomography Oct 2024 in Proceedings Optica Biophotonics Congress Biomedical Optics 2024 Translational Microscopy Oct Ots Brain Part of Optica Biophotonics Congress Biomedical Optics · January 1, 2024 We propose the use of spectroscopic OCT to characterize nuclear signatures of colon polyps ex vivo for early colorectal cancer detection. We justify using SOCT by accurately measuring the size of 4.78 µm polystyrene beads. ... Cite