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Felipe Medeiros

Adjunct Professor of Ophthalmology
Ophthalmology, Glaucoma

Selected Publications


Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Journal Article Ophthalmology · June 2024 PURPOSE: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months in the Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study. DESIGN: Prospective cohort ... Full text Link to item Cite

Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma.

Conference Br J Ophthalmol · April 15, 2024 BACKGROUND/AIMS: Although obesity, tobacco and alcohol consumption were linked to the progression of numerous chronic diseases, an association of these social history aspects with glaucoma progression is not yet determined. This study aims to investigate t ... Full text Link to item Cite

Association between statin use and rates of structural and functional loss in glaucoma.

Journal Article Br J Ophthalmol · September 2023 BACKGROUND/AIMS: To evaluate the association between statin use and rates of standard automated perimetry (SAP) and retinal nerve fibre layer (RNFL) change in patients with glaucoma and glaucoma suspects. METHODS: This retrospective cohort study included s ... Full text Link to item Cite

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression.

Journal Article Ophthalmology · May 2023 PURPOSE: To investigate whether rates of standard automated perimetry (SAP) mean deviation (MD) over an initial 2-year follow-up period were predictive of events of visual field progression over an extended follow-up. DESIGN: Longitudinal, prospective, obs ... Full text Link to item Cite

Comparison of 10-2 and 24-2 Perimetry to Diagnose Glaucoma Using OCT as an Independent Reference Standard.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To compare the performance of the 10-2 test versus 24-2 standard automated perimetry (SAP) test for the diagnosis of glaucoma using OCT as an independent standard for glaucomatous damage. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 137 ... Full text Link to item Cite

Association of an Objective Structural and Functional Reference Standard for Glaucoma with Quality of Life Outcomes.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To compare self-reported quality-of-life (QoL) outcomes of patients diagnosed as normal, glaucoma suspect, and glaucoma based on an objective reference standard for glaucomatous optic neuropathy (GON). DESIGN: Cross-sectional study. PARTICIPANTS: ... Full text Link to item Cite

Deep Learning-Assisted Detection of Glaucoma Progression in Spectral-Domain OCT.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To develop and validate a deep learning (DL) model for detection of glaucoma progression using spectral-domain (SD)-OCT measurements of retinal nerve fiber layer (RNFL) thickness. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 14 034 ... Full text Link to item Cite

The Definition of Glaucomatous Optic Neuropathy in Artificial Intelligence Research and Clinical Applications.

Journal Article Ophthalmol Glaucoma · 2023 OBJECTIVE: Although artificial intelligence (AI) models may offer innovative and powerful ways to use the wealth of data generated by diagnostic tools, there are important challenges related to their development and validation. Most notable is the lack of ... Full text Link to item Cite

Intraocular Pressure and Rates of Macular Thinning in Glaucoma.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To evaluate the effect of intraocular pressure (IOP) on the rates of macular thickness (ganglion cell layer [GCL] and ganglion cell-inner plexiform layer [GCIPL]) change over time measured by spectral-domain (SD) OCT. DESIGN: Retrospective cohort ... Full text Link to item Cite

Improved Prediction of Perimetric Loss in Glaucomatous Eyes Using Latent Class Mixed Modeling.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To evaluate whether the identification of distinct classes within a population of glaucoma patients improves estimates of future perimetric loss. DESIGN: Longitudinal cohort study. PARTICIPANTS: A total of 6558 eyes of 3981 subjects from the Duke ... Full text Link to item Cite

Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals.

Journal Article Br J Ophthalmol · August 2022 BACKGROUND/AIMS: To investigate racial differences in the variability of longitudinal visual field testing in a 'real-world' clinical population, evaluate how these differences are influenced by socioeconomic status, and estimate the impact of differences ... Full text Link to item Cite

A review of deep learning in structure and function in glaucoma

Journal Article Journal for Modeling in Ophthalmology · June 13, 2022 The relationship between structural damage and functional loss in glaucoma is of great importance for its diagnosis and management. The functional status is usually assessed through visual field examination, a subjective test that is burdensome and time-co ... Full text Cite

Corneal Hysteresis and Rates of Neuroretinal Rim Change in Glaucoma.

Journal Article Ophthalmol Glaucoma · 2022 PURPOSE: To evaluate the impact of corneal hysteresis (CH) as a risk factor for progressive neuroretinal rim loss in glaucoma, as measured by spectral-domain OCT of the Bruch's membrane opening minimum rim width (MRW). DESIGN: Prospective, observational co ... Full text Link to item Cite

Artificial Intelligence for Glaucoma: Creating and Implementing Artificial Intelligence for Disease Detection and Progression.

Conference Ophthalmol Glaucoma · 2022 On September 3, 2020, the Collaborative Community on Ophthalmic Imaging conducted its first 2-day virtual workshop on the role of artificial intelligence (AI) and related machine learning techniques in the diagnosis and treatment of various ophthalmic cond ... Full text Link to item Cite

Impact of anxiety and depression on progression to glaucoma among glaucoma suspects.

Journal Article Br J Ophthalmol · September 2021 AIMS: To assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time. METHODS: The study included a retrospective cohort of subjects with diagnosis of glaucoma suspect at baseline, e ... Full text Link to item Cite

Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning.

Journal Article Ophthalmology · March 2021 PURPOSE: To investigate whether predictions of retinal nerve fiber layer (RNFL) thickness obtained from a deep learning model applied to fundus photographs can detect progressive glaucomatous changes over time. DESIGN: Retrospective cohort study. PARTICIPA ... Full text Link to item Cite

Impact of Intraocular Pressure Control on Rates of Retinal Nerve Fiber Layer Loss in a Large Clinical Population.

Journal Article Ophthalmology · January 2021 PURPOSE: To investigate the impact of intraocular pressure (IOP) control on rates of change of spectral-domain OCT (SD-OCT) retinal nerve fiber layer (RNFL) thickness in a large clinical population. DESIGN: Retrospective cohort study. PARTICIPANTS: A total ... Full text Link to item Cite

Interests and needs of eye care providers in clinical decision support for glaucoma.

Journal Article BMJ Open Ophthalmol · 2021 OBJECTIVE: To study whether clinicians who treat glaucoma are interested in using clinical decision support (CDS) tools for glaucoma, what glaucoma clinical decisions they feel would benefit from CDS, and what characteristics of CDS design they feel would ... Full text Link to item Cite

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).

Journal Article Ophthalmology · December 2020 PURPOSE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. DESIGN: Randomized, 2 ... Full text Link to item Cite

The Effect of Age on Increasing Susceptibility to Retinal Nerve Fiber Layer Loss in Glaucoma.

Journal Article Invest Ophthalmol Vis Sci · November 2, 2020 PURPOSE: To determine whether aging modifies the effect of intraocular pressure (IOP) on progressive glaucomatous retinal nerve fiber layer (RNFL) thinning over time. METHODS: This was a retrospective cohort study involving patients with glaucoma or suspec ... Full text Open Access Link to item Cite

Short-term Detection of Fast Progressors in Glaucoma: The Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study.

Journal Article Ophthalmology · June 2024 PURPOSE: To evaluate the performance of an intensive, clustered testing approach in identifying eyes with rapid glaucoma progression over 6 months in the Fast Progression Assessment through Clustered Evaluation (Fast-PACE) Study. DESIGN: Prospective cohort ... Full text Link to item Cite

Social history and glaucoma progression: the effect of body mass index, tobacco and alcohol consumption on the rates of structural change in patients with glaucoma.

Conference Br J Ophthalmol · April 15, 2024 BACKGROUND/AIMS: Although obesity, tobacco and alcohol consumption were linked to the progression of numerous chronic diseases, an association of these social history aspects with glaucoma progression is not yet determined. This study aims to investigate t ... Full text Link to item Cite

Association between statin use and rates of structural and functional loss in glaucoma.

Journal Article Br J Ophthalmol · September 2023 BACKGROUND/AIMS: To evaluate the association between statin use and rates of standard automated perimetry (SAP) and retinal nerve fibre layer (RNFL) change in patients with glaucoma and glaucoma suspects. METHODS: This retrospective cohort study included s ... Full text Link to item Cite

Validation of Rates of Mean Deviation Change as Clinically Relevant End Points for Glaucoma Progression.

Journal Article Ophthalmology · May 2023 PURPOSE: To investigate whether rates of standard automated perimetry (SAP) mean deviation (MD) over an initial 2-year follow-up period were predictive of events of visual field progression over an extended follow-up. DESIGN: Longitudinal, prospective, obs ... Full text Link to item Cite

Comparison of 10-2 and 24-2 Perimetry to Diagnose Glaucoma Using OCT as an Independent Reference Standard.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To compare the performance of the 10-2 test versus 24-2 standard automated perimetry (SAP) test for the diagnosis of glaucoma using OCT as an independent standard for glaucomatous damage. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 137 ... Full text Link to item Cite

Association of an Objective Structural and Functional Reference Standard for Glaucoma with Quality of Life Outcomes.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To compare self-reported quality-of-life (QoL) outcomes of patients diagnosed as normal, glaucoma suspect, and glaucoma based on an objective reference standard for glaucomatous optic neuropathy (GON). DESIGN: Cross-sectional study. PARTICIPANTS: ... Full text Link to item Cite

Deep Learning-Assisted Detection of Glaucoma Progression in Spectral-Domain OCT.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To develop and validate a deep learning (DL) model for detection of glaucoma progression using spectral-domain (SD)-OCT measurements of retinal nerve fiber layer (RNFL) thickness. DESIGN: Retrospective cohort study. PARTICIPANTS: A total of 14 034 ... Full text Link to item Cite

The Definition of Glaucomatous Optic Neuropathy in Artificial Intelligence Research and Clinical Applications.

Journal Article Ophthalmol Glaucoma · 2023 OBJECTIVE: Although artificial intelligence (AI) models may offer innovative and powerful ways to use the wealth of data generated by diagnostic tools, there are important challenges related to their development and validation. Most notable is the lack of ... Full text Link to item Cite

Intraocular Pressure and Rates of Macular Thinning in Glaucoma.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To evaluate the effect of intraocular pressure (IOP) on the rates of macular thickness (ganglion cell layer [GCL] and ganglion cell-inner plexiform layer [GCIPL]) change over time measured by spectral-domain (SD) OCT. DESIGN: Retrospective cohort ... Full text Link to item Cite

Improved Prediction of Perimetric Loss in Glaucomatous Eyes Using Latent Class Mixed Modeling.

Journal Article Ophthalmol Glaucoma · 2023 PURPOSE: To evaluate whether the identification of distinct classes within a population of glaucoma patients improves estimates of future perimetric loss. DESIGN: Longitudinal cohort study. PARTICIPANTS: A total of 6558 eyes of 3981 subjects from the Duke ... Full text Link to item Cite

Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals.

Journal Article Br J Ophthalmol · August 2022 BACKGROUND/AIMS: To investigate racial differences in the variability of longitudinal visual field testing in a 'real-world' clinical population, evaluate how these differences are influenced by socioeconomic status, and estimate the impact of differences ... Full text Link to item Cite

A review of deep learning in structure and function in glaucoma

Journal Article Journal for Modeling in Ophthalmology · June 13, 2022 The relationship between structural damage and functional loss in glaucoma is of great importance for its diagnosis and management. The functional status is usually assessed through visual field examination, a subjective test that is burdensome and time-co ... Full text Cite

Corneal Hysteresis and Rates of Neuroretinal Rim Change in Glaucoma.

Journal Article Ophthalmol Glaucoma · 2022 PURPOSE: To evaluate the impact of corneal hysteresis (CH) as a risk factor for progressive neuroretinal rim loss in glaucoma, as measured by spectral-domain OCT of the Bruch's membrane opening minimum rim width (MRW). DESIGN: Prospective, observational co ... Full text Link to item Cite

Artificial Intelligence for Glaucoma: Creating and Implementing Artificial Intelligence for Disease Detection and Progression.

Conference Ophthalmol Glaucoma · 2022 On September 3, 2020, the Collaborative Community on Ophthalmic Imaging conducted its first 2-day virtual workshop on the role of artificial intelligence (AI) and related machine learning techniques in the diagnosis and treatment of various ophthalmic cond ... Full text Link to item Cite

Impact of anxiety and depression on progression to glaucoma among glaucoma suspects.

Journal Article Br J Ophthalmol · September 2021 AIMS: To assess the impact of anxiety and depression in the risk of converting to glaucoma in a cohort of glaucoma suspects followed over time. METHODS: The study included a retrospective cohort of subjects with diagnosis of glaucoma suspect at baseline, e ... Full text Link to item Cite

Detection of Progressive Glaucomatous Optic Nerve Damage on Fundus Photographs with Deep Learning.

Journal Article Ophthalmology · March 2021 PURPOSE: To investigate whether predictions of retinal nerve fiber layer (RNFL) thickness obtained from a deep learning model applied to fundus photographs can detect progressive glaucomatous changes over time. DESIGN: Retrospective cohort study. PARTICIPA ... Full text Link to item Cite

Impact of Intraocular Pressure Control on Rates of Retinal Nerve Fiber Layer Loss in a Large Clinical Population.

Journal Article Ophthalmology · January 2021 PURPOSE: To investigate the impact of intraocular pressure (IOP) control on rates of change of spectral-domain OCT (SD-OCT) retinal nerve fiber layer (RNFL) thickness in a large clinical population. DESIGN: Retrospective cohort study. PARTICIPANTS: A total ... Full text Link to item Cite

Interests and needs of eye care providers in clinical decision support for glaucoma.

Journal Article BMJ Open Ophthalmol · 2021 OBJECTIVE: To study whether clinicians who treat glaucoma are interested in using clinical decision support (CDS) tools for glaucoma, what glaucoma clinical decisions they feel would benefit from CDS, and what characteristics of CDS design they feel would ... Full text Link to item Cite

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).

Journal Article Ophthalmology · December 2020 PURPOSE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. DESIGN: Randomized, 2 ... Full text Link to item Cite

The Effect of Age on Increasing Susceptibility to Retinal Nerve Fiber Layer Loss in Glaucoma.

Journal Article Invest Ophthalmol Vis Sci · November 2, 2020 PURPOSE: To determine whether aging modifies the effect of intraocular pressure (IOP) on progressive glaucomatous retinal nerve fiber layer (RNFL) thinning over time. METHODS: This was a retrospective cohort study involving patients with glaucoma or suspec ... Full text Open Access Link to item Cite

The Relationship Between Asymmetries of Corneal Properties and Rates of Visual Field Progression in Glaucoma Patients.

Journal Article J Glaucoma · October 2020 UNLABELLED: PRéCIS:: In this study, asymmetries in corneal hysteresis (CH) between eyes of glaucoma patients were significantly associated with asymmetries in rates of visual field loss, suggesting a role of hysteresis as a risk factor for disease progress ... Full text Link to item Cite

Visual Field Outcomes in the Tube Versus Trabeculectomy Study.

Conference Ophthalmology · September 2020 PURPOSE: To describe visual field (VF) outcomes in the Tube Versus Trabeculectomy (TVT) Study. DESIGN: Cohort analysis of patients in a multicenter randomized clinical trial. PARTICIPANTS: A total of 122 eyes of 122 patients, with 61 eyes in both the tube ... Full text Link to item Cite

A Review of Deep Learning for Screening, Diagnosis, and Detection of Glaucoma Progression.

Journal Article Transl Vis Sci Technol · July 2020 UNLABELLED: Because of recent advances in computing technology and the availability of large datasets, deep learning has risen to the forefront of artificial intelligence, with performances that often equal, or sometimes even exceed, those of human subject ... Full text Link to item Cite

Specificity of various cluster criteria used for the detection of glaucomatous visual field abnormalities.

Journal Article Br J Ophthalmol · June 2020 PURPOSE: This study aimed to evaluate the specificity of commonly used cluster criteria for defining the presence of glaucomatous visual field abnormalities and the impact of variations in the criterion used. METHODS: This is an observational study includi ... Full text Link to item Cite

Assessment of a Segmentation-Free Deep Learning Algorithm for Diagnosing Glaucoma From Optical Coherence Tomography Scans.

Journal Article JAMA Ophthalmol · April 1, 2020 IMPORTANCE: Conventional segmentation of the retinal nerve fiber layer (RNFL) is prone to errors that may affect the accuracy of spectral-domain optical coherence tomography (SD-OCT) scans in detecting glaucomatous damage. OBJECTIVE: To develop a segmentat ... Full text Link to item Cite

Human Versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs.

Journal Article Am J Ophthalmol · March 2020 PURPOSE: To compare the diagnostic performance of human gradings vs predictions provided by a machine-to-machine (M2M) deep learning (DL) algorithm trained to quantify retinal nerve fiber layer (RNFL) damage on fundus photographs. DESIGN: Evaluation of a m ... Full text Link to item Cite

Artificial Intelligence Mapping of Structure to Function in Glaucoma.

Journal Article Transl Vis Sci Technol · March 2020 PURPOSE: To develop an artificial intelligence (AI)-based structure-function (SF) map relating retinal nerve fiber layer (RNFL) damage on spectral domain optical coherence tomography (SDOCT) to functional loss on standard automated perimetry (SAP). METHODS ... Full text Link to item Cite

Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.

Journal Article Am J Ophthalmol · February 2020 PURPOSE: To assess short- and long-term variability on standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT) in glaucoma. DESIGN: Prospective cohort. METHODS: Ordinary least squares linear regression of SAP mean devia ... Full text Link to item Cite

Quantification of Retinal Nerve Fibre Layer Thickness on Optical Coherence Tomography with a Deep Learning Segmentation-Free Approach.

Journal Article Sci Rep · January 15, 2020 This study describes a segmentation-free deep learning (DL) algorithm for measuring retinal nerve fibre layer (RNFL) thickness on spectral-domain optical coherence tomography (SDOCT). The study included 25,285 B-scans from 1,338 eyes of 706 subjects. Train ... Full text Link to item Cite

Sample Size Requirements of Glaucoma Clinical Trials When Using Combined Optical Coherence Tomography and Visual Field Endpoints.

Journal Article Sci Rep · December 11, 2019 Glaucoma clinical trials using visual field (VF) endpoints currently require large sample sizes because of the slowly-progressive nature of this disease. We sought to examine whether the combined use of VF testing and non-invasive optical coherence tomogra ... Full text Link to item Cite

Estimating Rates of Progression and Predicting Future Visual Fields in Glaucoma Using a Deep Variational Autoencoder.

Journal Article Sci Rep · December 2, 2019 In this manuscript we develop a deep learning algorithm to improve estimation of rates of progression and prediction of future patterns of visual field loss in glaucoma. A generalized variational auto-encoder (VAE) was trained to learn a low-dimensional re ... Full text Link to item Cite

Corneal Biomechanics and Visual Field Progression in Eyes with Seemingly Well-Controlled Intraocular Pressure.

Journal Article Ophthalmology · December 2019 PURPOSE: To investigate the incidence and risk factors for glaucomatous visual field progression in eyes with well-controlled intraocular pressure (IOP). DESIGN: Prospective cohort. PARTICIPANTS: A total of 460 eyes of 334 patients with glaucoma under trea ... Full text Link to item Cite

Deep Learning and Glaucoma Specialists: The Relative Importance of Optic Disc Features to Predict Glaucoma Referral in Fundus Photographs.

Journal Article Ophthalmology · December 2019 PURPOSE: To develop and validate a deep learning (DL) algorithm that predicts referable glaucomatous optic neuropathy (GON) and optic nerve head (ONH) features from color fundus images, to determine the relative importance of these features in referral dec ... Full text Link to item Cite

Racial Differences in the Association of Anterior Lamina Cribrosa Surface Depth and Glaucoma Severity in the African Descent and Glaucoma Evaluation Study (ADAGES).

Journal Article Invest Ophthalmol Vis Sci · October 1, 2019 PURPOSE: To determine if variation in anterior lamina cribrosa surface depth (ALCSD) differs between glaucoma patients of African (AD) and European descent (ED). METHODS: A total of 178 eyes from 123 glaucoma patients in the African Descent and Glaucoma Ev ... Full text Link to item Cite

Transnational review of visual standards for driving: How Australia compares with the rest of the world.

Journal Article Clin Exp Ophthalmol · September 2019 IMPORTANCE: Driving is a highly visual task and a primary mode of transportation for many people around the world. BACKGROUND: There appears to be little uniformity of vision standards across the world for driving. We reviewed the basic screening visual re ... Full text Link to item Cite

Detecting Retinal Nerve Fibre Layer Segmentation Errors on Spectral Domain-Optical Coherence Tomography with a Deep Learning Algorithm.

Journal Article Sci Rep · July 8, 2019 In this study we developed a deep learning (DL) algorithm that detects errors in retinal never fibre layer (RNFL) segmentation on spectral-domain optical coherence tomography (SDOCT) B-scans using human grades as the reference standard. A dataset of 25,250 ... Full text Link to item Cite

Is vision-related quality of life impaired in patients with preperimetric glaucoma?

Journal Article Br J Ophthalmol · July 2019 BACKGROUND/AIMS: To investigate whether subjects with preperimetric glaucoma exhibit decline in patient-reported vision-related quality of life (QoL) compared with healthy individuals. METHODS: This cross-sectional study included 45 patients with preperime ... Full text Link to item Cite

A Deep Learning Algorithm to Quantify Neuroretinal Rim Loss From Optic Disc Photographs.

Journal Article Am J Ophthalmol · May 2019 PURPOSE: To train a deep learning (DL) algorithm that quantifies glaucomatous neuroretinal damage on fundus photographs using the minimum rim width relative to Bruch membrane opening (BMO-MRW) from spectral-domain optical coherence tomography (SDOCT). DESI ... Full text Link to item Cite

Mobile Telephone Use and Reaction Time in Drivers With Glaucoma.

Journal Article JAMA Netw Open · April 5, 2019 IMPORTANCE: Combining mobile telephone use with driving is not unusual. However, distracted driving limits driving performance because of limited capacity for persons to divide attention. OBJECTIVES: To investigate the frequency of mobile telephone use whi ... Full text Link to item Cite

From Machine to Machine: An OCT-Trained Deep Learning Algorithm for Objective Quantification of Glaucomatous Damage in Fundus Photographs.

Journal Article Ophthalmology · April 2019 PURPOSE: Previous approaches using deep learning (DL) algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using quantitative spectra ... Full text Link to item Cite

Visual Crowding in Glaucoma.

Journal Article Invest Ophthalmol Vis Sci · February 1, 2019 PURPOSE: Crowding refers to the phenomenon in which objects that can be recognized when viewed in isolation are unrecognizable in clutter. Crowding sets a fundamental limit to the capabilities of the peripheral vision and is essential in explaining perform ... Full text Open Access Link to item Cite

Association between Rates of Visual Field Progression and Intraocular Pressure Measurements Obtained by Different Tonometers.

Journal Article Ophthalmology · January 2019 PURPOSE: To investigate the associations between intraocular pressure (IOP) measurements obtained by different tonometric methods and rates of visual field loss in a cohort of patients with glaucoma followed over time. DESIGN: Prospective, observational co ... Full text Link to item Cite

The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.

Journal Article Ophthalmology · January 2019 PURPOSE: To describe the study protocol and baseline characteristics of the African Descent and Glaucoma Evaluation Study (ADAGES) III. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: Three thousand two hundred sixty-six glaucoma patients and co ... Full text Link to item Cite

Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III.

Journal Article Ophthalmology · January 2019 PURPOSE: To find genetic contributions to glaucoma in African Americans. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: One thousand eight hundred seventy-five primary open-angle glaucoma (POAG) patients and 1709 controls, self-identified as be ... Full text Link to item Cite

What Is the Amount of Visual Field Loss Associated With Disability in Glaucoma?

Journal Article Am J Ophthalmol · January 2019 PURPOSE: To propose a new methodology for classifying patient-reported outcomes in glaucoma and for quantifying the amount of visual field damage associated with disability in the disease. DESIGN: Cross-sectional study. METHODS: A total of 263 patients wit ... Full text Link to item Cite

Assessing driving risk in patients with glaucoma.

Journal Article Arq Bras Oftalmol · 2019 Glaucoma is the leading cause of irreversible blindness worldwide and can affect a broad array of daily activities, including driving. Recently, studies investigating the relationship between driving performance and glaucoma have received a great deal of i ... Full text Link to item Cite

Psychometric properties of the Portuguese version of the National Eye Institute Visual Function Questionnaire-25.

Journal Article PLoS One · 2019 BACKGROUND: To investigate the psychometric properties of the Brazilian Portuguese version of the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) questionnaire in a group of patients with different eye diseases. METHODS: Cross-sectional s ... Full text Link to item Cite

Performance of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma.

Journal Article Am J Ophthalmol · December 2018 PURPOSE: To compare the performance of the pattern standard deviation (PSD) values derived from the central 12 locations of the 24-2 visual field test (C24-2) to the entire 10-2 test for detecting central visual field abnormalities in eyes with, suspected ... Full text Link to item Cite

Reply.

Journal Article Am J Ophthalmol · November 2018 Full text Link to item Cite

Use of Machine Learning on Contact Lens Sensor-Derived Parameters for the Diagnosis of Primary Open-angle Glaucoma.

Journal Article Am J Ophthalmol · October 2018 PURPOSE: To test the hypothesis that contact lens sensor (CLS)-based 24-hour profiles of ocular volume changes contain information complementary to intraocular pressure (IOP) to discriminate between primary open-angle glaucoma (POAG) and healthy (H) eyes. ... Full text Link to item Cite

Macular Pigment and Visual Function in Patients With Glaucoma: The San Diego Macular Pigment Study.

Journal Article Invest Ophthalmol Vis Sci · September 4, 2018 PURPOSE: Although recent studies have shown that macular pigment (MP) is significantly lower in glaucoma patients, this relationship merits further investigation. METHODS: This cross-sectional study included 85 glaucoma patients and 22 controls. All subjec ... Full text Link to item Cite

Event-based analysis of visual field change can miss fast glaucoma progression detected by a combined structure and function index.

Journal Article Graefes Arch Clin Exp Ophthalmol · July 2018 PURPOSE: To investigate the relationship between progression assessed by the visual field guided progression analysis (GPA) and rates of structural and functional change in glaucoma eyes. METHODS: This was a longitudinal observational study of 135 eyes of ... Full text Link to item Cite

Automated Beta Zone Parapapillary Area Measurement to Differentiate Between Healthy and Glaucoma Eyes.

Journal Article Am J Ophthalmol · July 2018 PURPOSE: To evaluate whether automated assessment of beta zone parapapillary atrophy (βPPA) area can differentiate between glaucomatous and healthy eyes of varying axial lengths (AL). DESIGN: Cross-sectional study. METHODS: βPPA was automatically identifie ... Full text Link to item Cite

Comparison of visual field point-wise event-based and global trend-based analysis for detecting glaucomatous progression

Journal Article Translational Vision Science and Technology · July 1, 2018 Purpose: To compare global trend-based and point-wise event-based analysis for detecting visual field progression in eyes with glaucoma. Methods: The study included a cohort of 367 glaucoma eyes from 265 participants seen over a mean follow-up period of 10 ... Full text Cite

Retinal Nerve Fiber Layer Features Identified by Unsupervised Machine Learning on Optical Coherence Tomography Scans Predict Glaucoma Progression.

Journal Article Invest Ophthalmol Vis Sci · June 1, 2018 PURPOSE: To apply computational techniques to wide-angle swept-source optical coherence tomography (SS-OCT) images to identify novel, glaucoma-related structural features and improve detection of glaucoma and prediction of future glaucomatous progression. ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · June 2018 Full text Link to item Cite

Development of a visual field simulation model of longitudinal point-wise sensitivity changes from a clinical glaucoma cohort

Journal Article Translational Vision Science and Technology · May 1, 2018 Purpose: To develop a new visual field simulation model that can recreate real-world longitudinal results at a point-wise level from a clinical glaucoma cohort. Methods: A cohort of 367 glaucoma eyes from 265 participants seen over 10.1 6 2.5 years were in ... Full text Cite

Detection of Glaucoma Progression in Individuals of African Descent Compared With Those of European Descent.

Journal Article JAMA Ophthalmol · April 1, 2018 IMPORTANCE: Individuals of African descent have been reported to be at higher risk for becoming visually impaired from glaucoma compared with individuals of European descent. OBJECTIVE: To investigate racial differences in longitudinal visual field variabi ... Full text Link to item Cite

Impact of Different Visual Field Testing Paradigms on Sample Size Requirements for Glaucoma Clinical Trials.

Journal Article Sci Rep · March 20, 2018 Visual field testing is an important endpoint in glaucoma clinical trials, and the testing paradigm used can have a significant impact on the sample size requirements. To investigate this, this study included 353 eyes of 247 glaucoma patients seen over a 3 ... Full text Link to item Cite

The Association Between Macula and ONH Optical Coherence Tomography Angiography (OCT-A) Vessel Densities in Glaucoma, Glaucoma Suspect, and Healthy Eyes.

Journal Article J Glaucoma · March 2018 PURPOSE: To evaluate strength of associations between optical coherence tomography (OCT)-angiography vessel density (VD) measurements in the macula and peripapillary region of the optic nerve head (ONH) with standard structural OCT thickness measures. MATE ... Full text Link to item Cite

Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis.

Journal Article Br J Ophthalmol · March 2018 AIM: To compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch's membrane opening minimum rim width (BMO-MRW). METHODS: Sixty healthy eyes and 189 glaucomatous eyes were included. Th ... Full text Link to item Cite

Recent developments in visual field testing for glaucoma.

Journal Article Curr Opin Ophthalmol · March 2018 PURPOSE OF REVIEW: Visual field testing remains one of the most important tools for characterizing and monitoring vision loss in glaucoma. Despite its current mainstream use, new developments continue to emerge on its current use and potentially better met ... Full text Link to item Cite

Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss.

Journal Article Am J Ophthalmol · March 2018 PURPOSE: Central visual field (VF) damage in glaucoma patients can significantly hinder daily activities. The present study investigates whether the presence of localized baseline damage to the central 10 degrees of the VF is predictive of faster global me ... Full text Link to item Cite

A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma.

Journal Article Am J Ophthalmol · March 2018 PURPOSE: To investigate the role of corneal hysteresis (CH) as a risk factor for development of glaucoma. DESIGN: Prospective observational cohort study. METHODS: Two hundred and eighty-seven eyes of 199 patients suspected of having glaucoma were followed ... Full text Link to item Cite

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.

Journal Article Invest Ophthalmol Vis Sci · February 1, 2018 PURPOSE: Sex hormones may be associated with primary open-angle glaucoma (POAG), although the mechanisms are unclear. We previously observed that gene variants involved with estrogen metabolism were collectively associated with POAG in women but not men; h ... Full text Link to item Cite

A Longitudinal Analysis of Peripapillary Choroidal Thinning in Healthy and Glaucoma Subjects.

Journal Article Am J Ophthalmol · February 2018 PURPOSE: To evaluate the rate of peripapillary choroidal thinning in glaucoma patients and healthy controls using spectral domain optical coherence tomography. DESIGN: Cohort study. METHODS: Participants from the multicenter African Descent and Glaucoma Ev ... Full text Link to item Cite

Automated algorithms combining structure and function outperform general ophthalmologists in diagnosing glaucoma.

Journal Article PLoS One · 2018 PURPOSE: To test the ability of machine learning classifiers (MLCs) using optical coherence tomography (OCT) and standard automated perimetry (SAP) parameters to discriminate between healthy and glaucomatous individuals, and to compare it to the diagnostic ... Full text Link to item Cite

Predicting Vision-Related Disability in Glaucoma.

Journal Article Ophthalmology · January 2018 PURPOSE: To present a new methodology for investigating predictive factors associated with development of vision-related disability in glaucoma. DESIGN: Prospective, observational cohort study. PARTICIPANTS: Two hundred thirty-six patients with glaucoma fo ... Full text Link to item Cite

Detecting Structural Progression in Glaucoma with Optical Coherence Tomography.

Journal Article Ophthalmology · December 2017 Optical coherence tomography (OCT) is increasingly used to obtain objective measurements of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma progression. Although OCT has been adopted widely in clinical practice, un ... Full text Link to item Cite

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis.

Journal Article Eur J Hum Genet · November 2017 Primary open-angle glaucoma (POAG) is the most common chronic optic neuropathy worldwide. Epidemiological studies show a robust positive relation between intraocular pressure (IOP) and POAG and modest positive association between IOP and blood pressure (BP ... Full text Link to item Cite

24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma.

Journal Article Ophthalmology · October 2017 PURPOSE: To investigate the prevalence of visual field defects in glaucomatous eyes, glaucoma suspects, and ocular hypertensives with 24-2 and 10-2 visual fields. DESIGN: Prospective, cross-sectional study. PARTICIPANTS: Patients with or suspected glaucoma ... Full text Link to item Cite

Impact of Normal Aging and Progression Definitions on the Specificity of Detecting Retinal Nerve Fiber Layer Thinning.

Journal Article Am J Ophthalmol · September 2017 PURPOSE: To evaluate the specificity of current definitions used to identify progressive change of the average peripapillary retinal nerve fiber layer (RNFL) thickness measurements obtained on optical coherence tomography (OCT) imaging. DESIGN: Prospective ... Full text Link to item Cite

Association Between Neurocognitive Decline and Visual Field Variability in Glaucoma.

Journal Article JAMA Ophthalmol · July 1, 2017 IMPORTANCE: Visual field variability may impair detection of glaucoma progression over time. Despite the possible overlap between neurocognitive disorders and glaucoma in older individuals, no study has investigated the association between cognitive change ... Full text Link to item Cite

Wayfinding and Glaucoma: A Virtual Reality Experiment.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2017 PURPOSE: Wayfinding, the process of determining and following a route between an origin and a destination, is an integral part of everyday tasks. The purpose of this study was to investigate the impact of glaucomatous visual field loss on wayfinding behavi ... Full text Link to item Cite

Detecting Glaucoma With a Portable Brain-Computer Interface for Objective Assessment of Visual Function Loss.

Journal Article JAMA Ophthalmol · June 1, 2017 IMPORTANCE: The current assessment of visual field loss in diseases such as glaucoma is affected by the subjectivity of patient responses and the lack of portability of standard perimeters. OBJECTIVE: To describe the development and initial validation of a ... Full text Link to item Cite

β-Zone Parapapillary Atrophy and Rates of Glaucomatous Visual Field Progression: African Descent and Glaucoma Evaluation Study.

Journal Article JAMA Ophthalmol · June 1, 2017 IMPORTANCE: β-zone parapapillary atrophy (βPPA) has been reported as a risk factor for glaucoma onset and progression. Previous studies have shown that the prevalence of βPPA differs between individuals of African descent (AD) and European descent (ED). OB ... Full text Link to item Cite

Comparing the Rates of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Loss in Healthy Eyes and in Glaucoma Eyes.

Journal Article Am J Ophthalmol · June 2017 PURPOSE: To compare the rates of circumpapillary retinal nerve fiber layer (RNFL) and macular retinal ganglion cell-inner plexiform layer (GCIPL) change over time in healthy and glaucoma eyes. DESIGN: Cohort study. METHODS: The rates of circumpapillary RNF ... Full text Link to item Cite

Frequency of Testing to Detect Visual Field Progression Derived Using a Longitudinal Cohort of Glaucoma Patients.

Journal Article Ophthalmology · June 2017 PURPOSE: To determine the time required to detect statistically significant progression for different rates of visual field loss using standard automated perimetry (SAP) when considering different frequencies of testing using a follow-up scheme that resemb ... Full text Link to item Cite

Decade-Long Profile of Imaging Biomarker Use in Ophthalmic Clinical Trials.

Journal Article Invest Ophthalmol Vis Sci · May 1, 2017 PURPOSE: The purpose of this study was to investigate the use of imaging biomarkers in published clinical trials (CTs) in ophthalmology and its eventual changes during the past 10 years. METHODS: We sampled from published CTs in the fields of cornea, retin ... Full text Link to item Cite

Biomarkers and Surrogate Endpoints: Lessons Learned From Glaucoma.

Journal Article Invest Ophthalmol Vis Sci · May 1, 2017 With the recent progress in imaging technologies for assessment of structural damage in glaucoma, a debate has emerged on whether these measurements can be used as valid surrogate endpoints in clinical trials evaluating new therapies for the disease. A dis ... Full text Link to item Cite

Peripapillary and Macular Vessel Density in Patients with Glaucoma and Single-Hemifield Visual Field Defect.

Journal Article Ophthalmology · May 2017 PURPOSE: To compare hemifield differences in the vessel density of the peripapillary and macula in open-angle glaucoma eyes with visual field (VF) defect confined to one hemifield using optical coherence tomography angiography (OCT-A). DESIGN: Cross-sectio ... Full text Link to item Cite

Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma.

Journal Article Am J Ophthalmol · March 2017 PURPOSE: "Floor effects" in retinal imaging are defined as the points at which no further structural loss can be detected. We estimated the measurement floors for spectral-domain optical coherence tomography (SDOCT) measurements and compared global change ... Full text Link to item Cite

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.

Journal Article Menopause · February 2017 OBJECTIVE: Several attributes of female reproductive history, including age at natural menopause (ANM), have been related to primary open-angle glaucoma (POAG). We assembled 18 previously reported common genetic variants that predict ANM to determine their ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · February 2017 Full text Link to item Cite

Fear of falling and postural reactivity in patients with glaucoma.

Journal Article PLoS One · 2017 PURPOSE: To investigate the relationship between postural metrics obtained by dynamic visual stimulation in a virtual reality environment and the presence of fear of falling in glaucoma patients. METHODS: This cross-sectional study included 35 glaucoma pat ... Full text Link to item Cite

Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma.

Journal Article Ophthalmology · December 2016 PURPOSE: To investigate factors associated with dropout of the parapapillary deep retinal layer microvasculature assessed by optical coherence tomography angiography (OCTA) in glaucomatous eyes. DESIGN: Cross-sectional study. PARTICIPANTS: Seventy-one eyes ... Full text Link to item Cite

Relationship between Optical Coherence Tomography Angiography Vessel Density and Severity of Visual Field Loss in Glaucoma.

Journal Article Ophthalmology · December 2016 PURPOSE: To evaluate the association between vessel density measurements using optical coherence tomography angiography (OCT-A) and severity of visual field loss in primary open-angle glaucoma. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A ... Full text Link to item Cite

Glaucoma and driving risk under simulated fog conditions

Journal Article Translational Vision Science and Technology · November 1, 2016 Purpose: We evaluate driving risk under simulated fog conditions in glaucoma and healthy subjects. Methods: This cross-sectional study included 41 glaucoma patients and 25 agematched healthy subjects who underwent driving simulation. Tests consisted of cur ... Full text Cite

Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects.

Journal Article Ophthalmology · November 2016 PURPOSE: To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: A total of 82 pa ... Full text Link to item Cite

Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography.

Conference Ophthalmology · October 2016 PURPOSE: To evaluate the relationship between intraocular pressure (IOP) and rates of retinal nerve fiber layer (RNFL) thickness change over time measured by spectral-domain (SD) optical coherence tomography (OCT). DESIGN: Observational cohort study. PARTI ... Full text Link to item Cite

Primary open-angle glaucoma

Journal Article Nature Reviews Disease Primers · September 22, 2016 Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible blindness worldwide, but typically remains asymptomatic until very severe. Op ... Full text Cite

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses.

Journal Article Invest Ophthalmol Vis Sci · September 1, 2016 PURPOSE: Recent studies indicate that mitochondrial proteins may contribute to the pathogenesis of primary open-angle glaucoma (POAG). In this study, we examined the association between POAG and common variations in gene-encoding mitochondrial proteins. ME ... Full text Link to item Cite

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.

Journal Article Invest Ophthalmol Vis Sci · August 1, 2016 PURPOSE: Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated with primary open-angle glaucoma (POAG). METHODS: Using the NEIGHBORHOOD data set (3853 ... Full text Link to item Cite

Association of Fast Visual Field Loss With Risk of Falling in Patients With Glaucoma.

Journal Article JAMA Ophthalmol · August 1, 2016 IMPORTANCE: Patients with glaucoma and a history of fast visual field loss might be at an increased risk for falls compared with those with a history of slow visual field loss, but, to date, this association has not been previously investigated in the lite ... Full text Link to item Cite

Comparison of Latanoprostene Bunod 0.024% and Timolol Maleate 0.5% in Open-Angle Glaucoma or Ocular Hypertension: The LUNAR Study.

Journal Article Am J Ophthalmol · August 2016 PURPOSE: To compare the intraocular pressure (IOP)-lowering effect of latanoprostene bunod (LBN) 0.024% with timolol maleate 0.5% in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). DESIGN: Prospective, randomized, double-masked, paral ... Full text Link to item Cite

Structural Change Can Be Detected in Advanced-Glaucoma Eyes.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: To compare spectral-domain optical coherence tomography (SD-OCT) standard structural measures and a new three-dimensional (3D) volume optic nerve head (ONH) change detection method for detecting change over time in severely advanced-glaucoma (open ... Full text Link to item Cite

The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The purpose of this study was to evaluate the effect of disease severity and number of tests acquired during follow-up on the relative odds of identifying progression by structural or functional tests in glaucoma. METHODS: This was an observationa ... Full text Link to item Cite

Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The purpose of this study was to compare retinal nerve fiber layer (RNFL) thickness and optical coherence tomography angiography (OCT-A) retinal vasculature measurements in healthy, glaucoma suspect, and glaucoma patients. METHODS: Two hundred six ... Full text Link to item Cite

African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy.

Journal Article Ophthalmology · July 2016 PURPOSE: To investigate the differences in the frequency of optic disc hemorrhage (DH) and prevalence of beta-zone parapapillary atrophy (βPPA) between individuals of African descent (AD) and European descent (ED). DESIGN: Prospective, multicenter, observa ... Full text Link to item Cite

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Journal Article Ophthalmology · June 1, 2016 Full text Cite

Corneal Hysteresis and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma.

Journal Article Am J Ophthalmol · June 2016 PURPOSE: To investigate the relationship between corneal hysteresis (CH) and progressive retinal nerve fiber layer (RNFL) loss in a cohort of patients with glaucoma followed prospectively over time. DESIGN: Prospective observational cohort study. METHODS: ... Full text Link to item Cite

What rates of glaucoma progression are clinically significant?

Journal Article Expert Review of Ophthalmology · May 3, 2016 ABSTRACT: Introduction: Clinically important rates of glaucoma progression (worsening) are ones that put a patient at risk of future functional impairment or reduction of vision-related quality of life (VRQoL). Most treated eyes do not progress at rates th ... Full text Cite

Unsupervised Gaussian mixture-model with expectation maximization for detecting glaucomatous progression in standard automated perimetry visual fields

Journal Article Translational Vision Science and Technology · May 1, 2016 Purpose. To validate Gaussian mixture-model with expectation maximization (GEM) and variational Bayesian independent component analysis mixture-models (VIM) for detecting glaucomatous progression along visual field (VF) defect patterns (GEM– progression of ... Full text Cite

Asymmetric Macular Structural Damage Is Associated With Relative Afferent Pupillary Defects in Patients With Glaucoma.

Journal Article Invest Ophthalmol Vis Sci · April 2016 PURPOSE: We examined the relationship between relative afferent pupillary defects (RAPDs) and macular structural damage measured by macular thickness and macular ganglion cell-inner plexiform layer (mGCIPL) thickness in patients with glaucoma. METHODS: A c ... Full text Link to item Cite

Fast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucoma.

Journal Article Ophthalmology · April 2016 PURPOSE: To evaluate the association between the rates of progressive visual field loss and the occurrence of depressive symptoms in patients with glaucoma followed over time. DESIGN: Prospective observational cohort study. PARTICIPANTS: The study included ... Full text Link to item Cite

Rate and Pattern of Rim Area Loss in Healthy and Progressing Glaucoma Eyes.

Journal Article Ophthalmology · April 2016 PURPOSE: To characterize the rate and pattern of age-related and glaucomatous neuroretinal rim area changes in subjects of African and European descent. DESIGN: Prospective longitudinal study. PARTICIPANTS: Two hundred ninety-six eyes of 157 healthy subjec ... Full text Link to item Cite

The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.

Journal Article Ophthalmology · March 2016 PURPOSE: To evaluate the association between rates of progressive loss in different regions of the visual field and longitudinal changes in quality of life (QoL). DESIGN: Prospective, observational cohort study. PARTICIPANTS: The study included 236 patient ... Full text Link to item Cite

Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes.

Journal Article Ophthalmology · February 2016 PURPOSE: To evaluate and compare the diagnostic accuracy of global and sector analyses for detection of early visual field (VF) damage using the retinal nerve fiber layer (RNFL) reference databases of the Spectralis (Heidelberg Engineering, Heidelberg, Ger ... Full text Link to item Cite

Does the Location of Bruch's Membrane Opening Change Over Time? Longitudinal Analysis Using San Diego Automated Layer Segmentation Algorithm (SALSA).

Journal Article Invest Ophthalmol Vis Sci · February 2016 PURPOSE: We determined if the Bruch's membrane opening (BMO) location changes over time in healthy eyes and eyes with progressing glaucoma, and validated an automated segmentation algorithm for identifying the BMO in Cirrus high-definition coherence tomogr ... Full text Link to item Cite

Macular Ganglion Cell Inner Plexiform Layer Thickness in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects.

Journal Article PLoS One · 2016 PURPOSE: To investigate macular ganglion cell-inner plexiform layer (mGCIPL) thickness in glaucomatous eyes with visible localized retinal nerve fiber layer (RNFL) defects on stereophotographs. METHODS: 112 healthy and 149 glaucomatous eyes from the Diagno ... Full text Link to item Cite

Augmenting VR/AR applications with EEG/EOG monitoring and oculo-vestibular recoupling

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2016 Head-mounted virtual reality and augmented reality displays (a.k.a. VR/AR goggles) created a revolutionary multimedia genre that is seeking ever-broadening applications and novel natural human interfaces. Adding neuromonitoring and neurofeedback to this ge ... Full text Cite

Management of advanced glaucoma: Characterization and monitoring.

Journal Article Surv Ophthalmol · 2016 Recent advances in glaucoma diagnosis focus on diagnosing the disease in early stages. Despite the importance of such efforts, a meaningful proportion of patients present in advanced stages. The cost for treatment and monitoring of advanced glaucoma often ... Full text Link to item Cite

Challenging Glaucomas: Update on Diagnosis and Management

Journal Article Journal of Ophthalmology · January 1, 2016 Full text Cite

Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor.

Journal Article Clin Exp Ophthalmol · December 2015 BACKGROUND: The aim of this article was to study the circadian intraocular pressure (IOP)-related effects of ocular hypotensive medications using a contact lens sensor (CLS). DESIGN: This is a university-based prospective, randomized, crossover trial. PART ... Full text Link to item Cite

Detecting glaucomatous change in visual fields: Analysis with an optimization framework.

Journal Article J Biomed Inform · December 2015 Detecting glaucomatous progression is an important aspect of glaucoma management. The assessment of longitudinal series of visual fields, measured using Standard Automated Perimetry (SAP), is considered the reference standard for this effort. We seek effic ... Full text Link to item Cite

Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods.

Journal Article Ophthalmology · November 2015 PURPOSE: To determine whether progressive retinal nerve fiber layer (RNFL) loss occurs in the contralateral eye of patients with glaucoma showing unilateral progression according to conventional diagnostic methods. DESIGN: Prospective, longitudinal, observ ... Full text Link to item Cite

Estimating Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects.

Journal Article Ophthalmology · October 2015 PURPOSE: To estimate the diagnostic accuracy and lead time gained by retinal nerve fiber layer (RNFL) thickness measurements from optical coherence tomography (OCT) for detecting glaucoma before the development of visual field defects. DESIGN: Observationa ... Full text Link to item Cite

Log-gamma linear-mixed effects models for multiple outcomes with application to a longitudinal glaucoma study.

Journal Article Biom J · September 2015 Glaucoma is a progressive disease due to damage in the optic nerve with associated functional losses. Although the relationship between structural and functional progression in glaucoma is well established, there is disagreement on how this association evo ... Full text Link to item Cite

Automated segmentation of anterior lamina cribrosa surface: How the lamina cribrosa responds to intraocular pressure change in glaucoma eyes?

Conference Proceedings - International Symposium on Biomedical Imaging · July 21, 2015 The lamina cribrosa is a sieve-like structure where retinal ganglion cell axons and central retinal vessels exit from the eye through the scleral canal. The lamina cribrosa has been known to play an essential role in the physiopathology of glaucoma and has ... Full text Cite

Frequency Doubling Technology Perimetry and Changes in Quality of Life of Glaucoma Patients: A Longitudinal Study.

Journal Article Am J Ophthalmol · July 2015 PURPOSE: To evaluate the relationship between rates of change on frequency doubling technology (FDT) perimetry and longitudinal changes in quality of life (QoL) of glaucoma patients. DESIGN: Prospective observational cohort study. METHODS: One hundred fift ... Full text Link to item Cite

Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent.

Journal Article Am J Ophthalmol · July 2015 PURPOSE: To perform a quantitative trait locus (QTL) analysis and evaluate whether a locus between SIX1 and SIX6 is associated with retinal nerve fiber layer (RNFL) thickness in individuals of European descent. DESIGN: Observational, multicenter, cross-sec ... Full text Link to item Cite

Learning from healthy and stable eyes: A new approach for detection of glaucomatous progression.

Journal Article Artif Intell Med · June 2015 UNLABELLED: Glaucoma is a chronic neurodegenerative disease characterized by loss of retinal ganglion cells, resulting in distinctive changes in the optic nerve head (ONH) and retinal nerve fiber layer. Important advances in technology for non-invasive ima ... Full text Link to item Cite

Evaluation of Postural Control in Patients with Glaucoma Using a Virtual Reality Environment.

Journal Article Ophthalmology · June 2015 PURPOSE: To evaluate postural control using a dynamic virtual reality environment and the relationship between postural metrics and history of falls in patients with glaucoma. DESIGN: Cross-sectional study. PARTICIPANTS: The study involved 42 patients with ... Full text Link to item Cite

Lamina Cribrosa in Glaucoma: Diagnosis and Monitoring

Journal Article Current Ophthalmology Reports · June 1, 2015 The lamina cribrosa is the putative site of retinal ganglion cell axonal injury in glaucoma. Although histological studies have provided evidence of structural changes to the lamina cribrosa, even in early stages of glaucoma, until recently, the ability to ... Full text Cite

Biomarkers and surrogate endpoints in glaucoma clinical trials.

Journal Article Br J Ophthalmol · May 2015 Surrogate endpoints are often used as replacements for true clinically relevant endpoints in several areas of medicine, as they enable faster and less expensive clinical trials. However, without proper validation, the use of surrogates may lead to incorrec ... Full text Link to item Cite

Ophthalmology issues in schizophrenia.

Journal Article Curr Psychiatry Rep · May 2015 Schizophrenia is a complex mental disorder associated with not only cognitive dysfunctions, such as memory and attention deficits, but also changes in basic sensory processing. Although most studies on schizophrenia have focused on disturbances in higher-o ... Full text Link to item Cite

Association between progressive retinal nerve fiber layer loss and longitudinal change in quality of life in glaucoma.

Journal Article JAMA Ophthalmol · April 2015 IMPORTANCE: Evaluation of structural optic nerve damage is a fundamental part of diagnosis and management of glaucoma. However, the relationship between structural measurements and disability associated with the disease is not well characterized. Quantific ... Full text Link to item Cite

The African Descent and Glaucoma Evaluation Study (ADAGES): predictors of visual field damage in glaucoma suspects.

Journal Article Am J Ophthalmol · April 2015 PURPOSE: To evaluate racial differences in the development of visual field (VF) damage in glaucoma suspects. DESIGN: Prospective, observational cohort study. METHODS: Six hundred thirty-six eyes from 357 glaucoma suspects with normal VF at baseline were in ... Full text Link to item Cite

Longitudinal changes in quality of life and rates of progressive visual field loss in glaucoma patients.

Journal Article Ophthalmology · February 2015 PURPOSE: To evaluate the association between longitudinal changes in quality of life (QoL) and rates of progressive visual field loss in glaucoma. DESIGN: Prospective observational cohort study. PARTICIPANTS: We recruited 322 eyes of 161 patients with glau ... Full text Link to item Cite

Strategies to improve early diagnosis in glaucoma.

Journal Article Prog Brain Res · 2015 Early diagnosis and treatment of glaucoma is important to reduce the risk of progressive and irreversible visual loss. The key to diagnosis is recognition of morphological changes to the optic nerve head and retinal nerve fiber layer, but in some patients, ... Full text Link to item Cite

A Portable Platform for Evaluation of Visual Performance in Glaucoma Patients.

Journal Article PLoS One · 2015 PURPOSE: To propose a new tablet-enabled test for evaluation of visual performance in glaucoma, the PERformance CEntered Portable Test (PERCEPT), and to evaluate its ability to predict history of falls and motor vehicle crashes. DESIGN: Cross-sectional stu ... Full text Link to item Cite

Predicting Risk of Motor Vehicle Collisions in Patients with Glaucoma: A Longitudinal Study.

Journal Article PLoS One · 2015 PURPOSE: To evaluate the ability of longitudinal Useful Field of View (UFOV) and simulated driving measurements to predict future occurrence of motor vehicle collision (MVC) in drivers with glaucoma. DESIGN: Prospective observational cohort study. PARTICIP ... Full text Link to item Cite

Optic Disc Imaging

Chapter · January 1, 2015 Optic nerve imaging instruments are improving rapidly. These instruments provide reproducible, objective measurements of the optic nerve head that can assist the clinician in detecting glaucomatous damage and change. It is important that the clinician unde ... Full text Cite

The use of spectral-domain optical coherence tomography to detect glaucoma progression

Journal Article Open Ophthalmology Journal · January 1, 2015 Detection of progression and measurement of rates of change is at the core of glaucoma management, and the use of Spectral Domain Optical Coherence Tomography (SD-OCT) has significantly improved our ability to evaluate change in the disease. In this review ... Full text Cite

Spectral-domain optical coherence tomography for glaucoma diagnosis

Journal Article Open Ophthalmology Journal · January 1, 2015 Identification of structural damage to the optic nerve and retinal nerve fiber layer (RNFL) is an essential component of diagnosis and management of glaucoma. The introduction of spectral-domain OCT (SD-OCT) has allowed objective quantification of damage t ... Full text Cite

Diagnostic ability of macular ganglion cell inner plexiform layer measurements in glaucoma using swept source and spectral domain optical coherence tomography.

Journal Article PLoS One · 2015 PURPOSE: To evaluate the diagnostic ability of macular ganglion cell and inner plexiform layer measurements in glaucoma, obtained using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) and to compare to circumpapillary retinal ... Full text Link to item Cite

Diagnostic ability of retinal nerve fiber layer imaging by swept-source optical coherence tomography in glaucoma.

Journal Article Am J Ophthalmol · January 2015 PURPOSE: To evaluate the diagnostic accuracies of swept-source optical coherence tomography (OCT) wide-angle and peripapillary retinal nerve fiber layer (RNFL) thickness measurements for glaucoma detection. DESIGN: Cross-sectional case-control study. METHO ... Full text Link to item Cite

Relationship between ganglion cell layer thickness and estimated retinal ganglion cell counts in the glaucomatous macula.

Journal Article Ophthalmology · December 2014 PURPOSE: To investigate the relationship between macular ganglion cell-inner plexiform layer (mGCIPL) thickness and estimated macular retinal ganglion cell (RGC) counts in glaucoma. DESIGN: Observational cohort study. PARTICIPANTS: Cross-sectional study of ... Full text Link to item Cite

Twenty-four-hour intraocular pressure patterns in a symptomatic patient after ab interno trabeculotomy surgery

Journal Article Clinical Ophthalmology · November 7, 2014 We report the results of repeated ambulatory continuous 24-hour intraocular pressure (IOP) monitoring with a contact lens sensor (CLS) in a glaucoma patient with ocular pain after ab interno trabeculotomy (Trabectome™) surgery. Our findings show that a com ... Full text Cite

Glaucomatous retinal nerve fiber layer thickness loss is associated with slower reaction times under a divided attention task.

Journal Article Am J Ophthalmol · November 2014 PURPOSE: To examine the relationship between glaucomatous structural damage and ability to divide attention during simulated driving. DESIGN: Cross-sectional observational study. SETTING: Hamilton Glaucoma Center, University of California San Diego. PATIEN ... Full text Link to item Cite

Glaucoma progression detection using nonlocal Markov random field prior

Journal Article Journal of Medical Imaging · October 1, 2014 Glaucoma is neurodegenerative disease characterized by distinctive changes in the optic nerve head and visual field. Without treatment, glaucoma can lead to permanent blindness. Therefore, monitoring glaucoma progression is important to detect uncontrolled ... Full text Cite

Function-Specific Perimetry

Chapter · September 3, 2014 Although standard achromatic perimetry is still considered the gold standard for functional evaluation in glaucoma, function-specific perimetric tests may offer several advantages for early diagnosis of functional loss. Hardware and software upgrades have ... Full text Cite

Use of statistical analyses in the ophthalmic literature.

Journal Article Ophthalmology · July 2014 PURPOSE: To identify the most commonly used statistical analyses in the ophthalmic literature and to determine the likely gain in comprehension of the literature that readers could expect if they were to add knowledge of more advanced techniques sequential ... Full text Link to item Cite

Rates of retinal nerve fiber layer thinning in glaucoma suspect eyes.

Journal Article Ophthalmology · July 2014 PURPOSE: To compare the rates of retinal nerve fiber layer (RNFL) loss in patients suspected of having glaucoma who developed visual field damage (VFD) with those who did not develop VFD and to determine whether the rate of RNFL loss can be used to predict ... Full text Link to item Cite

Learning from data: recognizing glaucomatous defect patterns and detecting progression from visual field measurements.

Journal Article IEEE Trans Biomed Eng · July 2014 A hierarchical approach to learn from visual field data was adopted to identify glaucomatous visual field defect patterns and to detect glaucomatous progression. The analysis pipeline included three stages, namely, clustering, glaucoma boundary limit detec ... Full text Link to item Cite

Detecting glaucoma using automated pupillography.

Journal Article Ophthalmology · June 2014 OBJECTIVE: To evaluate the ability of a binocular automated pupillograph to discriminate healthy subjects from those with glaucoma. DESIGN: Cross-sectional observational study. PARTICIPANTS: Both eyes of 116 subjects, including 66 patients with glaucoma in ... Full text Link to item Cite

Assessment of optic nerve head drusen using enhanced depth imaging and swept source optical coherence tomography.

Journal Article J Neuroophthalmol · June 2014 BACKGROUND: Optic nerve head drusen (ONHD) are calcific deposits buried or at the surface of the optic disc. Although ONHD may be associated with progressive visual field defects, the mechanism of drusen-related field loss is poorly understood. Methods for ... Full text Link to item Cite

The pathophysiology and treatment of glaucoma: a review.

Journal Article JAMA · May 14, 2014 IMPORTANCE: Glaucoma is a worldwide leading cause of irreversible vision loss. Because it may be asymptomatic until a relatively late stage, diagnosis is frequently delayed. A general understanding of the disease pathophysiology, diagnosis, and treatment m ... Full text Link to item Cite

Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts.

Journal Article Am J Ophthalmol · May 2014 PURPOSE: To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS OCT) and the frequency and type of scan artifacts. DESIGN: Prospective evaluation of new diagnostic technol ... Full text Link to item Cite

Glaucoma progression detection using structural retinal nerve fiber layer measurements and functional visual field points.

Journal Article IEEE Trans Biomed Eng · April 2014 Machine learning classifiers were employed to detect glaucomatous progression using longitudinal series of structural data extracted from retinal nerve fiber layer thickness measurements and visual functional data recorded from standard automated perimetry ... Full text Link to item Cite

Strategies for improving early detection of glaucoma: The combined structure-function index

Journal Article Clinical Ophthalmology · March 26, 2014 The early detection of glaucoma is important in order to enable appropriate monitoring and treatment, and to minimize the risk of irreversible visual field loss. Although advances in ocular imaging offer the potential for earlier diagnosis, the best method ... Full text Cite

Detecting glaucoma progression from localized rates of retinal changes in parametric and nonparametric statistical framework with type I error control.

Journal Article Invest Ophthalmol Vis Sci · March 19, 2014 PURPOSE: We evaluated three new pixelwise rates of retinal height changes (PixR) strategies to reduce false-positive errors while detecting glaucomatous progression. METHODS: Diagnostic accuracy of nonparametric PixR-NP cluster test (CT), PixR-NP single th ... Full text Link to item Cite

Predicting progression of glaucoma from rates of frequency doubling technology perimetry change.

Journal Article Ophthalmology · February 2014 PURPOSE: To evaluate the ability of longitudinal frequency doubling technology (FDT) to predict the development of glaucomatous visual field loss on standard automated perimetry (SAP) in glaucoma suspects. DESIGN: Prospective, observational cohort study. P ... Full text Link to item Cite

Glaucoma risk factors: Fluctuations in intraocular pressure

Chapter · January 1, 2014 Intraocular pressure (IOP) has been demonstrated to be associated with incidence, prevalence, and progression of glaucoma. However, although there is strong evidence to support mean IOP as a risk factor for both development and progression of the disease, ... Full text Cite

Estimated rates of retinal ganglion cell loss in glaucomatous eyes with and without optic disc hemorrhages.

Journal Article PLoS One · 2014 PURPOSE: To evaluate whether optic disc hemorrhages are associated with faster rates of estimated retinal ganglion cell (RGC) loss in glaucoma. METHODS: A longitudinal observational cohort study of 222 eyes of 122 patients with glaucoma recruited from the ... Full text Link to item Cite

Assessment of choroidal thickness in healthy and glaucomatous eyes using swept source optical coherence tomography.

Journal Article PLoS One · 2014 PURPOSE: To evaluate choroidal thickness (CT) in healthy and glaucomatous eyes using Swept Source Optical Coherence Tomography (SS-OCT). METHODS: A cross-sectional observational study of 216 eyes of 140 subjects with glaucoma and 106 eyes of 67 healthy sub ... Full text Link to item Cite

Recognizing patterns of visual field loss using unsupervised machine learning

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 Glaucoma is a potentially blinding optic neuropathy that results in a decrease in visual sensitivity. Visual field abnormalities (decreased visual sensitivity on psychophysical tests) are the primary means of glaucoma diagnosis. One form of visual field te ... Full text Cite

Glaucomatous patterns in Frequency Doubling Technology (FDT) perimetry data identified by unsupervised machine learning classifiers.

Journal Article PLoS One · 2014 PURPOSE: The variational Bayesian independent component analysis-mixture model (VIM), an unsupervised machine-learning classifier, was used to automatically separate Matrix Frequency Doubling Technology (FDT) perimetry data into clusters of healthy and gla ... Full text Link to item Cite

Evaluation of progressive neuroretinal rim loss as a surrogate end point for development of visual field loss in glaucoma.

Journal Article Ophthalmology · January 2014 PURPOSE: To evaluate the validity of using progressive loss of neuroretinal rim area as a surrogate end point for the development of visual field loss in glaucoma. DESIGN: Prospective, observational cohort study. PARTICIPANTS: The study group included 492 ... Full text Link to item Cite

Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss.

Journal Article Ophthalmology · January 2014 OBJECTIVE: To determine whether focal abnormalities of the lamina cribrosa (LC) are present in glaucomatous eyes with localized retinal nerve fiber layer (RNFL) defects. DESIGN: Cross-sectional, observational study. PARTICIPANTS: We analyzed 20 eyes of 14 ... Full text Link to item Cite

Assessment of choroidal thickness and volume during the water drinking test by swept-source optical coherence tomography.

Journal Article Ophthalmology · December 2013 OBJECTIVE: To evaluate changes in peripapillary and macular choroidal thickness and volume after the water-drinking test (WDT) using swept-source optical coherence tomography (SS OCT). DESIGN: Prospective, cross-sectional, observational study. PARTICIPANTS ... Full text Link to item Cite

Author reply: To PMID 23642371.

Journal Article Ophthalmology · December 2013 Full text Link to item Cite

Estimation of retinal ganglion cell loss in glaucomatous eyes with a relative afferent pupillary defect

Journal Article Investigative Ophthalmology and Visual Science · November 26, 2013 Purpose. To estimate retinal ganglion cell (RGC) losses associated with a relative afferent pupillary defect (RAPD) in glaucoma. Methods. A cross-sectional study was conducted including both eyes of 103 participants from the Diagnostic Innovations in Glauc ... Full text Cite

Global rates of glaucoma surgery.

Journal Article Graefes Arch Clin Exp Ophthalmol · November 2013 PURPOSE: To estimate global rates of glaucoma surgery. METHODS: National glaucoma and national ophthalmology societies were contacted to obtain rates of glaucoma surgery for the preceding 5 years. In countries without a professional society, leading ophtha ... Full text Link to item Cite

Likelihood ratios for glaucoma diagnosis using spectral-domain optical coherence tomography.

Journal Article Am J Ophthalmol · November 2013 PURPOSE: To present a methodology for calculating likelihood ratios for glaucoma diagnosis for continuous retinal nerve fiber layer (RNFL) thickness measurements from spectral-domain optical coherence tomography (spectral-domain OCT). DESIGN: Observational ... Full text Link to item Cite

The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.

Journal Article J Glaucoma · September 2013 Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association st ... Full text Link to item Cite

Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study.

Journal Article Ophthalmology · August 2013 PURPOSE: To evaluate the role of corneal hysteresis (CH) as a risk factor for the rate of visual field progression in a cohort of patients with glaucoma followed prospectively over time. DESIGN: Prospective observational cohort study. PARTICIPANTS: The stu ... Full text Link to item Cite

Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence.

Journal Article Acta Ophthalmol · August 2013 PURPOSE: To evaluate the reproducibility of measurements of area of β-zone parapapillary atrophy (β-PPA) using blue laser fundus autofluorescence (FAF) and confocal scanning laser ophthalmoscopy reflectance (CSLO) measurements and to assess agreement betwe ... Full text Link to item Cite

Predicting progression in glaucoma suspects with longitudinal estimates of retinal ganglion cell counts.

Journal Article Invest Ophthalmol Vis Sci · June 19, 2013 PURPOSE: We evaluated the ability of baseline and longitudinal estimates of retinal ganglion cell (RGC) counts in predicting progression in eyes suspected of having glaucoma. METHODS: The study included 288 glaucoma suspect eyes of 288 patients followed fo ... Full text Link to item Cite

Intraocular pressure changes during sexual activity.

Journal Article Acta Ophthalmol · June 2013 We report the results of repeated ambulatory continuous 24-h IOP monitoring with a contact lens sensor in a female glaucoma patient who engaged in sexual activity during each of three monitoring sessions. Our findings show that IOP patterns seemed to decre ... Full text Link to item Cite

The rate of structural change: the confocal scanning laser ophthalmoscopy ancillary study to the ocular hypertension treatment study.

Journal Article Am J Ophthalmol · June 2013 PURPOSE: To compare rates of topographic change in ocular hypertensive eyes that develop primary open-angle glaucoma (POAG) compared to eyes that do not, and to identify factors that influence the rate of change. DESIGN: Longitudinal, randomized clinical t ... Full text Link to item Cite

Advances in the Structural Evaluation of Glaucoma with Optical Coherence Tomography

Journal Article Current Ophthalmology Reports · June 1, 2013 Optical coherence tomography (OCT) is capable of providing quantitative and objective assessments of the optic disc, macula and retinal nerve fiber layer in glaucoma. The recent advent of spectral domain OCT (SD-OCT) has enhanced the resolution, decreased ... Full text Cite

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.

Journal Article Invest Ophthalmol Vis Sci · May 13, 2013 PURPOSE: To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage. METHODS: The study included 142 eyes fro ... Full text Link to item Cite

The relationship between cup-to-disc ratio and estimated number of retinal ganglion cells.

Journal Article Invest Ophthalmol Vis Sci · May 7, 2013 PURPOSE: To investigate the relationship between cup-to-disc ratio (CDR) and estimates of retinal ganglion cell (RGC) number. METHODS: This cross-sectional study included 156 healthy eyes, 53 glaucoma suspects, and 127 eyes with glaucoma. All eyes had stan ... Full text Link to item Cite

Is 24-hour intraocular pressure monitoring necessary in glaucoma?

Journal Article Semin Ophthalmol · May 2013 Although intraocular pressure (IOP) is the only treatable risk factor for glaucoma, its 24-hour behavior is poorly understood. Conflicting information is available in the literature with regard to the importance and predictive value of IOP peaks and fluctu ... Full text Link to item Cite

Validity of the results of a contact lens sensor? Reply

Journal Article JAMA Ophthalmology · May 1, 2013 Full text Cite

Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma.

Journal Article JAMA Ophthalmol · April 2013 IMPORTANCE: It is reasonable to hypothesize that for 2 patients with similar degrees of integrated binocular visual field (BVF) loss, the patient with a history of faster disease progression will report worse vision-related quality of life (VRQOL) than the ... Full text Link to item Cite

Retinal ganglion cell count estimates associated with early development of visual field defects in glaucoma.

Journal Article Ophthalmology · April 2013 PURPOSE: To estimate retinal ganglion cell (RGC) losses associated with the earliest development of visual field defects in glaucoma. DESIGN: Observational cohort study. PARTICIPANTS: The study group included 53 eyes of 53 patients with suspected glaucoma ... Full text Link to item Cite

Repeatability and reproducibility of Goldmann applanation, dynamic contour, and ocular response analyzer tonometry.

Journal Article J Glaucoma · February 2013 PURPOSE: To evaluate the repeatability and interoperator reproducibility of the Pascal dynamic contour tonometry (DCT), ocular response analyzer (ORA), and Goldmann applanation tonometer (GAT) in a single population of normal individuals. METHODS: The stud ... Full text Link to item Cite

African descent and glaucoma evaluation study: asymmetry of structural measures in normal participants.

Journal Article J Glaucoma · February 2013 PURPOSE: The purpose of the study is to determine the degree of intereye asymmetry of optic disc topography and retinal nerve fiber layer (RNFL) thickness in healthy individuals of African descent (AD) and European descent (ED). DESIGN: Observational, clin ... Full text Link to item Cite

Combining structure and function to evaluate glaucomatous progression: implications for the design of clinical trials.

Journal Article Curr Opin Pharmacol · February 2013 The selection of a suitable method for assessment of glaucomatous progression and estimation of rates of change is an essential component of the design of clinical trials investigating neuroprotective therapies for the disease. Due to the limitations of cu ... Full text Link to item Cite

Heidelberg edge perimetry for the detection of early glaucomatous damage: A case report

Journal Article Case Reports in Ophthalmology · January 1, 2013 Purpose: To illustrate the potential role for Heidelberg edge perimetry (HEP) in the assessment of early functional loss in glaucoma. Case Report: A 46-year-old male presented with raised intraocular pressure but healthy optic discs and normal standard aut ... Full text Cite

The relationship between visual field index and estimated number of retinal ganglion cells in glaucoma.

Journal Article PLoS One · 2013 PURPOSE: To evaluate the relationship between visual field index (VFI) and the estimated number of retinal ganglion cells (RGCs) in glaucoma. METHODS: A multicenter study of 1,245 healthy, glaucomatous and suspected glaucomatous eyes of 1,245 subjects recr ... Full text Link to item Cite

Estimated retinal ganglion cell counts in glaucomatous eyes with localized retinal nerve fiber layer defects

Journal Article American Journal of Ophthalmology · January 1, 2013 Purpose: To estimate retinal ganglion cell (RGC) losses associated with visible glaucomatous localized retinal nerve fiber layer (RNFL) defects. Design: Observational cross-sectional study. Methods: A multicenter study of 198 normal eyes (138 subjects) and ... Full text Cite

Analysis of continuous 24-hour intraocular pressure patterns in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · December 13, 2012 PURPOSE: To present a method to analyze circadian intraocular pressure (IOP) patterns in glaucoma patients and suspects undergoing repeated continuous 24-hour IOP monitoring. METHODS: Forty patients with established (n = 19) or suspected glaucoma (n = 21) ... Full text Link to item Cite

Optical coherence tomography in ophthalmology

Journal Article Journal of Ophthalmology · December 1, 2012 Full text Cite

Continuous 24-hour monitoring of intraocular pressure patterns with a contact lens sensor: safety, tolerability, and reproducibility in patients with glaucoma.

Journal Article Arch Ophthalmol · December 2012 OBJECTIVE: To examine the safety, tolerability, and reproducibility of intraocular pressure (IOP) patterns during repeated continuous 24-hour IOP monitoring with a contact lens sensor. METHODS: Forty patients suspected of having glaucoma(n=21) or with esta ... Full text Link to item Cite

Diagnosing preperimetric glaucoma with spectral domain optical coherence tomography.

Journal Article Ophthalmology · November 2012 PURPOSE: To evaluate the diagnostic accuracy of spectral domain optical coherence tomography (SD-OCT) for detection of preperimetric glaucoma and compare it with the performance of confocal scanning laser ophthalmoscopy (CSLO). DESIGN: Cohort study. PARTIC ... Full text Link to item Cite

Estimating the rate of retinal ganglion cell loss in glaucoma.

Journal Article Am J Ophthalmol · November 2012 PURPOSE: To present and evaluate a new method of estimating rates of retinal ganglion cell (RGC) loss in glaucoma by combining structural and functional measurements. DESIGN: Observational cohort study. METHODS: The study included 213 eyes of 213 glaucoma ... Full text Link to item Cite

The structure and function relationship in glaucoma: implications for detection of progression and measurement of rates of change.

Journal Article Invest Ophthalmol Vis Sci · October 5, 2012 PURPOSE: To evaluate the relationship between change in estimated retinal ganglion cell (RGC) counts and change in measures of functional and structural damage in glaucoma, from cross-sectional data. METHODS: The study included 397 eyes of 397 patients wit ... Full text Link to item Cite

Positional independence of optic nerve head and retinal nerve fiber layer thickness measurements with spectral-domain optical coherence tomography.

Journal Article Am J Ophthalmol · October 2012 PURPOSE: To evaluate repeatability and positional independence of optic nerve head (ONH) and retinal nerve fiber layer (RNFL) thickness measurements in sitting and supine body positions using portable spectral-domain optical coherence tomography (iVue SD-O ... Full text Link to item Cite

Progression of patterns (POP): a machine classifier algorithm to identify glaucoma progression in visual fields.

Journal Article Invest Ophthalmol Vis Sci · September 25, 2012 PURPOSE: We evaluated Progression of Patterns (POP) for its ability to identify progression of glaucomatous visual field (VF) defects. METHODS: POP uses variational Bayesian independent component mixture model (VIM), a machine learning classifier (MLC) dev ... Full text Link to item Cite

Twenty-four-hour effects of bimatoprost 0.01% monotherapy on intraocular pressure and ocular perfusion pressure

Journal Article BMJ Open · September 13, 2012 Objectives: To investigate the 24 h effects of bimatoprost 0.01% monotherapy on intraocular pressure (IOP) and ocular perfusion pressure (OPP). Design: Prospective, open-label experimental study. Setting: Single tertiary ophthalmic clinic. Participants: Si ... Full text Cite

A combined index of structure and function for staging glaucomatous damage.

Journal Article Arch Ophthalmol · September 2012 OBJECTIVES: To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage. METHODS: Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric gl ... Full text Link to item Cite

Predicting glaucomatous progression in glaucoma suspect eyes using relevance vector machine classifiers for combined structural and functional measurements.

Journal Article Invest Ophthalmol Vis Sci · April 30, 2012 PURPOSE: The goal of this study was to determine if glaucomatous progression in suspect eyes can be predicted from baseline confocal scanning laser ophthalmoscope (CSLO) and standard automated perimetry (SAP) measurements analyzed with relevance vector mac ... Full text Link to item Cite

Incorporating risk factors to improve the assessment of rates of glaucomatous progression.

Journal Article Invest Ophthalmol Vis Sci · April 24, 2012 PURPOSE: To present and evaluate a new method of integrating risk factors into the analysis of rates of visual field progression in glaucoma. METHODS: The study included 352 eyes of 250 glaucoma patients followed up for an average of 8.1 ± 3.5 years. Slope ... Full text Link to item Cite

Improved prediction of rates of visual field loss in glaucoma using empirical Bayes estimates of slopes of change.

Journal Article J Glaucoma · March 2012 PURPOSE: To describe and test a new methodology for estimation of rates of progressive visual field loss in glaucoma. METHODS: This observational cohort study enrolled 643 eyes of 368 patients recruited from the Diagnostic Innovations in Glaucoma Study, fo ... Full text Link to item Cite

Integrating event- and trend-based analyses to improve detection of glaucomatous visual field progression.

Journal Article Ophthalmology · March 2012 PURPOSE: To present and evaluate a new method of integrating event- and trend-based analyses of visual field progression in glaucoma. DESIGN: Observational cohort study. PARTICIPANTS: The study included 711 eyes of 357 glaucoma patients or suspects followe ... Full text Link to item Cite

Combining structural and functional measurements to improve estimates of rates of glaucomatous progression

Journal Article American Journal of Ophthalmology · January 1, 2012 Purpose: To evaluate whether a combination of topographic optic disc measurements and visual field data may improve the estimation of rates of structural and functional progression in glaucoma and the prediction of future outcomes in the disease. Design: O ... Full text Cite

Driving simulation as a performance-based test of visual impairment in glaucoma.

Journal Article J Glaucoma · 2012 The fundamental goal of glaucoma management is to prevent patients from developing visual impairments sufficient to produce disability in their daily lives and impair their quality of life. Ultimately, patients are interested in how their vision will impac ... Full text Link to item Cite

Association between corneal biomechanical properties and glaucoma severity

Journal Article American Journal of Ophthalmology · January 1, 2012 • Purpose: To investigate the association between corneal biomechanical parameters using the Ocular Response Analyzer (ORA) and glaucoma severity. • Design: Observational cross-sectional study. • Methods: Two hundred ninety-nine eyes of 191 patients with c ... Full text Cite

Comparison of unenhanced and enhanced imaging protocols for angle measurements with anterior segment optical coherence tomography.

Journal Article Ophthalmic Surg Lasers Imaging · 2012 BACKGROUND AND OBJECTIVE: To compare the intraobserver and interobserver agreement of anterior chamber angle measurements using unenhanced and enhanced imaging protocols for anterior segment optical coherence tomography (AS-OCT). PATIENTS AND METHODS: Ante ... Full text Link to item Cite

Structure-function relationships using the Cirrus spectral domain optical coherence tomograph and standard automated perimetry.

Journal Article J Glaucoma · January 2012 PURPOSE: To evaluate the relationship between glaucomatous structural damage assessed by the Cirrus Spectral Domain OCT (SDOCT) and functional loss as measured by standard automated perimetry (SAP). METHODS: Four hundred twenty-two eyes (78 healthy, 210 su ... Full text Link to item Cite

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

Journal Article PLoS Genet · 2012 Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease. We have performed a meta-analy ... Full text Link to item Cite

Detection of retinal nerve fibre layer progression: comparison of the fast and extended modes of GDx guided progression analysis.

Journal Article Br J Ophthalmol · December 2011 PURPOSE: To compare detection of retinal nerve fibre layer changes using GDx guided progression analysis (GPA) fast mode (which assumes fixed variability of a reference population) and extended mode (which measures individual variability), and to determine ... Full text Link to item Cite

The effects of race, optic disc area, age, and disease severity on the diagnostic performance of spectral-domain optical coherence tomography.

Journal Article Invest Ophthalmol Vis Sci · August 3, 2011 PURPOSE: To evaluate the effect of race (African or European descent), age, disc area, and severity of disease on the diagnostic ability of spectral-domain optical coherence tomography (SDOCT) imaging of the optic nerve, macula, and retinal nerve fiber lay ... Full text Link to item Cite

Combining structural and functional measurements to improve detection of glaucoma progression using Bayesian hierarchical models.

Journal Article Invest Ophthalmol Vis Sci · July 29, 2011 PURPOSE: To present and evaluate a new methodology for combining longitudinal information from structural and functional tests to improve detection of glaucoma progression and estimation of rates of change. METHODS: This observational cohort study included ... Full text Link to item Cite

Comparison of the diagnostic accuracies of the Spectralis, Cirrus, and RTVue optical coherence tomography devices in glaucoma.

Journal Article Ophthalmology · July 2011 PURPOSE: To compare the diagnostic accuracies of retinal nerve fiber layer (RNFL) thickness measurements obtained with the Spectralis (Heidelberg Engineering, Dossenheim, Germany), Cirrus (Carl Zeiss Meditec, Dublin, CA), and RTVue (Optovue Inc., Fremont, ... Full text Link to item Cite

Structure-function relationship in glaucoma using spectral-domain optical coherence tomography.

Journal Article Arch Ophthalmol · July 2011 OBJECTIVES: To determine the structure-function relationship in glaucoma using spectral-domain optical coherence tomography (SDOCT)-derived structural measurements and to evaluate this relationship using a linear model. METHODS: In a cross-sectional study, ... Full text Link to item Cite

Effect of disease severity and optic disc size on diagnostic accuracy of RTVue spectral domain optical coherence tomograph in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · March 2011 PURPOSE: To evaluate the effect of disease severity and optic disc size on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL), and macular parameters with RTVue (Optovue, Fremont, CA) spectral domain optical coherence tom ... Full text Link to item Cite

Glaucomatous optic neuropathy evaluation project: a standardized internet system for assessing skills in optic disc examination.

Journal Article Clin Exp Ophthalmol · 2011 BACKGROUND: Development of a standardized internet-based system to self-assess skills in optic disc examination for glaucoma risk assessment. DESIGN: Prospective internet-based observational study. PARTICIPANTS: Total of 197 participants (glaucoma subspeci ... Full text Link to item Cite

Agreement among spectral-domain optical coherence tomography instruments for assessing retinal nerve fiber layer thickness

Journal Article American Journal of Ophthalmology · January 1, 2011 Purpose To assess the agreement of parapapillary retinal nerve fiber layer (RNFL) thickness measurements among 3 spectral-domain optical coherence tomography (SD-OCT) instruments. Design Observational, cross-sectional study. Methods Three hundred thirty ey ... Full text Cite

Managing glaucoma in developing countries.

Journal Article Arq Bras Oftalmol · 2011 Full text Link to item Cite

Assessment of rates of structural change in glaucoma using imaging technologies

Journal Article Eye · January 1, 2011 Purpose To review the ability of current imaging technologies to provide estimates of rates of structural change in glaucoma patients.Patients and methodsReview of literature.ResultsImaging technologies, such as confocal scanning laser ophthalmoscopy (CSLO ... Full text Cite

Pattern electroretinogram association with spectral domain-OCT structural measurements in glaucoma

Journal Article Eye · January 1, 2011 PurposeTo describe the association between pattern electroretinogram (PERG) amplitude and spectral domain-optical coherence tomography (SD-OCT) macular thickness, retinal nerve fibre layer (RNFL) thickness and optic disc topography measurements.Subjects an ... Full text Cite

The role of standard automated perimetry and newer functional methods for glaucoma diagnosis and follow-up.

Conference Indian J Ophthalmol · January 2011 Automated perimetry has become the mainstream for assessment of functional glaucomatous loss and progressive damage. Recent improvements with the Swedish interactive thresholding algorithm (SITA) strategy and the guided progression analysis (GPA) have furt ... Full text Link to item Cite

Visual fields: Fluctuation and progression

Chapter · December 1, 2010 The primary obstacle in detecting whether or not a glaucoma patient's visual field loss is progressing is to separate true progression from changes due to variability or fluctuation between tests. Fluctuation is defined as the variability in the response t ... Full text Cite

Diurnal and nocturnal effects of brimonidine monotherapy on intraocular pressure.

Journal Article Ophthalmology · November 2010 PURPOSE: To investigate the effect of brimonidine monotherapy on intraocular pressure (IOP) during the nocturnal/sleep period. DESIGN: Prospective, open-label experimental study. PARTICIPANTS: Fifteen patients with newly diagnosed open-angle glaucoma or oc ... Full text Link to item Cite

The relationship between intraocular pressure reduction and rates of progressive visual field loss in eyes with optic disc hemorrhage.

Journal Article Ophthalmology · November 2010 PURPOSE: To evaluate rates of visual field progression in eyes with optic disc hemorrhages and the effect of intraocular pressure (IOP) reduction on these rates. DESIGN: Observational cohort study. PARTICIPANTS: The study included 510 eyes of 348 patients ... Full text Link to item Cite

Determinants of agreement between the confocal scanning laser tomograph and standardized assessment of glaucomatous progression.

Journal Article Ophthalmology · October 2010 PURPOSE: To estimate the agreement of confocal scanning laser tomograph (CSLT), topographic change analysis (TCA) with assessment of stereophotographs, and standard automated perimetry (SAP) for detecting glaucomatous progression and to identify factors as ... Full text Link to item Cite

Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis.

Journal Article Ophthalmology · September 2010 PURPOSE: To evaluate retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular thickness measurements for glaucoma detection using the RTVue spectral domain optical coherence tomograph. DESIGN: Diagnostic, case-control study. PARTICIPANTS: One ... Full text Link to item Cite

Effect of disease severity on the performance of Cirrus spectral-domain OCT for glaucoma diagnosis.

Journal Article Invest Ophthalmol Vis Sci · August 2010 PURPOSE: To evaluate the effect of disease severity on the diagnostic accuracy of the Cirrus Optical Coherence Tomograph (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) for glaucoma detection. METHODS: One hundred thirty-five glaucomatous eyes of 99 ... Full text Link to item Cite

Comparison of corneal biomechanical properties between healthy blacks and whites using the Ocular Response Analyzer.

Journal Article Am J Ophthalmol · August 2010 PURPOSE: To analyze and compare corneal biomechanical properties in healthy black and white subjects using the Ocular Response Analyzer (ORA) and to evaluate their relationship with other ocular parameters. DESIGN: Observational cross-sectional study. METH ... Full text Link to item Cite

A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma.

Journal Article Invest Ophthalmol Vis Sci · July 2010 PURPOSE. To evaluate and compare rates of change in neuroretinal rim area (RA) and retinal nerve fiber layer thickness (RNFLT) measurements in glaucoma patients, those with suspected glaucoma, and normal subjects observed over time. METHODS. In this observ ... Full text Link to item Cite

Rates of progressive retinal nerve fiber layer loss in glaucoma measured by scanning laser polarimetry.

Journal Article Am J Ophthalmol · June 2010 PURPOSE: To evaluate rates of change measured with scanning laser polarimetry with enhanced corneal compensation (GDx ECC) and compare them to those measured using the variable corneal compensation (GDx VCC) method in a cohort of glaucoma patients and indi ... Full text Link to item Cite

African Descent and Glaucoma Evaluation Study (ADAGES): II. Ancestry differences in optic disc, retinal nerve fiber layer, and macular structure in healthy subjects.

Journal Article Arch Ophthalmol · May 2010 OBJECTIVE: To define differences in optic disc, retinal nerve fiber layer, and macular structure between healthy participants of African (AD) and European descent (ED) using quantitative imaging techniques in the African Descent and Glaucoma Evaluation Stu ... Full text Link to item Cite

African Descent and Glaucoma Evaluation Study (ADAGES): III. Ancestry differences in visual function in healthy eyes.

Journal Article Arch Ophthalmol · May 2010 OBJECTIVE: To investigate differences in visual function between the healthy eyes of people of African (AD) and European descent (ED). METHODS: Visual function was assessed in 393 AD and 367 ED participants selected from the African Descent and Glaucoma Ev ... Full text Link to item Cite

Visual field progression.

Journal Article Ophthalmology · April 2010 Full text Link to item Cite

Agreement for detecting glaucoma progression with the GDx guided progression analysis, automated perimetry, and optic disc photography.

Journal Article Ophthalmology · March 2010 PURPOSE: To evaluate the ability of the GDx Variable Corneal Compensation (VCC) Guided Progression Analysis (GPA) software for detecting glaucomatous progression. DESIGN: Observational cohort study. PARTICIPANTS: The study included 453 eyes from 252 indivi ... Full text Link to item Cite

Reply

Journal Article American Journal of Ophthalmology · March 1, 2010 Full text Cite

Pattern electroretinogram and psychophysical tests of visual function for discriminating between healthy and glaucoma eyes.

Journal Article Am J Ophthalmol · March 2010 PURPOSE: To compare the diagnostic accuracy of the pattern electroretinogram (pattern ERG) to that of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), and frequency-doubling technology (FDT) perimetry for discriminating betw ... Full text Link to item Cite

Evaluating the optic nerve for glaucomatous progression

Chapter · January 1, 2010 Identification of progressive glaucomatous damage to the optic disc is one of the most important aspects of glaucoma management, yet it remains largely subjective and imprecise. Progressive change in the appearance of the optic disc or retinal nerve fiber ... Full text Cite

Glaucoma risk factors: Fluctuations in intraocular pressure

Chapter · January 1, 2010 Intraocular pressure (IOP) has been consistently demonstrated to be associated with incidence, prevalence, and progression of glaucoma. However, although there is strong evidence to support mean IOP as a risk factor for both development and progression of ... Full text Cite

[Reproducibility of water drinking test].

Journal Article Arq Bras Oftalmol · 2010 Full text Link to item Cite

Detection of glaucoma progression with stratus OCT retinal nerve fiber layer, optic nerve head, and macular thickness measurements.

Journal Article Invest Ophthalmol Vis Sci · December 2009 PURPOSE: To evaluate and compare the ability of optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to detect progressive structural damage in glaucoma. METHODS: This observational cohort ... Full text Link to item Cite

Prediction of functional loss in glaucoma from progressive optic disc damage.

Journal Article Arch Ophthalmol · October 2009 OBJECTIVE: To evaluate the ability of progressive optic disc damage detected by assessment of longitudinal stereophotographs to predict future development of functional loss in those with suspected glaucoma. METHODS: The study included 639 eyes of 407 pati ... Full text Link to item Cite

The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data.

Journal Article Arch Ophthalmol · September 2009 OBJECTIVE: To identify factors accounting for differences in glaucoma onset and rate of progression between individuals of African descent and European descent. DESIGN: A prospective, multicenter observational cohort study of 1221 participants of African d ... Full text Link to item Cite

Effect of signal strength and improper alignment on the variability of stratus optical coherence tomography retinal nerve fiber layer thickness measurements.

Journal Article Am J Ophthalmol · August 2009 PURPOSE: To evaluate the effect of signal strength and improper scan alignment on retinal nerve fiber layer (RNFL) thickness measurement variability. DESIGN: Retrospective, longitudinal clinical study. METHODS: All eyes of healthy subjects with at least 2 ... Full text Link to item Cite

Impact of atypical retardation patterns on detection of glaucoma progression using the GDx with variable corneal compensation.

Journal Article Am J Ophthalmol · July 2009 PURPOSE: To evaluate the impact of atypical retardation patterns (ARP) on detection of progressive retinal nerve fiber layer (RNFL) loss using scanning laser polarimetry with variable corneal compensation (VCC). DESIGN: Observational cohort study. METHODS: ... Full text Link to item Cite

Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements.

Journal Article Am J Ophthalmol · June 2009 PURPOSE: To evaluate RTVue spectral-domain optical coherence tomography (OCT) (Optovue Inc, Fremont, California, USA) reproducibility and to assess agreement with Stratus time-domain OCT (Carl Zeiss Meditec, Dublin, California, USA) measurements. DESIGN: O ... Full text Link to item Cite

Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness.

Journal Article Br J Ophthalmol · June 2009 BACKGROUND/AIMS: To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements. METHODS: Three Cirrus-SD-OCT scans and one ... Full text Link to item Cite

The Relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma.

Journal Article Ophthalmology · June 2009 PURPOSE: To evaluate the relationship between intraocular pressure (IOP) and progressive retinal nerve fiber layer (RNFL) loss, as measured by scanning laser polarimetry with enhanced corneal compensation (GDx ECC), in a cohort of glaucoma patients and ind ... Full text Link to item Cite

Relationship of the 24-hour pattern of intraocular pressure with optic disc appearance in primary open-angle glaucoma.

Journal Article Ophthalmology · May 2009 PURPOSE: To study the relationship between the 24-hour pattern of intraocular pressure (IOP) with optic disc appearance in primary open-angle glaucoma (POAG) patients. DESIGN: Observational clinical study. PARTICIPANTS: Seventy-five eyes of 45 POAG patient ... Full text Link to item Cite

Correlation among choroidal, parapapillary, and retrobulbar vascular parameters in glaucoma.

Journal Article Am J Ophthalmol · April 2009 PURPOSE: To study and compare the correlation among choroidal, parapapillary, and retrobulbar vascular parameters in healthy subjects, glaucoma suspects, and open-angle glaucoma (OAG) patients. DESIGN: Prospective observational clinical study. METHODS: The ... Full text Link to item Cite

Detection of progressive retinal nerve fiber layer loss in glaucoma using scanning laser polarimetry with variable corneal compensation.

Journal Article Invest Ophthalmol Vis Sci · April 2009 PURPOSE: To evaluate the ability of scanning laser polarimetry with variable corneal compensation to detect progressive retinal nerve fiber layer (RNFL) loss in glaucoma patients and patients suspected of having the disease. METHODS: This was an observatio ... Full text Link to item Cite

Spectral domain-optical coherence tomography to detect localized retinal nerve fiber layer defects in glaucomatous eyes.

Journal Article Opt Express · March 2, 2009 This study examines the ability of RTVue, Cirrus and Spectralis OCT Spectral domain-optical coherence tomographs (SD-OCT) to detect localized retinal nerve fiber layer defects in glaucomatous eyes. In this observational case series, four glaucoma patients ... Full text Link to item Cite

Comparing diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure in patients receiving latanoprost monotherapy.

Journal Article Ophthalmology · March 2009 PURPOSE: To compare the diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure (IOP) in patients already receiving monotherapy with latanoprost. DESIGN: Prospective, open-label, and crossover clinical trial. PARTICIPANTS: Twenty- ... Full text Link to item Cite

Scan tracking coordinates for improved centering of Stratus OCT scan pattern.

Journal Article J Glaucoma · January 2009 OBJECTIVE: To describe and evaluate a technique to optimize scan centering during the Stratus optical coherence tomography (OCT) image acquisition process using currently available scan tracking coordinates. DESIGN: Observational clinical study. PARTICIPAN ... Full text Link to item Cite

Clinicians agreement in establishing glaucomatous progression using the Heidelberg retina tomograph.

Journal Article Ophthalmology · January 2009 PURPOSE: To assess the degree of concordance among clinicians reviewing 3 Heidelberg retina tomograph (HRT) printouts used to detect progression, the Moorfields regression analysis (MRA), the topographic change analysis (TCA), and trend analysis (TA), and ... Full text Link to item Cite

Diagnostic tools for calculation of glaucoma risk.

Journal Article Surv Ophthalmol · November 2008 Risk calculators may simplify the management of ocular hypertension and glaucoma patients and provide evidence-based treatment. Risk calculators are not new to medicine. Medical providers use risk calculators to guide decision-making for the risk of a chro ... Full text Link to item Cite

Comparison of retinal nerve fiber layer and optic disc imaging for diagnosing glaucoma in patients suspected of having the disease.

Journal Article Ophthalmology · August 2008 PURPOSE: To compare retinal nerve fiber layer (RNFL) and optic disc topographic imaging for detection of optic nerve damage in patients suspected of having glaucoma. DESIGN: Observational cohort study. PARTICIPANTS: A cohort of 82 patients suspected of hav ... Full text Link to item Cite

Effect of improper scan alignment on retinal nerve fiber layer thickness measurements using Stratus optical coherence tomograph.

Journal Article J Glaucoma · August 2008 OBJECTIVE: Misalignment of the Stratus optical coherence tomograph scan circle placed by the operator around the optic nerve head (ONH) during each retinal nerve fiber layer (RNFL) examination can affect the instrument reproducibility and its theoretical a ... Full text Link to item Cite

Prevalence of ocular surface disease in glaucoma patients.

Journal Article J Glaucoma · August 2008 PURPOSE: To examine the prevalence of ocular surface disease (OSD) in glaucoma patients. METHODS: This was a cross-sectional study. One hundred and one patients, 18 years of age or older, with open-angle glaucoma or ocular hypertension were consecutively r ... Full text Link to item Cite

Long-term intraocular pressure fluctuations and risk of conversion from ocular hypertension to glaucoma.

Journal Article Ophthalmology · June 2008 PURPOSE: To investigate whether long-term intraocular pressure (IOP) fluctuations are a risk factor for conversion from ocular hypertension to glaucoma. DESIGN: Observational cohort study. PARTICIPANTS: The study included 252 eyes of 126 patients with ocul ... Full text Link to item Cite

Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · May 2008 PURPOSE: To assess whether baseline Glaucoma Probability Score (GPS; HRT-3; Heidelberg Engineering, Dossenheim, Germany) results are predictive of progression in patients with suspected glaucoma. The GPS is a new feature of the confocal scanning laser opht ... Full text Link to item Cite

Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve.

Journal Article Am J Ophthalmol · April 2008 PURPOSE: To compare the abilities of scanning laser polarimetry (SLP) with enhanced corneal compensation (ECC) and variable corneal compensation (VCC) modes for detection of retinal nerve fiber layer (RNFL) loss in eyes with band atrophy (BA) of the optic ... Full text Link to item Cite

Diagnostic accuracy of the Matrix 24-2 and original N-30 frequency-doubling technology tests compared with standard automated perimetry.

Journal Article Invest Ophthalmol Vis Sci · March 2008 PURPOSE: To compare the diagnostic accuracy of the Matrix frequency-doubling technology (FDT) 24-2, first-generation FDT N-30 (FDT N-30), and standard automated perimetry (SAP) tests of visual function. METHODS: One eye of each of 85 glaucoma patients and ... Full text Link to item Cite

Bayesian machine learning classifiers for combining structural and functional measurements to classify healthy and glaucomatous eyes.

Journal Article Invest Ophthalmol Vis Sci · March 2008 PURPOSE: To determine whether combining structural (optical coherence tomography, OCT) and functional (standard automated perimetry, SAP) measurements as input for machine learning classifiers (MLCs; relevance vector machine, RVM; and subspace mixture of G ... Full text Link to item Cite

Association of central corneal thickness and 24-hour intraocular pressure fluctuation.

Journal Article J Glaucoma · March 2008 PURPOSE: To evaluate the association between office-hour central corneal thickness (CCT) and 24-hour intraocular pressure (IOP) fluctuation in patients with glaucoma. DESIGN: Observational case-control study. METHODS: Measurements of IOP were obtained ever ... Full text Link to item Cite

The promise of spectral-domain optical coherence tomography

Journal Article Expert Review of Ophthalmology · January 1, 2008 Full text Cite

Predictive models to estimate the risk of glaucoma development and progression.

Book · 2008 In this chapter, we review the motivations and steps involved in the construction and validation of predictive models for the development and progression of glaucoma. We start with a critical review of the literature on the risk factors that have been iden ... Full text Link to item Cite

The impact of the perimetric measurement scale, sample composition, and statistical method on the structure-function relationship in glaucoma.

Journal Article J Glaucoma · December 2007 PURPOSE: To investigate the impact of perimetric measurement scales, sample composition, and 2 statistical methods on the structure-function relationship in glaucoma. METHODS: Three hundred eighty-five eyes of 385 participants, covering the full spectrum o ... Full text Link to item Cite

Reproducibility of visual field end point criteria for standard automated perimetry, full-threshold, and Swedish interactive thresholding algorithm strategies: diagnostic innovations in glaucoma study.

Journal Article Am J Ophthalmol · December 2007 PURPOSE: To compare the interthreshold and intrathreshold strategy agreement of visual field end point criteria for standard automated perimetry (SAP) with the full-threshold (FT) algorithm and the Swedish interactive threshold algorithm (SITA). DESIGN: Pr ... Full text Link to item Cite

Retinal nerve fiber layer thickness and visual sensitivity using scanning laser polarimetry with variable and enhanced corneal compensation.

Journal Article Ophthalmology · July 2007 PURPOSE: To compare the strength of the structure-function association between scanning laser polarimetry-measured retinal nerve fiber layer (RNFL) thickness and visual sensitivity. Two methods of corneal compensation were evaluated, variable corneal compe ... Full text Link to item Cite

Detection of glaucoma using scanning laser polarimetry with enhanced corneal compensation.

Journal Article Invest Ophthalmol Vis Sci · July 2007 PURPOSE: To evaluate and compare the diagnostic accuracies for glaucoma detection of scanning laser polarimetry (SLP) with enhanced corneal compensation (GDx ECC) and variable corneal compensation (GDx VCC; both by Carl Zeiss Meditec, Dublin, CA), accordin ... Full text Link to item Cite

American Chinese glaucoma imaging study: a comparison of the optic disc and retinal nerve fiber layer in detecting glaucomatous damage.

Journal Article Invest Ophthalmol Vis Sci · June 2007 PURPOSE: To compare the relationships between optic nerve structural measures and visual function, as well as the diagnostic sensitivity for glaucoma detection between the retinal nerve fiber layer (RNFL) and neuroretinal rim measurements. METHODS: A total ... Full text Link to item Cite

The effect of disc size and severity of disease on the diagnostic accuracy of the Heidelberg Retina Tomograph Glaucoma Probability Score.

Journal Article Invest Ophthalmol Vis Sci · June 2007 PURPOSE: To compare the effect of disc size and disease severity on the Heidelberg Retina Tomograph (HRT) Glaucoma Probability Score (GPS) and the Moorfields Regression Analysis (MRA) for discriminating between glaucomatous and healthy eyes. METHODS: Ninet ... Full text Link to item Cite

Long-term variability of GDx VCC retinal nerve fiber layer thickness measurements.

Journal Article J Glaucoma · May 2007 PURPOSE: To evaluate the long-term variability of GDx VCC retinal nerve fiber layer (RNFL) thickness measurements. METHODS: The study enrolled a cohort of glaucoma suspects who did not develop any evidence of visual field damage or change in the appearance ... Full text Link to item Cite

Intereye spatial relationship of abnormal neuroretinal rim locations in glaucoma patients from the diagnostic innovations in glaucoma study.

Journal Article Am J Ophthalmol · May 2007 PURPOSE: To determine the spatial relationship in neuroretinal rim parameter values between eyes in ocular hypertensives, glaucoma suspects, and glaucoma patients. DESIGN: Observational-cross-sectional study. METHODS: A total of 334 eyes of 167 patients we ... Full text Link to item Cite

Diagnostic ability of optical coherence tomography with a normative database to detect band atrophy of the optic nerve.

Journal Article Am J Ophthalmol · May 2007 PURPOSE: To evaluate the diagnostic ability of stratus optical coherence tomography (OCT) with a normative database to detect band atrophy (BA) of the optic nerve. DESIGN: Cross-sectional study. METHODS: StratusOCT retinal nerve fiber layer thickness scans ... Full text Link to item Cite

Comparison of dynamic contour tonometry and goldmann applanation tonometry in African American subjects.

Journal Article Ophthalmology · April 2007 PURPOSE: To evaluate the relationship between intraocular pressure (IOP) measurements obtained by dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in African Americans and to assess whether these measures were influenced by ocular p ... Full text Link to item Cite

Agreement between stereophotographic and confocal scanning laser ophthalmoscopy measurements of cup/disc ratio: effect on a predictive model for glaucoma development.

Journal Article J Glaucoma · March 2007 OBJECTIVE: To evaluate risk estimates obtained by incorporating confocal scanning laser ophthalmoscopy measurements of cup/disc (C/D) ratio into a previously described and validated predictive model to estimate the risk of glaucoma development in ocular hy ... Full text Link to item Cite

The effects of study design and spectrum bias on the evaluation of diagnostic accuracy of confocal scanning laser ophthalmoscopy in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · January 2007 PURPOSE: To assess the effects of study design and spectrum bias on the evaluation of diagnostic accuracy of confocal scanning laser ophthalmoscopy (CSLO) in glaucoma. METHODS: Analysis 1 included 67 eyes with glaucomatous visual field loss and 56 eyes of ... Full text Link to item Cite

Evaluation of macular thickness measurements for detection of band atrophy of the optic nerve using optical coherence tomography.

Journal Article Ophthalmology · January 2007 PURPOSE: To evaluate the ability of optical coherence tomography (OCT) macular thickness parameters to differentiate between eyes with band atrophy (BA) of the optic nerve and healthy eyes. DESIGN: Cross-sectional study. PARTICIPANTS: The study included 1 ... Full text Link to item Cite

The effect of atypical birefringence patterns on glaucoma detection using scanning laser polarimetry with variable corneal compensation.

Journal Article Invest Ophthalmol Vis Sci · January 2007 PURPOSE: The purpose of this study was to investigate the effect of the presence of atypical birefringence patterns, as measured by the typical scan score (TSS), on the diagnostic accuracy of a scanning laser polarimeter (the GDx VCC; Carl Zeiss Meditec, I ... Full text Link to item Cite

Progressive localized retinal nerve fiber layer loss following a retinal cotton wool spot.

Journal Article Semin Ophthalmol · 2007 Localized retinal nerve fiber layer (RNFL) defects can be an early sign of glaucomatous damage. However, their presence is not pathognomonic of the disease. We report a case of a localized RNFL defect developing after a retinal cotton-wool spot in a patien ... Full text Link to item Cite

Comparison of retinal nerve fibre layer measurements using optical coherence tomography versions 1 and 3 in eyes with band atrophy of the optic nerve and normal controls.

Journal Article Eye (Lond) · January 2007 AIMS: To compare retinal nerve fibre layer (RNFL) measurements were carried out with two different versions of an optical coherence tomography device in patients with band atrophy (BA) of the optic nerve and in normal controls. METHODS: The RNFL of 36 eyes ... Full text Link to item Cite

Optic disc melanocytoma and glaucoma.

Journal Article Semin Ophthalmol · 2007 An 82-year-old man presented with optic disc melanocytoma and glaucomatous optic neuropathy. The coexistence of these findings is particularly challenging, as there is no specific means for differentiating whether the optic nerve damage is glaucoma- or mel ... Full text Link to item Cite

Inconsistency of the published definition of ocular hypertension.

Journal Article J Glaucoma · December 2006 PURPOSE: To examine the variability and to evaluate the influence of the Ocular Hypertension Treatment Study (OHTS) on the criteria for published definition of ocular hypertension (OH). DESIGN: Systematic literature review. METHODS: All articles about OH p ... Full text Link to item Cite

In reply [6]

Journal Article Archives of Ophthalmology · October 16, 2006 Full text Cite

Evaluation of the influence of corneal biomechanical properties on intraocular pressure measurements using the ocular response analyzer.

Journal Article J Glaucoma · October 2006 PURPOSE: The Ocular Response Analyzer (ORA) proposes to measure corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when this structure is submitted to a force induced by an air jet. The purpose of this study was to ev ... Full text Link to item Cite

Baseline optical coherence tomography predicts the development of glaucomatous change in glaucoma suspects.

Journal Article Am J Ophthalmol · October 2006 PURPOSE: To assess whether baseline retinal nerve fiber layer (RNFL) measurements obtained with optical coherence tomography (OCT2; Carl Zeiss Meditec, Dublin, California, USA) are predictive of the development of glaucomatous change. DESIGN: Cohort study. ... Full text Link to item Cite

Combining structural and functional testing for detection of glaucoma.

Journal Article Ophthalmology · September 2006 PURPOSE: To assess whether the combined use of both structural and functional tests improves discrimination between healthy and glaucomatous eyes over either type of testing alone. DESIGN: Observational cross-sectional study. PARTICIPANTS: One hundred twen ... Full text Link to item Cite

Identifying glaucomatous vision loss with visual-function-specific perimetry in the diagnostic innovations in glaucoma study.

Journal Article Invest Ophthalmol Vis Sci · August 2006 PURPOSE: To compare the diagnostic results of four perimetric tests and to identify useful parameters from each for determining abnormality. METHODS: One hundred eleven eyes with glaucomatous optic neuropathy (GON), 31 with progressive optic neuropathy (PG ... Full text Link to item Cite

Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry.

Journal Article Invest Ophthalmol Vis Sci · July 2006 PURPOSE: To assess the strength of the association between retinal nerve fiber layer (RNFL) thickness and optic disc topography measured with confocal retinal tomography (HRT II; Heidelberg Engineering, Dossenheim, Germany), optical coherence tomography (S ... Full text Link to item Cite

Intereye concordance in locations of visual field defects in primary open-angle glaucoma: diagnostic innovations in glaucoma study.

Journal Article Ophthalmology · June 2006 PURPOSE: To determine the overlap in defective visual field locations between the right and left eyes of primary open-angle glaucoma patients. DESIGN: Cross-sectional retrospective analysis of data from a prospectively designed longitudinal study. PARTICIP ... Full text Link to item Cite

A statistical approach to the evaluation of covariate effects on the receiver operating characteristic curves of diagnostic tests in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · June 2006 PURPOSE: To describe an approach for the evaluation of covariate effects on receiver operating characteristic (ROC) curves and to apply this methodology to the investigation of the effects of disease severity and age on the diagnostic performance of freque ... Full text Link to item Cite

Retinal nerve fibre layer thickness measurements in patients using chloroquine.

Journal Article Clin Exp Ophthalmol · March 2006 PURPOSE: Previous investigations have suggested that initial retinal damage from chloroquine toxicity occurs in ganglion cells, and other ocular tissues are affected only later on. The aim of this study was to evaluate retinal nerve fibre layer (RNFL) thic ... Full text Link to item Cite

Relationship between patterns of visual field loss and retinal nerve fiber layer thickness measurements.

Journal Article Am J Ophthalmol · March 2006 PURPOSE: To investigate the association between patterns of visual field (VF) loss and retinal nerve fiber layer (RNFL) thickness measurements. DESIGN: Observational cross-sectional study. METHODS: One hundred twenty-one glaucoma patients and 65 healthy su ... Full text Link to item Cite

Influence of disease severity and optic disc size on the diagnostic performance of imaging instruments in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · March 2006 PURPOSE: To evaluate the influence of disease severity and optic disc size on the diagnostic accuracy of three imaging technologies for structural assessment in glaucoma: confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and optical coher ... Full text Link to item Cite

Repeatability and reproducibility of optic nerve head topography using the retinal thickness analyzer.

Journal Article Graefes Arch Clin Exp Ophthalmol · February 2006 OBJECTIVE: The objective was to determine the reproducibility and repeatability of topographic disk parameters with the retinal thickness analyzer (RTA). METHODS: Thirty-nine eyes of 39 healthy subjects were included. Three observers performed three consec ... Full text Link to item Cite

Agreement among 3 optical imaging methods for the assessment of optic disc topography.

Journal Article Ophthalmology · December 2005 PURPOSE: To assess the agreement of disc topography measurements between the Heidelberg Retina Tomograph (HRT II), Retinal Thickness Analyzer (RTA), and Optical Coherence Tomograph (StratusOCT). DESIGN: Observational cross-sectional study. PARTICIPANTS: Fo ... Full text Link to item Cite

Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice.

Journal Article Invest Ophthalmol Vis Sci · December 2005 PURPOSE: To determine the effect of bimatoprost on intraocular pressure in the prostaglandin FP receptor knockout mouse. METHODS: The IOP response to a single 1.2-microg (4 microL) dose of bimatoprost was measured in the treated and untreated fellow eyes o ... Full text Link to item Cite

Five rules to evaluate the optic disc and retinal nerve fiber layer for glaucoma.

Journal Article Optometry · November 2005 A systematic approach for the examination of the optic disc and retinal nerve fiber layer is described that will aid in the detection of glaucoma. This approach encompasses 5 rules: evaluation of optic disc size, neuroretinal rim size and shape, retinal ne ... Full text Link to item Cite

Differences in visual function and optic nerve structure between healthy eyes of blacks and whites.

Journal Article Arch Ophthalmol · November 2005 OBJECTIVE: To investigate differences in visual function, optic disc topography, and retinal nerve fiber layer (RNFL) thickness between healthy eyes of blacks and whites. METHODS: Visual function was assessed in healthy eyes of 50 blacks and 50 whites usin ... Full text Link to item Cite

Unsupervised machine learning with independent component analysis to identify areas of progression in glaucomatous visual fields.

Journal Article Invest Ophthalmol Vis Sci · October 2005 PURPOSE: To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHOD ... Full text Link to item Cite

Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma.

Journal Article Arch Ophthalmol · October 2005 OBJECTIVES: To develop and validate a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma. METHODS: Predictive models for the 5-year risk of conversion to glaucoma were derived from the results of the Ocular Hypertensio ... Full text Link to item Cite

Bimatoprost.

Journal Article Ophthalmology · August 2005 Full text Link to item Cite

Relationship of SITA and full-threshold standard perimetry to frequency-doubling technology perimetry in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · July 2005 PURPOSE: To compare full-threshold (FT) and SITA algorithms for standard automated perimetry (SAP) with frequency-doubling technology perimetry (FDT) in glaucoma, to help clinicians to relate results in patients who have had two or more of these tests duri ... Full text Link to item Cite

Use of progressive glaucomatous optic disk change as the reference standard for evaluation of diagnostic tests in glaucoma.

Journal Article Am J Ophthalmol · June 2005 PURPOSE: Progressive change in optic disk appearance has been suggested as the best available reference standard for glaucoma diagnosis. We evaluated the accuracy of scanning laser polarimetry (SLP) with variable corneal compensation to discriminate patien ... Full text Link to item Cite

Relevance vector machine and support vector machine classifier analysis of scanning laser polarimetry retinal nerve fiber layer measurements.

Journal Article Invest Ophthalmol Vis Sci · April 2005 PURPOSE: To classify healthy and glaucomatous eyes using relevance vector machine (RVM) and support vector machine (SVM) learning classifiers trained on retinal nerve fiber layer (RNFL) thickness measurements obtained by scanning laser polarimetry (SLP). M ... Full text Link to item Cite

Comparability of retinal nerve fiber layer thickness measurements of optical coherence tomography instruments.

Journal Article Invest Ophthalmol Vis Sci · April 2005 PURPOSE: To compare retinal nerve fiber layer (RNFL) measurements between two ocular coherence tomography (OCT) instruments (OCT 2000 and Stratus OCT; Carl Zeiss Meditec, Dublin, CA) and compare their diagnostic precision. METHODS: One hundred thirty-nine ... Full text Link to item Cite

Argon laser iridoplasty in the treatment of plateau-like iris configuration as result of numerous ciliary body cysts.

Journal Article Am J Ophthalmol · February 2005 PURPOSE: To report the use of argon laser peripheral iridoplasty in the treatment of plateau-like iris configuration as a result of iris and ciliary body cysts. DESIGN: Case report. METHODS: A 43-year-old male with plateau iris syndrome was demonstrated by ... Full text Link to item Cite

Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients.

Journal Article Ophthalmology · February 2005 PURPOSE: To examine the relationship between retinal nerve fiber layer (RNFL) measurements obtained using scanning laser polarimetry with variable corneal compensation and corneal thickness measurements in ocular hypertension (OHT) patients. DESIGN: Observ ... Full text Link to item Cite

Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography.

Journal Article Am J Ophthalmol · January 2005 PURPOSE: To compare the ability of optical coherence tomography retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to differentiate between healthy eyes and eyes with glaucomatous visual field loss. DESIGN: Observational c ... Full text Link to item Cite

Patterns of glaucomatous visual field progression identified by three progression criteria.

Journal Article Am J Ophthalmol · December 2004 PURPOSE: To determine typical patterns of repeatable glaucomatous visual field progression. DESIGN: Retrospective analysis of data obtained from two prospective studies. METHODS: Included were 72 eyes of 72 patients tested up to six times over 2 years, and ... Full text Link to item Cite

Retinal nerve fiber layer thickness measurements with scanning laser polarimetry predict glaucomatous visual field loss.

Journal Article Am J Ophthalmol · October 2004 PURPOSE: To assess whether baseline retinal nerve fiber layer (RNFL) measurements obtained with a scanning laser polarimeter, the GDx Nerve Fiber Analyzer, (Laser Diagnostic Technologies Inc., San Diego, California) are predictive of development of repeata ... Full text Link to item Cite

Intraocular pressure fluctuations in response to the water-drinking provocative test in patients using latanoprost versus unoprostone.

Journal Article J Ocul Pharmacol Ther · October 2004 Impairment of outflow facility in glaucoma causes large intraocular pressure (IOP) fluctuations that have been shown to be a risk factor for disease progression. The water-drinking provocative test (WDT) has been proposed as an indirect measurement of outf ... Full text Link to item Cite

Conjunctival hyperemia associated with bimatoprost use: a histopathologic study.

Journal Article Am J Ophthalmol · August 2004 PURPOSE: To evaluate histopathologic signs of conjunctival inflammation in patients with conjunctival hyperemia induced by bimatoprost treatment. DESIGN: Prospective interventional study. METHODS: The study included 15 eyes of 15 patients scheduled for cat ... Full text Link to item Cite

Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes.

Journal Article Invest Ophthalmol Vis Sci · July 2004 PURPOSE: To determine whether Heidelberg Retina Tomograph (HRT; Heidelberg Engineering, Dossenheim, Germany) classification techniques and investigational support vector machine (SVM) analyses can detect optic disc abnormalities in glaucoma-suspect eyes be ... Full text Link to item Cite

Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma.

Journal Article Arch Ophthalmol · June 2004 OBJECTIVE: To compare the abilities of current commercially available versions of 3 optical imaging techniques: scanning laser polarimetry with variable corneal compensation (GDx VCC), confocal scanning laser ophthalmoscopy (HRT II [Heidelberg Retina Tomog ... Full text Link to item Cite

Frequency doubling technology perimetry abnormalities as predictors of glaucomatous visual field loss.

Journal Article Am J Ophthalmol · May 2004 PURPOSE: To determine whether frequency doubling technology (FDT) perimetry results predict glaucomatous visual field defects, as assessed by standard automated perimetry (SAP), in a glaucoma suspect population. DESIGN: Longitudinal observational study. ME ... Full text Link to item Cite

Comparison of scanning laser polarimetry using variable corneal compensation and retinal nerve fiber layer photography for detection of glaucoma.

Journal Article Arch Ophthalmol · May 2004 OBJECTIVE: To compare retinal nerve fiber layer (RNFL) measurements obtained with scanning laser polarimetry (SLP) using variable corneal polarization compensation with standard red-free photography for detection of RNFL damage in glaucoma. METHODS: This o ... Full text Link to item Cite

Total plasma homocysteine and primary open-angle glaucoma.

Journal Article Am J Ophthalmol · March 2004 PURPOSE: To evaluate total plasma homocysteine (tHcy) levels in patients diagnosed with primary open-angle glaucoma (POAG) and normal subjects. DESIGN: Case-control study. METHODS: This study involved 55 POAG patients, 16 patients with secondary open-angle ... Full text Link to item Cite

Short-wavelength automated perimetry can predict glaucomatous standard visual field loss by ten years.

Journal Article Semin Ophthalmol · 2004 Examination of visual fields using standard achromatic automated perimetry (SAP) is essential for glaucoma management. However, as many as 35-50% of retinal ganglion cells can be lost before a visual field defect is detected. Previous studies have indicate ... Full text Link to item Cite

Corneal thickness as a risk factor for visual field loss in patients with preperimetric glaucomatous optic neuropathy.

Journal Article Am J Ophthalmol · November 2003 PURPOSE: To determine whether central corneal thickness (CCT) is a risk factor for visual field loss development among patients diagnosed with preperimetric glaucomatous optic neuropathy (GON). DESIGN: Observational cohort study. METHODS: The study include ... Full text Link to item Cite

Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes.

Journal Article Ophthalmology · October 2003 OBJECTIVE: It has been suggested that some patients currently diagnosed with ocular hypertension (OHT) may have thicker than average corneas that result in an overestimation of their true intraocular pressure. Consequently, patients with OHT with greater c ... Full text Link to item Cite

Fourier analysis of scanning laser polarimetry measurements with variable corneal compensation in glaucoma.

Journal Article Invest Ophthalmol Vis Sci · June 2003 PURPOSE: To apply Fourier analysis to the retinal nerve fiber layer (RNFL) thickness measurements obtained with scanning laser polarimetry (SLP), by using variable corneal compensation, and to evaluate the ability of this method to discriminate glaucomatou ... Full text Link to item Cite

Comparison of algorithms for detection of localised nerve fibre layer defects using scanning laser polarimetry.

Journal Article Br J Ophthalmol · April 2003 AIMS: To evaluate different algorithms used to analyse retinal nerve fibre layer thickness (RNFL) data obtained by scanning laser polarimetry, in order to compare their relative abilities to discriminate between patients with glaucomatous localised nerve f ... Full text Link to item Cite

Axonal loss after traumatic optic neuropathy documented by optical coherence tomography.

Journal Article Am J Ophthalmol · March 2003 PURPOSE: To report longitudinal retinal nerve fiber layer (RNFL) thickness measurements using optical coherence tomography (OCT) in a patient with traumatic optic neuropathy. DESIGN: Observational case report. METHODS: A 14-year-old boy with severe optic n ... Full text Link to item Cite

Corneal thickness measurements and visual function abnormalities in ocular hypertensive patients.

Journal Article Am J Ophthalmol · February 2003 PURPOSE: It has been suggested that a considerable subset of patients currently classified as having ocular hypertension may have thicker than average corneas that result in an overestimation of the true intraocular pressure (IOP). As a consequence, ocular ... Full text Link to item Cite

Quantitative analysis of axonal loss in band atrophy of the optic nerve using scanning laser polarimetry.

Journal Article Br J Ophthalmol · January 2003 AIMS: To measure axonal loss in patients with band atrophy from optic chiasm compression using scanning laser polarimetry (GDx, Laser Diagnostic Technologies, Inc, San Diego, CA, USA) and to evaluate the ability of this instrument to identify this pattern ... Full text Link to item Cite

Medical backgrounders: glaucoma.

Journal Article Drugs Today (Barc) · August 2002 Glaucoma is a leading cause of irreversible blindness in the world. Currently, glaucoma is diagnosed as a progressive optic neuropathy with characteristic optic disc and nerve fiber layer damage, usually associated with loss of visual function. The intraoc ... Full text Link to item Cite

Intraocular pressure fluctuations in medical versus surgically treated glaucomatous patients

Journal Article Journal of Ocular Pharmacology and Therapeutics · January 1, 2002 The purpose of this study was to compare the IOP fluctuations in the daytime tension curves of glaucoma patients under ocular hypotensive therapy with those of patients previously submitted to trabeculectomy. We also evaluated the IOP peaks and fluctuation ... Full text Cite

The pros and cons of different prostanoids in the medical management of glaucoma.

Journal Article Curr Opin Ophthalmol · April 2001 The prostaglandin analogs are new exciting drugs added to the therapeutic armamentarium for patients with glaucoma. Several studies have evaluated the ocular hypotensive properties and side effects of latanoprost in different forms of glaucoma. This drug, ... Full text Link to item Cite

Retinal nerve fiber layer measurements in patients with migraine with aura

Journal Article Arquivos Brasileiros de Oftalmologia · January 1, 2001 Purpose: To evaluate the possible alterations of the retinal nerve fiber layer (RNFL), as detected by scanning laser polarimetry (SLP), that may occur in patients with migraine with aura. Methods: Twenty patients with migraine with aura and twenty normal s ... Full text Cite

Correlation between intraocular pressure peaks in the diurnal tension curve and in the water-drinking provocative test. A study in primary open-angle glaucoma patients using timolol and dorzolamide

Journal Article Revista Brasileira de Oftalmologia · January 1, 2001 Purpose: To determine if the water-drinking provocative test is of value in predicting the peak of intraocular pressure (IOP) of a diurnal tension curve in patients with primary open-angle glaucoma (POAG) using timolol and dorzolamide. Methods: Thirteen pa ... Cite