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Overview


I got my B.Sc. + M.Sc. in Novosibirsk State University (Novosibirsk, Russia) in chemistry in 2006 and my PhD in chemistry (specialization:biochemistry) in Institute of Chemical Biology and Fundamental Medicine SB RAS (Novosibirsk, Russia) in 2011.
  In 2012-2022 I was occupying position of researcher in Institute of Chemical Biology and Fundamental Medicine SB RAS (Novosibirsk, Russia), that time my research was focused on enzymology of base excision repair (BER) enzymes, evaluation of BER proteins as potential targets for anti-pathogen and anti-cancer therapy and also developing of BER enzymes based artificial endonuclease and usage of BER enzymes for biotechnology. At the end of 2022 I decided to leave Russia by political reasons and started a postdoc associate position in Duke University.
  My current research interests are cryo-electron microscopy (Cryo-EM) single-particle protein structural analysis and use of Cryo-EM for elucidation of folding and refolding mechanisms of proteins in particular.

Current Appointments & Affiliations


Postdoctoral Associate Pratt School of Engineering

Recent Publications


Correlated Target Search by Vaccinia Virus Uracil-DNA Glycosylase, a DNA Repair Enzyme and a Processivity Factor of Viral Replication Machinery.

Journal Article International journal of molecular sciences · May 2023 The protein encoded by the vaccinia virus D4R gene has base excision repair uracil-DNA N-glycosylase (vvUNG) activity and also acts as a processivity factor in the viral replication complex. The use of a protein unlike PolN/PCNA sliding clamp ... Full text Cite

DNA Damage Response and Repair in Boron Neutron Capture Therapy.

Journal Article Genes · January 2023 Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cells accu ... Full text Cite

Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases.

Journal Article Cells · October 2022 Proteins that recognize specific DNA sequences or structural elements often find their cognate DNA lesions in a processive mode, in which an enzyme binds DNA non-specifically and then slides along the DNA contour by one-dimensional diffusion. Opposite to t ... Full text Cite
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