Scholars@Duke
Hillary Mulder

Hillary Mulder

Biostatistician, Senior
Duke Clinical Research Institute
hillary.mulder@duke.edu
2400 Pratt Street, Rm 0311 Terrace Level, Durham, NC 27705
2400 Pratt Street, Rm 0311 Terrace Level, Durham, NC 27705

Scholarly Works

Expression of complement pathway genes is associated with progression of idiopathic pulmonary fibrosis.

Journal article Respir Res · March 25, 2026 BACKGROUND: Studies suggest that the complement pathway may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We evaluated associations between complement pathway gene expression and clinical outcomes in patients with IPF. METHODS: RN ... Full text Link to item Cite

High density lipoproteins, disease severity and clinical outcomes in patients with idiopathic pulmonary fibrosis.

Conference Respir Res · February 17, 2026 BACKGROUND: Dysregulation of lipid metabolism is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We assessed associations between circulating levels of high-density lipoprotein-cholesterol (HDL-C) and its components apolipoprotein A- ... Full text Link to item Cite

MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics.

Journal article Ann Neurol · February 2026 OBJECTIVE: To establish a framework for validating candidate biomarkers of cerebral small vessel diseases (SVD) associated with cognitive impairment and characterize individuals enrolled by the MarkVCID2 consortium under this framework. METHODS: Participan ... Full text Link to item Cite

Racial and Educational Isolation are Associated with Worse Outcomes in Congenital Heart Disease.

Journal article Pediatr Cardiol · January 2026 Sociodemographic factors influence outcomes in children with congenital heart disease (CHD). We predict an association between measures of social isolation and outcomes in infants with complex CHD. These measures, racial (RI) and educational (EI) isolation ... Full text Link to item Cite

Prediction and Longer-Term Outcomes of All-cause and Cardiovascular Mortality in the HEART-FID Trial.

Journal article J Card Fail · December 2025 BACKGROUND: The HEART-FID trial (Randomized Placebo-Controlled Trial of Ferric Carboxymaltose [FCM] as Treatment for Heart Failure with Iron Deficiency) is the largest trial to test intravenous iron (ferric carboxymaltose [FCM]) vs placebo in patients with ... Full text Link to item Cite

Mass spectrometry-based peripheral blood proteomics for biomarker discovery in idiopathic pulmonary fibrosis.

Journal article Respir Res · October 22, 2025 BACKGROUND: The circulating proteome may provide insights into the pathobiology of idiopathic pulmonary fibrosis (IPF) and diagnostic or prognostic biomarkers. We applied liquid chromatography coupled to mass spectrometry to quantify the peripheral blood p ... Full text Link to item Cite

Association of study visit interval length with follow-up completeness and adherence to assigned study drug dose: A randomized comparison of participants in the ADAPTABLE trial.

Journal article Contemp Clin Trials · September 2025 BACKGROUND: Little is known of the frequency of follow-up visits impact on completion of scheduled study visits, adherence to randomized treatment assignment, and completion of the study. METHODS: In ADAPTABLE, participants with ASCVD were randomized to 81 ... Full text Link to item Cite

Systematic review and meta-analysis of intravenous iron therapy for patients with heart failure and iron deficiency.

Journal article Nat Med · August 2025 Uncertainty remains about the effect of intravenous (i.v.) iron on outcomes for heart failure (HF) with iron deficiency. In the present study, we summarize the efficacy and safety of i.v. iron from six trials (FAIR-HF, CONFIRM-HF, AFFIRM-AHF, IRONMAN, HEAR ... Full text Link to item Cite

Real-world exploration of LDL-cholesterol management in patients with atherosclerotic cardiovascular disease.

Journal article Am Heart J · January 2025 BACKGROUND: Although guidelines recommend low-density lipoprotein cholesterol (LDL-C) to be < 70 mg/dL in patients with atherosclerotic cardiovascular disease (ASCVD), the rate of achieving this goal remains suboptimal. We sought to understand real world c ... Full text Link to item Cite

Lipoprotein (a) Testing in Patients With Atherosclerotic Cardiovascular Disease in 5 Large US Health Systems.

Journal article J Am Heart Assoc · November 5, 2024 BACKGROUND: Lipoprotein (a) is an independent risk factor for atherosclerotic cardiovascular disease. However, lipoprotein (a) testing remains variable and it is unclear what factors influence testing and if testing changes clinical management. METHODS AND ... Full text Link to item Cite

Contribution of Clinical Trial Event Data by Data Source: A Prespecified Analysis of the ADAPTABLE Randomized Clinical Trial.

Journal article JAMA Cardiol · September 1, 2024 IMPORTANCE: Pragmatic randomized clinical trials (RCTs) often use multiple data sources to examine clinical events, but the relative contribution of data sources to clinical end-point rates is understudied. OBJECTIVE: To assess the contribution of data sou ... Full text Link to item Cite

Kidney and Cardiovascular Effectiveness of SGLT2 Inhibitors vs GLP-1 Receptor Agonists in Type 2 Diabetes.

Journal article J Am Coll Cardiol · August 20, 2024 BACKGROUND: Emerging data suggest that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve kidney outcomes for people with type 2 diabetes (T2D). Direct comparisons of the kidney and cardiovascular effectiveness of GLP-1 RA with sodium-glucose co ... Full text Open Access Link to item Cite

Impact of aspirin dose according to race in secondary prevention of atherosclerotic cardiovascular disease: a secondary analysis of the ADAPTABLE randomised controlled trial.

Journal article BMJ Open · August 7, 2024 OBJECTIVES: To evaluate whether the effectiveness and safety of low (81 mg daily) versus high-dose (325 mg daily) aspirin is consistent across races among patients with established atherosclerotic cardiovascular disease (ASCVD). DESIGN: A secondary analysi ... Full text Link to item Cite

Evaluating Factors Associated With Telehealth Appropriateness in Outpatient Rheumatoid Arthritis Encounters Using the Encounter Appropriateness Score for You (EASY).

Journal article J Rheumatol · August 1, 2024 OBJECTIVE: Telehealth has been proposed as a safe and effective alternative to in-person care for rheumatoid arthritis (RA). The purpose of this study was to evaluate factors associated with telehealth appropriateness in outpatient RA encounters. METHODS: ... Full text Open Access Link to item Cite

Kidney and Cardiovascular Effectiveness of Empagliflozin Compared With Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes.

Journal article Am J Cardiol · June 15, 2024 Placebo-controlled trials of sodium-glucose co-transporter-2 inhibitors demonstrate kidney and cardiovascular benefits for patients with type 2 diabetes and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effe ... Full text Open Access Link to item Cite

Concordance With Screening and Treatment Guidelines for Chronic Kidney Disease in Type 2 Diabetes.

Journal article JAMA Netw Open · June 3, 2024 IMPORTANCE: Chronic kidney disease (CKD) is an often-asymptomatic complication of type 2 diabetes (T2D) that requires annual screening to diagnose. Patient-level factors linked to inadequate screening and treatment can inform implementation strategies to f ... Full text Open Access Link to item Cite

Risk Factors and Outcomes Associated with Gaps in Care in Children with Congenital Heart Disease.

Conference Pediatr Cardiol · June 2024 Adults with congenital heart disease (CHD) benefit from cardiology follow-up at recommended intervals of ≤ 2 years. However, benefit for children is less clear given limited studies and unclear current guidelines. We hypothesize there are identifiable risk ... Full text Link to item Cite

Lipoprotein(a) testing in Patients with Atherosclerotic Cardiovascular Disease in Five Large U.S. Health Systems

Preprint · 2024 Introduction Lipoprotein (a) [Lp(a)] is an independent, causal risk factor for atherosclerotic cardiovascular disease (ASCVD). However, testing patterns remain variable and it is unclear what patient level factors are associated with Lp(a) testing ... Full text Cite

Impact of Prenatal Diagnosis of Critical Congenital Heart Disease on Preoperative and Postoperative Outcomes.

Journal article Pediatr Cardiol · October 2023 The objective of this study was to assess the relationship of prenatal diagnosis of critical congenital heart disease (CHD) to preoperative and postoperative patient findings. Retrospective analysis of neonates with critical CHD who underwent cardiothoraci ... Full text Link to item Cite

Assessing the utility of molecular diagnostic classification for cancers of unknown primary.

Journal article Cancer Med · October 2023 BACKGROUND: Roughly 5% of metastatic cancers present with uncertain origin, for which molecular classification could influence subsequent management; however, prior studies of molecular diagnostic classifiers have reported mixed results with regard to clin ... Full text Link to item Cite

BAL Fluid Eosinophilia Associates With Chronic Lung Allograft Dysfunction Risk: A Multicenter Study.

Journal article Chest · September 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) is the leading cause of death among lung transplant recipients. Eosinophils, effector cells of type 2 immunity, are implicated in the pathobiology of many lung diseases, and prior studies suggest their ... Full text Link to item Cite

Classification of Heart Failure Events by Severity: Insights From the VICTORIA Trial.

Journal article J Card Fail · August 2023 BACKGROUND: Hospitalization due to heart failure (HFH) is a major source of morbidity, consumes significant economic resources and is a key endpoint in HF clinical trials. HFH events vary in severity and implications, but they are typically considered equi ... Full text Link to item Cite

Internet Versus Noninternet Participation in a Decentralized Clinical Trial: Lessons From the ADAPTABLE Study.

Journal article J Am Heart Assoc · July 4, 2023 Background Internet-based participation has the potential to enhance pragmatic and decentralized trials, where representative study populations and generalizability to clinical practice are key. We aimed to study the differences between internet and nonint ... Full text Link to item Cite

Contemporary patterns of lipoprotein(a) testing and associated clinical care and outcomes.

Conference Am J Prev Cardiol · June 2023 OBJECTIVE: Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease, yet little is known about Lp(a) testing patterns in real-world practice. The objective of this analysis was to determine how Lp(a) testing is used in clin ... Full text Link to item Cite

Evaluation of weight change and cardiometabolic risk factors in a real-world population of US adults with overweight or obesity.

Journal article Prev Med · May 2023 Whether individuals in real-world settings are able to lose weight and improve cardiometabolic risk factors over time is unclear. We aimed to determine the management of and degree of body weight change over 2 years among individuals with overweight or obe ... Full text Link to item Cite

Seasonal variation in blood pressure control across US health systems.

Journal article J Hypertens · May 1, 2023 OBJECTIVE: We aimed to characterize seasonal variation in US population-based blood pressure (BP) control and BP-related metrics and evaluate the association between outdoor temperature and BP control variation. METHODS: We queried electronic health record ... Full text Link to item Cite

Hydroxychloroquine for pre-exposure prophylaxis of COVID-19 in health care workers: a randomized, multicenter, placebo-controlled trial Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine (HERO-HCQ).

Conference Int J Infect Dis · April 2023 OBJECTIVES: To determine whether hydroxychloroquine (HCQ) is safe and effective at preventing COVID-19 infections among health care workers (HCWs). METHODS: In a 1: 1 randomized, placebo-controlled, double-blind, parallel-group, superiority trial at 34 US ... Full text Link to item Cite

Concordance Between Patient-Reported Health Data and Electronic Health Data in the ADAPTABLE Trial.

Journal article JAMA Cardiol · December 1, 2022 IMPORTANCE: Patient-reported health data can facilitate clinical event capture in pragmatic clinical trials. However, few data are available on the fitness for use of patient-reported data in large-scale health research. OBJECTIVE: To evaluate the concorda ... Full text Link to item Cite

A Clinical-Molecular Signature of Progression of Idiopathic Pulmonary Fibrosis (IPF)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2022 Link to item Cite

World regional differences in outcomes for patients with peripheral artery disease: Insights from the EUCLID trial.

Journal article Vasc Med · February 2022 Regional variations exist in the epidemiology of peripheral artery disease (PAD), in comorbidities, use of secondary prevention, and outcomes. Large studies of these variations in worldwide populations are rare. The EUCLID (Examining Use of tiCagreLor In p ... Full text Open Access Link to item Cite

Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort.

Journal article Lung · February 2022 Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine ass ... Full text Link to item Cite

Understanding Study Drug Discontinuation Through EUCLID.

Journal article Front Cardiovasc Med · 2022 INTRODUCTION: Disparities in the care and outcomes of peripheral artery disease (PAD) have been well-established. In part this is due to disparities in enrollment of PAD trial cohorts. However, less attention has been paid to non-random protocol non-adhere ... Full text Link to item Cite

Validation of Cardiovascular End Points Ascertainment Leveraging Multisource Electronic Health Records Harmonized Into a Common Data Model in the ADAPTABLE Randomized Clinical Trial.

Journal article Circ Cardiovasc Qual Outcomes · December 2021 BACKGROUND: The ADAPTABLE trial (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness) is the first randomized trial conducted within the National Patient-Centered Clinical Research Network to use the electronic health rec ... Full text Link to item Cite

Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial.

Journal article J Am Heart Assoc · November 16, 2021 Background Although safety and tolerability of vericiguat were established in the VICTORIA (Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction) trial in patients with heart failure with reduced ejection fraction, some sub ... Full text Link to item Cite

Blood pressure response and safety outcomes with vericiguat in the VICTORIA trial

Conference EUROPEAN JOURNAL OF HEART FAILURE · September 2021 Link to item Cite

Renal function and the effects of vericiguat in patients with worsening heart failure with reduced ejection fraction: insights from the VICTORIA (Vericiguat Global Study in Subjects with HFrEF) trial.

Journal article Eur J Heart Fail · August 2021 AIMS: Vericiguat reduced the primary composite outcome of cardiovascular death or heart failure (HF) hospitalization in patients with worsening HF with reduced ejection fraction (HFrEF) and a lower limit of baseline estimated glomerular filtration rate (eG ... Full text Link to item Cite

Clinical Outcome Predictions for the VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA) Trial.

Journal article J Card Fail · June 24, 2021 BACKGROUND: The prediction of outcomes in patients with heart failure (HF) may inform prognosis, clinical decisions regarding treatment selection, and new trial planning. The VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Frac ... Full text Link to item Cite

Clinical Outcome Predictions for the VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA) Trial.

Journal article J Card Fail · June 24, 2021 BACKGROUND: The prediction of outcomes in patients with heart failure (HF) may inform prognosis, clinical decisions regarding treatment selection, and new trial planning. The VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Frac ... Full text Link to item Cite

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease.

Journal article N Engl J Med · May 27, 2021 BACKGROUND: The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy. METHODS: Using an open ... Full text Link to item Cite

The Dose-Response Relationship Between Physical Activity and Cardiometabolic Health in Adolescents.

Journal article Am J Prev Med · January 2021 INTRODUCTION: This study examines the dose-response relationship between moderate-to-vigorous physical activity and cardiometabolic measures in adolescents. METHODS: Cross-sectional spline analyses were performed using 2003-2016 National Health and Nutriti ... Full text Link to item Cite

Association of Chronic Obstructive Pulmonary Disease with Morbidity and Mortality in Patients with Peripheral Artery Disease: Insights from the EUCLID Trial.

Journal article Int J Chron Obstruct Pulmon Dis · 2021 BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of developing lower extremity peripheral artery disease (PAD) and suffering PAD-related morbidity and mortality. However, the effect and burden of COPD on patients ... Full text Link to item Cite

Utilization of Invasive Procedures for Adult Eustachian Tube Dysfunction.

Journal article Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · November 2020 ObjectiveEustachian tube dysfunction (ETD) is a common diagnosis among adults presenting for outpatient care. We sought to determine national utilization and the associated cost of invasive procedures for adult ETD.Study designCross-secti ... Full text Cite

Cause of Death Among Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

Journal article Circ Cardiovasc Qual Outcomes · November 2020 BACKGROUND: Peripheral artery disease is common and associated with high mortality. There are limited data detailing causes of death among patients with peripheral artery disease. METHODS: EUCLID (Examining Use of Ticagrelor in Peripheral Artery Disease) w ... Full text Link to item Cite

Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial.

Journal article J Am Heart Assoc · October 20, 2020 Background There are limited data on health status instruments in patients with peripheral artery disease and cardiovascular and limb events. We evaluated the relationship between health status changes and cardiovascular and limb events. Methods and Result ... Full text Link to item Cite

Association Between Triglycerides and Residual Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus and Established Cardiovascular Disease (From the Bypass Angioplasty Revascularization Investigation 2 Diabetes [BARI 2D] Trial).

Journal article Am J Cardiol · October 1, 2020 Triglyceride (TG) levels encompass several lipoproteins that have been implicated in atherogenic pathways. Whether TG levels independently associate with cardiovascular disease both overall and, in particular among patients with established coronary artery ... Full text Link to item Cite

Outcomes following revascularization with radial artery bypass grafts: Insights from the PREVENT-IV trial.

Journal article Am Heart J · October 2020 BACKGROUND: The optimal role of radial artery grafts in coronary artery bypass grafting (CABG) remains uncertain. The purpose of this study was to examine angiographic and clinical outcomes following CABG among patients who received a radial artery graft. ... Full text Link to item Cite

Angiotensin-Neprilysin Inhibition in Black Americans: Data From the PIONEER-HF Trial.

Journal article JACC Heart Fail · October 2020 OBJECTIVES: This study compared the efficacy and safety of sacubitril/valsartan to enalapril in Black and non-Black Americans with acute decompensated heart failure (ADHF). BACKGROUND: Black patients have a different response to treatment with angiotensin- ... Full text Link to item Cite

Association of Disease Progression With Cardiovascular and Limb Outcomes in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

Journal article Circ Cardiovasc Interv · October 2020 BACKGROUND: Patients with peripheral artery disease have a high risk of future cardiovascular disease events and mortality. Little is known about the changes in symptom classification over time in patients with peripheral artery disease and the association ... Full text Link to item Cite

The Dose-Response Relationship Between Physical Activity and Cardiometabolic Health in Young Adults.

Journal article J Adolesc Health · August 2020 PURPOSE: Guidelines recommend 150 minutes of weekly moderate-to-vigorous physical activity (MVPA) for all adults, although physical activity level correlation with cardiometabolic health is not well characterized for young adults. We determined the dose-re ... Full text Link to item Cite

Incidence and Factors Associated With Major Amputation in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

Journal article Circ Cardiovasc Qual Outcomes · July 2020 BACKGROUND: Peripheral artery disease (PAD) is associated with increased risk of mortality, cardiovascular morbidity, and major amputation. Data on major amputation from a large randomized trial that included a substantial cohort of patients without critic ... Full text Link to item Cite

The effect of lateral neck dissection on complication rate for total thyroidectomy.

Journal article American journal of otolaryngology · May 2020 PurposeTo determine the complication profile for total thyroidectomy with and without concomitant lateral neck dissection using a large administrative database.Materials and methodsThe IBM MarketScan® Commercial Database (2010-2014) analy ... Full text Cite

Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial.

Journal article Am Heart J · March 2020 OBJECTIVES: A history of gastrointestinal bleeding (GIB) in patients with atrial fibrillation (AF) may impact decisions about anticoagulation treatment. We sought to determine whether prior GIB in patients with AF taking anticoagulants was associated with ... Full text Link to item Cite

Regional variation in clinical characteristics and outcomes in patients with atrial fibrillation: Findings from the ARISTOTLE trial.

Journal article Int J Cardiol · March 1, 2020 BACKGROUND: Variation in patient characteristics and practice patterns may influence outcomes at a regional level. METHODS: We assessed differences in demographics, practice patterns, outcomes, and the effect of apixaban compared with warfarin in ARISTOTLE ... Full text Link to item Cite

Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial.

Journal article Circulation · January 7, 2020 BACKGROUND: The use of nonsteroidal anti-inflammatory drugs (NSAIDs) with oral anticoagulants has been associated with an increased risk of bleeding. We investigated the risk of bleeding and major cardiovascular outcomes in patients with atrial fibrillatio ... Full text Link to item Cite

Have the Major Cardiovascular Outcomes Trials Impacted Payer Approval Rates for PCSK9 Inhibitors?

Journal article Circulation. Cardiovascular quality and outcomes · January 2020 Full text Cite

The association between triglycerides and incident cardiovascular disease: What is "optimal"?

Journal article J Clin Lipidol · 2020 BACKGROUND: Elevated triglycerides (TGs) are associated with increased risk of cardiovascular disease (CVD), but the best way to both measure TGs and assess TG-related risk remains unknown. OBJECTIVE: The objective of the study was to evaluate the associat ... Full text Link to item Cite

Association of Circulating Proteins with Death or Lung Transplant in the IPF-PRO Registry Cohort

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Link to item Cite

Clinical Implications of the New York Heart Association Classification.

Journal article J Am Heart Assoc · December 3, 2019 Background The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. However, its ability to adequately ... Full text Link to item Cite

Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction.

Journal article J Am Coll Cardiol · September 3, 2019 BACKGROUND: The GUIDE-IT (GUIDing Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) trial demonstrated that a strategy to "guide" application of guideline-directed medical therapy (GDMT) by reducing amino-terminal pro-B-type na ... Full text Link to item Cite

Racial differences in long-term outcomes among black and white patients with drug-eluting stents.

Journal article Am Heart J · August 2019 BACKGROUND: Some studies suggest that black patients may have worse outcomes after drug-eluting stent (DES) placement. There are limited data characterizing long-term outcomes by race. The objective was to compare long-term outcomes between black and white ... Full text Link to item Cite

Health Care Utilization and Prescribing Patterns for Adult Eustachian Tube Dysfunction.

Journal article Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · June 2019 ObjectiveEustachian tube dysfunction (ETD) prompts >2 million adult visits in the United States annually. While disease prevalence and health care utilization are established for children, practice patterns for adults remain unknown. Our objective ... Full text Cite

Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score.

Journal article Eur J Heart Fail · June 2019 BACKGROUND: Most heart failure (HF) risk scores have been derived from cohorts of stable HF patients and may not incorporate up to date treatment regimens or deep phenotype characterization that change baseline risk over the short- and long-term follow-up ... Full text Link to item Cite

Comparison of Outcomes and Frequency of Graft Failure With Use of Free Versus In Situ Internal Mammary Artery Bypass Conduits (from the PREVENT IV Trial).

Journal article Am J Cardiol · February 15, 2019 Although in situ internal mammary artery (is-IMA) grafting remains the most frequent conduit in coronary artery bypass grafting (CABG), circumstances may necessitate free grafting of the IMA (f-IMA), though differences in outcomes have not been fully chara ... Full text Link to item Cite

Outcomes of apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial.

Journal article Am Heart J · February 2019 BACKGROUND: Patients with atrial fibrillation (AF) often have multi-morbidity, defined as ≥3 comorbid conditions. Multi-morbidity is associated with polypharmacy, adverse events, and frailty potentially altering response to anticoagulation. We sought to de ... Full text Link to item Cite

Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

Journal article JAMA Cardiol · January 1, 2019 IMPORTANCE: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI). OBJECTIVE: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of M ... Full text Open Access Link to item Cite

Influence of Weight Reduction and Enhanced Protein Intake on Biomarkers of Inflammation in Older Adults with Obesity.

Journal article J Nutr Gerontol Geriatr · 2019 Both aging and obesity are associated with increased levels of pro-inflammatory metabolites, while weight reduction is associated with improvements in inflammatory status. However, few studies have explored the response of key inflammatory markers to the c ... Full text Link to item Cite

Polyvascular Disease and Risk of Major Adverse Cardiovascular Events in Peripheral Artery Disease: A Secondary Analysis of the EUCLID Trial.

Journal article JAMA Netw Open · November 2, 2018 IMPORTANCE: The effect of polyvascular disease on cardiovascular outcomes in the background of peripheral artery disease (PAD) is unclear. OBJECTIVE: To determine the risk of ischemic events (both cardiac and limb) among patients with PAD and polyvascular ... Full text Open Access Link to item Cite

Steroid Use for Sudden Sensorineural Hearing Loss: A CHEER Network Study.

Journal article Otolaryngol Head Neck Surg · November 2018 OBJECTIVE: The objective of this study was to describe patterns of corticosteroid treatment for sudden sensorineural hearing loss and to evaluate effectiveness based on delivery mode (oral vs intratympanic vs both). STUDY DESIGN: Cross-sectional repeated m ... Full text Link to item Cite

Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.

Journal article Am Heart J · November 2018 BACKGROUND: The relationship between diuretic use or change in diuretic use and outcomes in chronic heart failure (HF) remains poorly defined. We evaluated the association between diuretic use and changes in health status, exercise capacity, and clinical e ... Full text Link to item Cite

Cardiovascular Outcomes After Lower Extremity Endovascular or Surgical Revascularization: The EUCLID Trial.

Journal article J Am Coll Cardiol · October 2, 2018 BACKGROUND: Lower extremity revascularization (LER) is a common treatment in patients with peripheral artery disease (PAD), but long-term outcomes are poorly defined. OBJECTIVES: The aim was to analyze LER in the EUCLID (Examining Use of tiCagreLor In paD) ... Full text Open Access Link to item Cite

Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction.

Journal article Am J Cardiol · September 15, 2018 Patients with chronic kidney disease (CKD) and/or end-stage renal disease are less active and experience significant functional limitations. The impact of a structured aerobic exercise intervention on outcomes in ambulatory heart failure (HF) patients with ... Full text Link to item Cite

Outcomes in anticoagulated patients with atrial fibrillation and with mitral or aortic valve disease.

Journal article Heart · August 2018 OBJECTIVE: To assess stroke/systemic embolism, major bleeding and other outcomes, and treatment effect of apixaban versus warfarin, in patients with atrial fibrillation (AF) and different types of valvular heart disease (VHD), using data from the Apixaban ... Full text Link to item Cite

Idiopathic Sudden Sensorineural Hearing Loss Is Not a Sentinel Event for Acute Myocardial Infarction.

Journal article Otol Neurotol · August 2018 OBJECTIVE: Given ongoing debate about the suggested association, the primary objective was to determine if idiopathic sudden sensorineural hearing loss (ISSNHL) was a sentinel event for acute myocardial infarction (AMI) in adults. STUDY DESIGN: Case-contro ... Full text Link to item Cite

Effect of race on the glycaemic response to sitagliptin: Insights from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS).

Journal article Diabetes Obes Metab · June 2018 AIM: Pooled efficacy studies suggest that glycaemic responses to dipeptidyl-peptidase 4 inhibitors in type 2 diabetes are greatest in Asians, who may also respond better to alpha-glucosidase inhibitors. We assessed the glycaemic impact of sitagliptin by ra ... Full text Link to item Cite

Right Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software.

Journal article J Am Soc Echocardiogr · June 2018 BACKGROUND: Right ventricular peak systolic longitudinal strain (RVLS) has emerged as an approach for quantifying right ventricular function in diseases such as pulmonary hypertension and congenital heart disease. A major limitation in applying RVLS is tha ... Full text Link to item Cite

Improving patient risk communication: Translating cardiovascular risk into standardized risk percentiles.

Journal article Am Heart J · April 2018 BACKGROUND: Current cholesterol guidelines recommend using 10-year risk of atherosclerotic cardiovascular disease (ASCVD) to guide informed decisions regarding statin therapy, yet patients may have difficulty conceptualizing absolute risk estimates. Peer c ... Full text Link to item Cite

Quality of Life and Mental Health in Older Adults with Obesity and Frailty: Associations with a Weight Loss Intervention.

Journal article J Nutr Health Aging · 2018 OBJECTIVE: To examine the bi-directional associations of a weight loss intervention with quality of life and mental health in obese older adults with functional limitations. DESIGN: Combined-group analyses of secondary variables from the MEASUR-UP randomiz ... Full text Link to item Cite

Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin.

Journal article Stroke · December 2017 BACKGROUND AND PURPOSE: Few data exist on the long-term outcomes of patients with spontaneous echo contrast (SEC), left atrial/left atrial appendage (LA/LAA) thrombus, and complex aortic plaque (CAP), in patients with atrial fibrillation receiving oral ant ... Full text Link to item Cite

Association of Prior Authorization and Out-of-pocket Costs With Patient Access to PCSK9 Inhibitor Therapy.

Journal article JAMA cardiology · November 2017 ImportanceAlthough PCSK9 inhibitors (PCSK9i) were approved in 2015, their high cost has led to strict prior authorization practices and high copays, and use of PSCK9i in clinical practice has been low.ObjectiveTo evaluate patient access t ... Full text Cite

The Metabolic Syndrome and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities Study.

Journal article J Am Heart Assoc · August 23, 2017 BACKGROUND: Prior studies have demonstrated a link between the metabolic syndrome and increased risk of cardiovascular mortality. Whether the metabolic syndrome is associated with sudden cardiac death is uncertain. METHODS AND RESULTS: We characterized the ... Full text Link to item Cite

Influence of Protein Intake, Race, and Age on Responses to a Weight-Reduction Intervention in Obese Women.

Journal article Curr Dev Nutr · May 1, 2017 BACKGROUND: Women have higher rates of obesity than men and develop more pronounced functional deficits as a result. Yet, little is known about how obesity reduction affects their functional status, including whether their responses differ when protein int ... Full text Link to item Cite

Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines.

Journal article JAMA · April 18, 2017 IMPORTANCE: There are important differences among guideline recommendations for using statin therapy in primary prevention. New recommendations from the US Preventive Services Task Force (USPSTF) emphasize therapy based on the presence of 1 or more cardiov ... Full text Link to item Cite