Scholars@Duke
Holly Leddy

Holly Leddy

Research Scientist, Senior
Pratt School of Engineering
Box 90271, Smif, Durham, NC 27708
ORCID iDhttps://orcid.org/0000-0002-1604-2876
1587 Fitzpatrick CIEMAS, Duke University, Durham, NC 27708

Featured Works

Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis.

Journal article Stem Cells · November 2021 Featured Publication Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of this channel has been associated with the proce ... Full text Open Access Link to item Cite

Obesity alters the collagen organization and mechanical properties of murine cartilage.

Journal article Sci Rep · January 15, 2021 Featured Publication Osteoarthritis is a debilitating disease characterized by cartilage degradation and altered cartilage mechanical properties. Furthermore, it is well established that obesity is a primary risk factor for osteoarthritis. The purpose of this study was to inve ... Full text Open Access Link to item Cite

TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.

Journal article Proc Natl Acad Sci U S A · February 5, 2019 Featured Publication Microarchitectural cues drive aligned fibrillar collagen deposition in vivo and in biomaterial scaffolds, but the cell-signaling events that underlie this process are not well understood. Utilizing a multicellular patterning model system that allows for ob ... Full text Link to item Cite

Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression

Journal article Biophysical Journal · February 16, 2016 Featured Publication Cite

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.

Journal article Proc Natl Acad Sci U S A · November 25, 2014 Featured Publication Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical l ... Full text Open Access Link to item Cite

Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.

Journal article FASEB J · June 2014 Featured Publication Point mutations in the calcium-permeable TRPV4 ion channel have been identified as the cause of autosomal-dominant human motor neuropathies, arthropathies, and skeletal malformations of varying severity. The objective of this study was to determine the mec ... Full text Link to item Cite

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.

Journal article Proc Natl Acad Sci U S A · January 28, 2014 Featured Publication Mechanical loading of joints plays a critical role in maintaining the health and function of articular cartilage. The mechanism(s) of chondrocyte mechanotransduction are not fully understood, but could provide important insights into new physical or pharma ... Full text Link to item Cite

Site-specific effects of compression on macromolecular diffusion in articular cartilage.

Journal article Biophysical journal · November 2008 Featured Publication Articular cartilage is the connective tissue that lines joints and provides a smooth surface for joint motion. Because cartilage is avascular, molecular transport occurs primarily via diffusion or convection, and cartilage matrix structure and composition ... Full text Cite