Scholarly Works - Book sections
Book section
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January 1, 2014
Cryptococcus neoformans and Cryptococcus gattii are closely related basidiomycetous fungi that commonly infect humans to predominantly cause meningoencephalitis. Both grow as budding yeasts in the environment and in the infected host yet undergo a dimorphi ...
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January 1, 2014
This chapter describes the genomic resources available for Cryptococcus neoformans and C. gattii and discusses selected examples of the application of the resources to address questions relevant to virulence. It appears that in C. neoformans, natural selec ...
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January 1, 2014
This chapter describes the epidemiology of antifungal drug resistance as identified by in vitro susceptibility testing and studies of the mechanisms of resistance in Cryptococcus neoformans and C. gattii. Taking into consideration the MIC distribution prof ...
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January 1, 2014
The fungal cell wall is an essential organelle, vital for maintaining cell integrity against various chemical, physical, and biological stressors. This chapter covers work on the cell wall of Cryptococcus, drawing on studies from fungi such as Saccharomyce ...
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January 1, 2014
This chapter explores the genetic and proteomic approaches that are now feasible for many fungal systems. Post-genomic approaches to the analysis of biological function, networks, and processes often include techniques that permit global analysis of gene e ...
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2012
Reverse genetics is commonly used to identify and characterize genes involved in a variety of cellular processes. There is a limited set of positive selectable markers available for use in making gene deletions or other genetic manipulations in Cryptococcu ...
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2012
Inducible promoters are invaluable tools for modulating gene expression (turning transcription on or off) and have been a key approach for ascertaining gene essentiality in Cryptococcus neoformans. Galactose-inducible promoters have been successfully used ...
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