Scholars@Duke
Jennifer Lodge

Jennifer Lodge

Vice President for Research and Innovation
Duke University
jennifer.lodge@duke.edu
PO Box 90037, 119 Allen Bldg, Durham, NC 27708
PO Box 90037, 119 Allen Bldg, Durham, NC 27708

Scholarly Works - Preprints

Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity.

Preprint · January 20, 2026 Cryptococcus exhibits inherent resistance to the echinocandin, caspofungin, which inhibits the synthesis of (1,3)-β-D-glucan, a key component of the polysaccharide cell wall. The essential FKS1 gene encodes the catalytic subunit of (1,3)-β-D-glucan synthas ... Full text Link to item Cite