Scholars@Duke
Jessica Moore

Scholarly Works

Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages.

Journal article The Journal of cell biology · August 2026 Regenerative organs, like the skin, depend on niche-stem cell interactions that sustain cellular turnover. In culture, skin fibroblasts promote epidermal stem cell proliferation and differentiation. Yet, it remains elusive how fibroblasts regulate epiderma ... Full text Cite

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca<sup>2+</sup> activity.

Journal article Proceedings of the National Academy of Sciences of the United States of America · June 2026 Ca2+ signaling and its regulation are important for endothelial cell (EC) function and signaling. Yet, the spatiotemporal organization of Ca2+ activity and its regulation across a vascular plexus is poorly understood in an in vivo mam ... Full text Cite

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

Preprint · July 14, 2025 AbstractAstrocytes are highly complex cells that mediate critical roles in synapse formation and maintenance by establishing thousands of direct contacts with synapses through their perisynaptic processes. Here, we ... Full text Cite

Neurospectrum: A Geometric and Topological Deep Learning Framework for Uncovering Spatiotemporal Signatures in Neural Activity.

Journal article bioRxiv · May 8, 2025 Neural signals are high-dimensional, noisy, and dynamic, making it challenging to extract interpretable features linked to behavior or disease. We introduce Neurospectrum, a framework that encodes neural activity as latent trajectories shaped by spatial an ... Full text Link to item Cite

Cell cycle controls long-range calcium signaling in the regenerating epidermis.

Journal article The Journal of cell biology · July 2023 Skin homeostasis is maintained by stem cells, which must communicate to balance their regenerative behaviors. Yet, how adult stem cells signal across regenerative tissue remains unknown due to challenges in studying signaling dynamics in live mice. We comb ... Full text Cite

Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis.

Journal article Science (New York, N.Y.) · November 2021 Clonal hematopoiesis results from enhanced fitness of a mutant hematopoietic stem and progenitor cell (HSPC), but how such clones expand is unclear. We developed a technique that combines mosaic mutagenesis with color labeling of HSPCs to study how acquire ... Full text Cite

Functional cell death, corneoptosis, requires temporally controlled intracellular acidification.

Journal article Proceedings of the National Academy of Sciences of the United States of America · June 2021 Full text Cite