Scholars@Duke
John J. Strouse

John J. Strouse

Associate Professor of Medicine
Medicine, Hematology

Scholarly Works - Conferences

Enhancing Communication and Trust in Advance Care Planning for Older Adults with Sickle Cell Disease

Conference Innovation in Aging · December 1, 2025 AbstractDespite advancements in treatments, life expectancy for sickle cell disease (SCD) remains 20 years shorter than people without SCD, making advance care planning (ACP) important. There is a gap in ... Full text Cite

Navigating Work and Aging in Older Adults with Sickle Cell Disease: Pursuits, Challenges, and Early Retirement

Conference Innovation in Aging · December 1, 2025 AbstractOlder adults with sickle cell disease (SCD) face age-related and SCD comorbidities leading to early functional decline, making it hard to work. This forces individuals to make tough decisions abou ... Full text Cite

Associations between chronic kidney disease, proteinuria, and thrombotic risk in SCD

Conference Blood · November 3, 2025 AbstractBackground: Sickle cell disease (SCD) is characterized by early onset of frailty and age-related complications, including heart dis ... Full text Cite

Mortality in sickle cell disease: A report from the grndad registry

Conference Blood · November 3, 2025 AbstractSickle cell disease (SCD) is associated with a high level of morbidity and early loss of life. A widely cited analysis modeling lif ... Full text Cite

Development of the sickle cell outcome grading system (SCOGS), a novel classification system for sickle cell disease severity

Conference Blood · November 3, 2025 AbstractBackground Sickle cell disease (SCD) is a chronic, multisystem condition. This disorder causes red blood cells to sickle, resulting ... Full text Cite

Increasing the proportion, accessibility, and quality of individualized pain plans for adults with sickle cell disease

Conference Blood · November 3, 2025 AbstractIntroduction: Sickle cell disease (SCD) is characterized by recurrent episodes of severe pain, often necessitating treatment in acu ... Full text Cite

Electronic heath record phenotypes to classify sickle cell anemia versus other subtypes of sickle cell disease in the ASH RC data hub

Conference Blood · November 3, 2025 AbstractIntroduction: Sickle cell disease (SCD) comprises a group of severe hemoglobinopathies caused by mutations in the β-globin gene (HB ... Full text Cite

Re-defining high emergency department use for sickle cell disease

Conference BRITISH JOURNAL OF HAEMATOLOGY · October 2025 Link to item Cite

SickleFit Exercise Program for Older Adults with Sickle Cell Disease

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 2025 Link to item Cite

Identifying Geriatric Syndromes Using the Sickle Cell Disease Functional Assessment

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 2025 Link to item Cite

SickleFit Exercise Program for Older Adults with Sickle Cell Disease

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 2025 Link to item Cite

Identifying Geriatric Syndromes Using the Sickle Cell Disease Functional Assessment

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 2025 Link to item Cite

Association of Surgical Splenectomy and Venous Thromboembolism and Stroke in People with Sickle Cell Disease

Conference Blood · November 5, 2024 A major complication for people with sickle cell disease (SCD) is acute splenic sequestration, which may cause rapid splenic enlargement and a marked decrease in hemoglobin levels. This c ... Full text Cite

Prevalence of Malignancies in Patients with Sickle Cell Disease in North Carolina

Conference Blood · November 5, 2024 Introduction:Significant advancements in sickle cell disease (SCD) management in recent decades have increased the life expectancy of patients. While r ... Full text Cite

Electronic Heath Record Phenotypes to Classify Sickle Cell Anemia Versus Other Subtypes of Sickle Cell Disease

Conference Blood · November 5, 2024 Introduction: Sickle cell disease (SCD) comprises a group of severe hemoglobinopathies caused by mutations in the β-globin gene (HBB) and includes sickle cell anemia (homozygous SCD, HbSS ... Full text Cite

The Sicklefit Exercise Program for Older Adults with Sickle Cell Disease: Feasibility, Acceptability, and Safety

Conference Blood · November 5, 2024 Despite increases in the lifespan for adults with sickle cell disease (SCD), older adults with SCD experience progressive functional impairment. There is a critical need for interventions ... Full text Cite

Reproductive Health Surveys Administered in Sickle Cell Clinics Can Inform Personalized Care and Multidisciplinary Collaboration

Conference Blood · November 5, 2024 Background: Females with sickle cell disease (SCD) aged 10-39 years old experience 26% more acute pain episodes than their male counterparts. An association between acute SCD pain and the ... Full text Cite

PIEZO1-TMEM16F coupling in red blood disorders

Conference BIOPHYSICAL JOURNAL · February 8, 2024 Link to item Cite

Sickle Cell Disease Births and Social Vulnerability (2016-2020): A Report from the Sickle Cell Data Collection Program

Conference Blood · November 2, 2023 IntroductionDespite national implementation of universal newborn screening for sickle cell disease (SCD) since 2006, data on the prevalence of SCD births in the United States are scarce. ... Full text Cite

Grndad and Disease Modifying Therapy (DMT): Shifts in Dmt Are Seen at the Adolescent/Young Adult Transition in Sickle Cell Disease in a Multi-Site Prospective Registry

Conference Blood · November 2, 2023 The ability to characterize the modern person living with SCD in the US has been limited by the lack of a well-curated longitudinal registry. The Globin Research Network for Data and Discovery ( GRNDaD) registry aims to ... Full text Cite

PIEZO1-TMEM16F Interplay in Hereditary Xerocytosis

Conference Blood · November 2, 2023 Cell surface exposure of phosphatidylserine (PS), an anionic phospholipid that is usually confined to the inner leaflet of the plasma membrane, triggers a plethora of cellular responses. PS exposure in RBCs contributes ... Full text Cite

Experiences with Delayed Diagnosis for Older Adults with SCD: “Looking Back It All Makes Sense”

Conference Blood · November 2, 2023 BackgroundImprovements in care over the last 50 years have extended the median lifespan of people living with sickle cell disease (SCD) from 14 years to as long as 61 years in cohorts fr ... Full text Cite

Personalized Exercise Intervention for Older Adults with Sickle Cell Disease: The Sicklefit Study

Conference Blood · November 2, 2023 BackgroundOlder adults with sickle cell disease (SCD) (defined as age ≥ 40 years) experience both SCD and age-related conditions such as recurrent pain episodes, avascular necrosis of th ... Full text Cite

Perception of Nutrition in Adults with Sickle Cell Disease: Concept Elicitation of Nutritional Status and the Mini Nutrition Assessment

Conference Blood · November 2, 2023 IntroductionSickle Cell Disease (SCD) is a genetic disorder that causes recurrent vaso-occlusive pain events, functional impairment, and nutritional deficiencies due to increased metabol ... Full text Cite

Experiences with Working: A Letter from Older Adults with Sickle Cell Disease

Conference Blood · November 2, 2023 IntroductionWith medical advancements over the past decades, the life expectancy for people with sickle cell disease (SCD) is longer than ever before. As they age, people with SCD acquir ... Full text Cite

COVID mRNA Vaccination Responses in Individuals with Sickle Cell Disease: An ASH Research Collaborative Clinical Trial Network Study

Conference Blood · November 2, 2023 A multi-state, long term follow-up study of individuals with sickle cell disease (SCD) demonstrated an increase in mortality and morbidity in children and adults with COVID. mRNA vaccines are recommended for all SCD pat ... Full text Cite

Role of Menstrual Bleeding Assessments in Sickle Cell Clinics in Improving Quality of Care for Women- a Multicenter Approach

Conference Blood · November 2, 2023 Introduction: Reproductive health education is lacking among individuals with sickle cell disease (SCD) despite many females reporting increased pain during menstruation. Research suggests that SCD-related pain associat ... Full text Cite

Identifying Geriatric Syndromes in Adults with Sickle Cell Disease Using the Sickle Cell Disease Functional Assessment (SCD-FA): The Sickle Cell Disease Functional Assessment Validation and Refinement (SILVR) Study

Conference Blood · November 2, 2023 IntroductionAs people with sickle cell disease (SCD) age, they experience accelerated functional decline. Since historically survival for SCD has been limited to middle age, geriatric sy ... Full text Cite

Using Patient-Reported Outcome Measures to Identify Factors Associated with Impaired Physical Function in Younger and Older Adults Living with Sickle Cell Disease

Conference Blood · November 2, 2023 BackgroundImprovements in disease management techniques have led to increases in the life expectancy of individuals with sickle cell disease (SCD). Despite the increasing number of older ... Full text Cite

Living Beyond Life Expectancy: Experience with Aging for Older Adults with Sickle Cell Disease

Conference Blood · November 5, 2021 AbstractBackgroundOver the last five decades, advancements in management of sickle cell disease (SCD) have led to more individuals living beyond the ... Full text Cite

Sickle Cell Screening in Children in a Resource Constrained Environment: Diagnosis and Follow up

Conference Blood · November 5, 2021 AbstractIntroduction: Sickle cell disease (SCD) is the most common hemoglobinopathy in the world and it disproportionately affects population in tropical, resource-constrained regions where there is a high p ... Full text Cite

National Survey of Pediatric Sickle Cell Providers on Their Contraceptive Practices for Female Patients

Conference Blood · November 5, 2021 AbstractIntroduction: Pregnancies of women with sickle cell disease (SCD) have increased risk of morbidity and mortality, with potential additional complications due to uncertain teratogenicity of hydroxyure ... Full text Cite

Barriers and Facilitators of Advance Care Planning for Older Adults with Sickle Cell Disease

Conference Blood · November 5, 2020 BackgroundLife expectancy for individuals with sickle cell disease (SCD) has improved significantly in the last 50 years, creating a new population of older adults with SCD; however, life expectancy of adults with S ... Full text Cite

Functional Assessment in Younger and Older Adults with Sickle Cell Disease

Conference Blood · November 5, 2020 BackgroundNearly 95% of individuals with sickle cell disease (SCD) live to become adults (age ≥ 18 years). As individuals with SCD age, they acquire both SCD and age-related complications leading to functional decli ... Full text Cite

Proteomic Discovery: Elevated Neurogranin Levels in Children with Sickle Cell Disease

Conference Blood · November 13, 2019 Sickle cell disease (SCD) is an inherited hemoglobinopathy that frequently causes neurological complications, such as stroke, silent cerebral infarct (SCI) and other forms of brain injury, including loss of cognition. SCI is defined as any ischemic ... Full text Cite

Disparities in Foundation and Federal Support and Development of New Therapeutics for Sickle Cell Disease and Cystic Fibrosis

Conference Blood · November 29, 2018 AbstractBACKGROUND: Sickle cell disease (SCD) and cystic fibrosis (CF) are rare inherited disorders of similar severity. Disparities in funding between these two diseases have been long recognized and likely ... Full text Cite

Allergic Sensitization Is Associated with Decreased Risk of ED Visits and Hospitalizations for Pain in Sickle Cell Disease

Conference Blood · November 29, 2018 AbstractRationale: Lower airway disease is common in pediatric sickle cell disease (SCD) and is often diagnosed as asthma. This condition may be a risk factor for acute chest syndrome (ACS) and pain episodes ... Full text Cite

Cost-Effectiveness of Blood Transfusions Versus Observation for Silent Cerebral Infarcts from the Silent Cerebral Infarct Trial

Conference Blood · December 2, 2016 AbstractBACKGROUND AND OBJECTIVE: In the Silent Cerebral Infarct Trial (SIT), regular blood transfusion therapy significantly reduced the incidence of recurrent cerebral infarctions ... Full text Cite

Simultaneous Measurement of Cerebral Blood Flow and Arterial Transit Time for Sickle Cell Disease

Conference Blood · December 2, 2016 AbstractIntroductionStudies of patients with ischemic stroke and silent cerebral infarcts from sickle cell anemia (SCA) have revealed abnormalities of both large and small ve ... Full text Cite

Lower Airway Obstruction Is Associated With Free Hemoglobin In Sickle Cell Disease

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Screening for Neurocognitive Dysfunction in an Adult Population with Sickle Cell Disease

Conference Blood · December 6, 2014 AbstractIntroduction: Studies have described neuroimaging abnormalities and neurocognitive dysfunction in adults living with sickle cell anemia and no previous history of neurological impairment. At the John ... Full text Cite

Perceived Discrimination In Health Care Is Associated With Daily Chronic Pain In Sickle Cell Disease

Conference Blood · November 15, 2013 AbstractIntroductionPerceived discrimination due to race or ethnicity has been associated with a greater burden of pain among minority ... Full text Cite

A Risk-Prediction Model For Identifying Venous Thromboembolism In Hospitalized Pediatric Patients: A Single Institution Retrospective Case-Control Analysis

Conference Blood · November 15, 2013 AbstractIntroductionVenous thromboembolism (VTE) is increasing in children, especially in the tertiary care setting. Hospital-associat ... Full text Cite

Describing Adherence to Recommended Preventative Care Behaviors Among Adults with Sickle Cell Disease

Conference Blood · November 16, 2012 AbstractAbstract 2058Background:Healthcare professionals caring for patients with sickle cell disease ... Full text Cite

NEONATAL AORTIC THROMBOSIS: A CASE SERIES

Conference PEDIATRIC BLOOD & CANCER · July 1, 2012 Link to item Cite

Safety and Efficacy of a Manual Isovolumetric Double Volume Exchange Transfusion Protocol in Children

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

DENGUE AMONG PATIENTS WITH UNDIFFERENTIATED FEVER IN SOUTHERN SRI LANKA

Conference AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE · November 1, 2009 Link to item Cite

Predictors of In-Hospital Mortality and Charges in Sickle Cell Disease: Results from the California Discharge Databases 1998–2005.

Conference Blood · November 16, 2007 AbstractMost studies of survival in sickle cell disease (SCD) include only patients followed at referral centers. We used the public set of the California Patient Discharge Databases (1998–2005) to compare i ... Full text Cite

Corticosteroids and Increased Risk of Readmission after Acute Chest Syndrome.

Conference Blood · November 16, 2005 AbstractAcute chest syndrome (ACS) is a cause of frequent hospitalization and death in patients with sickle cell disease (SCD). Therapies commonly used include antibiotics, inhaled B-agonists, oxygen, high-d ... Full text Cite

Risk Factors for Intracranial Hemorrhage in Children with Sickle Cell Anemia.

Conference Blood · November 16, 2004 Background: Intracranial hemorrhage (ICH) is an uncommon, but devastating, complication of sickle cell disease (SCD) with mortality from 30 to 65%. Most reported cases are in adults; little is known about children. Proposed risk factors include pre ... Full text Cite

Synthesis of N-1-aryl-purine nucleosides using copper-catalyzed C-N coupling of boronic acids

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · September 2003 Link to item Cite

Catalytic oxidation of alcohols with methyl sulfoxide using rhenium catecholate complexes.

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · April 1, 2001 Link to item Cite

Ecology and management of mahogany (Swietenia macrophylla King) in the Chimanes Forest, Beni, Bolivia

Conference Botanical Journal of the Linnean Society · January 1, 1996 Mahogany (Swietenia macrophylla King) regeneration in areas of erosion on high terraces and in forest killed by flooding and deposition of alluvial sediments in the Chimanes Forest, Bolivia. These hydrological disturbances are patchy, and only one of five ... Full text Cite