Ke Dong | Scholars@Duke

Ke Dong
Professor in Biology

Research in the Dong lab centers on the molecular, neuronal and behavioral bases of insect responses to natural/synthetic neuroactive compounds, including pyrethrum and pyrethroid insecticides. We aim to elucidate the mechanisms of action of neuroactive compounds on insect ion channels and receptors and mechanisms of insect resistance to neuroactive chemicals. We are also interested in understanding the physiological functions of various ion channels and receptors, particularly voltage-gated sodium channels, the DSC1 cation channel and odorant receptors, in Drosophila melanogaster (a genetically tractable model) and Aedes aegypti (a major vector of human diseases, such as yellow fever, Dengue and Zika). We take a combination of molecular genetic, neurophysiological, toxicological and behavioral approaches to evaluate the effects of neuroactive compounds at the molecular, cellular and organismal levels. Our goal is to make fundamental discoveries in insect-chemical interactions that impact practical solutions to control disease vectors in the global fight against vector-borne human diseases.

Office Hours

9 am - 5 pm, Mon - Fri

Current Appointments & Affiliations

Professor in Biology, Biology, Trinity College of Arts & Sciences 2020

Contact Information

ke.dong@duke.edu

Background
Education, Training, & Certifications
- Ph.D., Cornell University 1993
Previous Appointments & Affiliations
- Scholar In Residence in Biology, Biology, Trinity College of Arts & Sciences 2020
Academic Positions Outside Duke
- Professor , Michigan State University. 2007 - 2020
- Associate Professor, Michigan State University. 2002 - 2007
- Assistant Professor , Michigan State University. 1997 - 2002
Recognition
In the News
- AUG 1, 2021 Scientific American
  
  Natural Mosquito Repellent's Powers Finally Decoded
- MAY 11, 2021
  
  How One of the Oldest Natural Insecticides Keeps Mosquitoes Away
- NOV 20, 2020
  
  Duke Welcomes Professor Ke Dong, Insect Neurotoxicologist
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- High-resolution insights into insecticide interactions with voltage-gated sodium channels awarded by National Institutes of Health 2020 - 2024
Fellowships, Supported Research, & Other Grants
- High-resolution insights into insecticide interactions with voltage-gated sodium channels awarded by NIGMS 2020 - 2024
External Relationships
- Vestaron
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Andreazza, Felipe, Wilson Valbon, and Ke Dong. “Transfluthrin enhances odorant receptor-mediated spatial repellency in Aedes aegypti.” Pesticide Biochemistry and Physiology 192 (May 2023): 105387. https://doi.org/10.1016/j.pestbp.2023.105387.
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  - Qie, Xingtao, Yaxin Ren, Xueting Chen, Yuzhe Du, Ke Dong, and Zhaonong Hu. “Role of DSC1 in Drosophila melanogaster synaptic activities in response to haedoxan A.” Insect Science, February 2023. https://doi.org/10.1111/1744-7917.13180.
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  - Sun, Huahua, Yoshiko Nomura, Yuzhe Du, Zewen Liu, Boris S. Zhorov, and Ke Dong. “Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.” Insect Biochemistry and Molecular Biology 148 (September 2022): 103814. https://doi.org/10.1016/j.ibmb.2022.103814.
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  - Zhorov, Boris S., and Ke Dong. “Pyrethroids in an AlphaFold2 Model of the Insect Sodium Channel.” Insects 13, no. 8 (August 2022): 745. https://doi.org/10.3390/insects13080745.
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  - Qie, Xingtao, Yuzhe Du, Ahmed A. A. Aioub, Ke Dong, and Zhaonong Hu. “Negative cross-resistance of a pyrethroid-resistant Drosophila mutant to Phryma leptostachya-derived haedoxan A.” Insect Science 29, no. 3 (June 2022): 817–26. https://doi.org/10.1111/1744-7917.12973.
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  - Valbon, Wilson, Felipe Andreazza, Eugenio E. Oliveira, Feng Liu, Bo Feng, Maura Hall, James Klimavicz, Joel R. Coats, and Ke Dong. “Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti.” Pest Management Science 78, no. 2 (February 2022): 438–45. https://doi.org/10.1002/ps.6682.
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  - Li, Ben-Jie, Kun-Kun Wang, Dong-Ping Chen, Ying Yan, Xu-Ling Cai, Hui-Min Chen, Ke Dong, Fei Lin, and Han-Hong Xu. “Distinct roles of two RDL GABA receptors in fipronil action in the diamondback moth (Plutella xylostella).” Insect Science 28, no. 6 (December 2021): 1721–33. https://doi.org/10.1111/1744-7917.12892.
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  - Zhu, Qing, Yuzhe Du, Yoshiko Nomura, Rong Gao, Zixuan Cang, Guo-Wei Wei, Dalia Gordon, Michael Gurevitz, James Groome, and Ke Dong. “Charge substitutions at the voltage-sensing module of domain III enhance actions of site-3 and site-4 toxins on an insect sodium channel.” Insect Biochemistry and Molecular Biology 137 (October 2021): 103625. https://doi.org/10.1016/j.ibmb.2021.103625.
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  - Wang, Qiang, Peng Xu, Simon Sanchez, Phil Duran, Felipe Andreazza, Rufus Isaacs, and Ke Dong. “Behavioral and physiological responses of Drosophila melanogaster and D. suzukii to volatiles from plant essential oils.” Pest Management Science 77, no. 8 (August 2021): 3698–3705. https://doi.org/10.1002/ps.6282.
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  - Yan, Ru, Qiaoling Zhou, Zhanyi Xu, Yuyan Wu, Guonian Zhu, Mengcen Wang, Yirong Guo, Ke Dong, and Mengli Chen. “Pyrethrins elicit olfactory response and spatial repellency in Aedes albopictus.” Pest Management Science 77, no. 8 (August 2021): 3706–12. https://doi.org/10.1002/ps.6390.
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  - Andreazza, Felipe, Wilson R. Valbon, Qiang Wang, Feng Liu, Peng Xu, Elizabeth Bandason, Mengli Chen, et al. “Sodium channel activation underlies transfluthrin repellency in Aedes aegypti.” Plos Neglected Tropical Diseases 15, no. 7 (July 2021): e0009546. https://doi.org/10.1371/journal.pntd.0009546.
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  - Wang, Qiang, Peng Xu, Felipe Andreazza, Yahui Liu, Yoshiko Nomura, Phil Duran, Lan Jiang, et al. “Identification of multiple odorant receptors essential for pyrethrum repellency in Drosophila melanogaster.” Plos Genetics 17, no. 7 (July 2021): e1009677. https://doi.org/10.1371/journal.pgen.1009677.
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  - Zhorov, Boris S., Yuzhe Du, Weizhong Song, Ningguang Luo, Dalia Gordon, Michael Gurevitz, and Ke Dong. “Mapping the interaction surface of scorpion β-toxins with an insect sodium channel.” The Biochemical Journal 478, no. 14 (July 2021): 2843–69. https://doi.org/10.1042/bcj20210336.
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  - Liu, Feng, Qiang Wang, Peng Xu, Felipe Andreazza, Wilson R. Valbon, Elizabeth Bandason, Mengli Chen, et al. “A dual-target molecular mechanism of pyrethrum repellency against mosquitoes.” Nature Communications 12, no. 1 (May 2021): 2553. https://doi.org/10.1038/s41467-021-22847-0.
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  - Yan, Ru, Qiaoling Zhou, Zhanyi Xu, Guonian Zhu, Ke Dong, Boris S. Zhorov, and Mengli Chen. “Three sodium channel mutations from Aedes albopictus confer resistance to Type I, but not Type II pyrethroids.” Insect Biochemistry and Molecular Biology 123 (August 2020): 103411. https://doi.org/10.1016/j.ibmb.2020.103411.
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  - Chen, Mengli, Yuzhe Du, Yoshiko Nomura, Boris S. Zhorov, and Ke Dong. “Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti.” Archives of Insect Biochemistry and Physiology 104, no. 2 (June 2020): e21686. https://doi.org/10.1002/arch.21686.
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  - Sun, Huahua, Yuzhe Du, Zewen Liu, and Ke Dong. “Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens.” Insect Biochemistry and Molecular Biology 118 (March 2020): 103292. https://doi.org/10.1016/j.ibmb.2019.103292.
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  - Zhang, Jianqiang, Wenbo Hao, Boris S. Zhorov, Ke Dong, and Dingxin Jiang. “Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides.” Journal of Agricultural and Food Chemistry 67, no. 28 (July 2019): 7793–7809. https://doi.org/10.1021/acs.jafc.9b00826.
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  - Chen, Mengli, Yuzhe Du, Shaoying Wu, Yoshiko Nomura, Guonian Zhu, Boris S. Zhorov, and Ke Dong. “Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti.” Plos Neglected Tropical Diseases 13, no. 6 (June 2019): e0007432. https://doi.org/10.1371/journal.pntd.0007432.
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  - Chen, Mengli, Yuzhe Du, Guonian Zhu, Genki Takamatsu, Makoto Ihara, Kazuhiko Matsuda, Boris S. Zhorov, and Ke Dong. “Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes.” Pesticide Biochemistry and Physiology 151 (October 2018): 82–89. https://doi.org/10.1016/j.pestbp.2018.05.002.
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  - Du, Yuzhe, Denis B. Tikhonov, Yoshiko Nomura, Ke Dong, and Boris S. Zhorov. “Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels.” Archives of Biochemistry and Biophysics 652 (August 2018): 59–70. https://doi.org/10.1016/j.abb.2018.06.008.
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  - Ren, Miaomiao, Jianguo Niu, Bo Hu, Qi Wei, Cheng Zheng, Xiangrui Tian, Congfen Gao, Bingjun He, Ke Dong, and Jianya Su. “Block of Kir channels by flonicamid disrupts salivary and renal excretion of insect pests.” Insect Biochemistry and Molecular Biology 99 (August 2018): 17–26. https://doi.org/10.1016/j.ibmb.2018.05.007.
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  - Chen, Xueting, Yuanyuan Wang, Wenjun Wu, Ke Dong, and Zhaonong Hu. “DSC1 channel-dependent developmental regulation of pyrethroid susceptibility in Drosophila melanogaster.” Pesticide Biochemistry and Physiology 148 (June 2018): 190–98. https://doi.org/10.1016/j.pestbp.2018.04.014.
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  - Kirkpatrick, Danielle M., Heather L. Leach, Peng Xu, Ke Dong, Rufus Isaacs, and Larry J. Gut. “Comparative Antennal and Behavioral Responses of Summer and Winter Morph Drosophila suzukii (Diptera: Drosophilidae) to Ecologically Relevant Volatiles.” Environmental Entomology 47, no. 3 (June 2018): 700–706. https://doi.org/10.1093/ee/nvy046.
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  - Satar, G., M. R. Ulusoy, R. Nauen, and K. Dong. “Neonicotinoid insecticide resistance among populations of Bemisia tabaci in the Mediterranean region of Turkey.” Bulletin of Insectology 71, no. 2 (January 1, 2018): 171–77.
  - Wu, Shaoying, Yoshiko Nomura, Yuzhe Du, Boris S. Zhorov, and Ke Dong. “Molecular basis of selective resistance of the bumblebee BiNa_v1 sodium channel to tau-fluvalinate.” Proceedings of the National Academy of Sciences of the United States of America 114, no. 49 (December 2017): 12922–27. https://doi.org/10.1073/pnas.1711699114.
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  - Du, Y., Y. Nomura, B. S. Zhorov, and K. Dong. “Molecular mechanism of knockdown resistance to pyrethroid insecticides.” Acta Horticulturae 1169 (July 25, 2017): 25–32. https://doi.org/10.17660/ActaHortic.2017.1169.5.
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  - Chen, Mengli, Yuzhe Du, Yoshiko Nomura, Guonian Zhu, Boris S. Zhorov, and Ke Dong. “Alanine to valine substitutions in the pore helix IIIP1 and linker-helix IIIL45 confer cockroach sodium channel resistance to DDT and pyrethroids.” Neurotoxicology 60 (May 2017): 197–206. https://doi.org/10.1016/j.neuro.2016.06.009.
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  - Zhorov, Boris S., and Ke Dong. “Elucidation of pyrethroid and DDT receptor sites in the voltage-gated sodium channel.” Neurotoxicology 60 (May 2017): 171–77. https://doi.org/10.1016/j.neuro.2016.08.013.
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  - Soderlund, D. M., K. Dong, and V. Salgado. “Introduction.” Neurotoxicology 60 (May 1, 2017): 135–135. https://doi.org/10.1016/j.neuro.2017.02.012.
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  - Haddi, Khalid, Hudson V. V. Tomé, Yuzhe Du, Wilson R. Valbon, Yoshiko Nomura, Gustavo F. Martins, Ke Dong, and Eugênio E. Oliveira. “Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control.” Scientific Reports 7 (April 2017): 46549. https://doi.org/10.1038/srep46549.
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  - Chen, Mengli, Yuzhe Du, Yoshiko Nomura, Guonian Zhu, Boris S. Zhorov, and Ke Dong. “Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance.” Insect Biochemistry and Molecular Biology 82 (March 2017): 1–10. https://doi.org/10.1016/j.ibmb.2017.01.007.
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  - Silver, Kristopher, Ke Dong, and Boris S. Zhorov. “Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides.” Current Medicinal Chemistry 24, no. 27 (January 2017): 2912–24. https://doi.org/10.2174/0929867323666161216143844.
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  - Du, Yuzhe, Yoshiko Nomura, Boris S. Zhorov, and Ke Dong. “Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti.” Insects 7, no. 4 (October 2016): E60. https://doi.org/10.3390/insects7040060.
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  - Zhang, Yongqiang, Yuzhe Du, Dingxin Jiang, Caitlyn Behnke, Yoshiko Nomura, Boris S. Zhorov, and Ke Dong. “The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides.” The Journal of Biological Chemistry 291, no. 38 (September 2016): 20113–24. https://doi.org/10.1074/jbc.m116.742056.
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  - Du, Yuzhe, Yoshiko Nomura, Boris S. Zhorov, and Ke Dong. “Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels.” The Journal of Biological Chemistry 291, no. 9 (February 2016): 4638–48. https://doi.org/10.1074/jbc.m115.678672.
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  - Wang, Xing-Liang, Wen Su, Jian-Heng Zhang, Yi-Hua Yang, Ke Dong, and Yi-Dong Wu. “Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella.” Insect Science 23, no. 1 (February 2016): 50–58. https://doi.org/10.1111/1744-7917.12226.
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  - Hu, Zhaonong, Yuzhe Du, Xinmin Xiao, Ke Dong, and Wenjun Wu. “Insight into the Mode of Action of Haedoxan A from Phryma leptostachya.” Toxins 8, no. 2 (February 2016): 53. https://doi.org/10.3390/toxins8020053.
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  - Bourdin, Céline M., Nathalie C. Guérineau, Laurence Murillo, Sophie Quinchard, Ke Dong, and Christian Legros. “Molecular and functional characterization of a novel sodium channel TipE-like auxiliary subunit from the American cockroach Periplaneta americana.” Insect Biochemistry and Molecular Biology 66 (November 2015): 136–44. https://doi.org/10.1016/j.ibmb.2015.10.008.
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  - Jiang, Dingxin, Yuzhe Du, Yoshiko Nomura, Xingliang Wang, Yidong Wu, Boris S. Zhorov, and Ke Dong. “Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.” Insect Biochemistry and Molecular Biology 66 (November 2015): 88–95. https://doi.org/10.1016/j.ibmb.2015.09.011.
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  - Du, Yuzhe, Yoshiko Nomura, Boris S. Zhorov, and Ke Dong. “Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel.” Molecular Pharmacology 88, no. 2 (August 2015): 273–80. https://doi.org/10.1124/mol.115.098707.
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  - Dong, Ke, Yuzhe Du, Frank Rinkevich, Lingxin Wang, and Peng Xu. “The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels.” Pesticide Biochemistry and Physiology 120 (May 2015): 36–39. https://doi.org/10.1016/j.pestbp.2014.12.005.
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  - Wang, Lingxin, Yuzhe Du, Yoshiko Nomura, and Ke Dong. “Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants.” Insect Biochemistry and Molecular Biology 60 (May 2015): 24–32. https://doi.org/10.1016/j.ibmb.2015.02.006.
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  - Rinkevich, Frank D., Yuzhe Du, Josh Tolinski, Atsushi Ueda, Chun-Fang Wu, Boris S. Zhorov, and Ke Dong. “Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids.” Neurotoxicology 47 (March 2015): 99–106. https://doi.org/10.1016/j.neuro.2015.02.001.
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  - Wang, Lingxin, Yoshiko Nomura, Yuzhe Du, Nannan Liu, Boris S. Zhorov, and Ke Dong. “A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.” Molecular Pharmacology 87, no. 3 (January 2015): 421–29. https://doi.org/10.1124/mol.114.094730.
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  - Dong, Ke, Yuzhe Du, Frank Rinkevich, Yoshiko Nomura, Peng Xu, Lingxin Wang, Kristopher Silver, and Boris S. Zhorov. “Molecular biology of insect sodium channels and pyrethroid resistance.” Insect Biochemistry and Molecular Biology 50 (July 2014): 1–17. https://doi.org/10.1016/j.ibmb.2014.03.012.
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  - Gao, R., Y. Du, L. Wang, Y. Nomura, G. Satar, D. Gordon, M. Gurevitz, A. L. Goldin, and K. Dong. “Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.” Neuroscience 268 (May 2014): 297–308. https://doi.org/10.1016/j.neuroscience.2014.03.028.
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  - Oliveira, Eugênio E., Yuzhe Du, Yoshiko Nomura, and Ke Dong. “A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides.” Neurotoxicology 38 (September 2013): 42–50. https://doi.org/10.1016/j.neuro.2013.06.001.
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  - Rinkevich, Frank D., Yuzhe Du, and Ke Dong. “Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.” Pesticide Biochemistry and Physiology 106, no. 3 (July 2013): 93–100. https://doi.org/10.1016/j.pestbp.2013.02.007.
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  - Du, Yuzhe, Yoshiko Nomura, Gul Satar, Zhaonong Hu, Ralf Nauen, Sheng Yang He, Boris S. Zhorov, and Ke Dong. “Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel.” Proceedings of the National Academy of Sciences of the United States of America 110, no. 29 (July 2013): 11785–90. https://doi.org/10.1073/pnas.1305118110.
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  - Bourdin, Céline M., Bénédicte Moignot, Lingxin Wang, Laurence Murillo, Marjorie Juchaux, Sophie Quinchard, Bruno Lapied, Nathalie C. Guérineau, Ke Dong, and Christian Legros. “Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity.” Plos One 8, no. 8 (January 2013): e67290. https://doi.org/10.1371/journal.pone.0067290.
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  - Wang, Lingxin, Yoshiko Nomura, Yuzhe Du, and Ke Dong. “Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster.” Plos One 8, no. 7 (January 2013): e67551. https://doi.org/10.1371/journal.pone.0067551.
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  - Zhang, Tianxiang, Zhe Wang, Lingxin Wang, Ningguang Luo, Lan Jiang, Zhiqi Liu, Chun-Fang Wu, and Ke Dong. “Role of the DSC1 channel in regulating neuronal excitability in Drosophila melanogaster: extending nervous system stability under stress.” Plos Genetics 9, no. 3 (January 2013): e1003327. https://doi.org/10.1371/journal.pgen.1003327.
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  - Cui, Ying-Jun, Lin-Lin Yu, Hai-Jun Xu, Ke Dong, and Chuan-Xi Zhang. “Molecular characterization of DSC1 orthologs in invertebrate species.” Insect Biochemistry and Molecular Biology 42, no. 5 (May 2012): 353–59. https://doi.org/10.1016/j.ibmb.2012.01.005.
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  - Li, Ting, Lee Zhang, William R. Reid, Qiang Xu, Ke Dong, and Nannan Liu. “Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus.” Scientific Reports 2 (January 2012): 781. https://doi.org/10.1038/srep00781.
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  - Xu, Qiang, Lee Zhang, Ting Li, Lan Zhang, Lin He, Ke Dong, and Nannan Liu. “Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes.” Plos One 7, no. 10 (January 2012): e47609. https://doi.org/10.1371/journal.pone.0047609.
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  - Du, Yuzhe, Daniel Garden, Bhupinder Khambay, Boris S. Zhorov, and Ke Dong. “Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels.” Molecular Pharmacology 80, no. 3 (September 2011): 426–33. https://doi.org/10.1124/mol.111.072504.
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  - Du, Yuzhe, Bhupinder Khambay, and Ke Dong. “An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel.” Insect Biochemistry and Molecular Biology 41, no. 7 (July 2011): 446–50. https://doi.org/10.1016/j.ibmb.2011.03.005.
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  - Zhang, Tianxiang, Zhiqi Liu, Weizhong Song, Yuzhe Du, and Ke Dong. “Molecular characterization and functional expression of the DSC1 channel.” Insect Biochemistry and Molecular Biology 41, no. 7 (July 2011): 451–58. https://doi.org/10.1016/j.ibmb.2011.04.010.
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  - Song, Weizhong, Yuzhe Du, Zhiqi Liu, Ningguang Luo, Michael Turkov, Dalia Gordon, Michael Gurevitz, Alan L. Goldin, and Ke Dong. “Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin.” The Journal of Biological Chemistry 286, no. 18 (May 2011): 15781–88. https://doi.org/10.1074/jbc.m110.217000.
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  - Du, Yuzhe, Daniel P. Garden, Lingxin Wang, Boris S. Zhorov, and Ke Dong. “Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.” The Journal of Biological Chemistry 286, no. 15 (April 2011): 13151–60. https://doi.org/10.1074/jbc.m110.208496.
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  - Parker, Louise, Miguel Padilla, Yuzhe Du, Ke Dong, and Mark A. Tanouye. “Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures.” Genetics 187, no. 2 (February 2011): 523–34. https://doi.org/10.1534/genetics.110.123299.
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  - Hu, Zhaonong, Yuzhe Du, Yoshiko Nomura, and Ke Dong. “A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids.” Insect Biochemistry and Molecular Biology 41, no. 1 (January 2011): 9–13. https://doi.org/10.1016/j.ibmb.2010.09.005.
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  - Song, Weizhong, Kristopher S. Silver, Yuzhe Du, Zhiqi Liu, and Ke Dong. “Analysis of the action of lidocaine on insect sodium channels.” Insect Biochemistry and Molecular Biology 41, no. 1 (January 2011): 36–41. https://doi.org/10.1016/j.ibmb.2010.09.010.
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  - Du, Yuzhe, Weizhong Song, James R. Groome, Yoshiko Nomura, Ningguang Luo, and Ke Dong. “A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides.” Toxicology and Applied Pharmacology 247, no. 1 (August 2010): 53–59. https://doi.org/10.1016/j.taap.2010.05.016.
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  - Silver, Kristopher S., Weizhong Song, Yoshiko Nomura, Vincent L. Salgado, and Ke Dong. “Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels.” Pesticide Biochemistry and Physiology 97, no. 2 (June 2010): 87–92. https://doi.org/10.1016/j.pestbp.2009.09.001.
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  - Du, Yuzhe, Yoshiko Nomura, Zhiqi Liu, Zachary Y. Huang, and Ke Dong. “Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels.” The Journal of Biological Chemistry 284, no. 49 (December 2009): 33869–75. https://doi.org/10.1074/jbc.m109.045690.
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  - Thobakgale, Christina F., Andrew Prendergast, Hayley Crawford, Nompumelelo Mkhwanazi, Danni Ramduth, Sharon Reddy, Claudia Molina, et al. “Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.” Journal of Virology 83, no. 19 (October 2009): 10234–44. https://doi.org/10.1128/jvi.00921-09.
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  - Silver, Kristopher S., Yoshiko Nomura, Vincent L. Salgado, and Ke Dong. “Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides.” Neurotoxicology 30, no. 4 (July 2009): 613–21. https://doi.org/10.1016/j.neuro.2009.03.009.
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  - Du, Yuzhe, Jung-Eun Lee, Yoshiko Nomura, Tianxiang Zhang, Boris S. Zhorov, and Ke Dong. “Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides.” The Biochemical Journal 419, no. 2 (April 2009): 377–85. https://doi.org/10.1042/bj20082082.
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  - Shao, Ya-Ming, Ke Dong, Zhen-Hua Tang, and Chuan-Xi Zhang. “Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori.” Insect Biochemistry and Molecular Biology 39, no. 2 (February 2009): 145–51. https://doi.org/10.1016/j.ibmb.2008.10.005.
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  - Du, Yuzhe, Yoshiko Nomura, Ningguang Luo, Zhiqi Liu, Jung-Eun Lee, Bhupinder Khambay, and Ke Dong. “Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides.” Toxicology and Applied Pharmacology 234, no. 2 (January 2009): 266–72. https://doi.org/10.1016/j.taap.2008.10.006.
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  - Olson, Rachel O’Donnell, Zhiqi Liu, Yoshiko Nomura, Weizhong Song, and Ke Dong. “Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster.” Insect Biochemistry and Molecular Biology 38, no. 5 (May 2008): 604–10. https://doi.org/10.1016/j.ibmb.2008.01.003.
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  - Peterson, Randall T., Richard Nass, Windy A. Boyd, Jonathan H. Freedman, Ke Dong, and Toshio Narahashi. “Use of non-mammalian alternative models for neurotoxicological study.” Neurotoxicology 29, no. 3 (May 2008): 546–55. https://doi.org/10.1016/j.neuro.2008.04.006.
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  - Shao, Ya-Ming, Ke Dong, and Chuan-Xi Zhang. “The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori.” Bmc Genomics 8 (September 2007): 324. https://doi.org/10.1186/1471-2164-8-324.
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  - Dong, Ke. “Insect sodium channels and insecticide resistance.” Invertebrate Neuroscience : In 7, no. 1 (March 2007): 17–30. https://doi.org/10.1007/s10158-006-0036-9.
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  - Gordon, Dalia, Izhar Karbat, Nitza Ilan, Lior Cohen, Roy Kahn, Nicolas Gilles, Ke Dong, Walter Stühmer, Jan Tytgat, and Michael Gurevitz. “The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control.” Toxicon : Official Journal of the International Society on Toxinology 49, no. 4 (March 2007): 452–72. https://doi.org/10.1016/j.toxicon.2006.11.016.
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  - Gurevitz, Michael, Izhar Karbat, Lior Cohen, Nitza Ilan, Roy Kahn, Michael Turkov, Maria Stankiewicz, Walter Stühmer, Ke Dong, and Dalia Gordon. “The insecticidal potential of scorpion beta-toxins.” Toxicon : Official Journal of the International Society on Toxinology 49, no. 4 (March 2007): 473–89. https://doi.org/10.1016/j.toxicon.2006.11.015.
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  - Liu, Zhiqi, Jianguo Tan, Zachary Y. Huang, and Ke Dong. “Effect of a fluvalinate-resistance-associated sodium channel mutation from varroa mites on cockroach sodium channel sensitivity to fluvalinate, a pyrethroid insecticide.” Insect Biochemistry and Molecular Biology 36, no. 11 (November 2006): 885–89. https://doi.org/10.1016/j.ibmb.2006.08.006.
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  - Song, Weizhong, Zhiqi Liu, and Ke Dong. “Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb.” Neurotoxicology 27, no. 2 (March 2006): 237–44. https://doi.org/10.1016/j.neuro.2005.10.004.
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  - Du, Yuzhe, Zhiqi Liu, Yoshiko Nomura, Bhupinder Khambay, and Ke Dong. “An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant.” Insect Biochemistry and Molecular Biology 36, no. 2 (February 2006): 161–68. https://doi.org/10.1016/j.ibmb.2005.11.008.
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  - Tan, Jianguo, Zhiqi Liu, Ruiwu Wang, Zachary Y. Huang, Andrew C. Chen, Michael Gurevitz, and Ke Dong. “Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.” Molecular Pharmacology 67, no. 2 (February 2005): 513–22. https://doi.org/10.1124/mol.104.006205.
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  - Liu, Zhiqi, Weizhong Song, and Ke Dong. “Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel.” Proceedings of the National Academy of Sciences of the United States of America 101, no. 32 (August 2004): 11862–67. https://doi.org/10.1073/pnas.0307695101.
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  - Song, Weizhong, Zhiqi Liu, Jianguo Tan, Yoshiko Nomura, and Ke Dong. “RNA editing generates tissue-specific sodium channels with distinct gating properties.” The Journal of Biological Chemistry 279, no. 31 (July 2004): 32554–61. https://doi.org/10.1074/jbc.m402392200.
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  - Zhou, Wei, Inbum Chung, Zhiqi Liu, Alan L. Goldin, and Ke Dong. “A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.” Neuron 42, no. 1 (April 2004): 101–12. https://doi.org/10.1016/s0896-6273(04)00148-5.
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  - Wang, Ruiwu, Zachary Y. Huang, and Ke Dong. “Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor).” Insect Biochemistry and Molecular Biology 33, no. 7 (July 2003): 733–39. https://doi.org/10.1016/s0965-1748(03)00068-7.
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  - Tan, Jianguo, Zhiqi Liu, Yoshiko Nomura, Alan L. Goldin, and Ke Dong. “Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels.” The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 22, no. 13 (July 2002): 5300–5309.
  - Liu, Zhiqi, Jianguo Tan, Steven M. Valles, and Ke Dong. “Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide.” Insect Biochemistry and Molecular Biology 32, no. 4 (April 2002): 397–404. https://doi.org/10.1016/s0965-1748(01)00116-3.
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  - Tan, J., Z. Liu, T. -. D. Tsai, S. M. Valles, A. L. Goldin, and K. Dong. “Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin.” Insect Biochemistry and Molecular Biology 32, no. 4 (April 2002): 445–54. https://doi.org/10.1016/s0965-1748(01)00122-9.
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  - Wang, R., Z. Liu, K. Dong, P. J. Elzen, J. Pettis, and Z. Huang. “Association of novel mutations in a sodium channel gene with fluvalinate resistance in the mite, Varroa destructor.” Journal of Apicultural Research 41, no. 1–2 (January 1, 2002): 17–25. https://doi.org/10.1080/00218839.2002.11101064.
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  - Liu, Z., I. Chung, and K. Dong. “Alternative splicing of the BSC1 gene generates tissue-specific isoforms in the German cockroach.” Insect Biochemistry and Molecular Biology 31, no. 6–7 (April 2001): 703–13. https://doi.org/10.1016/s0965-1748(00)00178-8.
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  - Liu, Z., S. M. Valles, and K. Dong. “Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.” Insect Biochemistry and Molecular Biology 30, no. 10 (October 2000): 991–97. https://doi.org/10.1016/s0965-1748(00)00074-6.
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  - Valles, S. M., K. Dong, and R. J. Brenner. “Mechanisms responsible for cypermethrin resistance in a strain of German cockroach, Blattella germanica.” Pesticide Biochemistry and Physiology 66, no. 3 (January 1, 2000): 195–205. https://doi.org/10.1006/pest.1999.2462.
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  - Dong, K., S. M. Valles, M. E. Scharf, B. Zeichner, and G. W. Bennett. “The knockdown resistance (kdr) mutation in pyrethroid-resistant German cockroaches.” Pesticide Biochemistry and Physiology 60, no. 3 (August 1, 1998): 195–204. https://doi.org/10.1006/pest.1998.2339.
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  - Dong, K. “A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach.” Insect Biochemistry and Molecular Biology 27, no. 2 (February 1997): 93–100. https://doi.org/10.1016/s0965-1748(96)00082-3.
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  - Dong, K., D. Zhang, and D. L. Dahlman. “Down-Regulation of Juvenile Hormone Esterase and Arylphorin Production in Heliothis virescens Larvae Parasitized by Microplitis croceipes.” Archives of Insect Biochemistry and Physiology 32, no. 2 (January 1, 1996): 237–48. https://doi.org/10.1002/(SICI)1520-6327(1996)32:2<237::AID-ARCH7>3.0.CO;2-V.
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  - Scott, J. G., and K. Dong. “kdr-Type resistance in insects with special reference to the German cockroach, Blattella germanica.” Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology 109, no. 2–3 (October 1994): 191–98. https://doi.org/10.1016/0305-0491(94)90002-7.
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  - Dong, K., and J. G. Scott. “Linkage of kdr-type resistance and the para-homologous sodium channel gene in German cockroaches (Blattella germanica).” Insect Biochemistry and Molecular Biology 24, no. 7 (July 1994): 647–54. https://doi.org/10.1016/0965-1748(94)90051-5.
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  - Dong, K., J. G. Scott, and G. A. Weiland. “[³H]Batrachotoxinin A-20-α-benzoate Binding in Synaptosomes from Susceptible and kdr-Type Resistant German Cockroaches, Blattella germanica (L.).” Pesticide Biochemistry and Physiology 46, no. 2 (January 1, 1993): 141–48. https://doi.org/10.1006/pest.1993.1045.
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  - Dong, K., and J. G. Scott. “Synergism of chlorpyrifos against the German cockroach, Blattella germanica.” Medical and Veterinary Entomology 6, no. 3 (July 1992): 241–43. https://doi.org/10.1111/j.1365-2915.1992.tb00612.x.
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  - Dong, K., and J. G. Scott. “Neuropharmacology and genetics of kdr-type resistance in the German cockroach, Blattella germanica (L.).” Pesticide Biochemistry and Physiology 41, no. 2 (January 1, 1991): 159–69. https://doi.org/10.1016/0048-3575(91)90070-3.
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  - Scott, J. G., K. Dong, C. J. Geden, and D. A. Rutz. “Evaluation of the biochemical basis of insecticide selectivity between host and parasitoid species.” Environmental Entomology 19, no. 6 (December 1, 1990): 1722–25. https://doi.org/10.1093/ee/19.6.1722.
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- Book Sections
  - Gurevitz, M., D. Gordon, M. G. Barzilai, R. Kahn, L. Cohen, Y. Moran, N. Zilberberg, et al. “Molecular description of scorpion toxin interaction with voltage–gated sodium channels.” In Scorpion Venoms, 471–91, 2015. https://doi.org/10.1007/978-94-007-6404-0_10.
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  - Silver, Kristopher S., Yuzhe Du, Yoshiko Nomura, Eugenio E. Oliveira, Vincent L. Salgado, Boris S. Zhorov, and Ke Dong. “Voltage-Gated Sodium Channels as Insecticide Targets.,” 46:389–433, 2014. https://doi.org/10.1016/b978-0-12-417010-0.00005-7.
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  - Hollingworth, R. M., and K. Dong. “The biochemical and molecular genetic basis of resistance to pesticides in arthropods.” In Global Pesticide Resistance in Arthropods, 40–89, 2008.
Teaching & Mentoring
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- Editorial Board Member. Pest Manag. Sci. March 2021 2021
- Editorial Board Member. Insect Biochem. Molec. Biol.. 2008 - 2022 2008 - 2022
- Editorial Board Member. Pestic. Biochem. Physiol. 2008 - 2022 2008 - 2022

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