Kyle Walsh | Scholars@Duke

Kyle Walsh
Associate Professor of Neurosurgery

Dr. Walsh’s research program focuses on genetic and epigenetic factors contributing to cancer predisposition in children and adults, with a special interest in brain tumors. This research is informed by both epidemiology and anthropological genetics, with computational work stressing statistical methodologies for “gene hunting” (e.g. GWAS, fine-mapping, admixture mapping, whole-genome sequencing). The laboratory engages in functional genomics research, investigating the biological impact of genetic variants linked to cancer risk, with a particular focus on regulation of telomere maintenance in pre-malignant cells.

Current Appointments & Affiliations

Associate Professor of Neurosurgery, Neurosurgery, Neurosurgery 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017

Contact Information

571 Research Drive, Msrb-1, Rm 442, Durham, NC 27710
DUMC Box 3050, Durham, NC 27710
kyle.walsh@duke.edu (919) 684-8732

Background
Education, Training, & Certifications
- Ph.D., Yale University School of Medicine 2011
Leadership & Clinical Positions at Duke
- Director, Division of Neuro-epidemiology
  
  Genes and Biology Program Leader, Children's Health and Discovery Institute
Academic Positions Outside Duke
- Assistant Professor of Neurological Surgery, University of California, San Francisco. 2013 - 2017
Research
Selected Grants
- The role of rare and common variants in genetic predisposition to medulloblastoma awarded by Sontag Foundation 2017 - 2019
- Genetic Susceptibility to pediatric Osteosarcoma and Interaction with Measures of Childhood Growth awarded by Alex's Lemonade Stand 2017 - 2018
Publications & Artistic Works
Selected Publications
- Book Sections
  - Walsh, KM, and Wrensch, MR. "Epidemiology of Brain Tumors." In Youmans and Winn Neurological Surgery. Elsevier, November 30, 2016. (Chapter)
  - Walsh, KM, Ohgaki, H, and Wrensch, MR. "Epidemiology." In Gliomas, edited by MS Berger and M Weller, 3-18. Elsevier, June 3, 2016. (Chapter) Link to Item
  - Walsh, KM, Claus, EB, and Wrensch, MR. "Epidemiology." In Neuro-Oncology: The Essentials, edited by M Berstein and MS Berger. Thieme, August 1, 2014. (Chapter)
  - Walsh, KM, Berger, MS, and Wrensch, MR. "Central Nervous System Tumors." In Clinical Genomics: Practical Applications for Adult Patient Care, edited by MF Murray, MW Babyatsky, and MA Giovanni, 187-192. McGraw Hill Professional, November 7, 2013. (Chapter)
- Journal Articles
  - Wiemels, JL, Walsh, KM, de Smith, AJ, Metayer, C, Gonseth, S, Hansen, HM, Francis, SS, Ojha, J, Smirnov, I, Barcellos, L, Xiao, X, Morimoto, L, McKean-Cowdin, R, Wang, R, Yu, H, Hoh, J, DeWan, AT, and Ma, X. "GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21." Nature communications 9, no. 1 (January 18, 2018): 286-. Full Text
  - Wallace, AD, Francis, SS, Shao, X, de Smith, AJ, Walsh, KM, Mckean-Cowdin, R, Ma, X, Dahl, G, Barcellos, LF, Wiemels, JL, and Metayer, C. "A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology." Haematologica 103, no. 1 (January 2018): e29-e31. Full Text
  - Zhang, C, de Smith, AJ, Smirnov, IV, Wiencke, JK, Wiemels, JL, Witte, JS, and Walsh, KM. "Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma." Journal of Neuro-Oncology 135, no. 2 (November 2017): 237-244. Full Text
  - Hayes, J, Yu, Y, Jalbert, LE, Mazor, T, Jones, LE, Wood, MD, Walsh, KM, Bengtsson, H, Hong, C, Oberndorfer, S, Roetzer, T, Smirnov, IV, Clarke, JL, Aghi, MK, Chang, SM, Nelson, SJ, Woehrer, A, Phillips, JJ, Solomon, DA, and Costello, JF. "Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas." Neuro-Oncology (October 25, 2017). Full Text
  - Bazyka, D, Finch, SC, Ilienko, IM, Lyaskivska, O, Dyagil, I, Trotsiuk, N, Gudzenko, N, Chumak, VV, Walsh, KM, Wiemels, J, Little, MP, and Zablotska, LB. "Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures." Environmental Health 16, no. 1 (June 23, 2017): 70-. Full Text
  - Endicott, AA, Morimoto, LM, Kline, CN, Wiemels, JL, Metayer, C, and Walsh, KM. "Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents." Pediatric blood & cancer 64, no. 6 (June 2017). Full Text
  - Pekmezci, M, Rice, T, Molinaro, AM, Walsh, KM, Decker, PA, Hansen, H, Sicotte, H, Kollmeyer, TM, McCoy, LS, Sarkar, G, Perry, A, Giannini, C, Tihan, T, Berger, MS, Wiemels, JL, Bracci, PM, Eckel-Passow, JE, Lachance, DH, Clarke, J, Taylor, JW, Luks, T, Wiencke, JK, Jenkins, RB, and Wrensch, MR. "Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT." Acta neuropathologica 133, no. 6 (June 2017): 1001-1016. Full Text
  - Telomeres Mendelian Randomization Collaboration, , Haycock, PC, Burgess, S, Nounu, A, Zheng, J, Okoli, GN, Bowden, J, Wade, KH, Timpson, NJ, Evans, DM, Willeit, P, Aviv, A, Gaunt, TR, Hemani, G, Mangino, M, Ellis, HP, Kurian, KM, Pooley, KA, Eeles, RA, Lee, JE, Fang, S, Chen, WV, Law, MH, Bowdler, LM, Iles, MM, Yang, Q, Worrall, BB, Markus, HS, Hung, RJ, Amos, CI, Spurdle, AB, Thompson, DJ, O'Mara, TA, Wolpin, B, Amundadottir, L, Stolzenberg-Solomon, R, Trichopoulou, A, and Onland-Moret, NC et al. "Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study." JAMA oncology 3, no. 5 (May 2017): 636-651. Full Text
  - de Smith, AJ, Kaur, M, Gonseth, S, Endicott, A, Selvin, S, Zhang, L, Roy, R, Shao, X, Hansen, HM, Kang, AY, Walsh, KM, Dahl, GV, McKean-Cowdin, R, Metayer, C, and Wiemels, JL. "Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia." Cancer research 77, no. 7 (April 2017): 1674-1683. Full Text
  - Francis, SS, Wallace, AD, Wendt, GA, Li, L, Liu, F, Riley, LW, Kogan, S, Walsh, KM, de Smith, AJ, Dahl, GV, Ma, X, Delwart, E, Metayer, C, and Wiemels, JL. "In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia." Blood 129, no. 12 (March 2017): 1680-1684. Full Text
  - Ohba, S, Mukherjee, J, Johannessen, T-C, Mancini, A, Chow, TT, Wood, M, Jones, L, Mazor, T, Marshall, RE, Viswanath, P, Walsh, KM, Perry, A, Bell, RJA, Phillips, JJ, Costello, JF, Ronen, SM, and Pieper, RO. "Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process." Cancer research 76, no. 22 (November 2016): 6680-6689. Full Text
  - de Smith, AJ, Ojha, J, Francis, SS, Sanders, E, Endicott, AA, Hansen, HM, Smirnov, I, Termuhlen, AM, Walsh, KM, Metayer, C, and Wiemels, JL. "Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia." Oncotarget 7, no. 45 (November 2016): 72733-72745. Full Text Open Access Copy
  - Gonseth, S, de Smith, AJ, Roy, R, Zhou, M, Lee, S-T, Shao, X, Ohja, J, Wrensch, MR, Walsh, KM, Metayer, C, and Wiemels, JL. "Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates." Epigenetics 11, no. 9 (September 2016): 664-673. Full Text
  - Ojha, J, Codd, V, Nelson, CP, Samani, NJ, Smirnov, IV, Madsen, NR, Hansen, HM, de Smith, AJ, Bracci, PM, Wiencke, JK, Wrensch, MR, Wiemels, JL, Walsh, KM, and ENGAGE Consortium Telomere Group, . "Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 25, no. 7 (July 2016): 1043-1049. Full Text
  - Walsh, KM, Whitehead, TP, de Smith, AJ, Smirnov, IV, Park, M, Endicott, AA, Francis, SS, Codd, V, ENGAGE Consortium Telomere Group, , Samani, NJ, Metayer, C, and Wiemels, JL. "Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers." Carcinogenesis 37, no. 6 (June 2016): 576-582. Full Text
  - Wiemels, JL, de Smith, AJ, Xiao, J, Lee, S-T, Muench, MO, Fomin, ME, Zhou, M, Hansen, HM, Termuhlen, A, Metayer, C, and Walsh, KM. "A functional polymorphism in the CEBPE gene promoter influences acute lymphoblastic leukemia risk through interaction with the hematopoietic transcription factor Ikaros." Leukemia 30, no. 5 (May 2016): 1194-1197. (Letter) Full Text
  - Endicott, AA, Taylor, JW, and Walsh, KM. "Telomere length connects melanoma and glioma predispositions." Aging 8, no. 3 (March 29, 2016): 423-424. Full Text
  - David, SP, Wang, A, Kapphahn, K, Hedlin, H, Desai, M, Henderson, M, Yang, L, Walsh, KM, Schwartz, AG, Wiencke, JK, Spitz, MR, Wenzlaff, AS, Wrensch, MR, Eaton, CB, Furberg, H, Mark Brown, W, Goldstein, BA, Assimes, T, Tang, H, Kooperberg, CL, Quesenberry, CP, Tindle, H, Patel, MI, Amos, CI, Bergen, AW, Swan, GE, and Stefanick, ML. "Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans." EBioMedicine 4 (February 2016): 153-161. Full Text Open Access Copy
  - Walsh, KM, Codd, V, Rice, T, Nelson, CP, Smirnov, IV, McCoy, LS, Hansen, HM, Elhauge, E, Ojha, J, Francis, SS, Madsen, NR, Bracci, PM, Pico, AR, Molinaro, AM, Tihan, T, Berger, MS, Chang, SM, Prados, MD, Jenkins, RB, Wiemels, JL, ENGAGE Consortium Telomere Group, , Samani, NJ, Wiencke, JK, and Wrensch, MR. "Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk." Oncotarget 6, no. 40 (December 4, 2015): 42468-42477. Full Text
  - Walsh, KM, de Smith, AJ, Hansen, HM, Smirnov, IV, Gonseth, S, Endicott, AA, Xiao, J, Rice, T, Fu, CH, McCoy, LS, Lachance, DH, Eckel-Passow, JE, Wiencke, JK, Jenkins, RB, Wrensch, MR, Ma, X, Metayer, C, and Wiemels, JL. "A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution." Cancer research 75, no. 22 (November 2, 2015): 4884-4894. Full Text
  - Walsh, KM, Wiencke, JK, Lachance, DH, Wiemels, JL, Molinaro, AM, Eckel-Passow, JE, Jenkins, RB, and Wrensch, MR. "Telomere maintenance and the etiology of adult glioma." Neuro-oncology 17, no. 11 (November 2015): 1445-1452. (Review) Full Text
  - Eckel-Passow, JE, Lachance, DH, Molinaro, AM, Walsh, KM, Decker, PA, Sicotte, H, Pekmezci, M, Rice, T, Kosel, ML, Smirnov, IV, Sarkar, G, Caron, AA, Kollmeyer, TM, Praska, CE, Chada, AR, Halder, C, Hansen, HM, McCoy, LS, Bracci, PM, Marshall, R, Zheng, S, Reis, GF, Pico, AR, O'Neill, BP, Buckner, JC, Giannini, C, Huse, JT, Perry, A, Tihan, T, Berger, MS, Chang, SM, Prados, MD, Wiemels, J, Wiencke, JK, Wrensch, MR, and Jenkins, RB. "Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors." The New England journal of medicine 372, no. 26 (June 10, 2015): 2499-2508. Full Text
  - Bell, RJA, Rube, HT, Kreig, A, Mancini, A, Fouse, SD, Nagarajan, RP, Choi, S, Hong, C, He, D, Pekmezci, M, Wiencke, JK, Wrensch, MR, Chang, SM, Walsh, KM, Myong, S, Song, JS, and Costello, JF. "Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer." Science (New York, N.Y.) 348, no. 6238 (May 14, 2015): 1036-1039. Full Text
  - Reis, GF, Pekmezci, M, Hansen, HM, Rice, T, Marshall, RE, Molinaro, AM, Phillips, JJ, Vogel, H, Wiencke, JK, Wrensch, MR, Walsh, KM, and Perry, A. "CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas." Journal of neuropathology and experimental neurology 74, no. 5 (May 2015): 442-452. Full Text
  - Hsu, L-I, Chokkalingam, AP, Briggs, FBS, Walsh, K, Crouse, V, Fu, C, Metayer, C, Wiemels, JL, Barcellos, LF, and Buffler, PA. "Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children." Cancer causes & control : CCC 26, no. 4 (April 2015): 609-619. Full Text
  - Ostrom, QT, Bauchet, L, Davis, FG, Deltour, I, Fisher, JL, Langer, CE, Pekmezci, M, Schwartzbaum, JA, Turner, MC, Walsh, KM, Wrensch, MR, and Barnholtz-Sloan, JS. "Response to "the epidemiology of glioma in adults: a 'state of the science' review"." Neuro-oncology 17, no. 4 (April 2015): 624-626. (Letter) Full Text
  - Bainbridge, MN, Armstrong, GN, Gramatges, MM, Bertuch, AA, Jhangiani, SN, Doddapaneni, H, Lewis, L, Tombrello, J, Tsavachidis, S, Liu, Y, Jalali, A, Plon, SE, Lau, CC, Parsons, DW, Claus, EB, Barnholtz-Sloan, J, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, D, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Walsh, KM, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Thompson, PA, Muzny, DM, Gibbs, RA, Melin, BS, and Bondy, ML et al. "Germline mutations in shelterin complex genes are associated with familial glioma." Journal of the National Cancer Institute 107, no. 1 (January 2015): 384-. Full Text
  - Claus, EB, Walsh, KM, Wiencke, JK, Molinaro, AM, Wiemels, JL, Schildkraut, JM, Bondy, ML, Berger, M, Jenkins, R, and Wrensch, M. "Survival and low-grade glioma: the emergence of genetic information." Neurosurgical focus 38, no. 1 (January 2015): E6-. Full Text
  - Osorio, JA, Hervey-Jumper, SL, Walsh, KM, Clarke, JL, Butowski, NA, Prados, MD, and Berger, MS. "Familial gliomas: cases in two pairs of brothers." Journal of neuro-oncology 121, no. 1 (January 2015): 135-140. Full Text
  - de Smith, AJ, Walsh, KM, Hansen, HM, Endicott, AA, Wiencke, JK, Metayer, C, and Wiemels, JL. "Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA." PloS one 10, no. 11 (January 2015): e0143343-. Full Text
  - Ostrom, QT, Bauchet, L, Davis, FG, Deltour, I, Fisher, JL, Langer, CE, Pekmezci, M, Schwartzbaum, JA, Turner, MC, Walsh, KM, Wrensch, MR, and Barnholtz-Sloan, JS. "The epidemiology of glioma in adults: a "state of the science" review." Neuro-oncology 16, no. 7 (July 2014): 896-913. (Review) Full Text
  - Walsh, KM, Codd, V, Smirnov, IV, Rice, T, Decker, PA, Hansen, HM, Kollmeyer, T, Kosel, ML, Molinaro, AM, McCoy, LS, Bracci, PM, Cabriga, BS, Pekmezci, M, Zheng, S, Wiemels, JL, Pico, AR, Tihan, T, Berger, MS, Chang, SM, Prados, MD, Lachance, DH, O'Neill, BP, Sicotte, H, Eckel-Passow, JE, ENGAGE Consortium Telomere Group, , van der Harst, P, Wiencke, JK, Samani, NJ, Jenkins, RB, and Wrensch, MR. "Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk." Nature genetics 46, no. 7 (July 2014): 731-735. Full Text
  - Walsh, KM, de Smith, AJ, Welch, TC, Smirnov, I, Cunningham, MJ, Ma, X, Chokkalingam, AP, Dahl, GV, Roberts, W, Barcellos, LF, Buffler, PA, Metayer, C, and Wiemels, JL. "Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia." American journal of hematology 89, no. 7 (July 2014): 721-725. Full Text
  - de Smith, AJ, Walsh, KM, Ladner, MB, Zhang, S, Xiao, C, Cohen, F, Moore, TB, Chokkalingam, AP, Metayer, C, Buffler, PA, Trachtenberg, EA, and Wiemels, JL. "The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia." Blood 123, no. 16 (April 2014): 2497-2503. Full Text
  - Walsh, KM, Chokkalingam, AP, Hsu, L-I, Metayer, C, de Smith, AJ, Jacobs, DI, Dahl, GV, Loh, ML, Smirnov, IV, Bartley, K, Ma, X, Wiencke, JK, Barcellos, LF, Wiemels, JL, and Buffler, PA. "Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children." Leukemia 27, no. 12 (December 2013): 2416-2419. (Letter) Full Text
  - Walsh, KM, de Smith, AJ, Chokkalingam, AP, Metayer, C, Roberts, W, Barcellos, LF, Wiemels, JL, and Buffler, PA. "GATA3 risk alleles are associated with ancestral components in Hispanic children with ALL." Blood 122, no. 19 (November 2013): 3385-3387. (Letter) Full Text
  - Walsh, KM, Rice, T, Decker, PA, Kosel, ML, Kollmeyer, T, Hansen, HM, Zheng, S, McCoy, LS, Bracci, PM, Anderson, E, Hsuang, G, Wiemels, JL, Pico, AR, Smirnov, I, Molinaro, AM, Tihan, T, Berger, MS, Chang, SM, Prados, MD, Lachance, DH, Sicotte, H, Eckel-Passow, JE, Wiencke, JK, Jenkins, RB, and Wrensch, MR. "Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis." Neuro-oncology 15, no. 8 (August 2013): 1041-1047. Full Text
  - Walsh, KM, de Smith, AJ, Chokkalingam, AP, Metayer, C, Dahl, GV, Hsu, L-I, Barcellos, LF, Wiemels, JL, and Buffler, PA. "Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype." Blood 121, no. 23 (June 2013): 4808-4809. (Letter) Full Text
  - Rice, T, Zheng, S, Decker, PA, Walsh, KM, Bracci, P, Xiao, Y, McCoy, LS, Smirnov, I, Patoka, JS, Hansen, HM, Hsuang, G, Wiemels, JL, Tihan, T, Pico, AR, Prados, MD, Chang, SM, Berger, MS, Caron, A, Fink, S, Kollmeyer, T, Rynearson, A, Voss, J, Kosel, ML, Fridley, BL, Lachance, DH, Eckel-Passow, JE, Sicotte, H, O'Neill, BP, Giannini, C, Wiencke, JK, Jenkins, RB, and Wrensch, MR. "Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology." Neuro-Oncology 15, no. 5 (May 2013): 535-541. Full Text
  - Walsh, KM, Anderson, E, Hansen, HM, Decker, PA, Kosel, ML, Kollmeyer, T, Rice, T, Zheng, S, Xiao, Y, Chang, JS, McCoy, LS, Bracci, PM, Wiemels, JL, Pico, AR, Smirnov, I, Lachance, DH, Sicotte, H, Eckel-Passow, JE, Wiencke, JK, Jenkins, RB, and Wrensch, MR. "Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies." Genetic epidemiology 37, no. 2 (February 2013): 222-228. Full Text
  - Walsh, KM, Gorlov, IP, Hansen, HM, Wu, X, Spitz, MR, Zhang, H, Lu, EY, Wenzlaff, AS, Sison, JD, Wei, C, Lloyd, SM, Chen, W, Frazier, ML, Seldin, MF, Bierut, LJ, Bracci, PM, Wrensch, MR, Schwartz, AG, Wiencke, JK, and Amos, CI. "Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 22, no. 2 (February 2013): 251-260. Full Text
  - Zhao, L, Triche, EW, Walsh, KM, Bracken, MB, Saftlas, AF, Hoh, J, and Dewan, AT. "Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients." BMC Pregnancy and Childbirth 12, no. 1 (December 2012). Full Text
  - Walsh, KM, Amos, CI, Wenzlaff, AS, Gorlov, IP, Sison, JD, Wu, X, Spitz, MR, Hansen, HM, Lu, EY, Wei, C, Zhang, H, Chen, W, Lloyd, SM, Frazier, ML, Bracci, PM, Seldin, MF, Wrensch, MR, Schwartz, AG, and Wiencke, JK. "Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans." Oncotarget 3, no. 11 (November 2012): 1428-1438. Full Text
  - DeWan, AT, Egan, KB, Hellenbrand, K, Sorrentino, K, Pizzoferrato, N, Walsh, KM, and Bracken, MB. "Whole-exome sequencing of a pedigree segregating asthma." BMC medical genetics 13 (October 9, 2012): 95-. Full Text
  - Jenkins, RB, Xiao, Y, Sicotte, H, Decker, PA, Kollmeyer, TM, Hansen, HM, Kosel, ML, Zheng, S, Walsh, KM, Rice, T, Bracci, P, McCoy, LS, Smirnov, I, Patoka, JS, Hsuang, G, Wiemels, JL, Tihan, T, Pico, AR, Prados, MD, Chang, SM, Berger, MS, Caron, AA, Fink, SR, Halder, C, Rynearson, AL, Fridley, BL, Buckner, JC, O'Neill, BP, Giannini, C, Lachance, DH, Wiencke, JK, Eckel-Passow, JE, and Wrensch, MR. "A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation." Nature genetics 44, no. 10 (October 2012): 1122-1125. Full Text
  - Kochar, R, Walsh, KM, Jain, A, Spalding, SJ, and Hashkes, PJ. "Decreased use of non-steroidal anti-inflammatory drugs for the treatment of juvenile idiopathic arthritis in the era of modern aggressive treatment." Rheumatology international 32, no. 10 (October 2012): 3055-3060. Full Text
  - Bracci, PM, Sison, J, Hansen, H, Walsh, KM, Quesenberry, CP, Raz, DJ, Wrensch, M, and Wiencke, JK. "Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS)." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 7, no. 9 (September 2012): 1352-1360. Full Text
  - Claus, EB, Walsh, KM, Calvocoressi, L, Bondy, ML, Schildkraut, JM, Wrensch, M, and Wiemels, JL. "Cigarette smoking and risk of meningioma: the effect of gender." Cancer Epidemiol Biomarkers Prev 21, no. 6 (June 2012): 943-950. Full Text Link to Item
  - Sebastiani, P, Solovieff, N, Dewan, AT, Walsh, KM, Puca, A, Hartley, SW, Melista, E, Andersen, S, Dworkis, DA, Wilk, JB, Myers, RH, Steinberg, MH, Montano, M, Baldwin, CT, Hoh, J, and Perls, TT. "Genetic signatures of exceptional longevity in humans." PloS one 7, no. 1 (January 18, 2012): e29848-. Full Text
  - Jacobs, DI, Walsh, KM, Wrensch, M, Wiencke, J, Jenkins, R, Houlston, RS, Bondy, M, Simon, M, Sanson, M, Gousias, K, Schramm, J, Labussière, M, Di Stefano, AL, Wichmann, H-E, Müller-Nurasyid, M, Schreiber, S, Franke, A, Moebus, S, Eisele, L, Dewan, AT, and Dubrow, R. "Leveraging Ethnic Group Incidence Variation to Investigate Genetic Susceptibility to Glioma: A Novel Candidate SNP Approach." Frontiers in Genetics 3 (2012). Full Text
  - Walsh, KM, and Bracken, MB. "Copy number variation in the dosage-sensitive 16p11.2 interval accounts for only a small proportion of autism incidence: a systematic review and meta-analysis." Genetics in medicine : official journal of the American College of Medical Genetics 13, no. 5 (May 2011): 377-384. (Review) Full Text
  - Walsh, KM, Choi, M, Oberg, K, Kulke, MH, Yao, JC, Wu, C, Jurkiewicz, M, Hsu, L-I, Hooshmand, SM, Hassan, M, Janson, ET, Cunningham, JL, Vosburgh, E, Sackler, RS, Lifton, RP, Dewan, AT, and Hoh, J. "A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum." Endocrine-related cancer 18, no. 1 (February 2011): 171-180. Full Text
  - Murk, W, Walsh, K, Hsu, L-I, Zhao, L, Bracken, MB, and Dewan, AT. "Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma." Human heredity 71, no. 2 (January 2011): 97-105. Full Text
  - Wu, C, Walsh, KM, DeWan, AT, Hoh, J, and Wang, Z. "Disease risk prediction with rare and common variants." BMC Proceedings 5, no. Suppl 9 (2011): S61-S61. Full Text
  - Walsh, KM, Bracken, MB, Murk, WK, Hoh, J, and Dewan, AT. "Association between reduced copy-number at T-cell receptor gamma (TCRgamma) and childhood allergic asthma: A possible role for somatic mosaicism." Mutation research 690, no. 1-2 (August 2010): 89-94. Full Text
  - Clendenning, M, Baze, ME, Sun, S, Walsh, K, Liyanarachchi, S, Fix, D, Schunemann, V, Comeras, I, Deacon, M, Lynch, JF, Gong, G, Thomas, BC, Thibodeau, SN, Lynch, HT, Hampel, H, and de la Chapelle, A. "Origins and prevalence of the American Founder Mutation of MSH2." Cancer research 68, no. 7 (April 2008): 2145-2153. Full Text
  - Rice, T, Lachance, DH, Molinaro, AM, Eckel-Passow, JE, Walsh, KM, Barnholtz-Sloan, J, Ostrom, QT, Francis, SS, Wiemels, J, Jenkins, RB, Wiencke, JK, and Wrensch, MR. "Understanding inherited genetic risk of adult glioma – a review (Published online)." Neuro-Oncology Practice : npv026-npv026. Full Text

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

Selected Grants

Selected Publications

Book Sections

Journal Articles