Scholars@Duke
Lisa Kaltenbach

Lisa Kaltenbach

Biostatistician, Principal
Duke Clinical Research Institute
lisa.kaltenbach@duke.edu
200 Morris St, Durham, NC 27701

Selected Publications

Association of Race and Ethnicity With High-Potency P2Y12 Inhibitors Prescription Among Patients With Acute MI Undergoing PCI: An Analysis From the CathPCI Registry.

Journal Article Circ Cardiovasc Interv · February 2026 BACKGROUND: Racial and ethnic disparities exist in postacute myocardial infarction (AMI) care. High-potency P2Y12 inhibitors use among patients with AMI who undergo percutaneous coronary intervention (PCI) carries a class I indication in the guidelines. Th ... Full text Link to item Cite

Outcomes in Patients With Atrial Fibrillation Stratified by Body Mass Index and Heart Failure Status.

Journal Article JACC Adv · February 2026 BACKGROUND: An obesity-survival benefit, called the "obesity paradox," has been variably reported in patients with heart failure (HF) and those with atrial fibrillation (AF), but inconsistencies have been observed. OBJECTIVES: The purpose of this study was ... Full text Link to item Cite

Clinical and financial implications of inpatient and outpatient management of worsening heart failure.

Journal Article Eur J Heart Fail · November 2025 AIMS: Little is known regarding the clinical and financial implications of varying inpatient and outpatient management strategies for worsening heart failure (WHF). This analysis aimed to compare clinical outcomes, home-time, and healthcare expenditure fol ... Full text Link to item Cite

Characteristics of patients prescribed SGLT-2i and/or GLP-1RA among cardiology clinics in the US: insights from the COORDINATE-diabetes trial.

Journal Article Am J Prev Cardiol · September 2025 BACKGROUND: Antihyperglycemic agents with cardiovascular (CV) benefits, including SGLT-2i and GLP-1RA, are underused in clinical practice, particularly by cardiologists. Understanding the prescribing patterns of these agents by cardiologists may aid in imp ... Full text Link to item Cite

Discontinuation of SGLT-2i and GLP-1RA among persons with Type 2 diabetes and atherosclerotic cardiovascular disease treated in US cardiology clinics.

Journal Article Am Heart J · April 2025 BACKGROUND: SGLT-2i and GLP-1RA are recommended for persons with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD); for those prescribed, little is known about reasons for discontinuation. METHODS: From the COORDINATE-Diabetes randomized t ... Full text Link to item Cite

Guideline-Directed Medical Therapy After Hospitalization for Acute Heart Failure: Insights From the CONNECT-HF.

Journal Article J Am Heart Assoc · December 17, 2024 BACKGROUND: Significant gap remains in the implementation of guideline-directed medical therapy (GDMT) in patients with heart failure after a hospitalization. We aimed to evaluate the use and titration of GDMT at discharge and over a 12-month period after ... Full text Link to item Cite

Remote Follow-up in a Heart Failure Pragmatic Trial: Insights From the CONNECT-HF.

Journal Article J Card Fail · November 2024 BACKGROUND: Randomized controlled trials typically require study-specific visits, which can burden participants and sites. Remote follow-up, such as centralized call centers for participant-reported or site-reported, holds promise for reducing costs and en ... Full text Link to item Cite

RAndomized Cluster Evaluation of Cardiac ARrest Systems (RACE-CARS) trial: Study rationale and design.

Journal Article Am Heart J · November 2024 Out-of-hospital cardiac arrest (OHCA) occurs in nearly 350,000 people each year in the United States (US). Despite advances in pre and in-hospital care, OHCA survival remains low and is highly variable across systems and regions. The critical barrier to im ... Full text Open Access Link to item Cite

Effects of an Intervention to Improve Evidence-Based Care for People With Diabetes and Cardiovascular Disease Across Sex, Race, and Ethnicity Subgroups: Insights From the COORDINATE-Diabetes Trial.

Journal Article Circulation · July 16, 2024 BACKGROUND: Results from the COORDINATE-Diabetes trial (Coordinating Cardiology Clinics Randomized Trial of Interventions to Improve Outcomes - Diabetes) demonstrated that a multifaceted, clinic-based intervention increased prescription of evidence-based m ... Full text Link to item Cite

Off-Label Dosing of Direct Oral Anticoagulants Among Inpatients With Atrial Fibrillation in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · December 2023 BACKGROUND: Among patients hospitalized for atrial fibrillation, the frequency of off-label direct oral anticoagulant (DOAC) dosing, associated factors, hospital-level variation, and temporal trends in contemporary practice are unknown. METHODS: Using the ... Full text Link to item Cite

Challenge in Predicting Persistence to P2Y12 Inhibitors: A Perspective From the ARTEMIS Trial.

Journal Article J Am Heart Assoc · June 20, 2023 Background Premature discontinuation of P2Y12 inhibitor therapy has been associated with adverse cardiac events, which might be preventable by improving medication persistence. Current risk models have limited ability to predict patients at risk of P2Y12 i ... Full text Link to item Cite

Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial.

Journal Article JAMA · April 18, 2023 IMPORTANCE: Evidence-based therapies to reduce atherosclerotic cardiovascular disease risk in adults with type 2 diabetes are underused in clinical practice. OBJECTIVE: To assess the effect of a coordinated, multifaceted intervention of assessment, educati ... Full text Link to item Cite

Coordinating Cardiology clinics randomized trial of interventions to improve outcomes (COORDINATE) - Diabetes: rationale and design.

Journal Article Am Heart J · February 2023 Several medications that are proven to reduce cardiovascular events exist for individuals with type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease, however they are substantially underused in clinical practice. Clinician, patient, an ... Full text Link to item Cite

Comparing the Classification of Percutaneous Coronary Interventions Using the 2012 and 2017 Appropriate Use Criteria: Insights From 245,196 Patients in the NCDR CathPCI Registry.

Journal Article Am Heart J · January 2023 BACKGROUND: Appropriate use criteria (AUC) have been developed to promote the rational use of percutaneous coronary intervention (PCI) among clinicians and to provide benchmarking feedback to hospitals. The original AUC were published in 2012 and subsequen ... Full text Link to item Cite

Association of Race and Ethnicity With Oral Anticoagulation and Associated Outcomes in Patients With Atrial Fibrillation: Findings From the Get With The Guidelines-Atrial Fibrillation Registry.

Journal Article JAMA Cardiol · December 1, 2022 IMPORTANCE: Oral anticoagulation (OAC) is underprescribed in underrepresented racial and ethnic group individuals with atrial fibrillation (AF). Little is known of how differential OAC prescribing relates to inequities in AF outcomes. OBJECTIVE: To compare ... Full text Link to item Cite

Does the Effectiveness of a Medicine Copay Voucher Vary by Baseline Medication Out-Of-Pocket Expenses? Insights From ARTEMIS.

Journal Article J Am Heart Assoc · October 18, 2022 Background Persistence to P2Y12 inhibitors after myocardial infarction (MI) remains low. Out-of-pocket cost is cited as a factor affecting medication compliance. We examined whether a copayment intervention affected 1-year persistence to P2Y12 inhibitors a ... Full text Link to item Cite

The Association of Digital Health Application Use With Heart Failure Care and Outcomes: Insights From CONNECT-HF.

Journal Article J Card Fail · October 2022 BACKGROUND: It is unknown whether digital applications can improve guideline-directed medical therapy (GDMT) and outcomes in heart failure with reduced ejection fraction (HFrEF). METHODS AND RESULTS: Care Optimization Through Patient and Hospital Engagemen ... Full text Link to item Cite

Health System-Level Performance in Prescribing Guideline-Directed Medical Therapy for Patients With Heart Failure With Reduced Ejection Fraction: Results From the CONNECT-HF Trial.

Journal Article J Card Fail · August 2022 BACKGROUND: Health system-level interventions to improve use of guideline-directed medical therapy (GDMT) often fail in the acute care setting. We sought to identify factors associated with high performance in adoption of GDMT among health systems in CONNE ... Full text Link to item Cite

Patterns of care for first-detected atrial fibrillation: Insights from the Get With The Guidelines® - Atrial Fibrillation registry.

Journal Article Heart Rhythm · July 2022 BACKGROUND: Despite multiple trials comparing rate with rhythm control, there is no consensus on the optimal management of first-detected atrial fibrillation (AF). OBJECTIVE: We analyzed current patterns of care for first-detected AF in the nationwide Get ... Full text Link to item Cite

Use of Lipid-, Blood Pressure-, and Glucose-Lowering Pharmacotherapy in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease.

Journal Article JAMA Netw Open · February 1, 2022 IMPORTANCE: Based on contemporary estimates in the US, evidence-based therapies for cardiovascular risk reduction are generally underused among patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD). OBJECTIVE: To determine the us ... Full text Link to item Cite

Percutaneous Coronary Intervention Operator Profiles and Associations With In-Hospital Mortality.

Journal Article Circ Cardiovasc Interv · January 2022 BACKGROUND: Percutaneous coronary intervention is performed by operators with differing experience, technique, and case mix. It is unknown if operator practice patterns impact patient outcomes. We sought to determine if a cluster algorithm can identify dis ... Full text Link to item Cite

Trends in Use and Outcomes of Same-Day Discharge Following Elective Percutaneous Coronary Intervention.

Journal Article JACC Cardiovasc Interv · August 9, 2021 OBJECTIVES: The aims of this study were to describe trends and hospital variation in same-day discharge following elective percutaneous coronary intervention (PCI) and to evaluate the association between trends in same-day discharge and patient outcomes. B ... Full text Link to item Cite

Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial.

Journal Article JAMA · July 27, 2021 IMPORTANCE: Adoption of guideline-directed medical therapy for patients with heart failure is variable. Interventions to improve guideline-directed medical therapy have failed to consistently achieve target metrics, and limited data exist to inform efforts ... Full text Link to item Cite

Incorporating SGLT2i and GLP-1RA for Cardiovascular and Kidney Disease Risk Reduction: Call for Action to the Cardiology Community.

Journal Article Circulation · July 6, 2021 Multiple sodium glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to impart significant cardiovascular and kidney benefits, but are underused in clinical practice. Both SGLT-2i and GLP-1RA ... Full text Link to item Cite

Characteristics and Outcomes of Patients With History of CABG Undergoing Cardiac Catheterization Via the Radial Versus Femoral Approach.

Journal Article JACC Cardiovasc Interv · April 26, 2021 OBJECTIVES: The aims of this study were to examine rates of radial artery access in post-coronary artery bypass grafting (CABG) patients undergoing diagnostic catherization and/or percutaneous coronary intervention (PCI), whether operators with higher proc ... Full text Link to item Cite

Agreement and Accuracy of Medication Persistence Identified by Patient Self-report vs Pharmacy Fill: A Secondary Analysis of the Cluster Randomized ARTEMIS Trial.

Journal Article JAMA Cardiol · May 1, 2020 IMPORTANCE: Pharmacy fill data are increasingly accessible to clinicians and researchers to evaluate longitudinal medication persistence beyond patient self-report. OBJECTIVE: To assess the agreement and accuracy of patient-reported and pharmacy fill-based ... Full text Link to item Cite

Copayment Reduction Voucher Utilization and Associations With Medication Persistence and Clinical Outcomes: Findings From the ARTEMIS Trial.

Journal Article Circ Cardiovasc Qual Outcomes · May 2020 BACKGROUND: Cost is frequently cited as a barrier to optimal medication use, but the extent to which copayment assistance interventions are used when available, and their impact on evidence-based medication persistence and major adverse cardiovascular even ... Full text Link to item Cite

Impact of a Copayment Reduction Intervention on Medication Persistence and Cardiovascular Events in Hospitals With and Without Prior Medication Financial Assistance Programs.

Journal Article J Am Heart Assoc · April 21, 2020 Background Hospitals commonly provide a short-term supply of free P2Y12 inhibitors at discharge after myocardial infarction, but it is unclear if these programs improve medication persistence and outcomes. The ARTEMIS (Affordability and Real-World Antiplat ... Full text Link to item Cite

Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and design of CONNECT-HF.

Journal Article Am Heart J · February 2020 Many therapies have been shown to improve outcomes for patients with heart failure (HF) in controlled settings, but there are limited data available to inform best practices for hospital and post-discharge quality improvement initiatives. The CONNECT-HF st ... Full text Link to item Cite

Trends in Usage and Clinical Outcomes of Coronary Atherectomy: A Report From the National Cardiovascular Data Registry CathPCI Registry.

Journal Article Circ Cardiovasc Interv · February 2020 BACKGROUND: Adjunctive coronary atherectomy (CA) can be utilized in treating severely calcified coronary lesions; however, the temporal trends, patient selection, and variation in use of CA have not been well described. We sought to assess the trends in us ... Full text Link to item Cite

Association of a P2Y12 Inhibitor Copayment Reduction Intervention With Persistence and Adherence With Other Secondary Prevention Medications: A Post Hoc Analysis of the ARTEMIS Cluster-Randomized Clinical Trial.

Journal Article JAMA Cardiol · January 1, 2020 IMPORTANCE: The Affordability and Real-World Antiplatelet Treatment Effectiveness After Myocardial Infarction Study (ARTEMIS) cluster-randomized trial found that copayment reduction for P2Y12 inhibitors improved 1-year patient persistence in taking that me ... Full text Link to item Cite

Examining the Operator Learning Curve for Percutaneous Coronary Intervention of Chronic Total Occlusions.

Journal Article Circ Cardiovasc Interv · August 2019 BACKGROUND: Advances in chronic total occlusion percutaneous coronary intervention (CTO PCI) techniques have led to increased procedural success rates among operators. While utilization of CTO PCI has disseminated widely, the learning curve for new operato ... Full text Link to item Cite

Safety of Dual-Antiplatelet Therapy After Myocardial Infarction Among Patients With Chronic Kidney Disease.

Journal Article J Am Heart Assoc · May 21, 2019 Background Although recommended in the guidelines, the safety of chronic P2Y12 inhibitor therapy in patients with chronic kidney disease ( CKD ) after an acute myocardial infarction ( MI ) is not well studied. Methods and Results The TRANSLATE -ACS (Treatm ... Full text Link to item Cite

Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: SAFE-PCI for Women (Study of Access Site for Enhancement of PCI for Women), a randomized controlled trial comparing radial and femoral access in women undergoing cardiac catheterization or percutaneous coronary intervention (PCI), was terminate ... Full text Link to item Cite

Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study.

Journal Article Catheter Cardiovasc Interv · March 1, 2019 INTRODUCTION: Concomitant use of glycoprotein IIb/IIIa inhibitors (GPI) and P2Y12 inhibitors increases bleeding risk. How GPIs are being used with faster onset, higher potency P2Y12 inhibitors are unclear. METHODS AND RESULTS: We studied 11,781 myocardial ... Full text Link to item Cite

Relationship Between Operator Volume and Long-Term Outcomes After Percutaneous Coronary Intervention.

Journal Article Circulation · January 22, 2019 BACKGROUND: Although many studies show an inverse association between operator procedural volume and short-term adverse outcomes after percutaneous coronary intervention (PCI), the association between procedural volume and longer-term outcomes is unknown. ... Full text Link to item Cite

Usefulness of Antithrombotic Therapy in Patients With Atrial Fibrillation and Acute Myocardial Infarction.

Journal Article Am J Cardiol · January 1, 2019 To examine patterns of preadmission and discharge antithrombotic therapies in coronary artery disease (CAD) and atrial fibrillation (AF) patients admitted for acute myocardial infarction (AMI), we performed a retrospective analysis of the Acute Coronary Tr ... Full text Link to item Cite

Effect of Medication Co-payment Vouchers on P2Y12 Inhibitor Use and Major Adverse Cardiovascular Events Among Patients With Myocardial Infarction: The ARTEMIS Randomized Clinical Trial.

Journal Article JAMA · January 1, 2019 IMPORTANCE: Despite guideline recommendations, many patients discontinue P2Y12 inhibitor therapy earlier than the recommended 1 year after myocardial infarction (MI), and higher-potency P2Y12 inhibitors are underutilized. Cost is frequently cited as an exp ... Full text Link to item Cite

Adverse Change in Employment Status After Acute Myocardial Infarction: Analysis From the TRANSLATE-ACS Study.

Journal Article Circ Cardiovasc Qual Outcomes · June 2018 BACKGROUND: Inability to resume employment after acute myocardial infarction (MI) has important implications for patients. We sought to assess the prevalence of and outcomes associated with adverse change in employment after MI in a national US cohort. MET ... Full text Link to item Cite

Hospital Variation in Adherence Rates to Secondary Prevention Medications and the Implications on Quality.

Journal Article Circulation · May 15, 2018 BACKGROUND: Medication adherence is important to improve the long-term outcomes after acute myocardial infarction (MI). We hypothesized that there is significant variation among US hospitals in terms of medication adherence after MI, and that patients trea ... Full text Link to item Cite

Hospital evaluation of health literacy and associated outcomes in patients after acute myocardial infarction.

Journal Article Am Heart J · April 2018 BACKGROUND: Low health literacy is common in the United States and may affect outcomes after myocardial infarction (MI). How often hospitals screen for low health literacy is unknown. METHODS: We surveyed 122 hospitals in the TRANSLATE-ACS study and divide ... Full text Link to item Cite

Antiplatelet Therapy Changes for Patients With Myocardial Infarction With Recurrent Ischemic Events: Insights Into Contemporary Practice From the TRANSLATE-ACS (Treatment With ADP Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) Study.

Journal Article Journal of the American Heart Association · February 2018 BackgroundGuidelines recommend P2Y12 inhibitor therapy for 1 year after myocardial infarction (MI), yet little guidance is provided on antiplatelet management for patients with recurrent ischemic events during that year. We describe cha ... Full text Cite

Anticoagulant Use Among Patients With End-Stage Renal Disease Undergoing Percutaneous Coronary Intervention: An Analysis From the National Cardiovascular Data Registry.

Journal Article Circ Cardiovasc Interv · February 2018 BACKGROUND: Patients with end-stage renal disease undergoing percutaneous coronary intervention (PCI) have largely been excluded from trials of antithrombotic therapies leaving little data to guide agent choice in this population. METHODS AND RESULTS: The ... Full text Link to item Cite

Variation in the Adoption of Transradial Access for ST-Segment Elevation Myocardial Infarction: Insights From the NCDR CathPCI Registry.

Journal Article JACC Cardiovasc Interv · November 27, 2017 OBJECTIVES: The study sought to define patient, operator, and institutional factors associated with transradial access (TRA) in ST-segment elevation myocardial infarction (STEMI) percutaneous coronary intervention (PCI), the variation in use across operato ... Full text Link to item Cite

Management of Persistent Angina After Myocardial Infarction Treated With Percutaneous Coronary Intervention: Insights From the TRANSLATE-ACS Study.

Journal Article J Am Heart Assoc · October 19, 2017 BACKGROUND: Angina has important implications for patients' quality of life and healthcare utilization. Angina management after acute myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) is unknown. METHODS AND RESULTS: TRANSLAT ... Full text Link to item Cite

Multivessel Versus Culprit Vessel-Only Percutaneous Coronary Intervention Among Patients With Acute Myocardial Infarction: Insights From the TRANSLATE-ACS Observational Study.

Journal Article J Am Heart Assoc · October 5, 2017 BACKGROUND: Among patients with acute myocardial infarction (MI) who have multivessel disease, it is unclear if multivessel percutaneous coronary intervention (PCI) improves clinical and quality-of-life outcomes compared with culprit-only intervention. We ... Full text Link to item Cite

Magnitude and Characteristics of Patients Who Survived an Acute Myocardial Infarction.

Journal Article J Am Heart Assoc · September 25, 2017 BACKGROUND: The purpose of this study was to describe the magnitude and characteristics of patients who did not experience any significant major adverse cardiovascular event early (within 6 weeks) and late (during the first year) after hospital discharge f ... Full text Link to item Cite

Accuracy of Medical Claims for Identifying Cardiovascular and Bleeding Events After Myocardial Infarction : A Secondary Analysis of the TRANSLATE-ACS Study.

Journal Article JAMA Cardiol · July 1, 2017 IMPORTANCE: Pragmatic clinical trial designs have proposed the use of medical claims data to ascertain clinical events; however, the accuracy of billed diagnoses in identifying potential events is unclear. OBJECTIVES: To compare the 1-year cumulative incid ... Full text Link to item Cite

Outcomes of a multi-community hypertension implementation study: the American Heart Association's Check. Change. Control. program.

Journal Article J Clin Hypertens (Greenwich) · May 2017 UNLABELLED: Single-site, intensive, community-based blood pressure (BP) intervention programs have led to BP improvements. The authors examined the American Heart Association's Check. Change. CONTROL: (CCC) program (4069 patients/18 cities) to determine wh ... Full text Link to item Cite

Race and Sex Differences in Post-Myocardial Infarction Angina Frequency and Risk of 1-Year Unplanned Rehospitalization.

Journal Article Circulation · February 7, 2017 BACKGROUND: Race and sex disparities in in-hospital treatment and outcomes of patients with acute myocardial infarction (MI) have been described, but little is known about race and sex differences in post-MI angina and long-term risk of unplanned rehospita ... Full text Link to item Cite

Adoption of radial access and comparison of outcomes to femoral access in percutaneous coronary intervention: an updated report from the national cardiovascular data registry (2007-2012).

Journal Article Circulation · June 11, 2013 BACKGROUND: Radial access for percutaneous coronary intervention (r-PCI) is associated with reduced vascular complications; however, previous reports have shown that <2% of percutaneous coronary intervention (PCI) procedures in the United States are perfor ... Full text Link to item Cite

Nonsystem reasons for delay in door-to-balloon time and associated in-hospital mortality: a report from the National Cardiovascular Data Registry.

Journal Article J Am Coll Cardiol · April 23, 2013 OBJECTIVES: The goal of this study was to characterize nonsystem reasons for delay in door-to-balloon time (D2BT) and the impact on in-hospital mortality. BACKGROUND: Studies have evaluated predictors of delay in D2BT, highlighting system-related issues an ... Full text Link to item Cite

Non-adherence and drug-related interruptions are risk factors for delays in completion of treatment for tuberculosis.

Journal Article The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · April 2013 SettingA key program performance objective established by the Centers for Disease Control and Prevention (CDC) is that ≥93% of tuberculosis (TB) cases complete treatment within 12 months.ObjectiveTo determine the rate of and risk factors ... Full text Cite

The prevalence and outcomes of transradial percutaneous coronary intervention for ST-segment elevation myocardial infarction: analysis from the National Cardiovascular Data Registry (2007 to 2011).

Journal Article J Am Coll Cardiol · January 29, 2013 OBJECTIVES: The purpose of this study was to examine use and describe outcomes of radial access for percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Transradial PCI (TRI) is associate ... Full text Link to item Cite

Assessing stroke patients for rehabilitation during the acute hospitalization: findings from the get with the guidelines-stroke program.

Journal Article Arch Phys Med Rehabil · January 2013 OBJECTIVE: To examine the frequency and determinants of an assessment for rehabilitation during the hospitalization for acute stroke. DESIGN: Prospective cohort of patients admitted with acute stroke in the Get With The Guidelines-Stroke (GWTG-Stroke) prog ... Full text Link to item Cite

The impact of beta-blocker therapy on anemia after traumatic brain injury.

Journal Article Transfusion · October 2012 BackgroundAn increase in endogenous catecholamine levels after traumatic brain injury (TBI) is well described. Animal studies suggest that postinjury anemia is exacerbated by a persistent hyperadrenergic state. This study aims to determine if beta ... Full text Cite

Downstream testing and subsequent procedures after coronary computed tomographic angiography following coronary stenting in patients ≥65 years of age.

Journal Article Am J Cardiol · September 15, 2012 Limited data are available on the use of coronary computed tomographic angiography (CCTA) in patients who have received percutaneous coronary intervention (PCI). To evaluate patterns of cardiac testing including CCTA after PCI, we created a retrospective o ... Full text Link to item Cite

Blood pressure control among patients with hypertension and newly diagnosed diabetes.

Journal Article Diabetic medicine : a journal of the British Diabetic Association · September 2012 AimsTo determine the proportion of patients who achieved blood pressure control during the 2 years following new diabetes diagnosis.MethodsA retrospective cohort of veterans ≥ 18 years with hypertension who initiated a diabetes medication ... Full text Cite

Regional variation in recommended treatments for ischemic stroke and TIA: Get with the Guidelines--Stroke 2003-2010.

Journal Article Stroke · July 2012 BACKGROUND AND PURPOSE: Secondary stroke prevention treatments vary in different regions of the US. We determined the degree to which guideline-recommended stroke treatments vary by region for patients treated at hospitals participating in a voluntary nati ... Full text Link to item Cite

Use of tissue-type plasminogen activator before and after publication of the European Cooperative Acute Stroke Study III in Get With The Guidelines-Stroke.

Journal Article Circulation. Cardiovascular quality and outcomes · May 2012 BackgroundThe European Cooperative Acute Stroke Study (ECASS) III demonstrated benefit to expanding the intravenous tissue-type plasminogen activator (tPA) window from 3 to 4.5 hours for patients with acute ischemic stroke (AIS). We investigated h ... Full text Cite

Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trial.

Journal Article Am Heart J · April 2012 BACKGROUND: Nonadherence to cardiovascular medications is a significant public health problem. This randomized study evaluated the effect on medication adherence of linking hospital and community pharmacists. METHODS: Hospitalized patients with coronary ar ... Full text Link to item Cite

Clinical presentation, management, and outcomes of angiographically documented early, late, and very late stent thrombosis.

Journal Article JACC Cardiovasc Interv · February 2012 OBJECTIVES: The aim of this study was to describe differences in treatment and in-hospital mortality of early, late, and very late stent thrombosis (ST). BACKGROUND: Early, late, and very late ST may differ in clinical presentation, management, and in-hosp ... Full text Link to item Cite

Care and outcomes of Asian-American acute myocardial infarction patients: findings from the American Heart Association Get With The Guidelines-Coronary Artery Disease program.

Journal Article Circ Cardiovasc Qual Outcomes · January 2012 BACKGROUND: Asian-Americans represent an important United States minority population, yet there are limited data regarding the clinical care and outcomes of Asian-Americans following acute myocardial infarction (AMI). Using data from the American Heart Ass ... Full text Link to item Cite

Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P).

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · December 2011 BackgroundMuscle weakness and obesity are two significant threats to mobility facing the increasing number of older adults. To date, there are no studies that have examined the association of strength and body mass index (BMI) on event rates on a ... Full text Cite

Prevalence and outcomes of same-day discharge after elective percutaneous coronary intervention among older patients.

Journal Article JAMA · October 5, 2011 CONTEXT: Patients undergoing elective percutaneous coronary intervention (PCI) are generally observed overnight in the hospital. The association between same-day discharge of older patients and death or readmission is unclear. OBJECTIVE: To evaluate the pr ... Full text Link to item Cite

Comparative effectiveness of antibiotic treatment strategies for pediatric skin and soft-tissue infections.

Journal Article Pediatrics · September 2011 ObjectiveTo compare the effectiveness of clindamycin, trimethoprim-sulfamethoxazole, and β-lactams for the treatment of pediatric skin and soft-tissue infections (SSTIs).MethodsA retrospective cohort of children 0 to 17 years of age who w ... Full text Cite

Hospital variability in the rate of finding obstructive coronary artery disease at elective, diagnostic coronary angiography.

Journal Article J Am Coll Cardiol · August 16, 2011 OBJECTIVES: The purpose of this study was to describe hospital variability in the rate of finding obstructive coronary artery disease (CAD) at elective coronary angiography. BACKGROUND: A recent national study found that obstructive CAD was found in less t ... Full text Link to item Cite

Patient centered primary care is associated with patient hypertension medication adherence.

Journal Article Journal of behavioral medicine · August 2011 There is increasing evidence that patient centered care, including communication skills, is an essential component to chronic illness care. Our aim was to evaluate patient centered primary care as a determinant of medication adherence. We mailed 1,341 vete ... Full text Cite

Chronic lung disease and HIV infection are risk factors for recurrent tuberculosis in a low-incidence setting.

Journal Article The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · July 2011 SettingProgrammatic data from the United States on tuberculosis (TB) recurrence are limited.ObjectivesTo determine the TB recurrence rate and to determine if chronic lung disease (CLD) and human immunodeficiency virus (HIV) infection are ... Full text Cite

Patterns and predictors of evidence-based medication continuation among hospitalized heart failure patients (from Get With the Guidelines-Heart Failure).

Journal Article Am J Cardiol · June 15, 2011 Hospitalized patients with heart failure and decreased ejection fraction are at substantial risk for mortality and rehospitalization, yet no acute therapies are proven to decrease this risk. Therefore, in-hospital use of medications proved to decrease long ... Full text Link to item Cite

Patterns and intensity of medical therapy in patients undergoing percutaneous coronary intervention.

Journal Article JAMA · May 2011 ContextThe Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) study, which provided optimal medical therapy (OMT) to all patients and demonstrated no incremental advantage of percutaneous coronary intervention ( ... Full text Cite

Use of drugs known to cause fetal harm among women delivering infants in Haiti.

Journal Article Academic pediatrics · November 2010 ObjectiveTo estimate the prevalence of use of fetal-harm drugs among women who received postpartum care in hospitals in Haiti and to identify groups of women at higher risk for potentially harmful medication exposures.MethodsWomen who rec ... Full text Cite

Effects of exercise on mobility in obese and nonobese older adults.

Journal Article Obesity (Silver Spring, Md.) · June 2010 Coupled with an aging society, the rising obesity prevalence is likely to increase the future burden of physical disability. We set out to determine whether obesity modified the effects of a physical activity (PA) intervention designed to prevent mobility ... Full text Cite

Adherence to disease-modifying antirheumatic drugs and the effects of exposure misclassification on the risk of hospital admission.

Journal Article Arthritis care & research · May 2010 ObjectiveTo describe the effect of different exposure classification strategies for disease-modifying antirheumatic drugs (DMARDs) on drug-outcome associations.MethodsWe studied the association between DMARD initiation and all-cause hospi ... Full text Cite

Adherence to prophylactic antibiotic guidelines among Medicaid infants with sickle cell disease.

Journal Article Archives of pediatrics & adolescent medicine · March 2010 Full text Cite

Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.

Journal Article Annals of internal medicine · March 2010 BackgroundProton-pump inhibitors (PPIs) and clopidogrel are frequently coprescribed, although the benefits and harms of their concurrent use are unclear.ObjectiveTo examine the association between concurrent use of PPIs and clopidogrel an ... Full text Cite

Black race, sex, and extrapulmonary tuberculosis risk: an observational study.

Journal Article BMC infectious diseases · January 2010 BackgroundExtrapulmonary tuberculosis is likely a marker of underlying immune compromise. Our objective was to determine race and sex differences in extrapulmonary tuberculosis risk in order to identify the optimal population in which to assess fo ... Full text Cite

Initiation of rheumatoid arthritis treatments and the risk of serious infections.

Journal Article Rheumatology (Oxford, England) · January 2010 ObjectiveIn clinical trials of RA patients on traditional DMARDs, the addition of TNF-alpha antagonists increased infections compared with addition of placebo. Our objective was to compare serious infections following initiation of different RA re ... Full text Cite

An algorithm to identify incident myocardial infarction using Medicaid data.

Journal Article Pharmacoepidemiology and drug safety · November 2009 PurposeStudies of non-steroidal anti-inflammatory drugs (NSAIDs) and cardiovascular events using administrative data require identification of incident acute myocardial infarctions (AMIs) and information on whether confounders differ by NSAID stat ... Full text Cite

Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart disease.

Journal Article Pharmacoepidemiology and drug safety · November 2009 PurposeTo determine if certain non-steroidal anti-inflammatory drugs (NSAIDs) are associated with increased risk of cardiovascular events: acute myocardial infarction (AMI), stroke, and death from coronary heart disease (CHD).MethodsWe co ... Full text Cite

Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations.

Journal Article Paediatric and perinatal epidemiology · January 2009 This study was designed to assess the association between pregnancy-related exposures to antibiotics recommended for use in the event of a bioterrorism attack and major congenital malformations. A retrospective cohort study included 30 049 infants from Ten ... Full text Cite

Selected community characteristics and underage drinking.

Journal Article Substance use & misuse · January 2009 This study assessed the relationship between community characteristics and alcohol use among 6,636 youth, aged from 14 to 20, in 2004. After adjusting for individual-level characteristics, youth from communities with a greater proportion of grandparents as ... Full text Cite

Nonaspirin NSAIDs, cyclooxygenase 2 inhibitors, and the risk for stroke.

Journal Article Stroke · July 2008 Background and purposeThere is limited information regarding the cerebrovascular safety of cyclooxygenase 2 inhibitors (coxibs) and noncoxib nonsteroidal antiinflammatory drugs (NSAIDs). We determined whether specific NSAIDs, including coxibs, are ... Full text Cite

Adjustment for multiple cardiovascular risk factors using a summary risk score.

Journal Article Epidemiology (Cambridge, Mass.) · January 2008 BackgroundTo simultaneously adjust for confounding by multiple cardiovascular risk factors, recently published pharmacoepidemiologic studies have used an index of risk of cardiovascular disease (a cardiovascular risk score). This summary measure i ... Full text Cite