Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pulmonary and Critical Care Medicine Fellowship, Department Of Pulmonary, Critical Care, Sleep And Occupational Medicine, Indiana University, School of Medicine 2013 - 2016
  • Internal Medicine Residency, Michigan State University 2010 - 2013
  • Fellow in Infectious and Tropical Disease, Department Of Infectious And Tropical Disease, Sapienza University of Rome (Italy) 2004 - 2007
  • M.D., Sapienza University of Rome (Italy) 2004
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2021 - 2022
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2018 - 2020
  • Medical Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2016 - 2018
• Research
• 

  Selected Grants

  • Impact of Pre-transplant Anti-fibrotic Therapy for IPF Upon Lung Transplant Outcomes awarded by Steward St. Elizabeth's Medical Center of Boston Inc. 2019 - 2020
  • Evaluation of the host immune response and viral molecular phenotype in lung transplant recipients with PTLD awarded by Mount Sinai School of Medicine 2017 - 2018
  • Predictors and Outcomes of Post-transplant lymphoproliferative disorder in lung transplant recipients awarded by International Society for Heart & Lung Transplantation 2017 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zaffiri, Lorenzo, Joshua E. Messinger, Erika J. Bush, Janet S. Staats, Prekshaben Patel, Scott M. Palmer, Kent J. Weinhold, Laurie D. Snyder, and Micah A. Luftig. “Evaluation of host cellular responses to Epstein-Barr virus (EBV) in adult lung transplant patients with EBV-associated diseases.” J Med Virol 95, no. 4 (April 2023): e28724. https://doi.org/10.1002/jmv.28724.
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    • Hwang, Josephine, Alexander Yuen, Joshua Rhoades, Darina Barnes, Phillip Zakowski, Dominick J. Megna, Pedro Catarino, Lorenzo Zaffiri, and Reinaldo Rampolla. “Real-time transcription polymerase chain reaction cycle threshold values as criteria for utilization of incidental COVID-19 positive lung donors.” J Heart Lung Transplant 42, no. 3 (March 2023): 301–4. https://doi.org/10.1016/j.healun.2022.12.016.
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    • Swaminathan, Aparna C., Alec McConnell, Sarah Peskoe, Mustafa R. Bashir, Erika Bush Buckley, Courtney Frankel, Daniel Turner, et al. “Evaluation of Frailty Measures and Short-term Outcomes After Lung Transplantation.” Chest, January 18, 2023. https://doi.org/10.1016/j.chest.2023.01.017.
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    • Pavlisko, Elizabeth N., Megan L. Neely, Heather Kopetskie, David M. Hwang, Carol F. Farver, W Dean Wallace, Andrea Arrossi, et al. “Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.” Am J Transplant 22, no. 12 (December 2022): 3002–11. https://doi.org/10.1111/ajt.17183.
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    • Saullo, Jennifer L., Arthur W. Baker, Laurie D. Snyder, John M. Reynolds, Lorenzo Zaffiri, Emily M. Eichenberger, Alana Ferrari, et al. “Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.” J Heart Lung Transplant 41, no. 4 (April 2022): 508–15. https://doi.org/10.1016/j.healun.2021.12.005.
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    • Zaffiri, Lorenzo, Courtney Frankel, Erika J. Bush, Megan L. Neely, Elizabeth N. Pavlisko, Irina L. Mokrova, Micah A. Luftig, and Scott M. Palmer. “Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.” J Med Virol 93, no. 8 (August 2021): 5040–47. https://doi.org/10.1002/jmv.26936.
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    • Zaffiri, Lorenzo. “Desensitization and management of allograft rejection.” Curr Opin Organ Transplant 26, no. 3 (June 1, 2021): 314–20. https://doi.org/10.1097/MOT.0000000000000878.
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    • Clausen, Emily S., and Lorenzo Zaffiri. “Infection prophylaxis and management of viral infection.” Ann Transl Med 8, no. 6 (March 2020): 415. https://doi.org/10.21037/atm.2019.11.85.
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    • Zaffiri, Lorenzo, Rupal J. Shah, Robert S. Stearman, Katia Rothhaar, Amir M. Emtiazjoo, Momoko Yoshimoto, Amanda J. Fisher, et al. “Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation.” Transpl Immunol 56 (October 2019): 101224. https://doi.org/10.1016/j.trim.2019.101224.
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    • Zaffiri, L., A. Hulbert, and L. D. Snyder. “Pre-transplant Sensitization for Patient Awaiting Lung Transplant: Are We Concerned?” Current Transplantation Reports 4, no. 3 (September 1, 2017): 211–17. https://doi.org/10.1007/s40472-017-0155-8.
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    • Smith, Joshua, Lorenzo Zaffiri, Julie Clary, Tyler Davis, and Gabriel T. Bosslet. “The Effect of Paging Reminders on Fellowship Conference Attendance: A Multi-Program Randomized Crossover Study.” J Grad Med Educ 8, no. 3 (July 2016): 372–77. https://doi.org/10.4300/JGME-D-15-00487.1.
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    • Oberle, Amber, Khalil Diab, Lorenzo Zaffiri, and Aliya Noor. “Getting the Wind Knocked out of Your Chest: A Case of Endobronchial Valve Placement for Bronchocutaneous Fistula Following Thoracoplasty for Pulmonary Tuberculosis and Aspergillosis.” Chest 148, no. 4 (October 2015): 841A-841A. https://doi.org/10.1378/chest.2225466.
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    • Zaffiri, Lorenzo, Gabriella d’Ettorre, Giancarlo Ceccarelli, Mauro Andreotti, Sonia Marcellini, Noemi Giustini, Tommaso Ascoli-Bartoli, Claudio M. Mastroianni, Stefano Vella, and Vincenzo Vullo. “Recovery of interleukin-17 production from interleukin-15-stimulated CD4+ mononuclear cells in HIV-1-infected patients with sustained viral suppression.” J Interferon Cytokine Res 34, no. 1 (January 2014): 35–40. https://doi.org/10.1089/jir.2012.0011.
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    • Boyaji, Shafik, Lorenzo Zaffiri, Elizabeth Steensma, Imad Bagh, Giovanni Castellucci, Mark Remmler, James Kraatz, et al. “Caught in Transit. A Case of Paradoxical Embolism in Patient With a PFO: The Role of Obstructive Sleep Apnea.” Chest 144, no. 4 (October 2013): 343A-343A. https://doi.org/10.1378/chest.1700508.
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    • Zaffiri, Lorenzo, Shafik Boyaji, Imad Bagh, and Mark Loehrke. “Rapid Clinical and Radiological Improvement of ANCA-Negative Limited Granulomatosis With Polyangiitis Induced by Rituximab: Is the B Cell Depletion?” Chest 144, no. 4 (October 2013): 961A-961A. https://doi.org/10.1378/chest.1701151.
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    • Zaffiri, Lorenzo, Jared Gardner, and Luis H. Toledo-Pereyra. “History of antibiotics: from fluoroquinolones to daptomycin (Part 2).” J Invest Surg 26, no. 4 (August 2013): 167–79. https://doi.org/10.3109/08941939.2013.808461.
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    • Zaffiri, Lorenzo, Rasha Abdulmassih, Shafik Boyaji, Imad Bagh, Amanda R. Campbell, and Mark E. Loehrke. “Brain abscess induced by Propionibacterium acnes in a patient with severe chronic sinusitis.” New Microbiol 36, no. 3 (July 2013): 325–29.
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    • Zaffiri, Lorenzo, Rajanshu Verma, Kevin Struzzieri, Joanne Monterroso, Donald H. Batts, and Mark E. Loehrke. “Immune reconstitution inflammatory syndrome involving the central nervous system in a patient with HIV infection: a case report and review of literature.” New Microbiol 36, no. 1 (January 2013): 89–92.
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    • Zaffiri, L., E. Kohli, J. Monterroso, S. Abraham, M. V. Zaccheo, and E. Feucht. “Acute postobstructive pulmonary edema caused by a massive substernal thyroid goiter: A case report and a brief literature review.” Critical Care and Shock 15, no. 4 (December 1, 2012): 95–98.
    • Zaffiri, Lorenzo, Jared Gardner, and Luis H. Toledo-Pereyra. “History of antibiotics. From salvarsan to cephalosporins.” J Invest Surg 25, no. 2 (April 2012): 67–77. https://doi.org/10.3109/08941939.2012.664099.
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    • Ettorre, Gabriella d’, Mirko Paiardini, Lorenzo Zaffiri, Mauro Andreotti, Giancarlo Ceccarelli, Cecilia Rizza, Marileda Indinnimeo, et al. “HIV persistence in the gut mucosa of HIV-infected subjects undergoing antiretroviral therapy correlates with immune activation and increased levels of LPS.” Curr Hiv Res 9, no. 3 (April 2011): 148–53. https://doi.org/10.2174/157016211795945296.
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    • Gordon, Shari N., Anna R. Weissman, Valentina Cecchinato, Claudio Fenizia, Zhong-Min Ma, Tzong-Hae Lee, Lorenzo Zaffiri, et al. “Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques.” J Virol 84, no. 6 (March 2010): 3043–58. https://doi.org/10.1128/JVI.01655-09.
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    • Ettorre, Gabriella d’, Lorenzo Zaffiri, Giancarlo Ceccarelli, Claudio M. Mastroianni, and Vincenzo Vullo. “The role of HIV-DNA testing in clinical practice.” New Microbiol 33, no. 1 (January 2010): 1–11.
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    • Ettorre, G. d’, G. Ceccarelli, L. Zaffiri, M. Falcone, C. M. Mastroianni, M. Venditti, and V. Vullo. “Infectious aortitis and spondylodiscitis in patients with endovascular stents.” Minerva Med 100, no. 2 (April 2009): 167–70.
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    • Scagnolari, Carolina, Carla Selvaggi, Luisa Chiavuzzo, Teresa Carbone, Lorenzo Zaffiri, Gabriella d’Ettorre, Enrico Girardi, Ombretta Turriziani, Vincenzo Vullo, and Guido Antonelli. “Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy.” Intervirology 52, no. 2 (2009): 107–14. https://doi.org/10.1159/000218082.
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    • Cecchinato, V., C. J. Trindade, A. Laurence, J. M. Heraud, J. M. Brenchley, M. G. Ferrari, L. Zaffiri, et al. “Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques.” Mucosal Immunol 1, no. 4 (July 2008): 279–88. https://doi.org/10.1038/mi.2008.14.
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    • Zaffiri, L., G. d’Ettorre, A. P. Massetti, M. T. Mascellino, C. M. Mastroianni, and V. Vullo. “Atypical localization of Leishmaniasis in an intestinal polyp.” Infection 36, no. 2 (March 2008): 187–88. https://doi.org/10.1007/s15010-007-7038-3.
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    • D’Ettorre, G., L. Zaffiri, G. Ceccarelli, A. P. Massetti, C. M. Mastroianni, and V. Vullo. “Urolithiasis under atazanavir boosted and tenofovir therapy: a case report.” J Chemother 20, no. 1 (February 2008): 143–44. https://doi.org/10.1179/joc.2008.20.1.143.
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    • Ettorre, Gabriella d’, Lorenzo Zaffiri, Giancarlo Ceccarelli, Mauro Andreotti, Anna Paola Massetti, Stefano Vella, Claudio M. Mastroianni, and Vincenzo Vullo. “Simplified maintenance therapy with abacavir/lamivudine/zidovudine plus tenofovir after sustained HIV load suppression: four years of follow-up.” Hiv Clin Trials 8, no. 3 (2007): 182–88. https://doi.org/10.1310/hct0803-182.
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    • Ettorre, Gabriella d’, Giancarlo Ceccarelli, Martina Carnevalini, Gabriele Forcina, Lorenzo Zaffiri, Anna P. Massetti, Claudio M. Mastroianni, and Vincenzo Vullo. “Central role of interleukin-15 in human immunodeficiency virus (HIV)-infected patients with visceral leishmaniasis.” Acta Trop 99, no. 1 (August 2006): 83–87. https://doi.org/10.1016/j.actatropica.2006.08.002.
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    • Ettorre, Gabriella d’, Mauro Andreotti, Martina Carnevalini, Carolina Andreoni, Lorenzo Zaffiri, Vincenzo Vullo, Stefano Vella, and Claudio M. Mastroianni. “Interleukin-15 enhances the secretion of IFN-gamma and CC chemokines by natural killer cells from HIV viremic and aviremic patients.” Immunol Lett 103, no. 2 (March 15, 2006): 192–95. https://doi.org/10.1016/j.imlet.2005.10.001.
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  • Conference Papers

    • Salfity, H. V., B. Bottiger, M. Cooter, J. Poisson, L. Zaffiri, M. G. Hartwig, J. Haney, I. Welsby, and J. A. Klapper. “Transfusion Requirements during Lung Transplantation: Elective VA ECMO vs. Off-Pump.” In Journal of Heart and Lung Transplantation, 40:S331–S331, 2021.
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    • Zaffiri, L. “Challenges in Lung Re-Transplantation Following Antibody-Mediated Rejection.” In Journal of Heart and Lung Transplantation, 40:S509–S509, 2021.
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    • Zaffiri, Lorenzo, Alex Long, Megan L. Neely, Wida S. Cherikh, Daniel C. Chambers, and Laurie D. Snyder. “Incidence and outcome of post-transplant lymphoproliferative disorders in lung transplant patients: Analysis of ISHLT Registry.” In J Heart Lung Transplant, 39:1089–99, 2020. https://doi.org/10.1016/j.healun.2020.06.010.
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    • Najmeh, S., J. Klapper, J. Poisson, M. Fuller, L. Zaffiri, J. Haney, M. Hartwig, et al. “Perioperative Characteristics Associated with Transfusion-Free Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S317, 2020. https://doi.org/10.1016/j.healun.2020.01.715.
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    • Pollak, A. L., J. Poisson, M. Cooter, Y. D. Barac, B. Bryner, J. Haney, M. G. Hartwig, et al. “Effects of a Goal Directed Transfusion Protocol on Severe Primary Graft Dysfunction after Lung Transplantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S330, 2020. https://doi.org/10.1016/j.healun.2020.01.349.
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    • Astor, T. L., H. J. Goldberg, L. Snyder, A. Courtwright, R. Hachem, T. Pena, L. Zaffiri, et al. “Impact of Pre-Transplant Anti-Fibrotic Therapy for IPF Upon Lung Transplant Outcomes.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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    • Saullo, J. L., A. Ferrari, E. M. Eichenberger, J. M. Steinbrink, A. W. Baker, M. Bacchus, E. K. Maziarz, et al. “Use of Letermovir for Cytomegalovirus Management in Thoracic Organ Transplantation.” In American Journal of Transplantation, 20:379–80, 2020.
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    • Zaffiri, L., J. E. Messinger, J. Yi, K. J. Weinhold, G. Ferrari, M. Luftig, and S. M. Palmer. “Evaluation of Host Immune Responses to Epstein-Barr Virus in Lung Transplant Recipients.” In American Journal of Transplantation, 20:396–396, 2020.
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    • Barac, Y. D., J. Klapper, J. Poisson, L. Zaffiri, A. Pollack, T. Seay, O. Jawitz, et al. “Anticoagulation Strategies in the Perioperative Period for Lung Transplant: 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal.” In The Journal of Heart and Lung Transplantation, 38:S419–S419. Elsevier BV, 2019. https://doi.org/10.1016/j.healun.2019.01.1069.
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    • Ridder, Gustaaf de, Brandi Bottiger, Lorenzo Zaffiri, and Jessica Poisson. “Successful Lung Transplantation into Recipients with Anti-A1 Antibodies.” In Transfusion, 58:175A-175A. WILEY, 2018.
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    • Thaniyavarn, T., A. Strand, S. C. Hume, E. K. Maziarz, L. Zaffiri, and C. R. Wolfe. “Early Rhinovirus Infection After Lung Transplantation - Simply the Innocent Bystander?” In The Journal of Heart and Lung Transplantation, 37:S358–S358. Elsevier BV, 2018. https://doi.org/10.1016/j.healun.2018.01.919.
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    • Whitson, J. W., L. D. Snyder, and L. Zaffiri. “Post-Transplant Lymphoproliferative Disorder: A Retrospective 17-Year Analysis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Zaffiri, L., C. Frankel, E. N. Pavlisko, S. M. Palmer, and L. D. Snyder. “Post-Transplant Lymphoproliferative Disorder After Lung Transplantation: 10-Year Experience at Duke University.” In Journal of Heart and Lung Transplantation, 36:S95–S95. ELSEVIER SCIENCE INC, 2017.
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    • Gutteridge, D., L. Zaffiri, M. Duncan, D. Roe, and C. Hage. “Donor-Derived Disseminated Toxoplasmosis In Lung Transplant Recipient.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • Zaffiri, L., K. Rothhaar, A. J. Fisher, E. A. Mickler, M. Yoshimoto, and D. S. Wilkes. “Innate-Like B1 B Cells Recognize Type V Collagen As A Danger Signal And Initiate Humoral Immune Response.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • Zaffiri, L., N. L. Sigua, and G. Bosslet. “Changing Patters Of Pneumocystis Jiroveci Pneumonia In Immunocompromised Patients.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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    • Zaffiri, L., M. Scott, Y. Yuan, and C. R. Sears. “Rare Case Of Cyanosis: Severe Acute Lidocaine-Induced Methemoglobinemia Due To Local Anesthetic.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.
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    • Zaffiri, Lorenzo, Gabriella D’Ettorre, Mauro Andreotti, Cecilia Rizza, Sonia Marcellini, Giancarlo Ceccarelli, Claudio M. Mastroianni, and Vincenzo Vullo. “PS3-47 IL15 triggers the in vitro production of IL17 from CD4+ T cells of HIV-1 infected patients.” In Cytokine, 52:91–91. Elsevier BV, 2010. https://doi.org/10.1016/j.cyto.2010.07.386.
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    • Gordon, S., A. Weissman, V. Cecchinato, L. Zaffiri, V. Andresen, K. Jones, M. G. Ferrari, H. K. Chung, F. Ruscetti, and G. Franchini. “HTLV-II Establishes a Persistent Infection in Rhesus Macaques and Does Not Exacerbate SIV Infection.” In Aids Research and Human Retroviruses, 25:1212–1212. MARY ANN LIEBERT INC, 2009.
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