Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • General Surgery Resident, Surgery, Brigham and Women's Hospital 1999 - 2001
  • Clinical Fellow in Surgery, Surgery, Harvard Medical School 1994 - 2001
  • Surgical Oncology Research Fellow, Surgery, University of California, Los Angeles, David Geffen School of Medicine 1997 - 1999
  • General Surgery Resident, Surgery, Brigham and Women's Hospital 1995 - 1997
  • General Surgery Intern, Surgery, Brigham and Women's Hospital 1994 - 1995
  • M.D., Duke University School of Medicine 1994
  • B.S., Yale University 1989
• 

  Medical Licensure

  • 2021-02610. North Carolina. 2021
  • A62419. California. 2001
• 

  Leadership & Clinical Positions at Duke

  • Medical Director of Breast Cancer Services for Wake County 
• 

  Academic Positions Outside Duke

  • Professor of Surgery, University of California, Los Angeles (UCLA). 2020 - 2021
  • Chief of Breast Surgery, University of California, Los Angeles (UCLA). 2017 - 2021
  • Director, Breast Health, University of California, Los Angeles (UCLA). 2017 - 2021
  • Associate Professor of Surgery, University of California, Los Angeles (UCLA). 2016 - 2020
  • Assistant Professor of Surgery, John Wayne Cancer Institute. 2014 - 2016
  • Chief of General Surgery, Saint John's Health Center. 2009 - 2016
• Expertise
• 

  Subject Headings

  • Breast--Cancer--Patients--Care
  • Breast--Cancer--Surgery
  • Breast--Cancer--Treatment
  • Epigenetics
• Research
• 

  Fellowships, Supported Research, & Other Grants

  • Developing a PCR-based epigenetic assay predicting lymph node disease in patients with invasive breast cancer awarded by John Wayne Cancer Foundation 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ye, Linda, Dennis Rünger, Stephanie A. Angarita, Joseph Hadaya, Jennifer L. Baker, Minna K. Lee, Carlie K. Thompson, Deanna J. Attai, and Maggie L. DiNome. “Higher risk tumor features are not associated with higher nodal stage in patients with estrogen receptor-positive, node-positive breast cancer.” Breast Cancer Res Treat 193, no. 2 (June 2022): 429–36. https://doi.org/10.1007/s10549-022-06581-9.
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    • Ensenyat-Mendez, Miquel, Dennis Rünger, Javier I. J. Orozco, Julie Le, Jennifer L. Baker, Joanne Weidhaas, Diego M. Marzese, and Maggie L. DiNome. “ASO Visual Abstract: Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen-Receptor-Positive, Clinically Node-Positive Disease.” Ann Surg Oncol, April 16, 2022. https://doi.org/10.1245/s10434-022-11744-5.
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    • DiNome, Maggie L., and Diego M. Marzese. “ASO Author Reflections: Entering the Era of Biomarker-Driven Management of the Axilla.” Ann Surg Oncol, April 12, 2022. https://doi.org/10.1245/s10434-022-11767-y.
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    • Ensenyat-Mendez, Miquel, Dennis Rünger, Javier I. J. Orozco, Julie Le, Jennifer L. Baker, Joanne Weidhaas, Diego M. Marzese, and Maggie L. DiNome. “Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease.” Ann Surg Oncol, April 9, 2022. https://doi.org/10.1245/s10434-022-11684-0.
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    • Haji, Farnaz, Jennifer L. Baker, and Maggie L. DiNome. “Updates on treating ductal carcinoma in situ: what's to know in 2021.” Curr Opin Obstet Gynecol 34, no. 1 (February 1, 2022): 46–51. https://doi.org/10.1097/GCO.0000000000000753.
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    • Baker, Jennifer L., Farnaz Haji, Amy M. Kusske, Cheryce P. Fischer, Anne C. Hoyt, Carlie K. Thompson, Minna K. Lee, Deanna Attai, and Maggie L. DiNome. “SAVI SCOUT® localization of metastatic axillary lymph node prior to neoadjuvant chemotherapy for targeted axillary dissection: a pilot study.” Breast Cancer Res Treat 191, no. 1 (January 2022): 107–14. https://doi.org/10.1007/s10549-021-06416-z.
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    • COVIDSurg Collaborative, GlobalSurg, and GlobalSurg GlobalSurg Collaborative. “SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.” Anaesthesia 77, no. 1 (January 2022): 28–39. https://doi.org/10.1111/anae.15563.
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    • COVIDSurg Collaborative, GlobalSurg, and GlobalSurg GlobalSurg Collaborative. “Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study.” Anaesthesia 76, no. 11 (November 2021): 1454–64. https://doi.org/10.1111/anae.15560.
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    • Expert Panel on Breast Imaging, Linda, Ann Brown, Ana P. Lourenco, Bethany L. Niell, Beth Cronin, Elizabeth H. Dibble, Maggie L. DiNome, et al. “ACR Appropriateness Criteria® Transgender Breast Cancer Screening.” J Am Coll Radiol 18, no. 11S (November 2021): S502–15. https://doi.org/10.1016/j.jacr.2021.09.005.
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    • Mandelbaum, Ava, Morcos Nakhla, Young Ji Seo, Vishal Dobaria, Deanna J. Attai, Jennifer L. Baker, Carlie K. Thompson, Maggie L. DiNome, Peyman Benharash, and Minna K. Lee. “National trends and predictors of mastectomy with immediate breast reconstruction.” Am J Surg 222, no. 4 (October 2021): 773–79. https://doi.org/10.1016/j.amjsurg.2021.02.014.
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    • COVIDSurg Collaborative, GlobalSurg Collaborative, Mercedes. “SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.” Br J Surg 108, no. 9 (September 27, 2021): 1056–63. https://doi.org/10.1093/bjs/znab101.
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    • Llinàs-Arias, Pere, Sandra Íñiguez-Muñoz, Kelly McCann, Leonie Voorwerk, Javier I. J. Orozco, Miquel Ensenyat-Mendez, Borja Sesé, Maggie L. DiNome, and Diego M. Marzese. “Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer.” Cancers (Basel) 13, no. 16 (August 17, 2021). https://doi.org/10.3390/cancers13164139.
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    • COVIDSurg Collaborative, Deanna J., and Deanna J. GlobalSurg Collaborative. “Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.” Anaesthesia 76, no. 6 (June 2021): 748–58. https://doi.org/10.1111/anae.15458.
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    • Angarita, Stephanie, Linda Ye, Dennis Rünger, Joseph Hadaya, Jennifer L. Baker, Nicole Dawson, Carlie K. Thompson, Minna K. Lee, Deanna J. Attai, and Maggie L. DiNome. “Assessing the Burden of Nodal Disease for Breast Cancer Patients with Clinically Positive Nodes: Hope for More Limited Axillary Surgery.” Ann Surg Oncol 28, no. 5 (May 2021): 2609–18. https://doi.org/10.1245/s10434-020-09228-5.
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    • Angarita, Stephanie, and Maggie DiNome. “ASO Author Reflections: Moving the Ball Forward Toward De-Escalation of Axillary Surgery for Patients with Clinically Node-Positive Disease.” Ann Surg Oncol 28, no. 5 (May 2021): 2619–20. https://doi.org/10.1245/s10434-020-09253-4.
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    • Baker, Jennifer L., Don S. Dizon, Cachet M. Wenziger, Elani Streja, Carlie K. Thompson, Minna K. Lee, Maggie L. DiNome, and Deanna J. Attai. “"Going Flat" After Mastectomy: Patient-Reported Outcomes by Online Survey.” Ann Surg Oncol 28, no. 5 (May 2021): 2493–2505. https://doi.org/10.1245/s10434-020-09448-9.
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    • Berkowitz, Maurice J., Carlie K. Thompson, Laura T. Zibecchi, Minna K. Lee, Elani Streja, Jacob S. Berkowitz, Cachet M. Wenziger, Jennifer L. Baker, Maggie L. DiNome, and Deanna J. Attai. “How patients experience endocrine therapy for breast cancer: an online survey of side effects, adherence, and medical team support.” J Cancer Surviv 15, no. 1 (February 2021): 29–39. https://doi.org/10.1007/s11764-020-00908-5.
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    • Ensenyat-Mendez, Miquel, Pere Llinàs-Arias, Javier I. J. Orozco, Sandra Íñiguez-Muñoz, Matthew P. Salomon, Borja Sesé, Maggie L. DiNome, and Diego M. Marzese. “Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer.” Front Oncol 11 (2021): 681476. https://doi.org/10.3389/fonc.2021.681476.
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    • Baker, J. L., J. Hegde, C. K. Thompson, M. K. Lee, and M. L. DiNome. “Locoregional Management of Inflammatory Breast Cancer.” Current Breast Cancer Reports 12, no. 4 (December 1, 2020): 326–35. https://doi.org/10.1007/s12609-020-00389-6.
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    • DiNome, Maggie Lee. “Repurposing the Mammographic Breast Density Category for Predicting Lymphedema Risk in Patients With Breast Cancer.” Jama Netw Open 3, no. 11 (November 2, 2020): e2024923. https://doi.org/10.1001/jamanetworkopen.2020.24923.
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    • Mandelbaum, Ava D., Carlie K. Thompson, Deanna J. Attai, Jennifer L. Baker, Ginger Slack, Maggie L. DiNome, Peyman Benharash, and Minna K. Lee. “National Trends in Immediate Breast Reconstruction: An Analysis of Implant-Based Versus Autologous Reconstruction After Mastectomy.” Ann Surg Oncol 27, no. 12 (November 2020): 4777–85. https://doi.org/10.1245/s10434-020-08903-x.
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    • Krishna, Vikram, Corbin Muetterties, Maggie L. DiNome, and Charles Y. Tseng. “Anaphylactic Reaction to Lymphazurin 1% during Breast Reconstruction Surgery: An Uncommon but Serious Complication.” Plast Reconstr Surg Glob Open 8, no. 9 (September 2020): e3075. https://doi.org/10.1097/GOX.0000000000003075.
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    • Bandera, Bradley C., Amy Voci, Daniel W. Nelson, Stacey Stern, Dany Barrak, Trevan D. Fischer, Maggie L. DiNome, and Melanie Goldfarb. “Disparities in Risk Reduction Therapy Recommendations for Young Women With Lobular Carcinoma In-Situ.” Clin Breast Cancer 20, no. 4 (August 2020): e397–402. https://doi.org/10.1016/j.clbc.2020.01.006.
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    • Thompson, Carlie K., Minna K. Lee, Jennifer L. Baker, Deanna J. Attai, and Maggie L. DiNome. “Taking a Second Look at Neoadjuvant Endocrine Therapy for the Treatment of Early Stage Estrogen Receptor Positive Breast Cancer During the COVID-19 Outbreak.” Ann Surg 272, no. 2 (August 2020): e96–97. https://doi.org/10.1097/SLA.0000000000004027.
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    • Graham, Danielle, Maggie L. DiNome, and Patricia A. Ganz. “Breast Cancer Risk-Reducing Medications.” Jama 324, no. 3 (July 21, 2020): 310. https://doi.org/10.1001/jama.2020.11784.
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    • Lee, Minna K., Yas Sanaiha, Amy M. Kusske, Carlie K. Thompson, Deanna J. Attai, Jennifer L. Baker, Cheryce P. Fischer, and Maggie L. DiNome. “A comparison of two non-radioactive alternatives to wire for the localization of non-palpable breast cancers.” Breast Cancer Res Treat 182, no. 2 (July 2020): 299–303. https://doi.org/10.1007/s10549-020-05707-1.
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    • Tuite, Catherine M., Maggie L. DiNome, and Lori J. Goldstein. “Benefits of Digital Breast Tomosynthesis Beyond Baseline Screening.” Jama Netw Open 3, no. 7 (July 1, 2020): e2012361. https://doi.org/10.1001/jamanetworkopen.2020.12361.
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    • Cook, Kiri, and Maggie DiNome. “Additional Lumpectomy and Irradiation for In-Breast Recurrence of Cancer-When Less Is More.” Jama Oncol 6, no. 1 (January 1, 2020): 82–83. https://doi.org/10.1001/jamaoncol.2019.4319.
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    • DiNome, Maggie L., Javier I. J. Orozco, Chikako Matsuba, Ayla O. Manughian-Peter, Miquel Ensenyat-Mendez, Shu-Ching Chang, John R. Jalas, Matthew P. Salomon, and Diego M. Marzese. “Clinicopathological Features of Triple-Negative Breast Cancer Epigenetic Subtypes.” Ann Surg Oncol 26, no. 10 (October 2019): 3344–53. https://doi.org/10.1245/s10434-019-07565-8.
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    • DiNome, Maggie L., Amy M. Kusske, Deanna J. Attai, Cheryce P. Fischer, and Anne C. Hoyt. “Microchipping the breast: an effective new technology for localizing non-palpable breast lesions for surgery.” Breast Cancer Res Treat 175, no. 1 (May 2019): 165–70. https://doi.org/10.1007/s10549-019-05143-w.
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    • Voci, Amy, David Lee, Emily Ho, Rebecca Crane-Okada, and Maggie DiNome. “Impact of port site scar on perception of patients with breast cancer: patient-reported outcomes.” Breast Cancer Res Treat 170, no. 3 (August 2018): 569–72. https://doi.org/10.1007/s10549-018-4790-2.
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    • Voci, Amy, Bradley Bandera, Emily Ho, Jihey Lee, Melanie Goldfarb, and Maggie DiNome. “Variations in cancer care for adolescents and young adults (AYAs) with ductal carcinoma in situ.” Breast J 24, no. 4 (July 2018): 555–60. https://doi.org/10.1111/tbj.12999.
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    • Hegde, John V., Xiaoyan Wang, Deanna J. Attai, Maggie L. DiNome, Amy Kusske, Anne C. Hoyt, Sara A. Hurvitz, Joanne B. Weidhaas, Michael L. Steinberg, and Susan A. McCloskey. “Assessing the Effect of Lifetime Contralateral Breast Cancer Risk on the Selection of Contralateral Prophylactic Mastectomy for Unilateral Breast Cancer.” Clin Breast Cancer 18, no. 2 (April 2018): e205–18. https://doi.org/10.1016/j.clbc.2017.09.010.
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    • Hegde, John V., Xiaoyan Wang, Deanna J. Attai, Maggie L. DiNome, Amy Kusske, Anne C. Hoyt, Sara A. Hurvitz, Joanne B. Weidhaas, Michael L. Steinberg, and Susan A. McCloskey. “Predictors associated with MRI surveillance screening in women with a personal history of unilateral breast cancer but without a genetic predisposition for future contralateral breast cancer.” Breast Cancer Res Treat 166, no. 1 (November 2017): 145–56. https://doi.org/10.1007/s10549-017-4392-4.
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    • Bustos, Matias A., Matthew P. Salomon, Nellie Nelson, Sandy C. Hsu, Maggie L. DiNome, Dave S. B. Hoon, and Diego M. Marzese. “Genome-wide chromatin accessibility, DNA methylation and gene expression analysis of histone deacetylase inhibition in triple-negative breast cancer.” Genom Data 12 (June 2017): 14–16. https://doi.org/10.1016/j.gdata.2017.01.002.
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    • O’Connor, Victoria, Elizabeth Arena, Joslyn Albright, Nefertiti Brown, Ryan O’Connor, Maureen Chung, Maggie DiNome, and Jaime Shamonki. “Histological assessment of breast lesions identified exclusively by magnetic resonance.” Am Surg 80, no. 10 (October 2014): 944–47.
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    • Xuan, Caiyun, Jaime M. Shamonki, Alice Chung, Maggie L. Dinome, Maureen Chung, Peter A. Sieling, and Delphine J. Lee. “Microbial dysbiosis is associated with human breast cancer.” Plos One 9, no. 1 (2014): e83744. https://doi.org/10.1371/journal.pone.0083744.
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    • Bilchik, Anton J., Dave S. B. Hoon, Sukamal Saha, Roderick R. Turner, David Wiese, Maggie DiNome, Kazuo Koyanagi, et al. “Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trial.” Ann Surg 246, no. 4 (October 2007): 568–75. https://doi.org/10.1097/SLA.0b013e318155a9c7.
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    • Bilchik, Anton J., Maggie DiNome, Sukamal Saha, Roderick R. Turner, David Wiese, Martin McCarter, Dave S. B. Hoon, and Donald L. Morton. “Prospective multicenter trial of staging adequacy in colon cancer: preliminary results.” Arch Surg 141, no. 6 (June 2006): 527–33. https://doi.org/10.1001/archsurg.141.6.527.
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    • Rogers, Selwyn O., Maggie C. Lee, and Stanley W. Ashley. “Giant colonic lipoma as lead point for intermittent colo-colonic intussusception.” Surgery 131, no. 6 (June 2002): 687–88. https://doi.org/10.1067/msy.2002.116409.
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    • Lee, M. C., M. L. Alpaugh, M. Nguyen, M. Deato, L. Dishakjian, and S. H. Barsky. “Myoepithelial-specific CD44 shedding is mediated by a putative chymotrypsin-like sheddase.” Biochem Biophys Res Commun 279, no. 1 (December 9, 2000): 116–23. https://doi.org/10.1006/bbrc.2000.3918.
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    • Alpaugh, M. L., M. C. Lee, M. Nguyen, M. Deato, L. Dishakjian, and S. H. Barsky. “Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells.” Exp Cell Res 261, no. 1 (November 25, 2000): 150–58. https://doi.org/10.1006/excr.2000.5056.
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    • Nguyen, M., M. C. Lee, J. L. Wang, J. S. Tomlinson, Z. M. Shao, M. L. Alpaugh, and S. H. Barsky. “The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype.” Oncogene 19, no. 31 (July 20, 2000): 3449–59. https://doi.org/10.1038/sj.onc.1203677.
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    • Wang, J. L., Y. H. Liu, M. C. Lee, T. M. Nguyen, C. Lee, A. Kim, and M. Nguyen. “Identification of tumor angiogenesis-related genes by subtractive hybridization.” Microvasc Res 59, no. 3 (May 2000): 394–97. https://doi.org/10.1006/mvre.2000.2242.
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    • Ribas, A., L. H. Butterfield, B. Hu, V. B. Dissette, W. S. Meng, A. Koh, K. J. Andrews, et al. “Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice.” Cancer Res 60, no. 8 (April 15, 2000): 2218–24.
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    • Tomlinson, J., J. L. Wang, S. H. Barsky, M. C. Lee, J. Bischoff, and M. Nguyen. “Human colon cancer cells express multiple glycoprotein ligands for E-selectin.” Int J Oncol 16, no. 2 (February 2000): 347–53. https://doi.org/10.3892/ijo.16.2.347.
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    • Tomlinson, J., S. H. Barsky, S. Nelson, S. Singer, B. Pezeshki, M. C. Lee, F. Eilber, and M. Nguyen. “Different patterns of angiogenesis in sarcomas and carcinomas.” Clin Cancer Res 5, no. 11 (November 1999): 3516–22.
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    • Vollmer, C. M., F. C. Eilber, L. H. Butterfield, A. Ribas, V. B. Dissette, A. Koh, L. D. Montejo, et al. “Alpha-fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma.” Cancer Res 59, no. 13 (July 1, 1999): 3064–67.
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    • Offodile, R., T. Walton, M. Lee, A. Stiles, and M. Nguyen. “Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470.” Tumori 85, no. 1 (January 1999): 51–53.
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    • Lee, M. C., D. O. Jacobs, and G. M. Chertow. “Haemobilia mimicking acute cholecystitis following percutaneous renal biopsy.” Nephrol Dial Transplant 13, no. 8 (August 1998): 2118–20. https://doi.org/10.1093/ndt/13.8.2118.
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    • Lee, M. C., C. J. Grassi, M. Belkin, J. A. Mannick, A. D. Whittemore, and M. C. Donaldson. “Early operative intervention after thrombolytic therapy for primary subclavian vein thrombosis: an effective treatment approach.” J Vasc Surg 27, no. 6 (June 1998): 1101–7. https://doi.org/10.1016/s0741-5214(98)70012-6.
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    • Lee, M. C., P. J. Mannon, J. P. Grant, and T. N. Pappas. “Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain.” Physiol Behav 62, no. 6 (December 1997): 1219–23. https://doi.org/10.1016/s0031-9384(97)00203-5.
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    • Lee, M. C., D. C. Lawson, and T. N. Pappas. “Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.” Regul Pept 52, no. 3 (August 4, 1994): 227–34. https://doi.org/10.1016/0167-0115(94)90057-4.
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    • Lee, M. C., S. S. Schiffman, and T. N. Pappas. “Role of neuropeptides in the regulation of feeding behavior: a review of cholecystokinin, bombesin, neuropeptide Y, and galanin.” Neurosci Biobehav Rev 18, no. 3 (1994): 313–23. https://doi.org/10.1016/0149-7634(94)90045-0.
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    • Deutch, A. Y., M. C. Lee, and M. J. Iadarola. “Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action.” Mol Cell Neurosci 3, no. 4 (August 1992): 332–41. https://doi.org/10.1016/1044-7431(92)90030-6.
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    • Deutch, A. Y., M. C. Lee, M. H. Gillham, D. A. Cameron, M. Goldstein, and M. J. Iadarola. “Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex.” Cereb Cortex 1, no. 4 (July 1991): 273–92. https://doi.org/10.1093/cercor/1.4.273.
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