Maggie L DiNome

Preprint · November 5, 2025 Abstract Triple-negative breast cancer (TNBC) is a major cause of cancer mortality, with distant metastases presenting a significant clinical challenge. While epigenetic mechanisms like DNA methylation a ... Full text Cite

Epigenetic markers of tumor progression in estrogen receptor–positive breast cancer patients with high nodal involvement

Preprint · 2025 Abstract Background Management of axillary lymph node (LN) disease in breast cancer (BC) is evolving, with declining use of axillary lymph node dissection. Consequently, prognostic information from nodal assessment is becoming limited. ... Full text Cite

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

Preprint · 2023 Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome may contribute to matrix metalloprotease (MM ... Full text Cite

Tumor Size and Lobular Histology Predict for Higher Pathologic Nodal Stage Regardless of Clinical Presentation of Nodal Disease in Patients With Breast Cancer

Preprint · 2021 AbstractPurpose: Omission of axillary lymph node dissection (ALND) is considered for patients with sentinel lymph node-positive (SLN+) breast cancer, but ALND remains the standard of care for clinically node-positive (cN+) ... Full text Cite