Skip to main content

Matthew Vestal

Assistant Professor of Neurosurgery
Box 3272, Durham, NC 27710
Box 3272, Durham, NC 27710

Selected Publications

Flexible, high-resolution cortical arrays with large coverage capture microscale high-frequency oscillations in patients with epilepsy.

Journal Article Epilepsia · July 2023 OBJECTIVE: Effective surgical treatment of drug-resistant epilepsy depends on accurate localization of the epileptogenic zone (EZ). High-frequency oscillations (HFOs) are potential biomarkers of the EZ. Previous research has shown that HFOs often occur wit ... Full text Link to item Cite

Predictors of Blood Transfusion for Endoscopic Assisted Craniosynostosis Surgery.

Journal Article J Craniofac Surg · July 2022 Blood loss is a main cause of morbidity after craniofacial procedures. The purpose of this study is to identify the incidence and predictors for transfusion of blood products in the endoscopic assisted strip craniectomy population. Data was prospectively c ... Full text Link to item Cite

"Plugged In".

Journal Article Orbit · February 2020 Full text Link to item Cite

Antibacterial prophylaxis for gram-positive and gram-negative infections in cranial surgery: A meta-analysis.

Journal Article J Clin Neurosci · November 2017 BACKGROUND: Perioperative antibiotic prophylaxis against gram positive and gram negative infections is considered standard of care in the perioperative management of patients undergoing cranial surgery. The antibiotic regimen which best reduces the risk of ... Full text Link to item Cite

The Efficacy of Antibacterial Prophylaxis Against the Development of Meningitis After Craniotomy: A Meta-Analysis.

Journal Article World Neurosurg · June 2016 OBJECTIVE: Prophylactic antibiotics are widely used before craniotomy to prevent postoperative infections. A systematic review and meta-analysis was conducted to examine the effect of prophylactic antibiotics on meningitis after craniotomy. METHODS: PubMed ... Full text Link to item Cite

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation.

Journal Article Proc Natl Acad Sci U S A · August 11, 2015 We present a proof of concept study designed to support the clinical development of mass spectrometry imaging (MSI) for the detection of pituitary tumors during surgery. We analyzed by matrix-assisted laser desorption/ionization (MALDI) MSI six nonpatholog ... Full text Link to item Cite

Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.

Journal Article Proc Natl Acad Sci U S A · July 29, 2014 For many intraoperative decisions surgeons depend on frozen section pathology, a technique developed over 150 y ago. Technical innovations that permit rapid molecular characterization of tissue samples at the time of surgery are needed. Here, using desorpt ... Full text Link to item Cite

Cerebral melioidosis for the first time in the western hemisphere: Case report

Journal Article Journal of Neurosurgery · December 1, 2013 This report is the first published case of cerebral melioidosis in the western hemisphere. In this paper the authors review the literature on neurological melioidosis and its presentation and treatment in endemic areas, describe the clinical course of this ... Full text Cite

Symptoms of anxiety and depression in childhood absence epilepsy.

Journal Article Epilepsia · August 2011 Childhood absence epilepsy (CAE) has been recently linked to a number of cognitive, behavioral, and emotional disorders. Identification of affective disorders (anxiety and depression) presents unique challenges in pediatric populations, and successful earl ... Full text Link to item Cite

Impaired attention and network connectivity in childhood absence epilepsy.

Journal Article Neuroimage · June 15, 2011 Patients with childhood absence epilepsy (CAE) often demonstrate impaired interictal attention, even with control of their seizures. No previous study has investigated the brain networks involved in this impairment. We used the continuous performance task ... Full text Link to item Cite

Resting functional connectivity between the hemispheres in childhood absence epilepsy.

Journal Article Neurology · June 7, 2011 OBJECTIVE: The fundamental mechanisms by which childhood absence epilepsy (CAE) changes neural networks even between seizures remain poorly understood. During seizures, cortical and subcortical networks exhibit bihemspheric synchronous activity based on pr ... Full text Link to item Cite

Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures.

Journal Article Epilepsia · October 2010 PURPOSE: Absence seizures cause transient impairment of consciousness. Typical absence seizures occur in children, and are accompanied by 3-4-Hz spike-wave discharges (SWDs) on electroencephalography (EEG). Prior EEG-functional magnetic resonance imaging ( ... Full text Link to item Cite

Differentiation of attention-related problems in childhood absence epilepsy.

Journal Article Epilepsy Behav · September 2010 The current study examined the specific types of attention-related problems children with childhood absence epilepsy (CAE) experience and the role of disease factors in the development of attention-related problems. Thirty-eight subjects with CAE and 46 he ... Full text Link to item Cite

Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging.

Journal Article J Neurosci · April 28, 2010 Absence seizures are 5-10 s episodes of impaired consciousness accompanied by 3-4 Hz generalized spike-and-wave discharge on electroencephalography (EEG). The time course of functional magnetic resonance imaging (fMRI) changes in absence seizures in relati ... Full text Link to item Cite

Early treatment suppresses the development of spike-wave epilepsy in a rat model.

Journal Article Epilepsia · March 2008 PURPOSE: Current treatments for epilepsy may control seizures, but have no known effects on the underlying disease. We sought to determine whether early treatment in a model of genetic epilepsy would reduce the severity of the epilepsy phenotype in adultho ... Full text Link to item Cite