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Matthias Arnold

Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt Street, North Pavilion, 7th Floor, Room # 7018, Durham, NC 27705

Current Appointments & Affiliations


Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences · 2022 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences

Recent Publications


A seven-year longitudinal study of the Alzheimer's disease blood metabolome.

Journal Article medRxiv · December 8, 2025 Metabolic dysregulation is a hallmark of Alzheimer's disease (AD), yet the temporal nature of metabolite-phenotype associations remains poorly understood. We systematically evaluated 506 serum metabolites across 4,063 longitudinal samples from 1,430 partic ... Full text Link to item Cite

Basic Science and Pathogenesis.

Journal Article Alzheimers Dement · December 2025 BACKGROUND: Development of effective drugs for Alzheimer's Disease (AD) is challenging, likely due in part to poor recapitulation of AD in animal models. We developed the genetically diverse AD-BXD mouse model, a panel of reproducible strains that exhibit ... Full text Link to item Cite

Basic Science and Pathogenesis.

Journal Article Alzheimers Dement · December 2025 BACKGROUND: Alzheimer's disease (AD) patients exhibit diverse cognitive impairments, brain atrophy patterns, and pathological hallmarks, suggesting the existence of distinct subtypes. Molecular profiling offers a powerful approach to uncovering this variab ... Full text Link to item Cite
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Recent Grants


The Role of Chemical Exposures in Alzheimer's Disease (AD) and its Trajectory

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029

Targeted Metabolomics for Oxylipins and Endocannabinoids to Inform About a Role for Inflammation in Alzheimer's Disease

ResearchInvestigator · Awarded by Foundation for the National Institutes of Health · 2025 - 2027

The UCSD Microbiome and Metagenomic Center

ResearchBiostatistician · Awarded by University of California - San Diego · 2022 - 2026

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Education, Training & Certifications


Technical University of Munich (Germany) · 2016 D.Sc.