Myles Selig Wolf | Scholars@Duke

Myles Selig Wolf
Charles Johnson, M.D. Professor of Medicine

The focus of my research is disordered mineral metabolism across the spectrum of chronic kidney disease, including dialysis, kidney transplantation and earlier stages.

My research has been published in leading general medicine and subspecialty journals, including the New England Journal of Medicine, JAMA, the Journal of Clinical Investigation, Circulation, Cell Metabolism, Journal of the American Society of Nephrology, and Kidney International, among others.

My primary contributions have been in the area of hormonal regulation of phosphate homeostasis. I have helped to characterize the physiological role of fibroblast growth factor 23 in health and in chronic kidney disease, and the impact of elevated fibroblast growth factor 23 levels on adverse clinical outcomes in patients with kidney disease.

Current Appointments & Affiliations

Charles Johnson, M.D. Professor of Medicine, Medicine, Nephrology, Medicine 2018
Professor of Medicine, Medicine, Nephrology, Medicine 2017
Chief of Nephrology, Medicine, Nephrology, Medicine 2016
Member of the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 2017

Contact Information

myles.wolf@duke.edu

Background
Education, Training, & Certifications
- M.Med.Sc., Harvard Medical School 2002
- Research Fellowship in Nephrology, Massachusetts General Hospital 2000 - 2001
- Clinical Fellowship in Nephrology, Brigham and Women's Hospital 1999 - 2000
- Internal Medicine Residency, Massachusetts General Hospital 1996 - 1999
- M.D., State University of New York at Brooklyn 1996
Duke Appointment History
- Instructor, Temporary in the Department of Medicine, Medicine, Nephrology, Medicine 2016 - 2017
Research
Selected Grants
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- HiLo awarded by National Institutes of Health 2018 - 2019
- FGF23 and Cardiovascular Disease in CKD (CRIC) awarded by National Institutes of Health 2013 - 2019
- Role of FGF23 in Mineral Metabolism Across the Spectrum of Chronic Kidney Disease awarded by National Institutes of Health 2013 - 2019
- Pencast Videos to Boost Learning and Interest in Nephrology Among Internal Medicine Residents awarded by American Society of Nephrology 2017 - 2019
- Endocrinology and Metabolism Training Program awarded by National Institutes of Health 2014 - 2019
- Impact of phosphate and FGF23 reduction on intermediate end points in CKD awarded by Northwestern University 2017 - 2019
- Vitamin D Catabolism in Chronic Kidney Disease awarded by University of Washington 2016 - 2019
- FGF-23 and Clinical outcomes in ADPKD awarded by University of Colorado - Denver 2016 - 2018
- Pilot Studies Targeting Mineral Metabolism in CKD awarded by Northwestern University 2013 - 2018
- Mentored Patient-Oriented Research in Mineral Metabolism awarded by National Institutes of Health 2012 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Schrauben, SJ, Hsu, JY, Wright Nunes, J, Fischer, MJ, Srivastava, A, Chen, J, Charleston, J, Steigerwalt, S, Tan, TC, Fink, JC, Ricardo, AC, Lash, JP, Wolf, M, Feldman, HI, Anderson, AH, and CRIC Study Investigators, . "Health Behaviors in Younger and Older Adults With CKD: Results From the CRIC Study." Kidney International Reports 4, no. 1 (January 2019): 80-93. Full Text
  - Amdur, RL, Feldman, HI, Dominic, EA, Anderson, AH, Beddhu, S, Rahman, M, Wolf, M, Reilly, M, Ojo, A, Townsend, RR, Go, AS, He, J, Xie, D, Thompson, S, Budoff, M, Kasner, S, Kimmel, PL, Kusek, JW, Raj, DS, and CRIC Study Investigators, . "Use of Measures of Inflammation and Kidney Function for Prediction of Atherosclerotic Vascular Disease Events and Death in Patients With CKD: Findings From the CRIC Study." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation (December 10, 2018). Full Text
  - Prasad, PV, Li, W, Raj, DS, Carr, J, Carr, M, Thacker, J, Li, L-P, Wang, C, Sprague, SM, Ix, JH, Chonchol, M, Block, G, Cheung, AK, Raphael, K, Gassman, J, Wolf, M, Fried, LF, Isakova, T, and CKD Optimal Management with BInders and NicotinamidE (COMBINE) study group, . "Multicenter Study Evaluating Intrarenal Oxygenation and Fibrosis Using Magnetic Resonance Imaging in Individuals With Advanced CKD." Kidney International Reports 3, no. 6 (November 2018): 1467-1472. (Letter) Full Text
  - Robinson-Cohen, C, Bartz, TM, Lai, D, Ikizler, TA, Peacock, M, Imel, EA, Michos, ED, Foroud, TM, Akesson, K, Taylor, KD, Malmgren, L, Matsushita, K, Nethander, M, Eriksson, J, Ohlsson, C, Mellström, D, Wolf, M, Ljunggren, O, McGuigan, F, Rotter, JI, Karlsson, M, Econs, MJ, Ix, JH, Lutsey, PL, Psaty, BM, de Boer, IH, and Kestenbaum, BR. "Genetic Variants Associated with Circulating Fibroblast Growth Factor 23." Journal of the American Society of Nephrology : Jasn 29, no. 10 (October 2018): 2583-2592. Full Text
  - Scialla, JJ, Brown, L, Gurley, S, Corcoran, DL, Bain, JR, Muehlbauer, MJ, O'Neal, SK, M O'Connell, T, Wolf, M, Melamed, ML, Hostetter, TH, and Abramowitz, MK. "Metabolic Changes with Base-Loading in CKD." Clinical Journal of the American Society of Nephrology : Cjasn 13, no. 8 (August 2018): 1244-1246. Full Text Open Access Copy
  - Kolak, M, Bradley, M, Block, DR, Pool, L, Garg, G, Toman, CK, Boatright, K, Lipiszko, D, Koschinsky, J, Kershaw, K, Carnethon, M, Isakova, T, and Wolf, M. "Urban foodscape trends: Disparities in healthy food access in Chicago, 2007-2014." Health & Place 52 (July 9, 2018): 231-239. Full Text
  - Gerber, C, Cai, X, Lee, J, Craven, T, Scialla, J, Souma, N, Srivastava, A, Mehta, R, Paluch, A, Hodakowski, A, Frazier, R, Carnethon, MR, Wolf, MS, and Isakova, T. "Incidence and Progression of Chronic Kidney Disease in Black and White Individuals with Type 2 Diabetes." Clinical Journal of the American Society of Nephrology : Cjasn 13, no. 6 (June 2018): 884-892. Full Text
  - Nakayama, M, Tani, Y, Zhu, W-J, Watanabe, K, Yokoyama, K, Fukagawa, M, Akiba, T, Wolf, M, and Hirakata, H. "Oral Ferric Citrate Hydrate Associated With Less Oxidative Stress Than Intravenous Saccharated Ferric Oxide." Kidney International Reports 3, no. 2 (March 2018): 364-373. Full Text
  - Isakova, T, Cai, X, Lee, J, Xie, D, Wang, X, Mehta, R, Allen, NB, Scialla, JJ, Pencina, MJ, Anderson, AH, Talierco, J, Chen, J, Fischer, MJ, Steigerwalt, SP, Leonard, MB, Hsu, C-Y, de Boer, IH, Kusek, JW, Feldman, HI, Wolf, M, and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, . "Longitudinal FGF23 Trajectories and Mortality in Patients with CKD." Journal of the American Society of Nephrology : Jasn 29, no. 2 (February 2018): 579-590. Full Text
  - Husain, SA, Willey, JZ, Park Moon, Y, Elkind, MSV, Sacco, RL, Wolf, M, Cheung, K, Wright, CB, and Mohan, S. "Creatinine- versus cystatin C-based renal function assessment in the Northern Manhattan Study." Plos One 13, no. 11 (January 2018): e0206839-null. Full Text
  - Mitsnefes, MM, Betoko, A, Schneider, MF, Salusky, IB, Wolf, MS, Jüppner, H, Warady, BA, Furth, SL, and Portale, AA. "FGF23 and Left Ventricular Hypertrophy in Children with CKD." Clinical Journal of the American Society of Nephrology : Cjasn 13, no. 1 (January 2018): 45-52. Full Text
  - Mehta, R, Cai, X, Hodakowski, A, Lee, J, Leonard, M, Ricardo, A, Chen, J, Hamm, L, Sondheimer, J, Dobre, M, David, V, Yang, W, Go, A, Kusek, JW, Feldman, H, Wolf, M, Isakova, T, and CRIC Study Investigators, . "Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study." Clinical Journal of the American Society of Nephrology : Cjasn 12, no. 11 (November 2017): 1795-1803. Full Text
  - Khairallah, P, Isakova, T, Asplin, J, Hamm, L, Dobre, M, Rahman, M, Sharma, K, Leonard, M, Miller, E, Jaar, B, Brecklin, C, Yang, W, Wang, X, Feldman, H, Wolf, M, Scialla, JJ, and Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, . "Acid Load and Phosphorus Homeostasis in CKD." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation 70, no. 4 (October 2017): 541-550. Full Text
  - Batacchi, Z, Robinson-Cohen, C, Hoofnagle, AN, Isakova, T, Kestenbaum, B, Martin, KJ, Wolf, MS, and de Boer, IH. "Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD." Clinical Journal of the American Society of Nephrology : Cjasn 12, no. 9 (September 2017): 1498-1506. Full Text
  - Kim, S-J, Cheresh, P, Eren, M, Jablonski, RP, Yeldandi, A, Ridge, KM, Budinger, GRS, Kim, D-H, Wolf, M, Vaughan, DE, and Kamp, DW. "Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis." American journal of physiology. Lung cellular and molecular physiology 313, no. 1 (July 2017): L16-L26. Full Text
  - Munoz Mendoza, J, Isakova, T, Cai, X, Bayes, LY, Faul, C, Scialla, JJ, Lash, JP, Chen, J, He, J, Navaneethan, S, Negrea, L, Rosas, SE, Kretzler, M, Nessel, L, Xie, D, Anderson, AH, Raj, DS, Wolf, M, and CRIC Study Investigators, . "Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease." Kidney International 91, no. 3 (March 2017): 711-719. Full Text
  - Yuen, SN, Kramer, H, Luke, A, Bovet, P, Plange-Rhule, J, Forrester, T, Lambert, V, Wolf, M, Camacho, P, Harders, R, Dugas, L, Cooper, R, and Durazo-Arvizu, R. "Fibroblast Growth Factor-23 (FGF-23) Levels Differ Across Populations by Degree of Industrialization." The Journal of Clinical Endocrinology & Metabolism 101, no. 5 (May 2016): 2246-2253. Full Text
  - Ali, FN, Josefson, J, Mendez, AJ, Mestan, K, and Wolf, M. "Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates." The Journal of Clinical Endocrinology & Metabolism 101, no. 4 (April 2016): 1673-1679. Full Text
  - Leaf, DE, Christov, M, Jüppner, H, Siew, E, Ikizler, TA, Bian, A, Chen, G, Sabbisetti, VS, Bonventre, JV, Cai, X, Wolf, M, and Waikar, SS. "Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery." Kidney International 89, no. 4 (April 2016): 939-948. Full Text
  - Wright, CB, Shah, NH, Mendez, AJ, DeRosa, JT, Yoshita, M, Elkind, MSV, Sacco, RL, DeCarli, C, Rundek, T, Silverberg, S, Dong, C, and Wolf, M. "Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage." Stroke 47, no. 4 (April 2016): 923-928. Full Text
  - Scialla, JJ, and Wolf, M. "When there will never be a randomized controlled trial." Kidney International 88, no. 2 (August 2015): 220-222. Full Text
  - Wolf, M, and Bushinsky, DA. "Bones and stones, edition 2015." Current Opinion in Nephrology and Hypertension (June 2015): 1-1. Full Text
  - Wolf, M. "The Biomarker Niche for Fibroblast Growth Factor 23 Testing in CKD." Journal of the American Society of Nephrology 26, no. 1 (January 1, 2015): 7-9. Full Text
  - Wolf, M. "In Search of the Fountain of Youth." Journal of the American Society of Nephrology 25, no. 10 (October 1, 2014): 2143-2145. Full Text
  - Wolf, M, and Bushinsky, DA. "Innovations in bones and stones." Current Opinion in Nephrology and Hypertension 22, no. 4 (July 2013): 369-370. Full Text
- Conference Papers
  - Robinson-Cohen, C, Perwad, F, Wolf, MS, De Boer, IH, Kestenbaum, B, Lipworth, L, Hung, A, and Ikizler, TA. "Genetic Variants Associated with Circulating Parathyroid Hormone among Patients with Chronic Kidney Disease." Annual Meeting of the American-Society-for-Bone-and-Mineral-Research. Montreal, CANADA. September 28, 2018 - October 1, 2018.: WILEY, November 1, 2018. Link to Item
  - Neuburg, S, Dussold, C, Gerber, C, Wang, X, Francis, C, Qi, L, David, V, Wolf, M, and Martin, A. "Genetic background influences cardiac phenotype in murine chronic kidney disease." July 2018. Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers