Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Stanford University, School of Medicine 2000
  • Ph.D., Stanford University 1999
• 

  Previous Appointments & Affiliations

  • Associate Research Professor in the Institute for Genome Sciences & Policy, Institutes and Centers, School of Medicine 2009 - 2014
• Recognition
• 

  In the News

  • NOV 4, 2013

    Duke-NUS Scientists Advance Research on Bile Duct Cancers

  • AUG 27, 2013

    Three Subtypes of Gastric Cancer Suggest Different Treatment Approaches
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wu, Yonghui, Heike Grabsch, Tatiana Ivanova, Iain Beehuat Tan, Jacinta Murray, Chia Huey Ooi, Alexander Ian Wright, et al. “Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer.” Gut 62, no. 8 (August 2013): 1100–1111. https://doi.org/10.1136/gutjnl-2011-301373.
       Full Text  Link to Item
    • Koo, Si Lin, Jin Hang Wen, Axel Hillmer, Peh Yean Cheah, Patrick Tan, and Iain Beehuat Tan. “Current and emerging surveillance strategies to expand the window of opportunity for curative treatment after surgery in colorectal cancer.” Expert Rev Anticancer Ther 13, no. 4 (April 2013): 439–50. https://doi.org/10.1586/era.13.14.
       Full Text  Link to Item
    • Kreisberg, Jason F., Nicholas T. Ong, Aishwarya Krishna, Thomas L. Joseph, Jing Wang, Catherine Ong, Hui Ann Ooi, et al. “Growth inhibition of pathogenic bacteria by sulfonylurea herbicides.” Antimicrob Agents Chemother 57, no. 3 (March 2013): 1513–17. https://doi.org/10.1128/AAC.02327-12.
       Full Text  Link to Item
    • Thiem, Stefan, Thomas P. Pierce, Michelle Palmieri, Tracy L. Putoczki, Michael Buchert, Adele Preaudet, Ryan O. Farid, et al. “mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.” J Clin Invest 123, no. 2 (February 2013): 767–81. https://doi.org/10.1172/JCI65086.
       Full Text  Link to Item
    • Grabsch, H. I., and P. Tan. “Gastric cancer pathology and underlying molecular mechanisms.” Digestive Surgery 30, no. 2 (2013): 150–58. https://doi.org/10.1159/000350876.
       Full Text
    • Ivanova, Tatiana, Hermioni Zouridis, Yonghui Wu, Lai Ling Cheng, Iain Beehuat Tan, Veena Gopalakrishnan, Chia Huey Ooi, et al. “Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer.” Gut 62, no. 1 (January 2013): 22–33. https://doi.org/10.1136/gutjnl-2011-301113.
       Full Text  Link to Item
    • Scott, A. E., T. R. Laws, R. V. D’Elia, M. G. M. Stokes, T. Nandi, E. D. Williamson, P. Tan, J. L. Prior, and T. P. Atkins. “Protection against experimental melioidosis following immunization with live Burkholderia thailandensis expressing a manno-heptose capsule.” Clinical and Vaccine Immunology 20, no. 7 (2013): 1041–47. https://doi.org/10.1128/CVI.00113-13.
       Full Text
    • Sessions, October M., Ying Tan, Kenneth C. Goh, Yujing Liu, Patrick Tan, Steve Rozen, and Eng Eong Ooi. “Host cell transcriptome profile during wild-type and attenuated dengue virus infection.” Plos Negl Trop Dis 7, no. 3 (2013): e2107. https://doi.org/10.1371/journal.pntd.0002107.
       Full Text  Link to Item
    • Nagarajan, Niranjan, Denis Bertrand, Axel M. Hillmer, Zhi Jiang Zang, Fei Yao, Pierre-Étienne Jacques, Audrey S. M. Teo, et al. “Whole-genome reconstruction and mutational signatures in gastric cancer.” Genome Biol 13, no. 12 (December 13, 2012): R115. https://doi.org/10.1186/gb-2012-13-12-r115.
       Full Text  Link to Item
    • Lipsitz, Rebecca, Susan Garges, Rosemarie Aurigemma, Prasith Baccam, David D. Blaney, Allen C. Cheng, Bart J. Currie, et al. “Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010.” Emerg Infect Dis 18, no. 12 (December 2012): e2. https://doi.org/10.3201/eid1812.120638.
       Full Text  Link to Item
    • Ramachandran, Lalitha, Kanjoormana Aryan Manu, Muthu K. Shanmugam, Feng Li, Kodappully Sivaraman Siveen, Shireen Vali, Shweta Kapoor, et al. “Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.” J Biol Chem 287, no. 45 (November 2, 2012): 38028–40. https://doi.org/10.1074/jbc.M112.388702.
       Full Text  Link to Item
    • Zouridis, Hermioni, Niantao Deng, Tatiana Ivanova, Yansong Zhu, Bernice Wong, Dan Huang, Yong Hui Wu, et al. “Methylation subtypes and large-scale epigenetic alterations in gastric cancer.” Sci Transl Med 4, no. 156 (October 17, 2012): 156ra140. https://doi.org/10.1126/scitranslmed.3004504.
       Full Text  Link to Item
    • Tye, Hazel, Catherine L. Kennedy, Meri Najdovska, Louise McLeod, William McCormack, Norman Hughes, Anouk Dev, et al. “STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.” Cancer Cell 22, no. 4 (October 2012): 466–78. https://doi.org/10.1016/j.ccr.2012.08.010.
       Full Text
    • Zhou, Jin, Geng Bo Chen, Yew Chung Tang, Rohit Anthony Sinha, Yonghui Wu, Chui Sun Yap, Guihua Wang, et al. “Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library.” Bmc Med Genomics 5 (August 9, 2012): 34. https://doi.org/10.1186/1755-8794-5-34.
       Full Text  Link to Item
    • Cheng, Lai Ling, Yoko Itahana, Zheng Deng Lei, Na-Yu Chia, Yonghui Wu, Yingnan Yu, Shen Li Zhang, et al. “TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).” Clin Cancer Res 18, no. 15 (August 1, 2012): 4201–12. https://doi.org/10.1158/1078-0432.CCR-12-0036.
       Full Text  Link to Item
    • Koo, Ghee Chong, Soo Yong Tan, Tiffany Tang, Song Ling Poon, George E. Allen, Leonard Tan, Soo Ching Chong, et al. “Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.” Cancer Discov 2, no. 7 (July 2012): 591–97. https://doi.org/10.1158/2159-8290.CD-12-0028.
       Full Text  Link to Item
    • Ong, Choon Kiat, Chutima Subimerb, Chawalit Pairojkul, Sopit Wongkham, Ioana Cutcutache, Willie Yu, John R. McPherson, et al. “Exome sequencing of liver fluke-associated cholangiocarcinoma.” Nat Genet 44, no. 6 (May 6, 2012): 690–93. https://doi.org/10.1038/ng.2273.
       Full Text  Link to Item
    • Deng, Niantao, Liang Kee Goh, Hannah Wang, Kakoli Das, Jiong Tao, Iain Beehuat Tan, Shenli Zhang, et al. “A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets.” Gut 61, no. 5 (May 2012): 673–84. https://doi.org/10.1136/gutjnl-2011-301839.
       Full Text  Link to Item
    • Zang, Zhi Jiang, Ioana Cutcutache, Song Ling Poon, Shen Li Zhang, John R. McPherson, Jiong Tao, Vikneswari Rajasegaran, et al. “Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.” Nat Genet 44, no. 5 (May 2012): 570–74. https://doi.org/10.1038/ng.2246.
       Full Text  Link to Item
    • Manu, Kanjoormana A., Muthu K. Shanmugam, Lalitha Ramachandran, Feng Li, Chee Wai Fong, Alan Prem Kumar, Patrick Tan, and Gautam Sethi. “First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.” Clin Cancer Res 18, no. 8 (April 15, 2012): 2220–29. https://doi.org/10.1158/1078-0432.CCR-11-2470.
       Full Text  Link to Item
    • Yan, Benedict, Ee Xuan Yau, Sanjay Samanta, Chee Wee Ong, Kol Jia Yong, Lai Kuan Ng, Bhaskar Bhattacharya, et al. “Clinical and therapeutic relevance of PIM1 kinase in gastric cancer.” Gastric Cancer 15, no. 2 (April 2012): 188–97. https://doi.org/10.1007/s10120-011-0097-2.
       Full Text  Link to Item
    • Ng, King Pan, Axel M. Hillmer, Charles T. H. Chuah, Wen Chun Juan, Tun Kiat Ko, Audrey S. M. Teo, Pramila N. Ariyaratne, et al. “A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.” Nat Med 18, no. 4 (March 18, 2012): 521–28. https://doi.org/10.1038/nm.2713.
       Full Text  Link to Item
    • Chong, L. Y. Z., P. Y. Cheok, W. J. Tan, A. A. Thike, G. Allen, M. K. Ang, A. S. Ooi, P. Tan, B. T. Teh, and P. H. Tan. “Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: Novel markers in biological classification.” Breast Cancer Research and Treatment 132, no. 1 (2012): 143–51. https://doi.org/10.1007/s10549-011-1555-6.
       Full Text
    • Covey, Tracy M., Simran Kaur, Tina Tan Ong, Kyle D. Proffitt, Yonghui Wu, Patrick Tan, and David M. Virshup. “PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.” Plos One 7, no. 4 (2012): e34532. https://doi.org/10.1371/journal.pone.0034532.
       Full Text  Link to Item
    • McCormack, W., M. Oshima, P. Tan, and B. J. Jenkins. “Toll-like receptor 2: Therapeutic target for gastric carcinogenesis.” Oncotarget 3, no. 11 (2012): 1260–61.
    • Price, E. P., J. L. Dale, J. M. Cook, D. S. Sarovich, M. L. Seymour, J. L. Ginther, E. L. Kaufman, et al. “Development and validation of burkholderia pseudomallei-specific real-time pcr assays for clinical, environmental or forensic detection applications.” Plos One 7, no. 5 (2012). https://doi.org/10.1371/journal.pone.0037723.
       Full Text
    • Sem, X., J. F. Kreisberg, T. Kawli, M. W. Tan, M. Rhen, and P. Tan. “Modulation of caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein.” Cellular Microbiology 14, no. 10 (2012): 1584–99. https://doi.org/10.1111/j.1462-5822.2012.01824.x.
       Full Text
    • Tan, I. B., I. Ng, W. M. Tai, and P. Tan. “Understanding the genetic basis of gastric cancer: Recent advances.” Expert Review of Gastroenterology and Hepatology 6, no. 3 (2012): 335–41. https://doi.org/10.1586/egh.12.7.
       Full Text
    • Ooi, Chia Huey, Hue Kian Oh, Hannah Zhu’ai Wang, Angie Lay Keng Tan, Jeanie Wu, Minghui Lee, Sun Young Rha, Hyun Cheol Chung, David Marc Virshup, and Patrick Tan. “A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures.” Plos Genet 7, no. 12 (December 2011): e1002415. https://doi.org/10.1371/journal.pgen.1002415.
       Full Text  Link to Item
    • Chantratita, Narisara, Drew A. Rholl, Bernice Sim, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Premjit Amornchai, Aunchalee Thanwisai, et al. “Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei.” Proc Natl Acad Sci U S A 108, no. 41 (October 11, 2011): 17165–70. https://doi.org/10.1073/pnas.1111020108.
       Full Text  Link to Item
    • Kennedy, Catherine L., Meri Najdovska, Gareth W. Jones, Louise McLeod, Norman R. Hughes, Cody Allison, Chia Huey Ooi, et al. “The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17.” J Pathol 225, no. 2 (October 2011): 255–64. https://doi.org/10.1002/path.2933.
       Full Text  Link to Item
    • Yu, Willie, Waraporn Chan-On, Melissa Teo, Choon Kiat Ong, Ioana Cutcutache, George E. Allen, Bernice Wong, et al. “First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum.” Genome Biol 12, no. 9 (September 28, 2011): R96. https://doi.org/10.1186/gb-2011-12-9-r96.
       Full Text  Link to Item
    • Tan, Iain Beehuat, Tatiana Ivanova, Kiat Hon Lim, Chee Wee Ong, Niantao Deng, Julian Lee, Sze Huey Tan, et al. “Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy.” Gastroenterology 141, no. 2 (August 2011): 476-485.11. https://doi.org/10.1053/j.gastro.2011.04.042.
       Full Text  Link to Item
    • Tan, Iain Beehuat, Ioana Cutcutache, Zhi Jiang Zang, Jabed Iqbal, Seow Fong Yap, William Hwang, Wan-Teck Lim, et al. “Fanconi's anemia in adulthood: chemoradiation-induced bone marrow failure and a novel FANCA mutation identified by targeted deep sequencing.” J Clin Oncol 29, no. 20 (July 10, 2011): e591–94. https://doi.org/10.1200/JCO.2011.35.1064.
       Full Text  Link to Item
    • Cheong, J. K., T. H. Nguyen, H. Wang, P. Tan, P. M. Voorhoeve, S. H. Lee, and D. M. Virshup. “IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.” Oncogene 30, no. 22 (June 2, 2011): 2558–69. https://doi.org/10.1038/onc.2010.627.
       Full Text  Link to Item
    • Broët, Philippe, Cyril Dalmasso, Eng Huat Tan, Marco Alifano, Shenli Zhang, Jeanie Wu, Ming Hui Lee, et al. “Genomic profiles specific to patient ethnicity in lung adenocarcinoma.” Clin Cancer Res 17, no. 11 (June 1, 2011): 3542–50. https://doi.org/10.1158/1078-0432.CCR-10-2185.
       Full Text  Link to Item
    • Birkbak, Nicolai J., Aron C. Eklund, Qiyuan Li, Sarah E. McClelland, David Endesfelder, Patrick Tan, Iain B. Tan, Andrea L. Richardson, Zoltan Szallasi, and Charles Swanton. “Paradoxical relationship between chromosomal instability and survival outcome in cancer.” Cancer Res 71, no. 10 (May 15, 2011): 3447–52. https://doi.org/10.1158/0008-5472.CAN-10-3667.
       Full Text  Link to Item
    • Hillmer, Axel M., Fei Yao, Koichiro Inaki, Wah Heng Lee, Pramila N. Ariyaratne, Audrey S. M. Teo, Xing Yi Woo, et al. “Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes.” Genome Res 21, no. 5 (May 2011): 665–75. https://doi.org/10.1101/gr.113555.110.
       Full Text  Link to Item
    • Oh, Hue-Kian, Angie Lay-Keng Tan, Kakoli Das, Chia-Huey Ooi, Nian-Tao Deng, Iain Beehuat Tan, Emmanuel Beillard, et al. “Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.” Clin Cancer Res 17, no. 9 (May 1, 2011): 2657–67. https://doi.org/10.1158/1078-0432.CCR-10-3152.
       Full Text  Link to Item
    • Tao, Jiong, Nian Tao Deng, Kalpana Ramnarayanan, Baohua Huang, Hue Kian Oh, Siew Hong Leong, Seong Soo Lim, et al. “CD44-SLC1A2 gene fusions in gastric cancer.” Sci Transl Med 3, no. 77 (April 6, 2011): 77ra30. https://doi.org/10.1126/scitranslmed.3001423.
       Full Text  Link to Item
    • Goh, Liang, Geng Bo Chen, Ioana Cutcutache, Benjamin Low, Bin Tean Teh, Steve Rozen, and Patrick Tan. “Assessing matched normal and tumor pairs in next-generation sequencing studies.” Plos One 6, no. 3 (March 18, 2011): e17810. https://doi.org/10.1371/journal.pone.0017810.
       Full Text  Link to Item
    • Ang, M. K., A. S. Ooi, A. A. Thike, P. Tan, Z. Zhang, K. Dykema, K. Furge, B. T. Teh, and P. H. Tan. “Molecular classification of breast phyllodes tumors: Validation of the histologic grading scheme and insights into malignant progression.” Breast Cancer Research and Treatment 129, no. 2 (2011): 319–29. https://doi.org/10.1007/s10549-010-1204-5.
       Full Text
    • Cruz-Migoni, A., G. M. Hautbergue, P. J. Artymiuk, P. J. Baker, M. Bokori-Brown, C. T. Chang, M. J. Dickman, et al. “A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.” Science 334, no. 6057 (2011): 821–24. https://doi.org/10.1126/science.1211915.
       Full Text
    • Tan, I. B., and P. Tan. “Genetics: An 18-gene signature (ColoPrint®) for colon cancer prognosis.” Nature Reviews Clinical Oncology 8, no. 3 (2011): 131–33. https://doi.org/10.1038/nrclinonc.2010.229.
       Full Text
    • Zang, Zhi Jiang, Choon Kiat Ong, Ioana Cutcutache, Willie Yu, Shen Li Zhang, Dachuan Huang, Lian Dee Ler, et al. “Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.” Cancer Res 71, no. 1 (January 1, 2011): 29–39. https://doi.org/10.1158/0008-5472.CAN-10-1749.
       Full Text  Link to Item
    • Mohd Omar, Mohd Feroz, Ning Huang, Keli Ou, Kun Yu, Thomas C. Putti, Hiroyuki Jikuya, Tetsuo Ichikawa, Osamu Nishimura, Patrick Tan, and Manuel Salto-Tellez. “Molecular-assisted immunohistochemical optimization.” Acta Histochem 112, no. 6 (November 2010): 519–28. https://doi.org/10.1016/j.acthis.2009.05.010.
       Full Text  Link to Item
    • Palanisamy, Nallasivam, Bushra Ateeq, Shanker Kalyana-Sundaram, Dorothee Pflueger, Kalpana Ramnarayanan, Sunita Shankar, Bo Han, et al. “Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.” Nat Med 16, no. 7 (July 2010): 793–98. https://doi.org/10.1038/nm.2166.
       Full Text  Link to Item
    • Thike, Aye Aye, Jabed Iqbal, Poh Yian Cheok, Angela Phek Yoon Chong, Gary Man-Kit Tse, Benita Tan, Patrick Tan, Nan Soon Wong, and Puay Hoon Tan. “Triple negative breast cancer: outcome correlation with immunohistochemical detection of basal markers.” Am J Surg Pathol 34, no. 7 (July 2010): 956–64. https://doi.org/10.1097/PAS.0b013e3181e02f45.
       Full Text  Link to Item
    • Wang, Yu, Yiwei Lu, Soo Ting Toh, Wing-Kin Sung, Patrick Tan, Pierce Chow, Alexander Y. F. Chung, London L. P. Jooi, and Caroline G. L. Lee. “Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3.” J Hepatol 53, no. 1 (July 2010): 57–66. https://doi.org/10.1016/j.jhep.2009.12.043.
       Full Text  Link to Item
    • Sun, Guang Wen, Yahua Chen, Yichun Liu, Gek-Yen Gladys Tan, Catherine Ong, Patrick Tan, and Yunn-Hwen Gan. “Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei.” Mol Microbiol 76, no. 3 (May 2010): 677–89. https://doi.org/10.1111/j.1365-2958.2010.07124.x.
       Full Text  Link to Item
    • Nandi, Tannistha, Catherine Ong, Arvind Pratap Singh, Justin Boddey, Timothy Atkins, Mitali Sarkar-Tyson, Angela E. Essex-Lopresti, et al. “A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence.” Plos Pathog 6, no. 4 (April 1, 2010): e1000845. https://doi.org/10.1371/journal.ppat.1000845.
       Full Text  Link to Item
    • Losada, Liliana, Catherine M. Ronning, David DeShazer, Donald Woods, Natalie Fedorova, H Stanley Kim, Svetlana A. Shabalina, et al. “Continuing evolution of Burkholderia mallei through genome reduction and large-scale rearrangements.” Genome Biol Evol 2 (January 22, 2010): 102–16. https://doi.org/10.1093/gbe/evq003.
       Full Text  Link to Item
    • Nandi, T., C. Ong, A. P. Singh, J. Boddey, T. Atkins, M. Sarkar-Tyson, A. E. Essex-Lopresti, et al. “A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence.” Plos Pathogens 6, no. 4 (2010): e1000845.
    • Sim, Bernice Meng Qi, Narisara Chantratita, Wen Fong Ooi, Tannistha Nandi, Ryan Tewhey, Vanaporn Wuthiekanun, Janjira Thaipadungpanit, et al. “Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates.” Genome Biol 11, no. 8 (2010): R89. https://doi.org/10.1186/gb-2010-11-8-r89.
       Full Text  Link to Item
    • Tay, P. N., P. Tan, Y. Lan, C. H. W. Leung, M. Laban, T. C. Tan, H. Ni, et al. “Palladin, an actin-associated protein, is required for adherens junction formation and intercellular adhesion in HCT116 colorectal cancer cells.” International Journal of Oncology 37, no. 4 (2010): 909–26. https://doi.org/10.3892/ijo-00000742.
       Full Text
    • Thike, Aye Aye, Poh Yian Cheok, Ana Richelia Jara-Lazaro, Benita Tan, Patrick Tan, and Puay Hoon Tan. “Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer.” Mod Pathol 23, no. 1 (January 2010): 123–33. https://doi.org/10.1038/modpathol.2009.145.
       Full Text  Link to Item
    • Ooi, Chia Huey, Tatiana Ivanova, Jeanie Wu, Minghui Lee, Iain Beehuat Tan, Jiong Tao, Lindsay Ward, et al. “Oncogenic pathway combinations predict clinical prognosis in gastric cancer.” Plos Genet 5, no. 10 (October 2009): e1000676. https://doi.org/10.1371/journal.pgen.1000676.
       Full Text  Link to Item
    • Toh, Han C., Li Sun, Yatanar Soe, Yonghui Wu, Yee P. Phoon, Whay K. Chia, Jeanie Wu, Kee Y. Wong, and Patrick Tan. “G-CSF induces a potentially tolerant gene and immunophenotype profile in T cells in vivo.” Clin Immunol 132, no. 1 (July 2009): 83–92. https://doi.org/10.1016/j.clim.2009.03.509.
       Full Text  Link to Item
    • Broët, Philippe, Sophie Camilleri-Broët, Shenli Zhang, Marco Alifano, Dhinoth Bangarusamy, Maxime Battistella, Yonghui Wu, et al. “Prediction of clinical outcome in multiple lung cancer cohorts by integrative genomics: implications for chemotherapy selection.” Cancer Res 69, no. 3 (February 1, 2009): 1055–62. https://doi.org/10.1158/0008-5472.CAN-08-1116.
       Full Text  Link to Item
    • Brot, P., P. Tan, M. Alifano, S. Camilleri-Brot, and S. Richardson. “Finding exclusively deleted or amplified genomic areas in lung adenocarcinomas using a novel chromosomal pattern analysis.” Bmc Medical Genomics 2 (2009). https://doi.org/10.1186/1755-8794-2-43.
       Full Text
    • Chong, Yuk-Kien, Tan-Boon Toh, Norazean Zaiden, Anuradha Poonepalli, Siew Hong Leong, Catherine Ee Ling Ong, Yiting Yu, et al. “Cryopreservation of neurospheres derived from human glioblastoma multiforme.” Stem Cells 27, no. 1 (January 2009): 29–39. https://doi.org/10.1634/stemcells.2008-0009.
       Full Text  Link to Item
    • Ganesan, K., S. Banerjee, P. Gunasekaran, P. Tan, and S. K. Rayala. “Integrative functional genomics in cancer research and its clinical implications.” Journal of Cancer Molecules 5, no. 3 (2009): 65–71.
    • Lee, S. C., X. Xu, W. J. Chng, M. Watson, Y. W. Lim, C. I. Wong, P. Iau, et al. “Post-treatment tumor gene expression signatures are more predictive of treatment outcomes than baseline signatures in breast cancer.” Pharmacogenetics and Genomics 19, no. 11 (2009): 833–42. https://doi.org/10.1097/FPC.0b013e328330a39f.
       Full Text
    • Lee, S. C., X. Xu, Y. W. Lim, P. Lau, N. Sukri, S. E. Lim, H. L. Yap, et al. “Chemotherapy-induced tumor gene expression changes in human breast cancers.” Pharmacogenetics and Genomics 19, no. 3 (2009): 181–92. https://doi.org/10.1097/FPC.0b013e32831ebb5d.
       Full Text
    • Lim, E. H., S. L. Zhang, J. L. Li, W. S. Yap, T. C. Howe, B. P. Tan, Y. S. Lee, et al. “Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC).” Journal of Thoracic Oncology 4, no. 1 (2009): 12–21. https://doi.org/10.1097/JTO.0b013e3181913e28.
       Full Text
    • Pearson, T., P. Giffard, S. Beckstrom-Sternberg, R. Auerbach, H. Hornstra, A. Tuanyok, E. P. Price, et al. “Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer.” Bmc Biology 7 (2009). https://doi.org/10.1186/1741-7007-7-78.
       Full Text
    • Tan, P. “Divide and conquer: Progress in the molecular stratification of cancer.” Yonsei Medical Journal 50, no. 4 (2009): 464–73. https://doi.org/10.3349/ymj.2009.50.4.464.
       Full Text
    • Yang, Xiaojing, RK Murthy Karuturi, Feng Sun, Meiyee Aau, Kun Yu, Rongguang Shao, Lance D. Miller, Patrick Boon Ooi Tan, and Qiang Yu. “CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells.” Plos One 4, no. 4 (2009): e5011. https://doi.org/10.1371/journal.pone.0005011.
       Full Text  Link to Item
    • Sim, Siew Hoon, Yiting Yu, Chi Ho Lin, R Krishna M. Karuturi, Vanaporn Wuthiekanun, Apichai Tuanyok, Hui Hoon Chua, et al. “The core and accessory genomes of Burkholderia pseudomallei: implications for human melioidosis.” Plos Pathog 4, no. 10 (October 2008): e1000178. https://doi.org/10.1371/journal.ppat.1000178.
       Full Text  Link to Item
    • Yu, Kun, Kumaresan Ganesan, Lay Keng Tan, Mirtha Laban, Jeanie Wu, Xiao Dong Zhao, Hongmin Li, et al. “A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers.” Plos Genet 4, no. 7 (July 18, 2008): e1000129. https://doi.org/10.1371/journal.pgen.1000129.
       Full Text  Link to Item
    • Huynh, Hung, Pierce K. H. Chow, Nallasivam Palanisamy, Manuel Salto-Tellez, Boon Cher Goh, Chi Kuen Lee, Anaji Somani, et al. “Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma.” J Hepatol 49, no. 1 (July 2008): 52–60. https://doi.org/10.1016/j.jhep.2008.02.022.
       Full Text  Link to Item
    • Hou, Qingsong, Yong Hui Wu, Heike Grabsch, Yansong Zhu, Siew Hong Leong, Kumaresan Ganesan, Debra Cross, et al. “Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.” Cancer Res 68, no. 12 (June 15, 2008): 4623–30. https://doi.org/10.1158/0008-5472.CAN-07-5870.
       Full Text  Link to Item
    • Ganesan, Kumaresan, Tatiana Ivanova, Yonghui Wu, Vikneswari Rajasegaran, Jeanie Wu, Ming Hui Lee, Kun Yu, et al. “Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene.” Cancer Res 68, no. 11 (June 1, 2008): 4277–86. https://doi.org/10.1158/0008-5472.CAN-07-6517.
       Full Text  Link to Item
    • Wang, Yu, Alvin T. C. Lee, Joel Z. I. Ma, Jingbo Wang, Jianwei Ren, Yuchen Yang, Erwin Tantoso, et al. “Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.” J Biol Chem 283, no. 19 (May 9, 2008): 13205–15. https://doi.org/10.1074/jbc.M707629200.
       Full Text  Link to Item
    • Ou, Keli, Kun Yu, Djohan Kesuma, Michelle Hooi, Ning Huang, Wei Chen, Suet Ying Lee, et al. “Novel breast cancer biomarkers identified by integrative proteomic and gene expression mapping.” J Proteome Res 7, no. 4 (April 2008): 1518–28. https://doi.org/10.1021/pr700820g.
       Full Text  Link to Item
    • Tan, Kaia Davis, Yansong Zhu, Hiang Khoon Tan, Vikneswari Rajasegaran, Amit Aggarwal, Jeanie Wu, Hui Yong Wu, et al. “Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma.” Genes Chromosomes Cancer 47, no. 4 (April 2008): 353–62. https://doi.org/10.1002/gcc.20539.
       Full Text  Link to Item
    • Tan, Benita K. T., Lay Keng Tan, Kun Yu, Puay Hoon Tan, Ming Lee, Lang Hiong Sii, Chow Yin Wong, et al. “Clinical validation of a customized multiple signature microarray for breast cancer.” Clin Cancer Res 14, no. 2 (January 15, 2008): 461–69. https://doi.org/10.1158/1078-0432.CCR-07-0999.
       Full Text  Link to Item
    • Lin, C. H., G. Bourque, and P. Tan. “A comparative synteny map of Burkholderia species links large-scale genome rearrangements to fine-scale nucleotide variation in prokaryotes.” Molecular Biology and Evolution 25, no. 3 (2008): 549–58. https://doi.org/10.1093/molbev/msm282.
       Full Text
    • Peacock, S. J., H. P. Schweizer, D. A. B. Dance, T. L. Smith, J. E. Gee, V. Wuthiekanun, D. Deshazer, I. Steinmetz, P. Tan, and B. J. Currie. “Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei.” Emerging Infectious Diseases 14, no. 7 (2008): e2. https://doi.org/10.3201/eid1407.071501.
       Full Text
    • Tan, P. “Germline polymorphisms as modulators of cancer phenotypes.” Bmc Medicine 6 (2008). https://doi.org/10.1186/1741-7015-6-27.
       Full Text
    • Tringe, S. G., T. Zhang, X. Liu, Y. Yu, W. H. Lee, J. Yap, F. Yao, et al. “The airbone metagenome in an indoor urban environment.” Plos One 3, no. 4 (2008). https://doi.org/10.1371/journal.pone.0001862.
       Full Text
    • Varambally, S., Q. Cao, R. S. Mani, S. Shankar, X. Wang, B. Ateeq, B. Laxman, et al. “Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.” Science 322, no. 5908 (2008): 1695–99. https://doi.org/10.1126/science.1165395.
       Full Text
    • Tan, Jing, Xiaojing Yang, Li Zhuang, Xia Jiang, Wei Chen, Puay Leng Lee, RK Murthy Karuturi, Patrick Boon Ooi Tan, Edison T. Liu, and Qiang Yu. “Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.” Genes Dev 21, no. 9 (May 1, 2007): 1050–63. https://doi.org/10.1101/gad.1524107.
       Full Text  Link to Item
    • Chen, W., M. Salto-Tellez, N. Palanisamy, K. Ganesan, Q. Hou, L. K. Tan, L. H. Sii, et al. “Targets of genome copy number reduction in primary breast cancers identified by integrative genomics.” Genes Chromosomes and Cancer 46, no. 3 (2007): 288–301. https://doi.org/10.1002/gcc.20411.
       Full Text
    • Lim, E. H., S. L. Zhang, K. Yu, M. E. Nga, D. A. Ahmed, T. Agasthian, P. S. Wong, et al. “An alternative approach to determining therapeutic choices in advanced non-small cell lung carcinoma (NSCLC): Maximizing the diagnostic procedure and the use of low-volume lung biopsies.” Journal of Thoracic Oncology 2, no. 5 (2007): 387–96. https://doi.org/10.1097/01.JTO.0000268671.49378.c2.
       Full Text
    • Lim, E. H., and P. Tan. “Molecular diagnostics in advanced NSCLC: Trying to maximize a non-ideal situation.” Journal of Thoracic Oncology 2, no. 8 (2007): 782-. https://doi.org/10.1097/JTO.0b013e31811f479d.
       Full Text
    • Aggarwal, A., D. L. Guo, Y. Hoshida, S. T. Yuen, K. M. Chu, S. So, A. Boussioutas, et al. “Topological and functional discovery in a gene coexpression meta-network of gastric cancer.” Cancer Research 66, no. 1 (2006): 232–41. https://doi.org/10.1158/0008-5472.CAN-05-2232.
       Full Text
    • Cao, W., P. Tan, H. L. Chee, H. Zhang, and J. Lu. “Atransforming growth factor-β-induced protein stimulates endocytosis and is up-regulated in immature dendritic cells.” Blood 107, no. 7 (2006): 2777–85. https://doi.org/10.1182/blood-2005-05-1803.
       Full Text
    • Ou, K., D. Kesuma, K. Ganesan, K. Yu, S. Y. Soon, S. Y. Lee, X. P. Goh, et al. “Quantitative profiling of drug-associated proteomic alterations by combined 2-nitrobenzenesulfenyl chloride (NBS) isotope labeling and 2DE/MS identification.” Journal of Proteome Research 5, no. 9 (2006): 2194–2206. https://doi.org/10.1021/pr060115n.
       Full Text
    • Rodrigues, F., M. Sarkar-Tyson, S. V. Harding, H. S. Siew, H. C. Hui, H. L. Chi, X. Han, et al. “Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis.” Journal of Bacteriology 188, no. 23 (2006): 8178–88. https://doi.org/10.1128/JB.01006-06.
       Full Text
    • Soo, R. A., J. Wu, A. Aggarwal, Q. Tao, W. Hsieh, T. Putti, K. B. Tan, et al. “Celecoxib reduces microvessel density in patients treated with nasopharyngeal carcinoma and induces changes in gene expression.” Annals of Oncology 17, no. 11 (2006): 1625–30. https://doi.org/10.1093/annonc/mdl283.
       Full Text
    • Yu, K., K. Ganesan, L. D. Miller, and P. Tan. “A modular analysis of breast cancer reveals a novel low-grade molecular signature in estrogen receptor-positive tumors.” Clinical Cancer Research 12, no. 11 I (2006): 3288–96. https://doi.org/10.1158/1078-0432.CCR-05-1530.
       Full Text
    • Yu, Y., H. S. Kim, H. C. Hui, H. L. Chi, H. S. Siew, D. Lin, A. Derr, et al. “Genomic patterns of pathogen evolution revealed by comparison of Burkholderia pseudomallei, the causative agent of melioidosis, to avirulent Burkholderia thailandensis.” Bmc Microbiology 6 (2006). https://doi.org/10.1186/1471-2180-6-46.
       Full Text
    • Aggarwal, A., S. H. Leong, C. Lee, O. L. Kon, and P. Tan. “Wavelet transformations of tumor expression profiles reveals a pervasive genome-wide imprinting of aneuploidy on the cancer transcriptome.” Cancer Research 65, no. 1 (2005): 186–94.
    • Ou, K., C. Ong, S. Y. Koh, F. Rodrigues, S. H. Sim, D. Wong, C. H. Ooi, K. C. Ng, H. Jikuya, and E. al. “Integrative genomic, transcriptional, and proteomic diversity in natural isolates of the human pathogen Burkholderia pseudomallei.” Journal of Bacteriology 187, no. 12 (2005): 4276–85. https://doi.org/10.1128/JB.187.12.4276-4285.2005.
       Full Text
    • Siddique, M. M., C. Balram, L. Fiszer-Maliszewska, A. Aggarwal, A. Tan, P. Tan, K. C. Soo, and K. Sabapathy. “Evidence for selective expression of the p53 codon 72 polymorphs: Implications in cancer development.” Cancer Epidemiology Biomarkers and Prevention 14, no. 9 (2005): 2245–52. https://doi.org/10.1158/1055-9965.EPI-05-0153.
       Full Text
    • Tan, P. H., B. H. Bay, G. Yip, S. Selvarajan, P. Tan, J. Wu, C. H. Lee, and K. B. Li. “Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death.” Modern Pathology 18, no. 3 (2005): 374–81. https://doi.org/10.1038/modpathol.3800254.
       Full Text
    • Tan, P. “Drug discovery in the lion city.” Drug Discovery Today 10, no. 17 (2005): 1143–44. https://doi.org/10.1016/S1359-6446(05)03568-3.
       Full Text
    • Ong, C., C. H. Ooi, D. Wang, H. Chong, K. C. Ng, F. Rodrigues, M. A. Lee, and P. Tan. “Patterns of large-scale genomic variation in virulent and avirulent Burkholderia species.” Genome Research 14, no. 11 (2004): 2295–2307. https://doi.org/10.1101/gr.1608904.
       Full Text
    • Sun, L., P. Tan, C. Yap, W. Hwang, L. P. Koh, C. K. Lim, and S. E. Aw. “In vitro biological characteristics of human cord blood-derived megakaryocytes.” Annals of the Academy of Medicine Singapore 33, no. 5 (2004): 570–75.
    • Swamy, S. M. K., P. Tan, Y. Z. Zhu, J. Lu, H. N. Achuth, and S. Moochhala. “Role of phenytoin in wound healing: Microarray analysis of early transcriptional responses in human dermal fibroblasts.” Biochemical and Biophysical Research Communications 314, no. 3 (2004): 661–66. https://doi.org/10.1016/j.bbrc.2003.12.146.
       Full Text
    • Tan, D., W. Hwang, H. J. Ng, Y. T. Goh, and P. Tan. “Successful treatment of idiopathic hypereosinophilic syndrome with imatinib mesylate: A case report.” International Journal of Hematology 80, no. 1 (2004): 75–77. https://doi.org/10.1532/IJH97.A20309.
       Full Text
    • Wong, K. Y., Y. C. Chuan, A. Aggarwal, L. Tham, W. M. Kong, and P. Tan. “Identifying patterns of DNA for tumor diagnosis using capillary electrophoresis-amplified fragment length polymorphism (CE-AFLP) screening.” Journal of Bioinformatics and Computational Biology 2, no. 3 (2004): 569–87. https://doi.org/10.1142/S0219720004000740.
       Full Text
    • Yu, K., C. H. Lee, P. H. Tan, G. S. Hong, S. B. Wee, C. Y. Wong, and P. Tan. “A Molecular Signature of the Nottingham Prognostic Index in Breast Cancer.” Cancer Research 64, no. 9 (2004): 2962–68. https://doi.org/10.1158/0008-5472.CAN-03-2430.
       Full Text
    • Yu, K., C. H. Lee, P. H. Tan, and P. Tan. “Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations.” Clinical Cancer Research 10, no. 16 (2004): 5508–17. https://doi.org/10.1158/1078-0432.CCR-04-0085.
       Full Text
    • Kun, Y., L. C. How, T. P. Hoon, V. B. Bajic, T. S. Lam, A. Aggarwal, H. G. Sze, W. S. Bok, W. C. Yin, and P. Tan. “Classifying the estrogen receptor status of breast cancers by expression profiles reveals a poor prognosis subpopulation exhibiting high expression of the ERBB2 receptor.” Human Molecular Genetics 12, no. 24 (2003): 3245–58. https://doi.org/10.1093/hmg/ddg347.
       Full Text
    • Lim, E. H., A. Aggarwal, T. Agasthian, P. S. Wong, C. Tan, E. Sim, L. Tan, et al. “Feasibility of Using Low-Volume Tissue Samples for Gene Expression Profiling of Advanced Non-Small Cell Lung Cancers.” Clinical Cancer Research 9, no. 16 I (2003): 5980–87.
    • Ooi, C. H., and P. Tan. “Genetic algorithms applied to multi-class prediction for the analysis of gene expression data.” Bioinformatics 19, no. 1 (2003): 37–44. https://doi.org/10.1093/bioinformatics/19.1.37.
       Full Text
    • Tay, S. T., S. H. Leong, K. Yu, A. Aggarwal, S. Y. Tan, C. H. Lee, K. Wong, et al. “A combined comparative genomic hybridization and expression microarray analysis of gastric cancer reveals novel molecular subtypes.” Cancer Research 63, no. 12 (2003): 3309–16.
    • Gan, Y. H., K. L. Chua, H. H. Chua, B. Liu, C. S. Hii, H. L. Chong, and P. Tan. “Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system.” Molecular Microbiology 44, no. 5 (2002): 1185–97. https://doi.org/10.1046/j.1365-2958.2002.02957.x.
       Full Text
    • Tan, P., and G. Y. Hwen. “The use of animal infection models to study the pathogenesis of melioidosis and glanders.” Trends in Microbiology 10, no. 11 (2002): 484–85. https://doi.org/10.1016/S0966-842X(02)02465-4.
       Full Text
    • Rajalingam, V., J. Lou, M. H. Yong, S. Lam, P. Tan, M. Y. Chan, A. M. Tan, and C. L. Tan. “Fish analysis of tel-aml 1 in childhood leukaemia in a local multiracial asian population.” Blood 96, no. 11 PART II (2001): 196b.
    • Koh, L. P., Y. T. Goh, G. M. Yee, and P. Tan. “Randomised trial of fluconazole versus lowdose amphotericin b in prophylaxis against fungal infections in patients undergoing hematopoietic cell transplantation.” Blood 96, no. 11 PART I (2000): 189a.
    • Tan, P. B., and S. K. Kim. “Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans.” Trends Genet 15, no. 4 (April 1999): 145–49. https://doi.org/10.1016/s0168-9525(99)01694-7.
       Full Text  Link to Item
    • Tan, P. B., M. R. Lackner, and S. K. Kim. “MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction.” Cell 93, no. 4 (May 15, 1998): 569–80. https://doi.org/10.1016/s0092-8674(00)81186-1.
       Full Text  Link to Item
    • Chong, Y. Y., G. C. Wong, L. C. Lau, L. Knight, P. Lim, W. O. Lui, M. H. Yong, Y. T. Goh, and P. Tan. “Acute promyelocytic leukemia with a dicentric chromosome involving chromosomes 11, 17, and 18.” Cancer Genetics and Cytogenetics 105, no. 1 (1998): 69–73. https://doi.org/10.1016/S0165-4608(97)00431-7.
       Full Text
    • Chong, Y. Y., L. C. Lau, W. O. Lui, P. Lim, E. Lim, P. H. Tan, P. Tan, and Y. Y. Ong. “A case of t(8;14) with total and partial trisomy 3 in Waldenstrom macroglobulinemia.” Cancer Genetics and Cytogenetics 103, no. 1 (1998): 65–67. https://doi.org/10.1016/S0165-4608(97)00346-4.
       Full Text
    • Gansheroff, L. J., C. Dollard, P. Tan, and F. Winston. “The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo.” Genetics 139, no. 2 (1995): 523–36.
    • Low, S. H., S. H. Wong, B. L. Tang, P. Tan, V. N. Subramaniam, and W. Hong. “Inhibition by Brefeldin A of protein secretion from the apical cell surface of Madin-Darby canine kidney cells.” Journal of Biological Chemistry 266, no. 27 (1991): 17729–32.
    • Ong, Y. W., P. Tan, S. H. Lim, H. W. Ng, and Y. T. Goh. “Bone marrow transplantation for treatment of chronic myelogenous leukaemia (CML)--preliminary experience in Singapore.” Annals of the Academy of Medicine Singapore 19, no. 2 (1990): 169–74.
    • Tan, P., Y. W. Ong, Y. T. Goh, S. H. Lim, and H. W. Ng. “Allogeneic bone marrow transplantation for acute non-lymphoblastic leukaemia--the Singapore experience.” Annals of the Academy of Medicine Singapore 19, no. 2 (1990): 161–68.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.