Patty J Lee | Scholars@Duke

Patty J Lee
Professor of Medicine

My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system. Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health and cell fate, such as death and/or senescence.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2019
Professor of Cell Biology, Cell Biology, Basic Science Departments 2020

Contact Information

3110 MSRB 3, 3 Genome Court, Durham, NC 27710
Box 103050, MSRB 3 Room 5140, Durham, NC 27710
patty.lee@duke.edu (919) 684-0928

Background
Education, Training, & Certifications
- Pulmonary and Critical Care Medicine Fellowship, Johns Hopkins University School of Medicine 1994 - 1998
- Internal Medicine Residency, Johns Hopkins University School of Medicine 1991 - 1994
- M.D., Brown University 1991
Duke Appointment History
- Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2019
Recognition
In the News
- APR 23, 2021 School of Medicine Magnify
  
  We Are What We Breathe
Research
Selected Grants
- The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping Center awarded by National Institutes of Health 2021 - 2026
- Fixed Price Contract - Intramural Targeted Anti-COVID-19 program (ITAC) Harnessing the Extracellular Matrix to Treat COVID-19-Induced ARDS awarded by National Heart, Lung, and Blood Institute 2021 - 2023
- Data-driven Approaches to Healthcare Provider Resilience & Burnout during COVID-19 awarded by Department of Defense 2021 - 2022
- TLR4-MEDIATED EPIGENETIC AND SENESCENCE MECHANISMS IN EMPHYSEMA awarded by National Institutes of Health 2017 - 2022
- MIF-based Therapies for Severe Lung Disease awarded by Burroughs Wellcome Fund 2019 - 2021
- MIF-Based Therapies in Cigarette Smoke-Related COPD and Pneumonia awarded by Department of Defense 2020 - 2021
- IPA - Youwei Chen awarded by Durham Veterans Affairs Medical Center 2019 - 2020
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Chun, Hyung J., Elias Coutavas, Alexander B. Pine, Alfred I. Lee, Vanessa L. Yu, Marcus K. Shallow, Coral X. Giovacchini, et al. “Immunofibrotic drivers of impaired lung function in postacute sequelae of SARS-CoV-2 infection.” Jci Insight 6, no. 14 (July 22, 2021). https://doi.org/10.1172/jci.insight.148476.
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  - Zhang, Yi, Guoying Yu, Naftali Kaminski, and Patty J. Lee. “PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury.” Am J Physiol Lung Cell Mol Physiol 320, no. 6 (June 1, 2021): L1118–25. https://doi.org/10.1152/ajplung.00598.2020.
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  - Chun, Hyung J., Elias Coutavas, Alexander Pine, Alfred I. Lee, Vanessa Yu, Marcus Shallow, Coral X. Giovacchini, et al. “Immuno-fibrotic drivers of impaired lung function in post-acute sequelae of SARS-CoV-2 infection (PASC).” Medrxiv, April 21, 2021. https://doi.org/10.1101/2021.01.31.21250870.
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  - Yuan, Qianying, Abdul Basit, Wenhua Liang, Rihao Qu, Yi Luan, Chunguang Ren, Ao Li, et al. “Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.” Science Translational Medicine 13, no. 591 (April 2021). https://doi.org/10.1126/scitranslmed.abc2499.
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  - Nouws, Jessica, Feng Wan, Eric Finnemore, Willy Roque, So-Jin Kim, Isabel Bazan, Chuan-Xing Li, et al. “MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease.” Jci Insight 6, no. 2 (January 25, 2021). https://doi.org/10.1172/jci.insight.134218.
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  - Giri, Paresh C., Anand M. Chowdhury, Armando Bedoya, Hengji Chen, Hyun Suk Lee, Patty Lee, Craig Henriquez, Neil R. MacIntyre, and Yuh-Chin T. Huang. “Application of Machine Learning in Pulmonary Function Assessment Where Are We Now and Where Are We Going?” Front Physiol 12 (2021): 678540. https://doi.org/10.3389/fphys.2021.678540.
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  - Katsura, Hiroaki, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton, Arvind Konkimalla, et al. “Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.” Cell Stem Cell 27, no. 6 (December 3, 2020): 890-904.e8. https://doi.org/10.1016/j.stem.2020.10.005.
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  - Clapham, Katharine R., Youlan Rao, Sandeep Sahay, Maor Sauler, Patty J. Lee, Mitchell A. Psotka, Wassim H. Fares, and Tariq Ahmad. “PECAM-1 is Associated WithOutcomes and Response to Treatment in Pulmonary Arterial Hypertension.” Am J Cardiol 127 (July 15, 2020): 198–99. https://doi.org/10.1016/j.amjcard.2020.04.031.
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  - Kim, So-Jin, Peiying Shan, Cheol Hwangbo, Yi Zhang, Jin-Na Min, Xuchen Zhang, Taylor Ardito, et al. “Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a.” Aging Cell 18, no. 3 (June 2019): e12914. https://doi.org/10.1111/acel.12914.
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  - Lindow, Janet C., Elsio A. Wunder, Stephen J. Popper, Jin-Na Min, Praveen Mannam, Anup Srivastava, Yi Yao, et al. “Cathelicidin Insufficiency in Patients with Fatal Leptospirosis.” Plos Pathog 12, no. 11 (November 2016): e1005943. https://doi.org/10.1371/journal.ppat.1005943.
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  - Ingram, Jennifer L., Aurita Antao-Menezes, James B. Mangum, Otis Lyght, Patty J. Lee, Jack A. Elias, and James C. Bonner. “Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.” J Immunol 177, no. 6 (September 15, 2006): 4141–48. https://doi.org/10.4049/jimmunol.177.6.4141.
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  - Zhang, Xuchen, Peiying Shan, Salman Qureshi, Robert Homer, Ruslan Medzhitov, Paul W. Noble, and Patty J. Lee. “Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.” J Immunol 175, no. 8 (October 15, 2005): 4834–38. https://doi.org/10.4049/jimmunol.175.8.4834.
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  - Lee, Chun Geun, Soo Jung Cho, Min Jong Kang, Svetlana P. Chapoval, Patty J. Lee, Paul W. Noble, Teshome Yehualaeshet, et al. “Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.” J Exp Med 200, no. 3 (August 2, 2004): 377–89. https://doi.org/10.1084/jem.20040104.
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- Conference Papers
  - Kim, S., C. Hwangbo, P. Shan, Y. Zhang, L. Macadlo, J. Ou, P. Tata, E. Coutavas, and P. Lee. “Epigenetic Alterations in Cigarette Smoke-Induced Endothelial Cell Senescence.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Kim, S., C. Zhou, E. Coutavas, and P. Lee. “Effect of Toll-Like Receptor 4 on Tom70 Expression and Its Role in Mitochondria.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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  - Kim, S., F. Wan, X. Zhang, Y. Zhang, E. Ifedigbo, L. Leng, R. Bucala, P. Lee, and M. Sauler. “MIF-CD74 Signaling Protects Against Endothelial Senescence in Chronic Obstructive Pulmonary Disease.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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Scholarly, Clinical, & Service Activities
Service to the Profession
- Participant. Faculty Curriculum on Anti-Racism. Duke Office of Faculty Advancement. January 11, 2021 - January 14, 2021 2021

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Service to the Profession