Scholars@Duke
Paul Hofmann

Paul Hofmann

Assoc Dir, DCRI
Duke Clinical Research Institute
paul.hofmann@duke.edu
Box 104785, Durham, NC 27710
300 West Morgan St., Suite 800, Durham, NC 27701

Scholarly Works

Clinical Patterns and Appropriateness of Apixaban Dosing in Patients With Atrial Fibrillation.

Journal article JACC Adv · June 29, 2026 BACKGROUND: Apixaban is a direct oral anticoagulant for stroke prevention in patients with atrial fibrillation (AF) or atrial flutter (AFL), with dose reduction being recommended based on age, body weight, and creatinine. OBJECTIVES: The objective of the s ... Full text Link to item Cite

Predictors of ischemic stroke and major bleeding among patients with atrial fibrillation in clinical practice.

Journal article Am Heart J · May 19, 2026 BACKGROUND: Numerous risk scores exist to quantify the risk of ischemic stroke risk in patients with atrial fibrillation or flutter (AF/AFL). However, how these tools perform in cohorts or those already on oral anticoagulation (OAC) therapy is unclear. MET ... Full text Link to item Cite

Natural history of echocardiographic changes in atrial fibrillation: A case-controlled study of longitudinal remodeling.

Journal article Heart Rhythm · January 2024 BACKGROUND: Atrial fibrillation (AF) can be a cause and consequence of cardiac remodeling. The natural history of remodeling associated with AF is incompletely described. OBJECTIVE: The purpose of this study was to describe the frequency and timing of AF-a ... Full text Link to item Cite

Electronic health record characterization and outcomes of heart failure with preserved ejection fraction.

Conference Am Heart J · September 2023 BACKGROUND: Electronic health record (EHR)-based identification of heart failure with preserved ejection fraction (HFpEF) in the clinical setting may facilitate screening for clinical trials by improving the understanding of its epidemiology and outcomes; ... Full text Link to item Cite

Continuous Monitoring of Heart Rate Variability and Clinical Outcomes in Patients with Implantable Cardioverter Defibrillators.

Journal article Curr Probl Cardiol · March 2023 While heart rate variability (HRV) is an established marker of cardiovascular health, the extent to which continuously measured HRV changes over time and the relationship between these changes and clinical outcomes are less clear. We performed a health sys ... Full text Link to item Cite

Electrocardiographic parameters associated with pacemaker induced cardiomyopathy.

Journal article J Electrocardiol · 2023 BACKGROUND: Chronic right ventricular (RV) pacing can induce left ventricular (LV) dyssynchrony and cause pacemaker induced cardiomyopathy (PiCM). Identifying which patients are at risk for PiCM is limited. METHODS: Patients receiving RV-only permanent pac ... Full text Link to item Cite

Characteristics and Outcomes of Suspected Digoxin Toxicity and Immune Fab Treatment Over the Past Two Decades-2000-2020.

Journal article Am J Cardiol · November 15, 2022 The role of digoxin in clinical practice has narrowed over time. Data on digoxin toxicity trends and outcomes are variable and lack granularity for treatment outcomes. This study aimed to address data gaps in digoxin toxicity trends and outcomes in patient ... Full text Link to item Cite

Clinical trajectory of patients with a worsening heart failure event and reduced ventricular ejection fraction.

Journal article Am Heart J · March 2022 BACKGROUND: Recent data suggest that patients with heart failure with reduced ejection fraction (HFrEF) and worsening heart failure (WHF) have potential for greater benefit from newer HF therapies. We investigated characteristics and outcomes of patients w ... Full text Link to item Cite

Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera.

Journal article Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · December 2016 BackgroundNew multipinhole cadmium-zinc-telluride (CZT) cameras allow for faster imaging and lower radiation doses for single photon emission computed tomography (SPECT) studies, but assessment of prognostic ability is necessary.Methods and re ... Full text Cite

Outcomes after nonemergent electrical cardioversion for atrial arrhythmias.

Journal article Am J Cardiol · May 15, 2015 Electrical cardioversion (ECV) is recommended for rhythm control in patients with atrial arrhythmia; yet, ECV use and outcomes in contemporary practice are unknown. We reviewed all nonemergent ECVs for atrial arrhythmias at a tertiary care center (2010 to ... Full text Link to item Cite

Influence of QRS infarct score and QRS duration prior to transcatheter aortic valve replacement on follow-up left ventricular end systolic volume in patients with new persistent left bundle branch block.

Journal article J Electrocardiol · 2015 BACKGROUND: New-onset left bundle branch block (LBBB) is a known complication during Transcatheter Aortic Valve Replacement (TAVR). This study evaluated the influence of pre-TAVR cardiac conditions on left ventricular functions in patients with new persist ... Full text Link to item Cite