Peter Shrader

Journal article Med Care · February 1, 2026 BACKGROUND: Institutions that participate in PCORnet® transform their local electronic health record (EHR) data into the PCORnet® Common Data Model (CDM), which is then used to generate data extracts for PCORnet® Studies. PCORnet® Studies can also include ... Full text Open Access Link to item Cite

National Versus State-Level Racial Disparities in Acute Stroke Interventions Using Get With The Guidelines-Stroke Data.

Journal article Stroke · October 2025 BACKGROUND: Racial disparities have been reported in stroke care, but understanding if there is regional variability is critical to focusing policies and resources. Here, we sought to study racial and ethnic inequity in the administration of thrombolysis a ... Full text Link to item Cite

Disease activity trajectories in paediatric lupus and associations with socioeconomic factors and patient-reported pain.

Journal article Lupus Sci Med · August 14, 2025 OBJECTIVE: Using data from participants with paediatric SLE (pSLE) in the Childhood Arthritis and Rheumatology Research Alliance Registry, we aimed to: (1) describe 2-year disease activity trajectories, measured by the SLE Disease Activity Index 2000 (SLED ... Full text Link to item Cite

The Impact of COVID-19 on Home Healthcare Workers: Results From The Healthcare Worker Exposure Response and Outcomes (HERO) Registry

Journal article Home Health Care Management and Practice · May 1, 2025 The Covid-19 pandemic highlighted home healthcare (HHC) as a crucial part of the healthcare industry that faced challenges related to staffing, exposure, and limited access to personal protective equipment. It was unknown how these challenges impacted the ... Full text Cite

Achievement of guideline-based lipid goals among very-high-risk patients with atherosclerotic cardiovascular disease and type 2 diabetes: results in 213,380 individuals from the cvMOBIUS2 registry.

Journal article Am J Prev Cardiol · March 2025 OBJECTIVE: Lowering lipid to reach guideline-indicated goals significantly reduces cardiovascular outcomes in very-high-risk (VHR) patients with atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes (DM2). How well VHR patients currently achie ... Full text Link to item Cite

Stroke-bleeding risk score pairings within individuals in the outcomes registry for better informed treatment of atrial fibrillation (ORBIT-AF) registry.

Journal article Int J Cardiol · February 15, 2025 BACKGROUND: Decisions about stroke prevention strategies in atrial fibrillation (AF) typically balance thromboembolism reduction against increased bleeding from oral anticoagulation therapy (OAC). When determining eligibility for OAC, guidelines recommend ... Full text Link to item Cite

Appropriate and inappropriate ICD shocks in patients with LVADs: Prevalence, associated factors, and etiologies.

Journal article Heart Rhythm · February 2025 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are a common complication after left ventricular assist device (LVAD) implantation; however, data on their frequency and causes are limited. OBJECTIVE: The purpose of this study was to define ... Full text Link to item Cite

Abnormal Exercise Electrocardiography With Normal Stress Echocardiography Is Associated With Subclinical Coronary Atherosclerosis.

Journal article Circ Cardiovasc Imaging · February 2025 BACKGROUND: Patients with abnormal (positive) exercise electrocardiography, but normal stress echocardiography (+ECG/-Echo), have an increased risk of adverse cardiovascular events compared with patients with a normal (negative) ECG and a normal stress Ech ... Full text Link to item Cite

Achievement of LDL-C <55 mg/dL among US adults: Findings from the cvMOBIUS2 registry.

Journal article Am Heart J · January 2025 BACKGROUND: Reflecting clinical trial data showing improved outcomes with lower LDL-C levels, guidelines across the globe are increasingly recommending a goal of LDL-C <55 mg/dL in persons with atherosclerotic cardiovascular disease (ASCVD). What proportio ... Full text Link to item Cite

Analysis of North Carolina Medicaid Claims Data to Simulate a Pediatric Accountable Care Organization.

Journal article JAMA Netw Open · August 1, 2023 IMPORTANCE: Despite momentum for pediatric value-based payment models, little is known about tailoring design elements to account for the unique needs and utilization patterns of children and young adults. OBJECTIVE: To simulate attribution to a hypothetic ... Full text Link to item Cite

Disease Recapture Rates After Medication Discontinuation and Flare in Juvenile Idiopathic Arthritis: An Observational Study Within the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal article Arthritis Care Res (Hoboken) · April 2023 OBJECTIVE: Children with well-controlled juvenile idiopathic arthritis (JIA) frequently experience flares after medication discontinuation, but the outcomes of these flares have not been well described. The objective of this study was to characterize the r ... Full text Link to item Cite

Dosing Variation at Initiation of Adalimumab and Etanercept and Clinical Outcomes in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study.

Journal article Arthritis Care Res (Hoboken) · February 2023 OBJECTIVE: To determine the dose-response relationship of tumor necrosis factor (TNF) inhibition in the treatment of juvenile idiopathic arthritis (JIA). METHODS: Participants of the Childhood Arthritis and Rheumatology Research Alliance Registry were elig ... Full text Link to item Cite

Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal article Rheumatology (Oxford) · February 1, 2023 OBJECTIVE: To describe 2-year trajectories of the clinical Juvenile Arthritis Disease Activity Score, 10 joints (cJADAS10) and associated baseline characteristics in patients with JIA. METHODS: JIA patients in the Childhood Arthritis and Rheumatology Resea ... Full text Link to item Cite

Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation.

Journal article Heart Rhythm O2 · December 2022 BACKGROUND: Oral anticoagulation (OAC) reduces the risk of thromboembolic events in patients with atrial fibrillation (AF); however, thromboembolism (TE) still can occur despite OAC. Factors associated with residual risk for stroke, systemic embolism, or t ... Full text Link to item Cite

Effectiveness and Safety of High-Dose Biologics in Juvenile Idiopathic Arthritis in the Childhood Arthritis and Rheumatology Research Alliance.

Journal article Arthritis care & research · November 2022 ObjectiveTo describe high-dose biologic use when treating juvenile idiopathic arthritis (JIA).MethodsPatients with JIA enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry and treated with a biologic after enrol ... Full text Cite

Bimodal distribution of atrial fibrillation burden in 3 distinct cohorts: What is 'paroxysmal' atrial fibrillation?

Journal article Am Heart J · February 2022 BACKGROUND: Burden of atrial fibrillation (AF), as a continuous measure, is an emerging alternative classification often assumed to increase linearly with progression of disease. Yet there are no descriptions of AF burden distributions across populations. ... Full text Link to item Cite

Comparing health care use and costs among new Medicaid enrollees before and during the COVID-19 pandemic.

Journal article BMC Health Serv Res · October 25, 2021 BACKGROUND AND OBJECTIVE: To characterize health care use and costs among new Medicaid enrollees before and during the COVID pandemic. Results can help Medicaid non-expansion states understand health care use and costs of new enrollees in a period of enrol ... Full text Link to item Cite

Children with Heterozygous Familial Hypercholesterolemia in the United States: Data from the Cascade Screening for Awareness and Detection-FH Registry.

Journal article J Pediatr · February 2021 OBJECTIVE: To describe enrollment characteristics of youth in the Cascade Screening for Awareness and Detection of FH Registry. STUDY DESIGN: This is a cross-sectional analysis of 493 participants aged <18 years with heterozygous familial hypercholesterole ... Full text Link to item Cite

Provision and Utilization of Team- and Community-Based Operative Care for Patients With Cleft Lip/Palate in North Carolina.

Journal article Cleft Palate Craniofac J · November 2020 OBJECTIVE: To characterize operative care for cleft lip and/or palate (CL/P) based on location (ie, from American Cleft Palate Craniofacial Association [ACPA]-approved multidisciplinary teams or from community providers). DESIGN: Cross-sectional analysis o ... Full text Open Access Link to item Cite

Children And The Opioid Epidemic: Age-Stratified Exposures And Harms.

Journal article Health Aff (Millwood) · October 2020 Using North Carolina Medicaid 2016-18 claims data, we found that approximately one in ten adolescents (10.8 percent) filled at least one opioid prescription per year. Dentists, advanced practice providers, and surgeons were common prescribers of opioids to ... Full text Link to item Cite

Patterns of amiodarone use and outcomes in clinical practice for atrial fibrillation.

Journal article Am Heart J · February 2020 BACKGROUND: Amiodarone is the most effective antiarrhythmic drug (AAD) for atrial fibrillation (AF), but it has a high incidence of adverse effects. METHODS: Using the ORBIT AF registry, patients with AF on amiodarone at enrollment, prescribed amiodarone d ... Full text Link to item Cite

Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation.

Journal article Am Heart J · January 2020 BACKGROUND: Comorbidities are common in patients with atrial fibrillation (AF) and affect prognosis, yet are often undertreated. However, contemporary rates of use of guideline-directed therapies (GDT) for non-AF comorbidities and their association with ou ... Full text Link to item Cite

Outcomes and Anticoagulation Use After Catheter Ablation for Atrial Fibrillation.

Journal article Circulation. Arrhythmia and electrophysiology · December 2019 BackgroundStudies evaluating the effects of atrial fibrillation (AF) catheter ablation versus antiarrhythmic therapy on outcomes have shown mixed results. In addition, guidelines recommend continuing oral anticoagulation (OAC) after ablation for t ... Full text Cite

Comparison of echocardiographic measurements to invasive measurements of diastolic function in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial.

Journal article Cardiol Young · October 2019 BACKGROUND: While echocardiographic parameters are used to quantify ventricular function in infants with single ventricle physiology, there are few data comparing these to invasive measurements. This study correlates echocardiographic measures of diastolic ... Full text Link to item Cite

Longitudinal low density lipoprotein cholesterol goal achievement and cardiovascular outcomes among adult patients with familial hypercholesterolemia: The CASCADE FH registry.

Journal article Atherosclerosis · October 2019 BACKGROUND AND AIMS: There are limited data from the US on outcomes of patients in specialty care for familial hypercholesterolemia (FH). METHODS: CASCADE FH Registry data were analyzed to assess longitudinal changes in medication usage, in low density lip ... Full text Link to item Cite

The patient journey with proprotein convertase subtilisin/kexin type 9 inhibitors in community practice.

Journal article Journal of clinical lipidology · September 2019 BackgroundTrials have demonstrated that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are effective as an adjunct to statin therapy, but access and cost issues have limited their use in community practice.ObjectiveThe a ... Full text Cite

Treatment of atrial fibrillation with concomitant coronary or peripheral artery disease: Results from the outcomes registry for better informed treatment of atrial fibrillation II.

Journal article Am Heart J · July 2019 BACKGROUND: Treatment patterns and outcomes of individuals with vascular disease who have new-onset atrial fibrillation (AF) are not well characterized. METHODS: Among patients with new-onset AF, we analyzed treatment and outcomes in those with or without ... Full text Link to item Cite

Comparison of Patient-Reported Care Satisfaction, Quality of Warfarin Therapy, and Outcomes of Atrial Fibrillation: Findings From the ORBIT - AF Registry.

Journal article J Am Heart Assoc · May 7, 2019 Background Patient satisfaction with therapy is an important metric of care quality and has been associated with greater medication persistence. We evaluated the association of patient satisfaction with warfarin therapy to other metrics of anticoagulation ... Full text Link to item Cite

Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal article J Thromb Thrombolysis · November 2018 Anticoagulation is highly effective for the prevention of stroke in patients with atrial fibrillation (AF) but it is dependent on patients continuing therapy. While studies have demonstrated suboptimal therapeutic persistence on warfarin, few have studied ... Full text Link to item Cite

Mineralocorticoid Receptor Antagonism in Patients With Atrial Fibrillation: Findings From the ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) Registry.

Journal article J Am Heart Assoc · April 13, 2018 BACKGROUND: Mineralocorticoid receptor antagonist (MRA) therapy may be beneficial to patients with atrial fibrillation (AF), but little is known about their use in patients with AF and subsequent outcomes. METHODS AND RESULTS: In order to better understand ... Full text Link to item Cite

Frequency and Outcomes of Reduced Dose Non-Vitamin K Antagonist Anticoagulants: Results From ORBIT-AF II (The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II).

Journal article J Am Heart Assoc · February 16, 2018 BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are indicated for stroke prevention in atrial fibrillation (AF) but require lower doses in certain patients. We sought to describe the frequency, appropriateness (according to Food and Drug A ... Full text Link to item Cite

Reply: Graphing Ratio Measures on Forest Plot.

Journal article J Am Coll Cardiol · February 6, 2018 Full text Link to item Cite

Association of of Atrial Fibrillation Clinical Phenotypes With Treatment Patterns and Outcomes: A Multicenter Registry Study.

Journal article JAMA Cardiol · January 1, 2018 IMPORTANCE: Atrial fibrillation (AF) is usually classified on the basis of the disease subtype. However, this characterization does not capture the full heterogeneity of AF, and a data-driven cluster analysis reveals different possible classifications of p ... Full text Link to item Cite

Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF (Outcomes Registry for Better Informed Treatment for Atrial Fibrillation).

Journal article J Am Heart Assoc · December 22, 2017 BACKGROUND: The presence of valvular heart disease (VHD) may affect the risk of stroke and mortality in patients with atrial fibrillation (AF). Community-based estimates of prevalence and outcomes of specific forms of VHD in patients with AF are lacking. M ... Full text Link to item Cite

International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: Results from the GARFIELD-AF, ORBIT-AF I, and ORBIT-AF II registries.

Journal article Am Heart J · December 2017 UNLABELLED: Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world. We aimed to provide comprehensive data on international patterns of AF stroke prevention treatment. METHODS: Demographics, comorbidities, and stroke risk of the patien ... Full text Link to item Cite

Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry.

Journal article Atherosclerosis · December 2017 BACKGROUND AND AIMS: Most familial hypercholesterolemia (FH) patients remain undertreated, and it is unclear what role health disparities may play for FH patients in the US. We sought to describe sex and racial/ethnic disparities in a national registry of ... Full text Link to item Cite

Care Patterns and Outcomes in Atrial Fibrillation Patients With and Without Diabetes: ORBIT-AF Registry.

Journal article J Am Coll Cardiol · September 12, 2017 BACKGROUND: Diabetes is a well-established risk factor for thromboembolism in patients with atrial fibrillation (AF), but less is known about how diabetes influences outcomes among AF patients. OBJECTIVES: This study assessed whether symptoms, health statu ... Full text Link to item Cite

Ranolazine reduces atrial fibrillatory wave frequency.

Journal article Europace · July 1, 2017 AIMS: Antiarrhythmic medications for the treatment of atrial fibrillation (AF) have limited efficacy and rare but potentially life-threatening side effects. Ranolazine is an antianginal agent that may have antiarrhythmic activity in AF. METHODS AND RESULTS ... Full text Link to item Cite

Factors associated with non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).

Journal article Am Heart J · July 2017 BACKGROUND: Several non-vitamin K antagonist oral anticoagulant (NOAC) alternatives to warfarin are available for stroke prevention in atrial fibrillation (AF). We aimed to describe the factors associated with selection of NOACs versus warfarin in patients ... Full text Link to item Cite

Management and outcomes of patients with atrial fibrillation and a history of cancer: the ORBIT-AF registry.

Journal article Eur Heart J Qual Care Clin Outcomes · July 1, 2017 AIMS: The presence of cancer can complicate treatment choices for patients with atrial fibrillation (AF) increasing both the risk of thrombotic and bleeding events. METHODS AND RESULTS: Using data from Outcomes Registry for Better Informed Treatment of Atr ... Full text Open Access Link to item Cite

Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life Scores in Patients With Heart Failure (from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation [ORBIT-AF]).

Journal article Am J Cardiol · June 1, 2017 The degree to which clinical outcomes are worsened in patients with atrial fibrillation (AF) with heart failure (HF) compared with those without HF is not well described. This study aimed to determine the impact of HF on clinical outcomes in patients with ... Full text Link to item Cite

Off-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes: The ORBIT-AF II Registry.

Journal article J Am Coll Cardiol · December 20, 2016 BACKGROUND: Although non-vitamin K antagonist oral anticoagulants (NOACs) do not require frequent laboratory monitoring, each compound requires dose adjustments on the basis of certain clinical criteria. OBJECTIVES: This study assessed the frequency of off ... Full text Link to item Cite

Relation of Post-Coronary Artery Bypass Graft Creatine Kinase-MB Elevations and New Q Waves With Long-Term Cardiovascular Death in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease.

Journal article Am J Cardiol · December 1, 2016 Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large po ... Full text Link to item Cite

How well does physician risk assessment predict stroke and bleeding in atrial fibrillation? Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF).

Journal article Am Heart J · November 2016 BACKGROUND: Assessments of stroke and bleeding risks are essential to selecting oral anticoagulation in patients with atrial fibrillation (AF). We aimed to assess outcomes according to physician assessed risk, with comparison to empirical risk scores. METH ... Full text Link to item Cite

Influence of Kidney Function Estimation Methods on Eligibility for Edoxaban Population Impact of the US Food and Drug Administration's Approach for Its Product Labeling.

Journal article Circulation · October 11, 2016 Full text Link to item Cite

Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.

Journal article Circ Cardiovasc Genet · June 2016 BACKGROUND: Cardiovascular disease burden and treatment patterns among patients with familial hypercholesterolemia (FH) in the United States remain poorly described. In 2013, the FH Foundation launched the Cascade Screening for Awareness and Detection (CAS ... Full text Link to item Cite

Association of Body Mass Index With Care and Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.

Journal article JACC Clin Electrophysiol · June 2016 OBJECTIVES: This study sought to determine the association between body mass index (BMI) and clinical outcomes among patients with prevalent atrial fibrillation (AF). BACKGROUND: Higher BMI is an independent risk factor for incident AF. However, its impact ... Full text Link to item Cite

Rhythm Control Versus Rate Control and Clinical Outcomes in Patients With Atrial Fibrillation: Results From the ORBIT-AF Registry.

Journal article JACC Clin Electrophysiol · April 2016 OBJECTIVES: The study sought to evaluate clinical outcomes in clinical practice with rhythm control versus rate control strategy for management of atrial fibrillation (AF). BACKGROUND: Randomized trials have not demonstrated significant differences in stro ... Full text Link to item Cite

Assessment of Quality of Life in Young Patients with Single Ventricle after the Fontan Operation.

Journal article J Pediatr · March 2016 OBJECTIVES: To assess self-reported quality of life (QOL) in a large multicenter cohort of adolescent and young adults surviving Fontan. STUDY DESIGN: Cross-sectional. The Pediatric Quality of Life Inventory (PedsQL) was administered to 408 survivors of Fo ... Full text Link to item Cite

Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles.

Journal article J Pediatr · January 2016 OBJECTIVE: To assess the variability in asymmetric growth and its association with neurodevelopment in infants with single ventricle (SV). STUDY DESIGN: We analyzed weight-for-age z-score minus head circumference-for-age z-score (HCAZ), relative head growt ... Full text Link to item Cite

US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.

Journal article J Clin Lipidol · 2016 BACKGROUND: In the US familial hypercholesterolemia (FH), patients are underidentified, despite an estimated prevalence of 1:200 to 1:500. Criteria to identify FH patients include Simon Broome, Dutch Lipid Clinic Network (DLCN), or Make Early Diagnosis to ... Full text Link to item Cite

Predictors of stroke associated with coronary artery bypass grafting in patients with diabetes mellitus and multivessel coronary artery disease.

Journal article The American journal of cardiology · May 2015 This study assesses demographic and clinical variables associated with perioperative and late stroke in diabetes mellitus patients after multivessel coronary artery bypass grafting (CABG). Future Revascularization Evaluation in Patients with Diabetes Melli ... Full text Cite

Survival data and predictors of functional outcome an average of 15 years after the Fontan procedure: the pediatric heart network Fontan cohort.

Journal article Congenit Heart Dis · 2015 OBJECTIVE: Multicenter longitudinal outcome data for Fontan patients surviving into adulthood are lacking. The aim of this study was to better understand contemporary outcomes in Fontan survivors by collecting follow-up data in a previously well-characteri ... Full text Link to item Cite

Impact of pre-stage II hemodynamics and pulmonary artery anatomy on 12-month outcomes in the Pediatric Heart Network Single Ventricle Reconstruction trial.

Journal article J Thorac Cardiovasc Surg · October 2014 OBJECTIVE: To compare the interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for the Pediatric Heart Network Single Ventricle Reconstruction trial. The trial, which randomized subjects to a modified Blalock-Taussig ... Full text Link to item Cite

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Journal article PLoS Genet · August 2014 Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GW ... Full text Link to item Cite

Dental sealants and composite restorations and longitudinal changes in immune function markers in children.

Journal article International journal of paediatric dentistry · May 2014 ObjectiveResins used in dental composites, derived from bisphenol-A (BPA), have been shown to alter immune cells. The objective of this study was to explore children's immune function changes in relation to resin composite treatment.Design Full text Cite

The relationship of patient medical and laboratory characteristics to changes in functional health status in children and adolescents after the Fontan procedure.

Journal article Pediatr Cardiol · April 2014 Despite hypothesized concerns about deterioration beginning in adolescence, longitudinal data and associated factors regarding standardized assessment of physical functioning are not available for Fontan patients. Parents who participated in the Fontan Cro ... Full text Link to item Cite

Trends in the association of parental history of obesity over 60 years.

Journal article Obesity (Silver Spring) · March 2014 OBJECTIVE: The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain. METHODS: Participants from the Framingham Heart Study were classified according to parent ... Full text Link to item Cite

Summary of: dental composite materials and renal function in children.

Journal article British dental journal · January 2014 ObjectiveTo examine whether greater exposure to resin-based composite materials, which may intra-orally release bisphenol A (BPA), is associated with worse renal function outcomes in children.DesignProspective multi-centre study.Setti ... Full text Cite

Dental sealants and flowable composite restorations and psychosocial, neuropsychological, and physical development in children.

Journal article Pediatric dentistry · January 2014 PurposeDental sealant materials may intraorally release their components, including bisphenol-A (BPA), but long-term health effects are uncertain. The New England Children's Amalgam Trial (NECAT) found that composite restorations were associated w ... Cite

Dental composite materials and renal function in children.

Predictors of disease progression in pediatric dilated cardiomyopathy.

Journal article Circ Heart Fail · November 2013 BACKGROUND: Despite medical advances, children with dilated cardiomyopathy (DCM) remain at high risk of death or need for cardiac transplantation. We sought to identify predictors of disease progression in pediatric DCM. METHODS AND RESULTS: The Pediatric ... Full text Link to item Cite

Pretreatment, psychological, and behavioral predictors of weight outcomes among lifestyle intervention participants in the Diabetes Prevention Program (DPP).

Journal article Diabetes care · January 2013 ObjectiveTo identify the most important pretreatment characteristics and changes in psychological and behavioral factors that predict weight outcomes in the Diabetes Prevention Program (DPP).Research design and methodsApproximately 25% of ... Full text Cite

Dental composites and amalgam and physical development in children.

Journal article Journal of dental research · November 2012 Resin-based composite dental restoration materials may release bisphenol-A, an endocrine-disrupting chemical. Using secondary analysis of a randomized clinical safety trial of amalgam vs. composites, we tested the hypothesis that dental restoration materia ... Full text Cite

Dental composite restorations and neuropsychological development in children: treatment level analysis from a randomized clinical trial.

Journal article Neurotoxicology · October 2012 BackgroundResin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children.ObjectivesTo examine whether exposure ... Full text Cite

Cause, timing, and location of death in the Single Ventricle Reconstruction trial.

Journal article J Thorac Cardiovasc Surg · October 2012 OBJECTIVES: The Single Ventricle Reconstruction trial randomized 555 subjects with a single right ventricle undergoing the Norwood procedure at 15 North American centers to receive either a modified Blalock-Taussig shunt or right ventricle-to-pulmonary art ... Full text Link to item Cite

Dental composite restorations and psychosocial function in children.

Journal article Pediatrics · August 2012 Background and objectiveResin-based dental materials may intraorally release their chemical components and bisphenol A. The New England Children's Amalgam Trial found that children randomized to amalgam had better psychosocial outcomes than those ... Full text Cite

Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium.

Journal article Diabetes · June 2012 Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction of association with 20 T2D risk variants generalizes across six major racial/ethnic groups ... Full text Cite

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Journal article Diabetes · May 2012 Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. Howeve ... Full text Cite

Parental intermittent claudication as risk factor for claudication in adults.

Journal article Am J Cardiol · March 1, 2012 Little is known about the familial aggregation of intermittent claudication (IC). Our objective was to examine whether parental IC increased the risk of IC in adult offspring, independent of the established cardiovascular risk factors. We evaluated the Off ... Full text Link to item Cite

A genome-wide association search for type 2 diabetes genes in African Americans.

Journal article PLoS One · 2012 African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African Ameri ... Full text Link to item Cite

Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.

Journal article Metabolic syndrome and related disorders · December 2011 BackgroundElevated insulin resistance (IR), triglycerides (TG), body mass index (BMI), and waist circumference (WC) are features of the metabolic syndrome. Although several single-nucleotide polymorphisms (SNPs) associated with these traits have b ... Full text Cite

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Journal article Nat Genet · October 16, 2011 Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are n ... Full text Link to item Cite

Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.

Journal article Obesity (Silver Spring, Md.) · October 2011 Inhibition of the endocannabinoid receptor CB1 improves insulin sensitivity, lowers glycemia, and slows atherosclerosis. We analyzed whether common variants in the gene encoding CB1, CNR1, are associated with insulin resistance, risk of type 2 diabetes (T2 ... Full text Cite

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies.

Journal article Diabetes research and clinical practice · August 2011 ObjectiveParental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown.MethodsWe examined the association between parental history of diabetes ... Full text Cite

Insulin resistance influences the association of adiponectin levels with diabetes incidence in two population-based cohorts: the Cooperative Health Research in the Region of Augsburg (KORA) S4/F4 study and the Framingham Offspring Study.

Journal article Diabetologia · May 2011 Aims/hypothesisLower adiponectin levels are associated with higher risk of incident type 2 diabetes. Most analyses have been adjusted for confounding factors, but few have taken into account insulin resistance per se. We tested the hypothesis that ... Full text Cite

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

Journal article PLoS Genet · February 10, 2011 Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- and HDL-cholesterol (LDL-C and HDL-C), hypertension, smoking, and type-2 diabetes) ... Full text Link to item Cite

Erratum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Journal article Nature Genetics · February 1, 2011 Full text Cite

Higher adiponectin levels predict greater weight gain in healthy women in the Nurses' Health Study.

Journal article Obesity (Silver Spring, Md.) · February 2011 Adiponectin and resistin's possible roles in weight regulation have received little attention. We tested the hypothesis that adipokine levels predict future weight gain in women in the Nurses' Health Study. Among women who provided blood samples in 1990, w ... Full text Cite

Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

Journal article Diabetes Care · January 2011 OBJECTIVE: To test if knowledge of type 2 diabetes genetic variants improves disease prediction. RESEARCH DESIGN AND METHODS: We tested 40 single nucleotide polymorphisms (SNPs) associated with diabetes in 3,471 Framingham Offspring Study subjects followed ... Full text Link to item Cite

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.

Journal article Diabetes · December 2010 OBJECTIVE: Glycated hemoglobin (HbA₁(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated wi ... Full text Link to item Cite

Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population.

Journal article Diabetes care · November 2010 ObjectiveTo estimate allele frequencies and the marginal and combined effects of novel fasting glucose (FG)-associated single nucleotide polymorphisms (SNPs) on FG levels and on risk of impaired FG (IFG) among non-Hispanic white, non-Hispanic blac ... Full text Cite

Effectiveness of a computerized insulin order template in general medical inpatients with type 2 diabetes: a cluster randomized trial.

Journal article Diabetes care · October 2010 ObjectiveTo determine whether an electronic order template for basal-bolus insulin ordering improves mean blood glucose in hospitalized general medical patients with hyperglycemia and type 2 diabetes.Research design and methodsWe randomly ... Full text Cite

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Journal article Nature genetics · July 2010 By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified ... Full text Cite

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

Journal article Nature Genetics · May 1, 2010 Full text Cite

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.

Journal article Diabetes · May 2010 OBJECTIVE Recent genome-wide association studies have revealed loci associated with glucose and insulin-related traits. We aimed to characterize 19 such loci using detailed measures of insulin processing, secretion, and sensitivity to help elucidate their ... Full text Cite

The association of tumor necrosis factor alpha receptor 2 and tumor necrosis factor alpha with insulin resistance and the influence of adipose tissue biomarkers in humans.

Journal article Metabolism: clinical and experimental · April 2010 Tumor necrosis factor alpha (TNFalpha) is a proinflammatory adipokine hypothesized to link obesity with insulin resistance. Functional studies suggest that TNFalpha acts through pathways involving adipokines and fatty acids to induce insulin resistance. We ... Full text Cite

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.

Journal article Nature genetics · February 2010 Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up ... Full text Cite

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

Journal article Nature genetics · February 2010 Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA ... Full text Cite

Diabetes Risk Perception and Intention to Adopt Healthy Lifest yles Among Primary Care Patients.

Journal article Diabetes care · October 2009 ObjectiveTo examine perceived risk of developing diabetes in primary care patients.Research design and methodsWe recruited 150 nondiabetic primary care patients. We made standard clinical measurements, collected fasting blood samples, and ... Full text Cite

Circulating IL-18 and the risk of type 2 diabetes in women.

Journal article Diabetologia · October 2009 Aims/hypothesisThe pathophysiology of type 2 diabetes involves pro-inflammatory pathways. We tested the hypothesis that IL-18 predicts future diabetes cases.MethodsWe used a nested case-control design based in the Nurses' Health Study. Ba ... Full text Cite

Identifying primary care patients at risk for future diabetes and cardiovascular disease using electronic health records.

Journal article BMC health services research · September 2009 BackgroundPrevention of diabetes and coronary heart disease (CHD) is possible but identification of at-risk patients for targeting interventions is a challenge in primary care.MethodsWe analyzed electronic health record (EHR) data for 122 ... Full text Cite

Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus.

Journal article Clinica chimica acta; international journal of clinical chemistry · August 2009 BackgroundDiabetes mellitus is a major risk factor for coronary heart disease (CHD), renal failure, retinopathy, and neuropathy. Lowering glycosylated hemoglobin (HbA1c) as well as low-density lipoprotein-cholesterol (LDL-C) has been associated wi ... Full text Cite

Genotype score in addition to common risk factors for prediction of type 2 diabetes.

Journal article The New England journal of medicine · November 2008 BackgroundMultiple genetic loci have been convincingly associated with the risk of type 2 diabetes mellitus. We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors al ... Full text Cite

Temporal trends in self-reported functional limitations and physical disability among the community-dwelling elderly population: the Framingham heart study.

Journal article Am J Public Health · July 2008 OBJECTIVES: We sought to determine change in the prevalence of functional limitations and physical disability among the community-dwelling elderly population across 3 decades. METHODS: We studied original participants of the Framingham Heart Study, aged 79 ... Full text Link to item Cite