Qianben Wang
Professor of Pathology
Dr. Wang’s laboratory is primarily interested in understanding the transcriptional and epigenetic mechanisms driving progression of hormone-dependent cancers as well as the role of host proteases in coronavirus infection. His recent studies are designed to combine CRISPR/Cas13 technologies with nanotechnology to target undruggable transcription factors in cancers and host proteases for controlling SARS-CoV-2 infection.
Current Appointments & Affiliations
- Professor of Pathology, Pathology, Clinical Science Departments 2018
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
Contact Information
- Room 1027A, Gsrb1, Box #103864,, Durham, NC 27710
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qianben.wang@duke.edu
(919) 613-9982
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Qianben Wang Laboratory
- Background
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Education, Training, & Certifications
- Postdoctoral Fellow/Instructor in Molecular and Cellular Oncology, Dana Farber Cancer Institute, Harvard Medical School 2003 - 2008
- Ph.D., University of Maryland, Baltimore 2002
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Previous Appointments & Affiliations
- Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2017 - 2018
- Recognition
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In the News
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AUG 20, 2022 The Telegraph, UK -
AUG 3, 2022 NBC10 -
AUG 1, 2022 FOX8 -
JUL 31, 2022 CBS17 -
JUL 26, 2022 MedicalXpress.com -
JUL 26, 2022 The News & Observer -
JUL 26, 2022 -
JUL 25, 2022 Duke University School of Medicine News Room -
JUL 25, 2022 ABC11 -
JUN 4, 2021 DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS -
MAY 31, 2018 Duke University School of Medicine
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- Research
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Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Targeting oncogenomic function of N-Myc to inhibit neuroendocrine prostate cancer visceral metastasis awarded by Department of Defense 2023 - 2026
- Systems analysis of the prostate cancer epigenome awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Role of JMJD1A modifications in castration resistance of prostate cancer awarded by University of Maryland, Baltimore 2022 - 2025
- Exploiting Ferroptosis for the Treatment of RB1-Deficient Lethal Prostate Cancer awarded by Department of Defense 2022 - 2024
- Targeting neuroendocrine prostate cancer by engineering 3' untranslated regions awarded by Department of Defense 2020 - 2024
- Targeting the Oncogenomic Function of the E2F8 Transcription Factor in Lethal Cancer awarded by Department of Defense 2022 - 2024
- Computational and Experimental Modeling of Alternative Polyadenylation awarded by University of California - Irvine 2022 - 2024
- Adjuvant Comparison for Peanut Allergy Immunotherapy awarded by National Institutes of Health 2022 - 2023
- FOXA2-targeted organ-selective nanotherapy for prostate cancer visceral metastasis awarded by Mike Slive Foundation 2022
- Role of oncogenic phosphorylated MED1 in aggressive prostate cancer awarded by National Institutes of Health 2017 - 2022
- Systems Analysis of Epigenomic Architecture in Cancer Progression (Outreach Core) awarded by University of Texas Health Science Center at San Antonio 2019 - 2022
- Systems Analysis of Epigenomic Architecture in Cancer Progression (Administrative Core) awarded by University of Texas Health Science Center at San Antonio 2017 - 2022
- Systems Analysis of Epigenomic Architecture in Cancer Progression (Project 2: Fine-scale nucleosome repositioning of enhancers for hormone-independent genomic function) awarded by University of Texas Health Science Center at San Antonio 2017 - 2022
- Novel genomic mechanism for ligand-dependent transcription by androgen receptor awarded by National Institutes of Health 2017 - 2022
- Targeting castration-resistant prostate cancer by engineering 3'UTR awarded by Department of Defense 2020 - 2022
- Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer awarded by Ohio State University 2017 - 2021
- Systems Analysis of Epigenomic Architecture in Cancer Progression (Carryover) awarded by University of Texas Health Science Center at San Antonio 2020 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Population/single-cell profiling of chromatin accessibility for hormone-dependent cancers awarded by University of Texas Health Science Center at San Antonio 2018 - 2019
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External Relationships
- NIH, Ohio State University, University of Kentucky, Journal editorial board: Molecular Cancer Research, American Journal of Cancer Research, and Cancer Innovation.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Wang, Mu-En, Jiaqi Chen, Yi Lu, Alyssa R. Bawcom, Jinjin Wu, Jianhong Ou, John M. Asara, et al. “RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis.” J Clin Invest 133, no. 10 (May 15, 2023). https://doi.org/10.1172/JCI166647.Full Text Open Access Copy Link to Item
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Jeon, Hee-Young, Majid Pornour, Hyunju Ryu, Sudeep Khadka, Rui Xu, Jihyun Jang, Deqiang Li, et al. “SMAD3 promotes expression and activity of the androgen receptor in prostate cancer.” Nucleic Acids Res 51, no. 6 (April 11, 2023): 2655–70. https://doi.org/10.1093/nar/gkad043.Full Text Link to Item
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Cui, Zhifen, Cong Zeng, Furong Huang, Fuwen Yuan, Jingyue Yan, Yue Zhao, Yufan Zhou, et al. “Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection.” Nat Chem Biol 18, no. 10 (October 2022): 1056–64. https://doi.org/10.1038/s41589-022-01094-4.Full Text Link to Item
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Li, Tianbao, Qi Liu, Zhong Chen, Kun Fang, Furong Huang, Xueqi Fu, Qianben Wang, and Victor X. Jin. “Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model.” Nat Commun 13, no. 1 (June 7, 2022): 3145. https://doi.org/10.1038/s41467-022-30960-x.Full Text Open Access Copy Link to Item
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Chen, Zhong, Zhenqing Ye, Raymond E. Soccio, Tomoyoshi Nakadai, William Hankey, Yue Zhao, Furong Huang, et al. “Phosphorylated MED1 links transcription recycling and cancer growth.” Nucleic Acids Res 50, no. 8 (May 6, 2022): 4450–63. https://doi.org/10.1093/nar/gkac246.Full Text Link to Item
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Frankhouser, David E., Sarah Steck, Michael G. Sovic, Martha A. Belury, Qianben Wang, Steven K. Clinton, Ralf Bundschuh, Pearlly S. Yan, and Lisa D. Yee. “Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study.” J Nutr Biochem 99 (January 2022): 108839. https://doi.org/10.1016/j.jnutbio.2021.108839.Full Text Link to Item
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Chen, Zhong, William Hankey, Yue Zhao, Jeff Groth, Furong Huang, Hongyan Wang, Alexandre Rosa Campos, Jiaoti Huang, Robert G. Roeder, and Qianben Wang. “Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling.” Nat Commun 12, no. 1 (November 3, 2021): 6318. https://doi.org/10.1038/s41467-021-26604-1.Full Text Link to Item
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Xu, Lingfan, Yu Yin, Yanjing Li, Xufeng Chen, Yan Chang, Hong Zhang, Juan Liu, et al. “A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.” Proc Natl Acad Sci U S A 118, no. 13 (March 30, 2021). https://doi.org/10.1073/pnas.2012748118.Full Text Link to Item
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Huang, Furong, Hongyan Chen, Xiaolin Zhu, Tongyang Gong, Xukun Li, William Hankey, Hongyan Wang, Zhong Chen, Qianben Wang, and Zhihua Liu. “The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3.” Cell Res 31, no. 3 (March 2021): 362–65. https://doi.org/10.1038/s41422-020-00428-y.Full Text Link to Item
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Yuan, Fuwen, William Hankey, Eric J. Wagner, Wei Li, and Qianben Wang. “Alternative polyadenylation of mRNA and its role in cancer.” Genes Dis 8, no. 1 (January 2021): 61–72. https://doi.org/10.1016/j.gendis.2019.10.011.Full Text Link to Item
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Hankey, William, Benjamin Sunkel, Fuwen Yuan, Haiyan He, Jennifer M. Thomas-Ahner, Zhong Chen, Steven K. Clinton, Jiaoti Huang, and Qianben Wang. “Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range.” Transl Oncol 13, no. 9 (September 2020): 100797. https://doi.org/10.1016/j.tranon.2020.100797.Full Text Link to Item
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Hankey, William, Zhong Chen, and Qianben Wang. “Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors.” Cancer Res 80, no. 12 (June 15, 2020): 2427–36. https://doi.org/10.1158/0008-5472.CAN-19-3447.Full Text Link to Item
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Li, Yanjing, Yiping He, William Butler, Lingfan Xu, Yan Chang, Kefeng Lei, Hong Zhang, et al. “Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer.” Sci Transl Med 11, no. 521 (December 4, 2019). https://doi.org/10.1126/scitranslmed.aax0428.Full Text Link to Item
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Yuan, Fuwen, William Hankey, Dayong Wu, Hongyan Wang, Jason Somarelli, Andrew J. Armstrong, Jiaoti Huang, Zhong Chen, and Qianben Wang. “Molecular determinants for enzalutamide-induced transcription in prostate cancer.” Nucleic Acids Res 47, no. 19 (November 4, 2019): 10104–14. https://doi.org/10.1093/nar/gkz790.Full Text Open Access Copy Link to Item
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Lee, Ying-Ying, Myth Ts Mok, Wei Kang, Weiqin Yang, Wenshu Tang, Feng Wu, Liangliang Xu, et al. “Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.” Nucleic Acids Res 46, no. 17 (September 28, 2018): 8832–47. https://doi.org/10.1093/nar/gky589.Full Text Open Access Copy Link to Item
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Hankey, William, Zhong Chen, Maxwell J. Bergman, Max O. Fernandez, Baris Hancioglu, Xun Lan, Anil G. Jegga, et al. “Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.” Oncotarget 9, no. 58 (July 27, 2018): 31214–30. https://doi.org/10.18632/oncotarget.25781.Full Text Open Access Copy Link to Item
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Chen, Zhong, Dayong Wu, Jennifer M. Thomas-Ahner, Changxue Lu, Pei Zhao, Qingfu Zhang, Connor Geraghty, et al. “Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13.” Proc Natl Acad Sci U S A 115, no. 26 (June 26, 2018): 6810–15. https://doi.org/10.1073/pnas.1718811115.Full Text Link to Item
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Horning, Aaron M., Yao Wang, Che-Kuang Lin, Anna D. Louie, Rohit R. Jadhav, Chia-Nung Hung, Chiou-Miin Wang, et al. “Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response.” Cancer Res 78, no. 4 (February 15, 2018): 853–64. https://doi.org/10.1158/0008-5472.CAN-17-1924.Full Text Link to Item
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McNair, C., A. Urbanucci, C. E. S. Comstock, M. A. Augello, J. F. Goodwin, R. Launchbury, S. G. Zhao, et al. “Cell cycle-coupled expansion of AR activity promotes cancer progression.” Oncogene 36, no. 12 (March 23, 2017): 1655–68. https://doi.org/10.1038/onc.2016.334.Full Text
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Ye, Zhenqing, Zhong Chen, Benjamin Sunkel, Seth Frietze, Tim H-M Huang, Qianben Wang, and Victor X. Jin. “Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1.” Nucleic Acids Res 44, no. 16 (September 19, 2016): 7540–54. https://doi.org/10.1093/nar/gkw659.Full Text Link to Item
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Sunkel, Benjamin, Dayong Wu, Zhong Chen, Chiou-Miin Wang, Xiangtao Liu, Zhenqing Ye, Aaron M. Horning, et al. “Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.” Nucleic Acids Res 44, no. 9 (May 19, 2016): 4105–22. https://doi.org/10.1093/nar/gkv1528.Full Text Link to Item
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Tang, Xing, Huayang Liu, Arunima Srivastava, Thierry Pécot, Zhong Chen, Qianben Wang, Kun Huang, et al. “Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.” Sci Data 3 (February 16, 2016): 160008. https://doi.org/10.1038/sdata.2016.8.Full Text Link to Item
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Chen, Kaifu, Zhong Chen, Dayong Wu, Lili Zhang, Xueqiu Lin, Jianzhong Su, Benjamin Rodriguez, et al. “Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.” Nat Genet 47, no. 10 (October 2015): 1149–57. https://doi.org/10.1038/ng.3385.Full Text Link to Item
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Chen, Zhong, Xun Lan, Dayong Wu, Benjamin Sunkel, Zhenqing Ye, Jiaoti Huang, Zhihua Liu, Steven K. Clinton, Victor X. Jin, and Qianben Wang. “Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer.” Nat Commun 6 (September 16, 2015): 8323. https://doi.org/10.1038/ncomms9323.Full Text Link to Item
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Liu, Huayang, Xing Tang, Arunima Srivastava, Thierry Pécot, Piotr Daniel, Benjamin Hemmelgarn, Stephan Reyes, et al. “Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.” Nat Cell Biol 17, no. 8 (August 2015): 1036–48. https://doi.org/10.1038/ncb3210.Full Text Link to Item
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He, Huiling, Wei Li, Sandya Liyanarachchi, Mukund Srinivas, Yanqiang Wang, Keiko Akagi, Yao Wang, et al. “Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.” Proceedings of the National Academy of Sciences 112, no. 19 (May 12, 2015): 6128–33. https://doi.org/10.1073/pnas.1506255112.Full Text
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Chen, Zhong, Xun Lan, Jennifer M. Thomas-Ahner, Dayong Wu, Xiangtao Liu, Zhenqing Ye, Liguo Wang, et al. “Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer.” Embo J 34, no. 4 (February 12, 2015): 502–16. https://doi.org/10.15252/embj.201490306.Full Text Link to Item
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Wu, Dayong, Benjamin Sunkel, Zhong Chen, Xiangtao Liu, Zhenqing Ye, Qianjin Li, Cassandra Grenade, et al. “Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.” Nucleic Acids Res 42, no. 6 (April 2014): 3607–22. https://doi.org/10.1093/nar/gkt1382.Full Text Link to Item
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Ye, Zhenqing, Zhong Chen, Xun Lan, Stephen Hara, Benjamin Sunkel, Tim H-M Huang, Laura Elnitski, Qianben Wang, and Victor X. Jin. “Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors.” Nucleic Acids Res 42, no. 5 (March 2014): 2856–69. https://doi.org/10.1093/nar/gkt1338.Full Text Link to Item
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Zhang, Mei, Parmeet K. Manchanda, Dayong Wu, Qianben Wang, and Lawrence S. Kirschner. “Knockdown of PRKAR1A, the Gene Responsible for Carney Complex, Interferes With Differentiation in Osteoblastic Cells.” Molecular Endocrinology 28, no. 3 (March 1, 2014): 295–307. https://doi.org/10.1210/me.2013-1152.Full Text
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Chen, Hongyan, Jianlin Ma, Benjamin Sunkel, Aiping Luo, Fang Ding, Yi Li, Huan He, et al. “S100A14: Novel Modulator of Terminal Differentiation in Esophageal Cancer.” Molecular Cancer Research 11, no. 12 (December 1, 2013): 1542–53. https://doi.org/10.1158/1541-7786.mcr-13-0317.Full Text
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He, Huiling, Wei Li, Dayong Wu, Rebecca Nagy, Sandya Liyanarachchi, Keiko Akagi, Jaroslaw Jendrzejewski, et al. “Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance.” Edited by Xiao-Ping Miao. Plos One 8, no. 5 (May 14, 2013): e61920–e61920. https://doi.org/10.1371/journal.pone.0061920.Full Text
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Cai, Changmeng, Hongyun Wang, Housheng Hansen He, Sen Chen, Lingfeng He, Fen Ma, Lorelei Mucci, et al. “ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.” Journal of Clinical Investigation 123, no. 3 (March 1, 2013): 1109–22. https://doi.org/10.1172/jci66666.Full Text
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Cui, Jiajun, Katherine Germer, Tianying Wu, Jiang Wang, Jia Luo, Shao-chun Wang, Qianben Wang, and Xiaoting Zhang. “Cross-talk between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells.” Cancer Research 72, no. 21 (November 1, 2012): 5625–34. https://doi.org/10.1158/0008-5472.can-12-1305.Full Text
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Sunkel, Benjamin, and Qianben Wang. “Mapping mutations in prostate cancer exomes.” Asian Journal of Andrology 14, no. 6 (November 2012): 801–2. https://doi.org/10.1038/aja.2012.75.Full Text
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Lan, Xun, Heather Witt, Koichi Katsumura, Zhenqing Ye, Qianben Wang, Emery H. Bresnick, Peggy J. Farnham, and Victor X. Jin. “Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages.” Nucleic Acids Research 40, no. 16 (September 2012): 7690–7704. https://doi.org/10.1093/nar/gks501.Full Text
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Taslim, Cenny, Zhong Chen, Kun Huang, Tim Hui-Ming Huang, Qianben Wang, and Shili Lin. “Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.” Nucleic Acids Res 40, no. 11 (June 2012): 4754–64. https://doi.org/10.1093/nar/gks139.Full Text Link to Item
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Zhao, Jonathan C., Jianjun Yu, Christine Runkle, Longtao Wu, Ming Hu, Dayong Wu, Jun S. Liu, Qianben Wang, Zhaohui S. Qin, and Jindan Yu. “Cooperation between Polycomb and androgen receptor during oncogenic transformation.” Genome Research 22, no. 2 (February 2012): 322–31. https://doi.org/10.1101/gr.131508.111.Full Text
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Wu, Dayong, Chunpeng Zhang, Yanping Shen, Kenneth P. Nephew, and Qianben Wang. “Androgen receptor-driven chromatin looping in prostate cancer.” Trends in Endocrinology &Amp; Metabolism 22, no. 12 (December 2011): 474–80. https://doi.org/10.1016/j.tem.2011.07.006.Full Text
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Zhang, Chunpeng, Liguo Wang, Dayong Wu, Hongyan Chen, Zhong Chen, Jennifer M. Thomas-Ahner, Debra L. Zynger, et al. “Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.” Cancer Res 71, no. 21 (November 1, 2011): 6738–48. https://doi.org/10.1158/0008-5472.CAN-11-1882.Full Text Link to Item
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Wang, Hongyan, Chunpeng Zhang, Anna Rorick, Dayong Wu, Ming Chiu, Jennifer Thomas-Ahner, Zhong Chen, et al. “CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability.” Cancer Res 71, no. 14 (July 15, 2011): 4866–76. https://doi.org/10.1158/0008-5472.CAN-10-4576.Full Text Link to Item
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Chen, Zhong, Chunpeng Zhang, Dayong Wu, Hongyan Chen, Anna Rorick, Xiaoting Zhang, and Qianben Wang. “Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.” Embo J 30, no. 12 (May 10, 2011): 2405–19. https://doi.org/10.1038/emboj.2011.154.Full Text Link to Item
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Chen, Chun-Han, Po-Hsien Huang, Po-Chen Chu, Mei-Chuan Chen, Chih-Chien Chou, Dasheng Wang, Samuel K. Kulp, Che-Ming Teng, Qianben Wang, and Ching-Shih Chen. “Energy Restriction-mimetic Agents Induce Apoptosis in Prostate Cancer Cells in Part through Epigenetic Activation of KLF6 Tumor Suppressor Gene Expression.” Journal of Biological Chemistry 286, no. 12 (March 2011): 9968–76. https://doi.org/10.1074/jbc.m110.203240.Full Text
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Frigo, Daniel E., Matthew K. Howe, Bryan M. Wittmann, Abigail M. Brunner, Ian Cushman, Qianben Wang, Myles Brown, Anthony R. Means, and Donald P. McDonnell. “CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells.” Cancer Res 71, no. 2 (January 15, 2011): 528–37. https://doi.org/10.1158/0008-5472.CAN-10-2581.Full Text Link to Item
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Chen, Zhong, Liguo Wang, Qianben Wang, and Wei Li. “Histone modifications and chromatin organization in prostate cancer.” Epigenomics 2, no. 4 (August 2010): 551–60. https://doi.org/10.2217/epi.10.31.Full Text Link to Item
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Hsu, Pei-Yin, Hang-Kai Hsu, Gregory A. C. Singer, Pearlly S. Yan, Benjamin A. T. Rodriguez, Joseph C. Liu, Yu-I Weng, et al. “Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.” Genome Res 20, no. 6 (June 2010): 733–44. https://doi.org/10.1101/gr.101923.109.Full Text Link to Item
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He, Housheng Hansen, Clifford A. Meyer, Hyunjin Shin, Shannon T. Bailey, Gang Wei, Qianben Wang, Yong Zhang, et al. “Nucleosome dynamics define transcriptional enhancers.” Nature Genetics 42, no. 4 (April 2010): 343–47. https://doi.org/10.1038/ng.545.Full Text
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Frigo, Daniel E., Andrea B. Sherk, Bryan M. Wittmann, John D. Norris, Qianben Wang, James D. Joseph, Aidan P. Toner, Myles Brown, and Donald P. McDonnell. “Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.” Mol Endocrinol 23, no. 9 (September 2009): 1385–96. https://doi.org/10.1210/me.2009-0010.Full Text Link to Item
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Wang, Qianben, Wei Li, Yong Zhang, Xin Yuan, Kexin Xu, Jindan Yu, Zhong Chen, et al. “Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.” Cell 138, no. 2 (July 23, 2009): 245–56. https://doi.org/10.1016/j.cell.2009.04.056.Full Text Link to Item
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Sun, Tong, Qianben Wang, Steven Balk, Myles Brown, Gwo-Shu Mary Lee, and Philip Kantoff. “The Role of microRNA-221 and microRNA-222 in Androgen-Independent Prostate Cancer Cell Lines.” Cancer Research 69, no. 8 (April 15, 2009): 3356–63. https://doi.org/10.1158/0008-5472.can-08-4112.Full Text
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Nwachukwu, Jerome C., Paolo Mita, Rachel Ruoff, Susan Ha, Qianben Wang, S Joseph Huang, Samir S. Taneja, et al. “Genome-Wide Impact of Androgen Receptor Trapped clone-27 Loss on Androgen-Regulated Transcription in Prostate Cancer Cells.” Cancer Research 69, no. 7 (April 1, 2009): 3140–47. https://doi.org/10.1158/0008-5472.can-08-3738.Full Text
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Agoulnik, Irina U., William E. Bingman, Manjula Nakka, Wei Li, Qianben Wang, X Shirley Liu, Myles Brown, and Nancy L. Nancy L. “Target Gene-Specific Regulation of Androgen Receptor Activity by p42/p44 Mitogen-Activated Protein Kinase.” Molecular Endocrinology 22, no. 11 (November 1, 2008): 2420–32. https://doi.org/10.1210/me.2007-0481.Full Text
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Bao, Bo-Ying, Bin-Fay Chuang, Qianben Wang, Oliver Sartor, Steven P. Balk, Myles Brown, Philip W. Kantoff, and Gwo-Shu Mary Lee. “Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes.” The Prostate 68, no. 8 (June 1, 2008): 839–48. https://doi.org/10.1002/pros.20749.Full Text
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Lupien, Mathieu, Jérôme Eeckhoute, Clifford A. Meyer, Qianben Wang, Yong Zhang, Wei Li, Jason S. Carroll, X Shirley Liu, and Myles Brown. “FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription.” Cell 132, no. 6 (March 2008): 958–70. https://doi.org/10.1016/j.cell.2008.01.018.Full Text
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Wang, Qianben, Wei Li, X Shirley Liu, Jason S. Carroll, Olli A. Jänne, Erika Krasnickas Keeton, Arul M. Chinnaiyan, Kenneth J. Pienta, and Myles Brown. “A Hierarchical Network of Transcription Factors Governs Androgen Receptor-Dependent Prostate Cancer Growth.” Molecular Cell 27, no. 3 (August 2007): 380–92. https://doi.org/10.1016/j.molcel.2007.05.041.Full Text
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Carroll, Jason S., Clifford A. Meyer, Jun Song, Wei Li, Timothy R. Geistlinger, Jérôme Eeckhoute, Alexander S. Brodsky, et al. “Genome-wide analysis of estrogen receptor binding sites.” Nature Genetics 38, no. 11 (November 2006): 1289–97. https://doi.org/10.1038/ng1901.Full Text
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Wang, Qianben, Jason S. Carroll, and Myles Brown. “Spatial and Temporal Recruitment of Androgen Receptor and Its Coactivators Involves Chromosomal Looping and Polymerase Tracking.” Molecular Cell 19, no. 5 (September 2005): 631–42. https://doi.org/10.1016/j.molcel.2005.07.018.Full Text
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Wang, Qianben, T. S. Udayakumar, Tadas S. Vasaitis, Angela M. Brodie, and Joseph D. Fondell. “Mechanistic Relationship between Androgen Receptor Polyglutamine Tract Truncation and Androgen-dependent Transcriptional Hyperactivity in Prostate Cancer Cells.” Journal of Biological Chemistry 279, no. 17 (April 2004): 17319–28. https://doi.org/10.1074/jbc.m400970200.Full Text
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Wang, Qianben, Dipali Sharma, Yunsheng Ren, and Joseph D. Fondell. “A Coregulatory Role for the TRAP-Mediator Complex in Androgen Receptor-mediated Gene Expression.” Journal of Biological Chemistry 277, no. 45 (November 2002): 42852–58. https://doi.org/10.1074/jbc.m206061200.Full Text
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Zhang, Yuexing, Joseph D. Fondell, Qianben Wang, Xianmin Xia, Aiwu Cheng, Michael L. Lu, and Anne W. Hamburger. “Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1.” Oncogene 21, no. 36 (August 15, 2002): 5609–18. https://doi.org/10.1038/sj.onc.1205638.Full Text
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Wang, Qianben, and Joseph D. Fondell. “Generation of a Mammalian Cell Line Stably Expressing a Tetracycline-Regulated Epitope-Tagged Human Androgen Receptor: Implications for Steroid Hormone Receptor Research.” Analytical Biochemistry 289, no. 2 (February 2001): 217–30. https://doi.org/10.1006/abio.2000.4960.Full Text
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Ren, Yunsheng, Evan Behre, Zhaojun Ren, Jiachang Zhang, Qianben Wang, and Joseph D. Fondell. “Specific Structural Motifs Determine TRAP220 Interactions with Nuclear Hormone Receptors.” Molecular and Cellular Biology 20, no. 15 (August 1, 2000): 5433–46. https://doi.org/10.1128/mcb.20.15.5433-5446.2000.Full Text
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Other Articles
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Hankey, William, Zhong Chen, and Qianben Wang. “Supplementary Table 1 from Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors,” March 31, 2023. https://doi.org/10.1158/0008-5472.22423572.v1.Full Text
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Hankey, William, Zhong Chen, and Qianben Wang. “Data from Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors,” March 31, 2023. https://doi.org/10.1158/0008-5472.c.6511524.Full Text
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Hankey, William, Zhong Chen, and Qianben Wang. “Data from Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors,” March 31, 2023. https://doi.org/10.1158/0008-5472.c.6511524.v1.Full Text
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Hankey, William, Zhong Chen, and Qianben Wang. “Supplementary Table 1 from Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors,” March 31, 2023. https://doi.org/10.1158/0008-5472.22423572.Full Text
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