Overview
Dr. Wang's laboratory is primarily focused on understanding the transcriptional and epigenetic mechanisms that drive the progression of hormone-dependent cancers. Additionally, they investigate the role of host proteases in coronavirus infection. Their recent studies aim to combine CRISPR/Cas13 technologies with nanotechnology to target undruggable transcription factors in cancers and host proteases for controlling infections caused by SARS-CoV-2 and related coronaviruses.
Current Appointments & Affiliations
Banks Anderson, Sr. Distinguished Professor
·
2024 - Present
Pathology,
Clinical Science Departments
Professor of Pathology
·
2018 - Present
Pathology,
Clinical Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2018 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
SCORT-Cas13d Nanotherapy Precisely Targets the 'Undruggable' Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo.
Journal Article Adv Sci (Weinh) · May 11, 2025 Metastatic cancer, the primary cause of cancer mortality, frequently exhibits heightened dependence on certain transcription factors (TFs), which serve as master regulators of oncogenic signaling yet are often untargetable by small molecules. Selective Cel ... Full text Link to item CiteIntegrative analysis identifies the atypical repressor E2F8 as a targetable transcriptional activator driving lethal prostate cancer.
Journal Article Oncogene · March 2025 Acquired resistance to androgen receptor (AR)-targeted therapies underscores the need to identify alternative therapeutic targets for treating lethal prostate cancer. In this study, we evaluated the prognostic significance of 1635 human transcription facto ... Full text Link to item CiteHormone-induced enhancer assembly requires an optimal level of hormone receptor multivalent interactions.
Journal Article Mol Cell · October 5, 2023 Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in response to signals, but our understanding of enhancer assembly during signaling events is incomplete. Here, we show that androgen receptor (AR) forms condensates throug ... Full text Link to item CiteRecent Grants
Targeting Undruggable Transcription Factor HoxB13 to Inhibit Prostate Cancer Metastasis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029Elucidating alternative polyadenylation regulation during prostate cancer progression to castration-resistance
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Targeting MED31-driven transcription recycling in lethal prostate cancer
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2023 - 2028View All Grants
Education, Training & Certifications
University of Maryland, Baltimore ·
2002
Ph.D.