Qingwen Chen

Journal Article Nature genetics · December 2025 Most studies to date of protein quantitative trait loci (pQTLs) have relied on affinity proteomics platforms, which provide only limited information about the targeted protein isoforms and may be affected by genetic variation in their epitope binding. Here ... Full text Cite

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · November 2025 Epigenetic clocks in blood have shown promise as tools to quantify biological age, displaying robust associations with morbidity and all-cause mortality. Whilst the effect of cell-type heterogeneity on epigenetic clock estimates has been explored, such stu ... Full text Cite

Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins.

Journal Article medRxiv · August 26, 2025 OBJECTIVES: To construct multi-trait polygenic scores (PRS) predicting chronic obstructive pulmonary disease (COPD) and exacerbations, validate their performance in diverse cohorts, and identify PRS-related proteins for potential therapeutic targeting. DES ... Full text Link to item Cite

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