Current Duke Appointments & Affiliations
Assistant Professor in Surgery
·
2023 - Present
Surgery, Cardiovascular and Thoracic Surgery,
Surgery
Recent Scholarly Works
GRK2 and GRK5-The 2 critical kinases in cardiac pathophysiology.
Journal article Mol Pharmacol · January 2026 G protein-coupled receptor kinases (GRKs) are a class of serine/threonine kinases that shut down active signaling mediated by agonist-bound G protein-coupled receptors. Of all the diseases that arise from dysfunctional G protein-coupled receptor-GRK intera ... Full text Link to item CiteAbstract 4369579: Loss of G Protein-Coupled Receptor Kinase 2 S-Nitrosylation Abolishes Beta 3 Adrenergic Receptor-Mediated Cardioprotection Evidence from Functional and Proteomic Analyses
Conference Circulation · November 4, 2025 Background: G Protein-Coupled Receptor Kinase 2 (GRK2) contributes to cardiac dysfunction through β-Adrenoceptor (βAR) desensitization following its upregulation. Inhibition of GRK2 ha ... Full text CiteAbstract Fri171: MiRNA-181a-mediated Downregulation of GRK2 as a Potential Therapeutic Strategy for Heart Failure
Conference Circulation Research · August 2025 Background: G protein-coupled receptor kinase 2 (GRK2) is a key regulator of β-adrenergic receptor (β-AR) signaling and a promising therapeutic target for heart failure (HF). Pathological upregulation ... Full text CiteRecent Grants
Project 2: Novel Adrenergic-Linked Communicative Signals from Myocardium Acting Distant and Locally
ResearchPhysiologist · Awarded by Temple University · 2024 - 2029Role of S-Nitrosylation on Beta-Adrenergic Signaling in Cardiac Injury and Repair
ResearchInvestigator · Awarded by National Institutes of Health · 2024 - 2026Targeting GRK2 in the Heart
ResearchScientist · Awarded by National Institutes of Health · 2024 - 2024View All Grants
Education
Charite Universitatsmedizin Berlin (Germany) ·
2014
Ph.D.
Manipal Institute of Regenerative Medicine (India) ·
2009
M.S.
Sivananda Sarma Memorial RV College (India) ·
2007
B.S.