Ralph Abi Hachem
Assistant Professor of Head and Neck Surgery and Communication Sciences
Current Research Interests
Sinonasal malignancies: population health outcomes, treatment outcomes, developing in vitro and in vivo models for targeted therapies
Skull base surgery
CSF leak repair
Endoscopic sinus surgery
Revision sinus surgery
Frontal sinus surgery
Balloon sinus dilation procedure
Sinus surgery outcomes in cystic fibrosis
Olfactory disorders and neuronal regeneration
Skull base surgery
CSF leak repair
Endoscopic sinus surgery
Revision sinus surgery
Frontal sinus surgery
Balloon sinus dilation procedure
Sinus surgery outcomes in cystic fibrosis
Olfactory disorders and neuronal regeneration
Current Appointments & Affiliations
- Assistant Professor of Head and Neck Surgery and Communication Sciences, Head and Neck Surgery & Communication Sciences, Section of Surgical Disciplines 2021
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2017
Contact Information
- Background
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Education, Training, & Certifications
- Clinical Fellow-Advanced Rhinology & Skull Base Surgery, Otolaryngology Head & Neck Surgery, Ohio State University 2015 - 2016
- Resident, Otolaryngology Head & Neck Surgery, University of Miami 2010 - 2015
- Research Fellow, Otolaryngology Head & Neck Surgery, University of Miami 2009 - 2010
- M.D., St. Joseph University of Beirut (Lebanon) 2008
- M.S., St. Joseph University of Beirut (Lebanon) 2008
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Duke Appointment History
- Assistant Professor of Head and Neck Surgery and Communication Sciences, Head and Neck Surgery & Communication Sciences, Section of Surgical Disciplines 2016 - 2020
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Leadership & Clinical Positions at Duke
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- Fellowship Co-Director Rhinology and Skull Base Surgery
- Medical Director: Duke Skull Base Center
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- Fellowship Co-Director Rhinology and Skull Base Surgery
- Research
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External Relationships
- Medtronic Foundation
- Publications & Artistic Works
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Selected Publications
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Books
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Younis, R. T., and R. A. Hachem. Pediatric and adult sinonasal disorders, 2015.
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Younis, R. T., and R. A. Hachem. Preface, 2015.
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Academic Articles
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Issa, Khalil, Feras Ackall, Sin-Ho Jung, Jianghao Li, David W. Jang, Sanjeet V. Rangarajan, and Ralph Abi Hachem. “Survival outcomes in sinonasal carcinoma with neuroendocrine differentiation: A NCDB analysis.” Am J Otolaryngol 42, no. 2 (December 17, 2020): 102851. https://doi.org/10.1016/j.amjoto.2020.102851.Full Text Link to Item
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Teitelbaum, Jordan I., Khalil Issa, Ian R. Barak, Feras Y. Ackall, Sin-Ho Jung, David W. Jang, and Ralph Abi Hachem. “Sinonasal Squamous Cell Carcinoma Outcomes: Does Treatment at a High-Volume Center Confer Survival Benefit?” Otolaryngol Head Neck Surg 163, no. 5 (November 2020): 986–91. https://doi.org/10.1177/0194599820935395.Full Text Link to Item
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Issa, Khalil, Jordan I. Teitelbaum, David W. Jang, Bradley J. Goldstein, Lyndon Chan, and Ralph Abi Hachem. “Sinus Irrigation Penetration After Proposed Modified Draf IIa Technique in a Side-to-Side Cadaveric Model.” Am J Rhinol Allergy, October 21, 2020, 1945892420969141. https://doi.org/10.1177/1945892420969141.Full Text Link to Item
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Jang, David W., Derek D. Cyr, Kristine Schulz, Richard Scher, Phil Ryan, Ralph Abi Hachem, and David L. Witsell. “The use of balloon dilation in revision sinus surgery.” Int Forum Allergy Rhinol 10, no. 10 (October 2020): 1158–64. https://doi.org/10.1002/alr.22571.Full Text Link to Item
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Ackall, Feras Y., Khalil Issa, Ian Barak, Jordan Teitelbaum, David W. Jang, Sin-H Jung, Bradley Goldstein, Ricardo Carrau, and Ralph Abi Hachem. “Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.” Laryngoscope, September 22, 2020. https://doi.org/10.1002/lary.29090.Full Text Link to Item
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Teitelbaum, Jordan I., Catie Grasse, Dennis Quan, Ralph Abi Hachem, Bradley J. Goldstein, Xiaoyang Hua, and David W. Jang. “General Complications after Endoscopic Sinus Surgery in Smokers: A 2005-2016 NSQIP Analysis.” The Annals of Otology, Rhinology, and Laryngology, August 20, 2020, 3489420952481. https://doi.org/10.1177/0003489420952481.Full Text
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Brann, David H., Tatsuya Tsukahara, Caleb Weinreb, Marcela Lipovsek, Koen Van den Berge, Boying Gong, Rebecca Chance, et al. “Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.” Sci Adv 6, no. 31 (July 31, 2020). https://doi.org/10.1126/sciadv.abc5801.Full Text Link to Item
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VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.Full Text Open Access Copy Link to Item
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Choi, Kevin J., David W. Jang, Ali R. Zomorodi, Patrick J. Codd, Allan Friedman, and Ralph Abi Hachem. “Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma.” J Neurol Surg B Skull Base 80, no. 5 (October 2019): 500–504. https://doi.org/10.1055/s-0038-1675751.Full Text Link to Item
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Ji, Keven, Thomas J. Risoli, Maragatha Kuchibhatla, Lyndon Chan, Ralph Abi Hachem, and David W. Jang. “Symptom Profile of Chronic Rhinosinusitis Versus Obstructive Sleep Apnea in a Tertiary Rhinology Clinic.” Ann Otol Rhinol Laryngol 128, no. 10 (October 2019): 963–69. https://doi.org/10.1177/0003489419851527.Full Text Link to Item
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Choi, Kevin J., Feras Y. Ackall, Tracy Truong, Tracy Z. Cheng, Maragatha Kuchibhatla, Ali R. Zomorodi, Patrick J. Codd, Peter E. Fecci, Ralph Abi Hachem, and David W. Jang. “Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base.” J Neurol Surg B Skull Base 80, no. 4 (August 2019): 416–23. https://doi.org/10.1055/s-0038-1675592.Full Text Link to Item
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Raikundalia, Milap D., Tracy Z. Cheng, Tracy Truong, Maragatha Kuchibhatla, Jiyoung Ryu, Ralph Abi Hachem, and David W. Jang. “Factors associated with opioid use after endoscopic sinus surgery.” Laryngoscope 129, no. 8 (August 2019): 1751–55. https://doi.org/10.1002/lary.27921.Full Text Link to Item
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Cheng, Tracy Z., Kevin J. Choi, Adam L. Honeybrook, Rasheedat T. Zakare-Fagbamila, Alice L. Gray, Laurie D. Snyder, Scott M. Palmer, Ralph Abi-Hachem, and David W. Jang. “Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation.” Am J Rhinol Allergy 33, no. 4 (July 2019): 354–58. https://doi.org/10.1177/1945892419830624.Full Text Link to Item
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Jang, David W., Cecily Abraham, Derek D. Cyr, Kristine Schulz, Ralph Abi Hachem, and David L. Witsell. “Preoperative Management of Chronic Rhinosinusitis Prior to Office Balloon Sinus Dilation: A 2011-2014 MarketScan® Analysis.” Am J Rhinol Allergy 33, no. 4 (July 2019): 347–53. https://doi.org/10.1177/1945892419829335.Full Text Link to Item
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Cooper, Matthew, Tracy Cheng, Tracy Truong, Maragatha Kuchibhatla, Ralph Abi Hachem, and David W. Jang. “Factors Associated with Revision Surgery after Balloon Sinuplasty.” Otolaryngol Head Neck Surg 160, no. 4 (April 2019): 734–39. https://doi.org/10.1177/0194599818813044.Full Text Link to Item
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Khoury, Tawfiq, David Jang, Ricardo Carrau, Neal Ready, Ian Barak, and Ralph Abi Hachem. “Role of induction chemotherapy in sinonasal malignancies: a systematic review.” Int Forum Allergy Rhinol 9, no. 2 (February 2019): 212–19. https://doi.org/10.1002/alr.22229.Full Text Link to Item
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Brown, C Scott, Ralph Abi Hachem, Avani Pendse, John F. Madden, and Howard W. Francis. “Low-Grade Papillary Schneiderian Carcinoma of the Sinonasal Cavity and Temporal Bone.” The Annals of Otology, Rhinology, and Laryngology 127, no. 12 (December 2018): 974–77. https://doi.org/10.1177/0003489418803391.Full Text
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Jang, David W., Cecily Abraham, Derek D. Cyr, Kristine Schulz, Ralph Abi Hachem, and David L. Witsell. “Balloon Catheter Dilation of the Sinuses: A 2011-2014 MarketScan Analysis.” Otolaryngol Head Neck Surg, August 7, 2018, 194599818791811. https://doi.org/10.1177/0194599818791811.Full Text Link to Item
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Brown, Clifford Scott, Ralph Abi-Hachem, and David Woojin Jang. “Management of epistaxis in patients with ventricular assist device: a retrospective review.” Journal of Otolaryngology Head & Neck Surgery = Le Journal D’Oto Rhino Laryngologie Et De Chirurgie Cervico Faciale 47, no. 1 (August 2, 2018): 48. https://doi.org/10.1186/s40463-018-0295-6.Full Text
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Abi Hachem, Ralph, Stefania Goncalves, Thomas Walker, and Simon Angeli. “Middle ear irrigation using a hydrodebrider decreases biofilm surface area in an animal model of otitis media.” Laryngoscope Investig Otolaryngol 3, no. 3 (June 2018): 231–37. https://doi.org/10.1002/lio2.164.Full Text Link to Item
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Kang, Stephen Y., Antoine Eskander, Ralph Abi Hachem, Enver Ozer, Theodoros N. Teknos, Matthew O. Old, Daniel M. Prevedello, and Ricardo L. Carrau. “Salvage skull base reconstruction in the endoscopic era: Vastus lateralis free tissue transfer.” Head Neck 40, no. 4 (April 2018): E45–52. https://doi.org/10.1002/hed.25094.Full Text Link to Item
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Choi, Kevin J., Tracy Z. Cheng, Adam L. Honeybrook, Alice L. Gray, Laurie D. Snyder, Scott M. Palmer, Ralph Abi Hachem, and David W. Jang. “Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis.” Int Forum Allergy Rhinol 8, no. 3 (March 2018): 389–93. https://doi.org/10.1002/alr.22067.Full Text Link to Item
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Choi, Kevin J., David W. Jang, and Ralph Abi Hachem. “Endoscopic Endonasal Approaches to the Orbit.” Int Ophthalmol Clin 58, no. 2 (2018): 85–99. https://doi.org/10.1097/IIO.0000000000000222.Full Text Link to Item
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Johnson, Sean M., Adam L. Honeybrook, Vaibhav H. Ramprasad, Ralph Abi Hachem, and David W. Jang. “Radiodensity of the Ostiomeatal Complex in Recurrent Acute Rhinosinusitis.” Otolaryngol Head Neck Surg 157, no. 5 (November 2017): 887–90. https://doi.org/10.1177/0194599817717682.Full Text Link to Item
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Elkhatib, Ahmad, Kyle McMullen, Ralph Abi Hachem, Ricardo L. Carrau, and Nicholas Mastros. “Rapidly Progressive Maxillary Atelectasis.” J Craniofac Surg 28, no. 5 (July 2017): e451–53. https://doi.org/10.1097/SCS.0000000000002890.Full Text Link to Item
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Rangarajan, Sanjeet, Ralph Abi Hachem, Enver Ozer, Andre Beer-Furlan, Daniel Prevedello, and Ricardo L. Carrau. “Robotics in Sinus and Skull Base Surgery.” Otolaryngol Clin North Am 50, no. 3 (June 2017): 633–41. https://doi.org/10.1016/j.otc.2017.01.013.Full Text Link to Item
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Hachem, Ralph Abi, Sanjeet Rangarajan, Andre Beer-Furlan, Daniel Prevedello, Enver Ozer, and Ricardo L. Carrau. “The Role of Robotic Surgery in Sinonasal and Ventral Skull Base Malignancy.” Otolaryngol Clin North Am 50, no. 2 (April 2017): 385–95. https://doi.org/10.1016/j.otc.2016.12.012.Full Text Link to Item
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Elkhatib, Ahmad H., Liuba Soldatova, Ricardo L. Carrau, Ralph Abi Hachem, Leo Ditzel, Raewyn Campbell, Daniel M. Prevedello, Luciano Prevedello, Leo FS Ditzel Filho, and Raewyn G. Campbell. “Role of 18 F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma.” Laryngoscope 127, no. 2 (February 2017): 321–24. https://doi.org/10.1002/lary.26194.Full Text Link to Item
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Beer-Furlan, Andre, Ralph Abi-Hachem, Ali O. Jamshidi, Ricardo L. Carrau, and Daniel M. Prevedello. “ndoscopic trans-sphenoidal surgery for petroclival and clival meningiomas.” Journal of Neurosurgical Sciences 60, no. 4 (December 1, 2016): 495–502.Link to Item
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Beer-Furlan, André, Ralph Abi-Hachem, Ali O. Jamshidi, Ricardo L. Carrau, and Daniel M. Prevedello. “Endoscopic trans-sphenoidal surgery for petroclival and clival meningiomas.” J Neurosurg Sci 60, no. 4 (December 2016): 495–502.Link to Item
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Beer-Furlan, André, Ralph Abi-Hachem, Behiye Goksel, José J. Otero, Ricardo L. Carrau, and Daniel M. Prevedello. “Letter: Radiation-Induced Malignant Transformation of Craniopharyngiomas.” Neurosurgery 79, no. 2 (August 2016): E313–15. https://doi.org/10.1227/NEU.0000000000001292.Full Text Link to Item
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Perez, Enrique, Ralph Abi Hachem, Daniel Carlton, Isabel Bueno, Stephen Vernon, Thomas R. Van De Water, and Simon I. Angeli. “Comparison of packing material in an animal model of middle ear trauma.” Am J Otolaryngol 37, no. 4 (July 2016): 323–29. https://doi.org/10.1016/j.amjoto.2016.02.009.Full Text Link to Item
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Hachem, Ralph Abi, Ahmad Elkhatib, Andre Beer-Furlan, Daniel Prevedello, and Ricardo Carrau. “Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices.” Curr Opin Otolaryngol Head Neck Surg 24, no. 2 (April 2016): 91–97. https://doi.org/10.1097/MOO.0000000000000233.Full Text Link to Item
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Bollig, Craig, Laura C. Huang, Ralph Abi-Hachem, Oleksandr N. Kryvenko, and Jason M. Leibowitz. “Base of Tongue Mass. Mucoepidermoid carcinoma.” Jama Otolaryngol Head Neck Surg 141, no. 10 (October 2015): 935–36. https://doi.org/10.1001/jamaoto.2015.1727.Full Text Link to Item
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Ghorra, Claude, Habib Rizk, Ralph Abi Hachem, Jenny Tannoury, and Bassam Abboud. “Association of parathyroid pathology with well-differentiated thyroid carcinoma.” Presse Med 41, no. 6 Pt 1 (June 2012): e265–71. https://doi.org/10.1016/j.lpm.2011.12.016.Full Text Link to Item
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Angeli, Simon I., Ralph N. Abi-Hachem, Richard J. Vivero, Fred T. Telischi, and John J. Machado. “L-N-Acetylcysteine treatment is associated with improved hearing outcome in sudden idiopathic sensorineural hearing loss.” Acta Otolaryngol 132, no. 4 (April 2012): 369–76. https://doi.org/10.3109/00016489.2011.647359.Full Text Link to Item
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Eshraghi, A. A., C. T. Dinh, J. Bohorquez, S. Angeli, R. Abi-Hachem, and T. R. Van De Water. “Local drug delivery to conserve hearing: mechanisms of action of eluted dexamethasone within the cochlea.” Cochlear Implants Int 12 Suppl 1 (May 2011): S51–53. https://doi.org/10.1179/146701011X13001035753254.Full Text Link to Item
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Lipan, Michael Julian, Ibrahim Alava, Ralph Abi-Hachem, Stephen Vernon, Thomas R. Van De Water, and Simon I. Angeli. “Middle ear packing: comparison of materials in an animal model of mucosal trauma.” Otolaryngol Head Neck Surg 144, no. 5 (May 2011): 763–69. https://doi.org/10.1177/0194599810395115.Full Text Link to Item
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Abi-Hachem, Ralph N., Azel Zine, and Thomas R. Van De Water. “The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.” Recent Pat Cns Drug Discov 5, no. 2 (June 2010): 147–63. https://doi.org/10.2174/157488910791213121.Full Text Link to Item
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Van De Water, Thomas R., Ralph N. Abi Hachem, Christine T. Dinh, Esperanza Bas, Scott M. Haake, Gia Hoosien, Richard Vivero, et al. “Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms.” Cochlear Implants Int 11 Suppl 1 (June 2010): 42–55. https://doi.org/10.1179/146701010X12671178390834.Full Text Link to Item
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Hachem, Ralph N Abi, Anthony Bared, Joseph Zeitouni, and Ramzi T. Younis. “Single-stage total endoscopic resection of a plexiform neurofibroma of the maxillary sinus in a child with type 1 neurofibromatosis.” Int J Pediatr Otorhinolaryngol 74, no. 4 (April 2010): 426–29. https://doi.org/10.1016/j.ijporl.2009.12.012.Full Text Link to Item
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Book Sections
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Hachem, R. A., A. Beer-Furlan, A. Jamshidi, A. ElKhatib, R. L. Carrau, and D. M. Prevedello. “Skull base reconstruction following resection of skull base chordomas and chondrosarcomas.” In Chordomas and Chondrosarcomas of the Skull Base and Spine, 259–70, 2018. https://doi.org/10.1016/B978-0-12-804257-1.00022-0.Full Text
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Beer-Furlan, A., R. Abi-Hachem, A. O. Jamshidi, R. L. Carrau, and D. M. Prevedello. “Anatomical approaches to giant pituitary tumors.” In Transsphenoidal Surgery: Complication Avoidance and Management Techniques, 517–29, 2017. https://doi.org/10.1007/978-3-319-56691-7_30.Full Text
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Jamshidi, A. O., D. M. Prevedello, A. Beer-Furlan, R. A. Hachem, B. Otto, and R. Carrau. “Surgical Management of Pituitary Apoplexy.” In Primer on Cerebrovascular Diseases: Second Edition, 830–35, 2017. https://doi.org/10.1016/B978-0-12-803058-5.00158-2.Full Text
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Hachem, R. A., A. Rose, and R. T. Younis. “Congenital nasal and paranasal masses.” In Pediatric and Adult SinoNasal Disorders, 255–69, 2015.
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Hachem, R. A., S. Goncalves, A. Rivera, and R. Younis. “Choanal atresia: Anatomy, etiology, pathophysiology and management.” In Pediatric and Adult SinoNasal Disorders, 241–54, 2015.
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Younis, R., M. Abouyared, B. Herman, and R. A. Hachem. “Juvenile nasopharyngeal angiofibroma: Anatomy, pathophysiology and management.” In Pediatric and Adult SinoNasal Disorders, 271–84, 2015.
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Reports
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Hachem, R. A., A. Beer-Furlan, A. Elkhatib, S. Rangarajan, D. Prevedello, D. Blakaj, A. Bhatt, and R. Carrau. “Modern Treatment Outcomes in Sinonasal Malignancies,” December 1, 2016. https://doi.org/10.1007/s40136-016-0133-1.Full Text
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Conference Papers
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Van De Water, Thomas R., Ralph Abi Hachem, Jorge Bohorquez, Adrien A. Eshraghi, Simon Angeli, and Thomas J. Balkany. “Polymer-eluted Dexamethasone Protects Hearing and Hair Cells Against Trauma-induced Loss.” In Faseb Journal, Vol. 24. FEDERATION AMER SOC EXP BIOL, 2010.Link to Item
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