Ralph Abi Hachem | Scholars@Duke

Ralph Abi Hachem
Assistant Professor of Head and Neck Surgery and Communication Sciences

Current Research Interests

Sinonasal malignancies: population health outcomes, treatment outcomes, developing in vitro and in vivo models for targeted therapies
Skull base surgery
CSF leak repair
Frontal sinus surgery
Sinus surgery in cystic fibrosis
Olfactory neuronal regeneration

Current Appointments & Affiliations

Assistant Professor of Head and Neck Surgery and Communication Sciences, Head and Neck Surgery & Communication Sciences, Section of Surgical Disciplines 2016
Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2017

Contact Information

ralph.abi.hachem@duke.edu

Background
Education, Training, & Certifications
- Clinical Fellow-Advanced Rhinology & Skull Base Surgery, Otolaryngology Head & Neck Surgery, Ohio State University 2015 - 2016
- Resident, Otolaryngology Head & Neck Surgery, University of Miami 2010 - 2015
- Research Fellow, Otolaryngology Head & Neck Surgery, University of Miami 2009 - 2010
- M.D., St. Joseph University of Beirut (Lebanon) 2008
- M.S., St. Joseph University of Beirut (Lebanon) 2008
Research
External Relationships
- Medtronic Foundation
Publications & Artistic Works
Selected Publications
- Books
  - Younis, R. T., and R. A. Hachem. Pediatric and adult sinonasal disorders, 2015.
  - Younis, R. T., and R. A. Hachem. Preface, 2015.
- Academic Articles
  - Ackall, Feras Y., Khalil Issa, Ian Barak, Jordan Teitelbaum, David W. Jang, Sin-H Jung, Bradley Goldstein, Ricardo Carrau, and Ralph Abi Hachem. “Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.” Laryngoscope, September 22, 2020. https://doi.org/10.1002/lary.29090.
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  - Teitelbaum, Jordan I., Catie Grasse, Dennis Quan, Ralph Abi Hachem, Bradley J. Goldstein, Xiaoyang Hua, and David W. Jang. “General Complications after Endoscopic Sinus Surgery in Smokers: A 2005-2016 NSQIP Analysis.” Ann Otol Rhinol Laryngol, August 20, 2020, 3489420952481. https://doi.org/10.1177/0003489420952481.
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  - Brann, David H., Tatsuya Tsukahara, Caleb Weinreb, Marcela Lipovsek, Koen Van den Berge, Boying Gong, Rebecca Chance, et al. “Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.” Sci Adv 6, no. 31 (July 31, 2020). https://doi.org/10.1126/sciadv.abc5801.
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  - Teitelbaum, Jordan I., Khalil Issa, Ian R. Barak, Feras Y. Ackall, Sin-Ho Jung, David W. Jang, and Ralph Abi Hachem. “Sinonasal Squamous Cell Carcinoma Outcomes: Does Treatment at a High-Volume Center Confer Survival Benefit?” Otolaryngol Head Neck Surg, June 30, 2020, 194599820935395. https://doi.org/10.1177/0194599820935395.
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  - Jang, David W., Derek D. Cyr, Kristine Schulz, Richard Scher, Phil Ryan, Ralph Abi Hachem, and David L. Witsell. “The use of balloon dilation in revision sinus surgery.” Int Forum Allergy Rhinol, May 29, 2020. https://doi.org/10.1002/alr.22571.
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  - VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.
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  - Choi, Kevin J., David W. Jang, Ali R. Zomorodi, Patrick J. Codd, Allan Friedman, and Ralph Abi Hachem. “Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma.” J Neurol Surg B Skull Base 80, no. 5 (October 2019): 500–504. https://doi.org/10.1055/s-0038-1675751.
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  - Ji, Keven, Thomas J. Risoli, Maragatha Kuchibhatla, Lyndon Chan, Ralph Abi Hachem, and David W. Jang. “Symptom Profile of Chronic Rhinosinusitis Versus Obstructive Sleep Apnea in a Tertiary Rhinology Clinic.” Ann Otol Rhinol Laryngol 128, no. 10 (October 2019): 963–69. https://doi.org/10.1177/0003489419851527.
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  - Choi, Kevin J., Feras Y. Ackall, Tracy Truong, Tracy Z. Cheng, Maragatha Kuchibhatla, Ali R. Zomorodi, Patrick J. Codd, Peter E. Fecci, Ralph Abi Hachem, and David W. Jang. “Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base.” J Neurol Surg B Skull Base 80, no. 4 (August 2019): 416–23. https://doi.org/10.1055/s-0038-1675592.
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  - Raikundalia, Milap D., Tracy Z. Cheng, Tracy Truong, Maragatha Kuchibhatla, Jiyoung Ryu, Ralph Abi Hachem, and David W. Jang. “Factors associated with opioid use after endoscopic sinus surgery.” Laryngoscope 129, no. 8 (August 2019): 1751–55. https://doi.org/10.1002/lary.27921.
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  - Cheng, Tracy Z., Kevin J. Choi, Adam L. Honeybrook, Rasheedat T. Zakare-Fagbamila, Alice L. Gray, Laurie D. Snyder, Scott M. Palmer, Ralph Abi-Hachem, and David W. Jang. “Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation.” Am J Rhinol Allergy 33, no. 4 (July 2019): 354–58. https://doi.org/10.1177/1945892419830624.
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  - Jang, David W., Cecily Abraham, Derek D. Cyr, Kristine Schulz, Ralph Abi Hachem, and David L. Witsell. “Preoperative Management of Chronic Rhinosinusitis Prior to Office Balloon Sinus Dilation: A 2011-2014 MarketScan® Analysis.” Am J Rhinol Allergy 33, no. 4 (July 2019): 347–53. https://doi.org/10.1177/1945892419829335.
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  - Cooper, Matthew, Tracy Cheng, Tracy Truong, Maragatha Kuchibhatla, Ralph Abi Hachem, and David W. Jang. “Factors Associated with Revision Surgery after Balloon Sinuplasty.” Otolaryngol Head Neck Surg 160, no. 4 (April 2019): 734–39. https://doi.org/10.1177/0194599818813044.
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  - Khoury, Tawfiq, David Jang, Ricardo Carrau, Neal Ready, Ian Barak, and Ralph Abi Hachem. “Role of induction chemotherapy in sinonasal malignancies: a systematic review.” Int Forum Allergy Rhinol 9, no. 2 (February 2019): 212–19. https://doi.org/10.1002/alr.22229.
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  - Brown, C Scott, Ralph Abi Hachem, Avani Pendse, John F. Madden, and Howard W. Francis. “Low-Grade Papillary Schneiderian Carcinoma of the Sinonasal Cavity and Temporal Bone.” Ann Otol Rhinol Laryngol 127, no. 12 (December 2018): 974–77. https://doi.org/10.1177/0003489418803391.
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  - Jang, David W., Cecily Abraham, Derek D. Cyr, Kristine Schulz, Ralph Abi Hachem, and David L. Witsell. “Balloon Catheter Dilation of the Sinuses: A 2011-2014 MarketScan Analysis.” Otolaryngol Head Neck Surg, August 7, 2018, 194599818791811. https://doi.org/10.1177/0194599818791811.
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  - Brown, Clifford Scott, Ralph Abi-Hachem, and David Woojin Jang. “Management of epistaxis in patients with ventricular assist device: a retrospective review.” J Otolaryngol Head Neck Surg 47, no. 1 (August 2, 2018): 48. https://doi.org/10.1186/s40463-018-0295-6.
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  - Abi Hachem, Ralph, Stefania Goncalves, Thomas Walker, and Simon Angeli. “Middle ear irrigation using a hydrodebrider decreases biofilm surface area in an animal model of otitis media.” Laryngoscope Investig Otolaryngol 3, no. 3 (June 2018): 231–37. https://doi.org/10.1002/lio2.164.
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  - Kang, Stephen Y., Antoine Eskander, Ralph Abi Hachem, Enver Ozer, Theodoros N. Teknos, Matthew O. Old, Daniel M. Prevedello, and Ricardo L. Carrau. “Salvage skull base reconstruction in the endoscopic era: Vastus lateralis free tissue transfer.” Head Neck 40, no. 4 (April 2018): E45–52. https://doi.org/10.1002/hed.25094.
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  - Choi, Kevin J., Tracy Z. Cheng, Adam L. Honeybrook, Alice L. Gray, Laurie D. Snyder, Scott M. Palmer, Ralph Abi Hachem, and David W. Jang. “Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis.” Int Forum Allergy Rhinol 8, no. 3 (March 2018): 389–93. https://doi.org/10.1002/alr.22067.
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  - Choi, Kevin J., David W. Jang, and Ralph Abi Hachem. “Endoscopic Endonasal Approaches to the Orbit.” Int Ophthalmol Clin 58, no. 2 (2018): 85–99. https://doi.org/10.1097/IIO.0000000000000222.
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  - Johnson, Sean M., Adam L. Honeybrook, Vaibhav H. Ramprasad, Ralph Abi Hachem, and David W. Jang. “Radiodensity of the Ostiomeatal Complex in Recurrent Acute Rhinosinusitis.” Otolaryngol Head Neck Surg 157, no. 5 (November 2017): 887–90. https://doi.org/10.1177/0194599817717682.
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  - Elkhatib, Ahmad, Kyle McMullen, Ralph Abi Hachem, Ricardo L. Carrau, and Nicholas Mastros. “Rapidly Progressive Maxillary Atelectasis.” J Craniofac Surg 28, no. 5 (July 2017): e451–53. https://doi.org/10.1097/SCS.0000000000002890.
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  - Rangarajan, Sanjeet, Ralph Abi Hachem, Enver Ozer, Andre Beer-Furlan, Daniel Prevedello, and Ricardo L. Carrau. “Robotics in Sinus and Skull Base Surgery.” Otolaryngol Clin North Am 50, no. 3 (June 2017): 633–41. https://doi.org/10.1016/j.otc.2017.01.013.
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  - Hachem, Ralph Abi, Sanjeet Rangarajan, Andre Beer-Furlan, Daniel Prevedello, Enver Ozer, and Ricardo L. Carrau. “The Role of Robotic Surgery in Sinonasal and Ventral Skull Base Malignancy.” Otolaryngol Clin North Am 50, no. 2 (April 2017): 385–95. https://doi.org/10.1016/j.otc.2016.12.012.
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  - Elkhatib, Ahmad H., Liuba Soldatova, Ricardo L. Carrau, Ralph Abi Hachem, Leo Ditzel, Raewyn Campbell, Daniel M. Prevedello, Luciano Prevedello, Leo FS Ditzel Filho, and Raewyn G. Campbell. “Role of 18 F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma.” Laryngoscope 127, no. 2 (February 2017): 321–24. https://doi.org/10.1002/lary.26194.
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  - Beer-Furlan, Andre, Ralph Abi-Hachem, Ali O. Jamshidi, Ricardo L. Carrau, and Daniel M. Prevedello. “ndoscopic trans-sphenoidal surgery for petroclival and clival meningiomas.” Journal of Neurosurgical Sciences 60, no. 4 (December 1, 2016): 495–502.
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  - Beer-Furlan, André, Ralph Abi-Hachem, Ali O. Jamshidi, Ricardo L. Carrau, and Daniel M. Prevedello. “Endoscopic trans-sphenoidal surgery for petroclival and clival meningiomas.” J Neurosurg Sci 60, no. 4 (December 2016): 495–502.
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  - Beer-Furlan, André, Ralph Abi-Hachem, Behiye Goksel, José J. Otero, Ricardo L. Carrau, and Daniel M. Prevedello. “Letter: Radiation-Induced Malignant Transformation of Craniopharyngiomas.” Neurosurgery 79, no. 2 (August 2016): E313–15. https://doi.org/10.1227/NEU.0000000000001292.
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  - Perez, Enrique, Ralph Abi Hachem, Daniel Carlton, Isabel Bueno, Stephen Vernon, Thomas R. Van De Water, and Simon I. Angeli. “Comparison of packing material in an animal model of middle ear trauma.” Am J Otolaryngol 37, no. 4 (July 2016): 323–29. https://doi.org/10.1016/j.amjoto.2016.02.009.
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  - Hachem, Ralph Abi, Ahmad Elkhatib, Andre Beer-Furlan, Daniel Prevedello, and Ricardo Carrau. “Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices.” Curr Opin Otolaryngol Head Neck Surg 24, no. 2 (April 2016): 91–97. https://doi.org/10.1097/MOO.0000000000000233.
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  - Bollig, Craig, Laura C. Huang, Ralph Abi-Hachem, Oleksandr N. Kryvenko, and Jason M. Leibowitz. “Base of Tongue Mass. Mucoepidermoid carcinoma.” Jama Otolaryngol Head Neck Surg 141, no. 10 (October 2015): 935–36. https://doi.org/10.1001/jamaoto.2015.1727.
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  - Ghorra, Claude, Habib Rizk, Ralph Abi Hachem, Jenny Tannoury, and Bassam Abboud. “Association of parathyroid pathology with well-differentiated thyroid carcinoma.” Presse Med 41, no. 6 Pt 1 (June 2012): e265–71. https://doi.org/10.1016/j.lpm.2011.12.016.
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  - Angeli, Simon I., Ralph N. Abi-Hachem, Richard J. Vivero, Fred T. Telischi, and John J. Machado. “L-N-Acetylcysteine treatment is associated with improved hearing outcome in sudden idiopathic sensorineural hearing loss.” Acta Otolaryngol 132, no. 4 (April 2012): 369–76. https://doi.org/10.3109/00016489.2011.647359.
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  - Eshraghi, A. A., C. T. Dinh, J. Bohorquez, S. Angeli, R. Abi-Hachem, and T. R. Van De Water. “Local drug delivery to conserve hearing: mechanisms of action of eluted dexamethasone within the cochlea.” Cochlear Implants Int 12 Suppl 1 (May 2011): S51–53. https://doi.org/10.1179/146701011X13001035753254.
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  - Lipan, Michael Julian, Ibrahim Alava, Ralph Abi-Hachem, Stephen Vernon, Thomas R. Van De Water, and Simon I. Angeli. “Middle ear packing: comparison of materials in an animal model of mucosal trauma.” Otolaryngol Head Neck Surg 144, no. 5 (May 2011): 763–69. https://doi.org/10.1177/0194599810395115.
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  - Abi-Hachem, Ralph N., Azel Zine, and Thomas R. Van De Water. “The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.” Recent Pat Cns Drug Discov 5, no. 2 (June 2010): 147–63. https://doi.org/10.2174/157488910791213121.
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  - Van De Water, Thomas R., Ralph N. Abi Hachem, Christine T. Dinh, Esperanza Bas, Scott M. Haake, Gia Hoosien, Richard Vivero, et al. “Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms.” Cochlear Implants International 11 Suppl 1 (June 2010): 42–55. https://doi.org/10.1179/146701010x12671178390834.
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  - Hachem, Ralph N Abi, Anthony Bared, Joseph Zeitouni, and Ramzi T. Younis. “Single-stage total endoscopic resection of a plexiform neurofibroma of the maxillary sinus in a child with type 1 neurofibromatosis.” International Journal of Pediatric Otorhinolaryngology 74, no. 4 (April 2010): 426–29. https://doi.org/10.1016/j.ijporl.2009.12.012.
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- Book Sections
  - Hachem, R. A., A. Beer-Furlan, A. Jamshidi, A. ElKhatib, R. L. Carrau, and D. M. Prevedello. “Skull base reconstruction following resection of skull base chordomas and chondrosarcomas.” In Chordomas and Chondrosarcomas of the Skull Base and Spine, 259–70, 2018. https://doi.org/10.1016/B978-0-12-804257-1.00022-0.
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  - Beer-Furlan, A., R. Abi-Hachem, A. O. Jamshidi, R. L. Carrau, and D. M. Prevedello. “Anatomical approaches to giant pituitary tumors.” In Transsphenoidal Surgery: Complication Avoidance and Management Techniques, 517–29, 2017. https://doi.org/10.1007/978-3-319-56691-7_30.
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  - Jamshidi, A. O., D. M. Prevedello, A. Beer-Furlan, R. A. Hachem, B. Otto, and R. Carrau. “Surgical Management of Pituitary Apoplexy.” In Primer on Cerebrovascular Diseases: Second Edition, 830–35, 2017. https://doi.org/10.1016/B978-0-12-803058-5.00158-2.
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  - Hachem, R. A., A. Rose, and R. T. Younis. “Congenital nasal and paranasal masses.” In Pediatric and Adult SinoNasal Disorders, 255–69, 2015.
  - Hachem, R. A., S. Goncalves, A. Rivera, and R. Younis. “Choanal atresia: Anatomy, etiology, pathophysiology and management.” In Pediatric and Adult SinoNasal Disorders, 241–54, 2015.
  - Younis, R., M. Abouyared, B. Herman, and R. A. Hachem. “Juvenile nasopharyngeal angiofibroma: Anatomy, pathophysiology and management.” In Pediatric and Adult SinoNasal Disorders, 271–84, 2015.
- Reports
  - Hachem, Ralph Abi, Andre Beer-Furlan, Ahmad Elkhatib, Sanjeet Rangarajan, Daniel Prevedello, Dukagjin Blakaj, Aashish Bhatt, and Ricardo Carrau. “Modern Treatment Outcomes in Sinonasal Malignancies.” Springer Science and Business Media LLC, December 2016. https://doi.org/10.1007/s40136-016-0133-1.
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- Conference Papers
  - Van De Water, Thomas R., Ralph Abi Hachem, Jorge Bohorquez, Adrien A. Eshraghi, Simon Angeli, and Thomas J. Balkany. “Polymer-eluted Dexamethasone Protects Hearing and Hair Cells Against Trauma-induced Loss.” In Faseb Journal, Vol. 24. FEDERATION AMER SOC EXP BIOL, 2010.
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Education, Training, & Certifications

External Relationships

Selected Publications

Books

Academic Articles

Book Sections

Reports

Conference Papers