Samantha Spellicy

Journal article J Immunother Cancer · March 24, 2026 BACKGROUND: Glioblastoma (GBM) remains uniformly lethal due to pronounced intratumoral heterogeneity and a highly immunosuppressive microenvironment that limits the efficacy of targeted therapies. METHODS: We engineered chimeric antigen receptor (CAR) T ce ... Full text Link to item Cite

Subthalamic nucleus or globus pallidus internus deep brain stimulation for the treatment of parkinson's disease: An artificial intelligence approach.

Journal article J Clin Neurosci · August 2025 BACKGROUND: Generative artificial intelligence (AI) in deep brain stimulation (DBS) is currently unvalidated in its content. This study sought to analyze AI responses to questions and recommendations from the 2018 Congress of Neurological Surgeons (CNS) gu ... Full text Link to item Cite

Statins and middle meningeal artery embolization: a literature review in the treatment of chronic subdural hematoma.

Journal article J Neurosurg Sci · April 2025 Chronic subdural hematoma (cSDH) presents a multifaceted challenge in contemporary neurological practice, necessitating innovative therapeutic strategies. This comprehensive review explores the convergence of two promising interventions: statins and middle ... Full text Link to item Cite

Case Report: SPECT-CT-guided minimally invasive transverse process resection for Bertolotti syndrome.

Journal article Front Surg · 2025 Lumbosacral transitional vertebrae (LSTV) are a common congenital anomaly that often manifests as chronic low back or radicular pain, a condition clinically referred to as Bertolotti syndrome. One specific cause of Bertolotti syndrome is pseudoarticulation ... Full text Link to item Cite

MR-proANP levels in Acute ischemic stroke and clinical outcomes: a systematic review and meta-analysis.

Journal article Neurosurg Rev · November 5, 2024 In patients with acute ischemic stroke, midregional proatrial natriuretic peptide (MR-proANP) has shown promise in preliminary studies for risk stratification. The objective of this study is to evaluate the prognostic utility of MR-proANP in AIS, focusing ... Full text Link to item Cite

The impact of regular aspirin use on aneurysm recanalization rates after endovascular coiling.

Journal article J Neurosurg · October 1, 2024 OBJECTIVE: Intracranial aneurysms (IAs) pose a significant health risk, often leading to subarachnoid hemorrhage and severe neurological outcomes. Endovascular coiling has been a principal treatment method, but it comes with the challenge of high recanaliz ... Full text Link to item Cite

Efficacy and safety of tranexamic acid in the management of chronic subdural hematoma: a systematic review and meta-analysis.

Journal article J Neurosurg · October 1, 2024 OBJECTIVE: Chronic subdural hematoma (CSDH) is a prevalent neurosurgical condition, particularly among the elderly. Various treatment options exist, but recurrence rates remain high. This systematic review and meta-analysis aims to assess the efficacy and ... Full text Link to item Cite

Comparison of pipeline embolization device and flow redirection endoluminal device in the treatment of intracranial aneurysms: A systematic review and meta-analysis.

Journal article Interv Neuroradiol · July 25, 2024 BACKGROUND: Advancements in flow diversion technology have revolutionized the treatment of intracranial aneurysms. The pipeline embolization device (PED) and the flow redirection endoluminal device (FRED) have emerged as prominent tools in this field. This ... Full text Link to item Cite

Balloon-mounting stent versus balloon angioplasty for intracranial arterial stenosis: A systematic review and meta-analysis.

Journal article J Stroke Cerebrovasc Dis · May 2024 BACKGROUND: Intracranial artery atherosclerotic stenosis (ICAS) is a major cause of stroke, especially in Asian countries. Current treatment options, including balloon-mounted stent (BMS) and balloon angioplasty (BA), lack sufficient evidence to determine ... Full text Link to item Cite

Reduced Acute Ischemic Stroke-Induced Neural Inflammation Using Neural Stem Cell-Derived Extracellular Vesicles (AB126)

Preprint · April 2, 2024 The therapeutic, attenuative, and morphological effects of proprietary neural stem cell-derived extracellular vesicles (NSC EVs, AB126) produced by Aruna Bio, Inc. were assessed in a range of in vitro and in vivo models of stroke. We emphasize that ... Full text Cite

Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.

Journal article J Am Heart Assoc · March 19, 2024 BACKGROUND: Cerebral cavernous malformations are complex vascular anomalies in the central nervous system associated with a risk of intracranial hemorrhage. Traditional guidelines have been cautious about the use of antithrombotic therapy in this patient g ... Full text Link to item Cite

Comparative outcomes of middle meningeal artery embolization with statins versus embolization alone in the treatment of chronic subdural hematoma: a systematic review and meta-analysis.

Journal article Neurosurg Rev · October 3, 2023 Chronic subdural hematoma (cSDH) is common among the elderly, with surgical evacuation as a prevalent treatment, facing recurrence rates up to 30%. Recently, middle meningeal artery embolization (MMAE) has emerged as a promising approach, offering reduced ... Full text Link to item Cite

Recycled Translation: Repurposing Drugs for Stroke.

Journal article Translational stroke research · December 2022 Stroke, which continues to be a leading cause of death and long-term disability worldwide, has often been described as a clinical graveyard. While multiple small molecule therapeutics have undergone clinical trials in stroke, currently only one Food and Dr ... Full text Cite

Principles for the design of multicellular engineered living systems.

Journal article APL bioengineering · March 2022 Remarkable progress in bioengineering over the past two decades has enabled the formulation of fundamental design principles for a variety of medical and non-medical applications. These advancements have laid the foundation for building multicellular engin ... Full text Cite

Reflections in Coiling

Fine art · January 12, 2022 I had the opportunity to rotate on a vascular neurosurgery elective during my fourth year of medical school, an invaluable opportunity for a neurosurgery residency applicant. From my first angiogram, I was struck by the absolute beauty of the cerebrovascul ... Link to item Cite

Assessment of clinical continuity strategies offered by dual-degree training programs in the USA.

Journal article Journal of clinical and translational science · January 2022 BackgroundIntegration of clinical skills during graduate training in dual-degree programs remains a challenge. The present study investigated the availability and self-perceived efficacy of clinical continuity strategies for dual-degree trainees p ... Full text Cite

Reflections in Coiling.

Journal article Stroke (Hoboken, N.J.) · January 2022 Full text Cite

Tethered brain: disentangling unintentional brain-mesh interfaces. Illustrative case.

Journal article Journal of neurosurgery. Case lessons · June 2021 BackgroundSurgical meshes have found widespread use in neurosurgical practice. While commonly recognized risks of synthetic mesh include infection, exposure of mesh implants, and foreign body reaction, the risk of mesh tethering to neural structur ... Full text Cite

Tissue and Stem Cell Sourced Extracellular Vesicle Communications with Microglia.

Journal article Stem cell reviews and reports · April 2021 Extracellular vesicles (EVs), nano- to micro- sized vesicles released from cells, have garnered attention in recent years for their role in intercellular communication. Specifically, EVs from various cell sources including stem cells, have shown to have an ... Full text Cite

Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model.

Journal article Scientific reports · February 2021 Harnessing the maximum diagnostic potential of magnetic resonance imaging (MRI) by including stroke lesion location in relation to specific structures that are associated with particular functions will likely increase the potential to predict functional de ... Full text Cite

MD/DO-PhD trainees: Flexing, adapting, and progressing during COVID-19

Journal article Journal of Clinical and Translational Science · January 1, 2021 Full text Cite

The Immunomodulatory Capacity of Induced Pluripotent Stem Cells in the Post-stroke Environment.

Journal article Frontiers in cell and developmental biology · January 2021 Inflammation has proven to be a key contributing factor to the pathogenesis of ischemic and hemorrhagic stroke. This sequential and progressive response, marked by proliferation of resident immune cells and recruitment of peripheral immune populations, res ... Full text Cite

Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke Model.

Journal article Translational stroke research · August 2020 Magnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a s ... Full text Cite

Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury.

Journal article Journal of neurotrauma · June 2020 The lack of effective therapies for moderate-to-severe traumatic brain injuries (TBIs) leaves patients with lifelong disabilities. Neural stem cells (NSCs) have demonstrated great promise for neural repair and regeneration. However, direct evidence to supp ... Full text Cite

Magnetic Resonance Imaging and Gait Analysis Indicate Similar Outcomes Between Yucatan and Landrace Porcine Ischemic Stroke Models.

Journal article Frontiers in neurology · January 2020 The Stroke Therapy Academic Industry Roundtable (STAIR) has recommended that novel therapeutics be tested in a large animal model with similar anatomy and physiology to humans. The pig is an attractive model due to similarities in brain size, organization, ... Full text Cite

Semi-Automated Cell and Tissue Analyses Reveal Regionally Specific Morphological Alterations of Immune and Neural Cells in a Porcine Middle Cerebral Artery Occlusion Model of Stroke.

Journal article Frontiers in cellular neuroscience · January 2020 Histopathological analysis of cellular changes in the stroked brain provides critical information pertaining to inflammation, cell death, glial scarring, and other dynamic injury and recovery responses. However, commonly used manual approaches are hindered ... Full text Cite

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke.

Journal article Stroke · May 2018 Background and purposeRecent work from our group suggests that human neural stem cell-derived extracellular vesicle (NSC EV) treatment improves both tissue and sensorimotor function in a preclinical thromboembolic mouse model of stroke. In this st ... Full text Cite

Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial.

Journal article Stroke · October 2017 Background and purposeMinocycline is under investigation as a neurovascular protective agent for stroke. This study evaluated the pharmacokinetic, anti-inflammatory, and safety profile of minocycline after intracerebral hemorrhage.Methods ... Full text Cite