Saratchandra Singh Khumukcham

Journal article Frontiers in cell and developmental biology · January 2026 Small G proteins are molecular switches in the realm of cell biology, switching from the GTP-bound active form to the GDP-bound inactive form. They participate in controlling various essential cellular functions, one of which is cell migration. Cell migrat ... Full text Cite

Obesity promotes conserved inflammatory and metabolic transcriptional programs in colon tumors: evidence from mouse models and the ColoCare Study Patient Cohort.

Journal article Am J Clin Nutr · December 2025 BACKGROUND: The global prevalence of obesity, an established risk and progression factor for colon cancer, is high and rising. Unfortunately, the mechanisms underlying the obesity-colon cancer association are incompletely understood, and new molecular targ ... Full text Link to item Cite

Potential role of Hematopoietic PBX-Interacting Protein (HPIP) in trophoblast fusion and invasion: Implications in pre-eclampsia pathogenesis.

Journal article Cellular signalling · April 2025 Pre-eclampsia is a known hypertensive disorder of pregnancy. While abnormal placentation and poor trophoblast invasion into maternal endometrium during blastocyst implantation are primary causes of pre-eclampsia, the underlying mechanisms remain elusive. H ... Full text Cite

Stimuli‐Responsive Amino Acid Based Polymeric Nanomicelles With Antimicrobial and Anticancer Activities

Journal article Journal of Applied Polymer Science · March 5, 2025 ABSTRACTHerein this work, a biocompatible polymer synthesis approach has been established for the designing of α‐methoxy‐ω‐amino poly(ethylene glycol)‐L‐glutamate‐L‐aspartate [MeO‐PEG‐NH‐b‐(L‐GluA ... Full text Cite

HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover.

Journal article The Journal of biological chemistry · November 2023 While the role of endocytosis in focal adhesion turnover-coupled cell migration has been established in addition to its conventional role in cellular functions, the molecular regulators and precise molecular mechanisms that underlie this process remain lar ... Full text Open Access Cite

Colorectal Cancer Immunotherapy: State of the Art and Future Directions.

Journal article Gastro Hep Adv · 2023 Cancer immunotherapy has become an indispensable mode of treatment for a multitude of solid tumor cancers. Colorectal cancer (CRC) has been one of the many cancer types to benefit from immunotherapy, especially in advanced disease where standard treatment ... Full text Link to item Cite

Hematopoietic PBX-interacting protein is a novel regulator of mammary epithelial cell differentiation.

Journal article The FEBS journal · March 2022 Hematopoietic PBX-interacting protein (HPIP, also known as PBXIP1) is an estrogen receptor (ER) interacting protein that regulates estrogen-mediated breast cancer cell proliferation and tumorigenesis. However, its functional significance in the context of ... Full text Cite

A reciprocal feedback loop between HIF-1α and HPIP controls phenotypic plasticity in breast cancer cells.

Journal article Cancer letters · February 2022 While phenotypic plasticity is a critical factor contributing to tumor heterogeneity, molecular mechanisms underlying this process are largely unknown. Here we report that breast cancer cells display phenotypic diversity in response to hypoxia or normoxia ... Full text Cite

HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways.

Journal article Cancer letters · October 2021 While cancer cells rewire metabolic pathways to sustain growth and survival under metabolic stress in solid tumors, the molecular mechanisms underlying these processes remain largely unknown. In this study, cancer cells switched from survival to death duri ... Full text Cite

Two decades of a protooncogene HPIP/PBXIP1: Uncovering the tale from germ cell to cancer.

Journal article Biochimica et biophysica acta. Reviews on cancer · August 2021 Hematopoietic PBX interacting protein (HPIP or pre-B-cell leukemia transcription factor interacting protein (PBXIP1) was discovered two decades ago as a corepressor of pre-B-cell leukemia homeobox (PBX) 1 with a vital functional role in hematopoiesis. Late ... Full text Cite

Effective in vitro delivery of paclitaxel by nanocargo of mesoporous polycaprolactone against triple negative breast cancer cells by minimalizing drug dose.

Journal article RSC advances · June 2020 Among the breast cancers, triple negative breast cancer (TNBC) has relatively poor outcomes with a lower survival rate and personalised chemotherapy is the only option available for treatment. Currently in the biomedical domain, nanomaterials with porous m ... Full text Cite

Hematopoietic PBX-interacting protein is a substrate and an inhibitor of the APC/C-Cdc20 complex and regulates mitosis by stabilizing cyclin B1.

Journal article The Journal of biological chemistry · June 2019 Proper cell division relies on the coordinated regulation between a structural component, the mitotic spindle, and a regulatory component, anaphase-promoting complex/cyclosome (APC/C). Hematopoietic PBX-interacting protein (HPIP) is a microtubule-associate ... Full text Cite

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy.

Journal article PLoS biology · April 2018 Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofugino ... Full text Cite

A transcriptional repressive role for epithelial-specific ETS factor ELF3 on oestrogen receptor alpha in breast cancer cells.

Journal article The Biochemical journal · April 2016 Oestrogen receptor-α (ERα) is a ligand-dependent transcription factor that primarily mediates oestrogen (E2)-dependent gene transcription required for mammary gland development. Coregulators critically regulate ERα transcription functions by directly inter ... Full text Cite