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Shanley Roach CV CV

Postdoctoral Associate
Integrative Immunobiology
CV CV

Overview


I earned my B.A. in Biology and Psychology from The College of St. Benedict/St. John's University in 2017. I then graduated from the University of Minnesota in 2023 with a Ph.D. in Biochemistry and Molecular Biology after completing my thesis work in the laboratory of Dr. Ryan Langlois. My thesis broadly focused on host-pathogen interactions, with focuses on viral infections and innate immunity at barrier surfaces, virus-induced microbiome alterations, and virus transmission and evolution.

In the Coyne lab, my work centers around understanding the innate and adaptive immune responses to Enterovirus infections.

Current Appointments & Affiliations


Recent Publications


Naturally transmitted mouse viruses highlight the heterogeneity of virus transmission dynamics in the dirty mouse model.

Journal Article Journal of virology · June 2025 Specific-pathogen-free (SPF) mice are widely used in biomedical research to model human infections. However, these animals do not always accurately recapitulate human immune responses. This is due, in part, to their lack of infection history. A growing num ... Full text Cite

Virus-induced perturbations in the mouse microbiome are impacted by microbial experience.

Journal Article mSphere · March 2025 The bacterial microbiome has a major impact on health and can shape metabolism, host tolerance, immune responses, and the outcome of future infections. The bacterial microbiome is highly variable between individuals. Specific pathogen-free animals have red ... Full text Cite

Experimental viral spillover across 25 million year gap in Rodentia reveals limited viral transmission and purifying selection of a picornavirus.

Journal Article mBio · October 2024 When a virus crosses from one host species to another, the consequences can be devastating. However, animal models to empirically evaluate cross-species transmission can fail to recapitulate natural transmission routes, physiologically relevant doses of pa ... Full text Cite
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Recent Grants


Enterovirus Infection of Polarized Intestinal Cells

ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026

The Role of FcRn in Echovirus Entry and Pathogenesis

ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2026

View All Grants

External Links


ORCiD Scopus