Shanley Roach

Journal article Journal of virology · June 2025 Specific-pathogen-free (SPF) mice are widely used in biomedical research to model human infections. However, these animals do not always accurately recapitulate human immune responses. This is due, in part, to their lack of infection history. A growing num ... Full text Cite

Virus-induced perturbations in the mouse microbiome are impacted by microbial experience.

Journal article mSphere · March 2025 The bacterial microbiome has a major impact on health and can shape metabolism, host tolerance, immune responses, and the outcome of future infections. The bacterial microbiome is highly variable between individuals. Specific pathogen-free animals have red ... Full text Cite

Experimental viral spillover across 25 million year gap in Rodentia reveals limited viral transmission and purifying selection of a picornavirus.

Journal article mBio · October 2024 When a virus crosses from one host species to another, the consequences can be devastating. However, animal models to empirically evaluate cross-species transmission can fail to recapitulate natural transmission routes, physiologically relevant doses of pa ... Full text Cite

Tropism for ciliated cells is the dominant driver of influenza viral burst size in the human airway.

Journal article Proceedings of the National Academy of Sciences of the United States of America · July 2024 Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and burden in the airways is not fully understood. U ... Full text Cite

Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination.

Journal article mSphere · February 2024 Specific pathogen-free (SPF) laboratory mice dominate preclinical studies for immunology and vaccinology. Unfortunately, SPF mice often fail to accurately model human responses to vaccination and other immunological perturbations. Several groups have taken ... Full text Cite

Respiratory Influenza Virus Infection Causes Dynamic Tuft Cell and Innate Lymphoid Cell Changes in the Small Intestine.

Journal article Journal of virology · May 2022 Influenza A viruses (IAV) can cause severe disease and death in humans. IAV infection and the accompanying immune response can result in systemic inflammation, leading to intestinal damage and disruption of the intestinal microbiome. Here, we demonstrate t ... Full text Cite

Natural rodent model of viral transmission reveals biological features of virus population dynamics.

Journal article The Journal of experimental medicine · February 2022 Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent path ... Full text Cite

Intra- and Cross-Species Transmission of Astroviruses.

Journal article Viruses · June 2021 Astroviruses are non-enveloped, single-stranded RNA viruses that infect mammalian and avian species. In humans, astrovirus infections are one of the most common causes of gastroenteritis in children. Infection has also been linked to serious neurological c ... Full text Cite