ConferencePhysiology · May 2026
Introduction: Vascular smooth muscle cells (VSMCs) retain extraordinary plasticity throughout adulthood to maintain arterial homeostasis. Aging results in in VSMC dysregulation that is marked by loss of contractile markers and pathological extracel ...
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ConferenceOptical Coherence Tomography Proceedings Optica Biophotonics Congress 2026 · January 1, 2026
We applied qSV-OCT to quantify vascular remodeling in hydrogel-Treated mice wounds. Stiff gels supported stable vascular activity, while soft gels showed transient responses, demonstrating the potential of our non-invasive method to monitor and guide treat ...
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ConferenceOptical Coherence Tomography Proceedings Optica Biophotonics Congress 2026 · January 1, 2026
We developed a deep learning-based 3D OCT segmentation framework to quantify in vivo tissue remodeling. This platform revealed how hydrogel stiffness affects wound regeneration, providing an objective approach to evaluate healing and guide therapies. ...
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ConferencePhysiology · May 2025
Introduction: Depending on surrounding cells, substrate mechanics, and biochemical signaling, vascular cell types – including smooth muscle cells (VSMC) – modulate their behavior to maintain short- and long-term vascular homeostasis. Aging perturbs ...
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ConferenceProgress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025
Optical coherence tomography (OCT) is a powerful non-invasive imaging technique, providing high-resolution three-dimensional images of biological tissues. However, accurately segmenting regions-of-interest from large 3D images is challenging and often reli ...
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Conference2025 Conference on Lasers and Electro Optics CLEO 2025 · January 1, 2025
Using OCT and advanced image processing, we demonstrate a quantitative method to monitor wound healing in hydrogel-treated mouse models. Our approach enables an objective assessment of tissue regeneration and treatment optimization for improving clinical o ...
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ConferenceCLEO Applications and Technology Proceedings CLEO 2025 · January 1, 2025
We demonstrate the application of quantified speckle variance OCT to track angiogenesis in hydrogel-treated mice wounds. Compared to traditional SV algorithms, this technique enhances vascular imaging, offering improved monitoring and optimization of wound ...
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ConferenceCLEO Applications and Technology Proceedings CLEO 2025 · January 1, 2025
Using OCT and advanced image processing, we demonstrate a quantitative method to monitor wound healing in hydrogel-treated mouse models. Our approach enables an objective assessment of tissue regeneration and treatment optimization for improving clinical o ...
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ConferencePhysiology · May 2024
Introduction: Depending on surrounding cell types, substrate mechanics, and chemical agonists, vascular cell types – including endothelial (ECs) and smooth muscle cells (VSMC) — modulate their behavior to maintain homeostasis. Aging perturbs this ...
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ConferenceOptical Coherence Tomography, OCT 2024 in Proceedings Optica Biophotonics Congress: Biomedical Optics 2024, Translational, Microscopy, OCT, OTS, BRAIN - Part of Optica Biophotonics Congress: Biomedical Optics · January 1, 2024
We demonstrate in vivo monitoring of wound healing dynamics in mice treated with hydrogels of varying stiffness using OCT. Distinct cellular responses were visualized and tracked, revealing the potential of OCT for optimizing hydrogel-based treatments. ...
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ConferenceOptical Coherence Tomography Oct 2024 in Proceedings Optica Biophotonics Congress Biomedical Optics 2024 Translational Microscopy Oct Ots Brain Part of Optica Biophotonics Congress Biomedical Optics · January 1, 2024
We demonstrate in vivo monitoring of wound healing dynamics in mice treated with hydrogels of varying stiffness using OCT. Distinct cellular responses were visualized and tracked, revealing the potential of OCT for optimizing hydrogel-based treatments. ...
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ConferencePhysiology · May 2023
Introduction: Depending on surrounding cell types, substrate mechanics, and chemical agonists, vascular smooth muscle cells (VSMCs) alternate between a contractile and synthetic phenotype. While endothelial cells (ECs) do not modulate their phenot ...
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ConferenceClinical Cancer Research · September 15, 2022
AbstractCD8+ T cell dysfunction, characterized by reduced effector function, impaired proliferation, and inhibitory receptor upregulation, is a fundamental barrier to anti-tumor immunity. However, molecular ...
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ConferenceThe FASEB Journal · April 2020
Cardiovascular diseases are one of the leading causes of death worldwide with age mediated endothelial dysfunction as one of the major risk factors. Endothelial dysfunction is caused ...
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ConferenceTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium · January 1, 2019
Statement of Purpose: Transplantation of therapeutic vasculature has been proposed as a treatment for many vascular disorders. Endothelial colony-forming cells (ECFCs) are sought as a potential therapeutic for treating vascular disease and generating engin ...
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ConferenceCancer Research · July 1, 2017
AbstractHypoxia is a critical factor in the progression and metastasis of many cancers, including soft tissue sarcomas. Frequently, oxygen (O2) gradients develop in tumors as they grow beyond their vascular ...
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ConferenceCancer Research · January 15, 2017
AbstractHypoxia is a critical factor in the progression and metastasis of many cancers including soft tissue sarcomas. Frequently, oxygen (O2) gradients develop in tumors as they grow beyond their vascular s ...
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ConferenceCancer Research · August 1, 2015
AbstractThe genetic aberrations responsible for soft tissue sarcoma formation in adults are largely unknown, and targeted therapies are sorely needed for this complex and heterogeneous family of diseases. He ...
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ConferenceFood Pharmaceutical and Bioengineering Division 2013 Core Programming Area at the 2013 Aiche Annual Meeting Global Challenges for Engineering A Sustainable Future · January 1, 2013Cite
ConferenceTechnical Proceedings of the 2008 Nsti Nanotechnology Conference and Trade Show Nsti Nanotech Nanotechnology 2008 · October 1, 2008
Tissue engineering scaffolds often aim to control cell behavior using a variety of signaling modalities including chemistry, mechanical properties, and local microenvironmental factors such as oxygen concentration. However, few efforts have explored the us ...
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ConferenceAiche Annual Meeting Conference Proceedings · December 1, 2005
Human embryonic stem cells (hESCs) possess enormous potential for functional tissue engineering and regenerative medicine. However, their therapeutic use will require a means to accurately differentiate them in vitro, i.e., by controlling the microenvironm ...
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ConferenceAiche Annual Meeting Conference Proceedings · December 1, 2005
Functional engineered cardiac tissue can serve as a model for in vitro pharmacological study and for regenerative medicine concerning congenital and postischemical diseases. We have previously demonstrated that electrical stimulation of myocardiocyte const ...
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ConferenceAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · January 2004
Many degenerative human diseases reflect damage to cells that are not normally repaired or replaced, such as diabetes, Parkinson's disease, hepatic failure and congestive heart failure. Preliminary studies in animals and humans have suggested that these di ...
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