Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Neuropathology, Medical Center, Columbia University 2014 - 2016
  • Residency, Anatomic Pathology, Medical Center, Columbia University 2012 - 2014
  • Ph.D., Johns Hopkins University 2012
  • M.D., National Taiwan University (Taiwan) 2003
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2018 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wu, Jieyu, Liuyang Wang, John F. Ervin, Shih-Hsiu J. Wang, Erik Soderblom, Dennis Ko, and Dong Yan. “GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans.” Sci Adv 8, no. 51 (December 21, 2022): eadc9236. https://doi.org/10.1126/sciadv.adc9236.
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    • Nelson, Peter T., Edward B. Lee, Matthew D. Cykowski, Irina Alafuzoff, Konstantinos Arfanakis, Johannes Attems, Carol Brayne, et al. “LATE-NC staging in routine neuropathologic diagnosis: an update.” Acta Neuropathol, December 13, 2022. https://doi.org/10.1007/s00401-022-02524-2.
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    • Wu, Ling, Nailya Gilyazova, John F. Ervin, Shih-Hsiu J. Wang, and Bin Xu. “Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation.” Acs Chem Neurosci 13, no. 23 (December 7, 2022): 3281–90. https://doi.org/10.1021/acschemneuro.2c00342.
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    • Harada, Yohei, Shih-Hsiu Wang, and Vern C. Juel. “Clinical Reasoning: A 36-Year-Old Man With Asymmetric Muscle Weakness.” Neurology, September 21, 2022. https://doi.org/10.1212/WNL.0000000000201379.
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    • Wander, Connor M., Tamy Harumy Moraes Tsujimoto, John F. Ervin, Chanung Wang, Spencer M. Maranto, Vanya Bhat, Julian D. Dallmeier, et al. “Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.” Acta Neuropathol Commun 10, no. 1 (August 8, 2022): 110. https://doi.org/10.1186/s40478-022-01409-5.
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    • Nelson, Peter T., Carol Brayne, Margaret E. Flanagan, Erin L. Abner, Sonal Agrawal, Johannes Attems, Rudolph J. Castellani, et al. “Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.” Acta Neuropathol 144, no. 1 (July 2022): 27–44. https://doi.org/10.1007/s00401-022-02444-1.
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    • Wang, Shih-Hsiu J., Yuanyuan Guo, John F. Ervin, Jay B. Lusk, and Sheng Luo. “Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old.” Acta Neuropathol 144, no. 1 (July 2022): 45–57. https://doi.org/10.1007/s00401-022-02432-5.
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    • Liu, Andy J., Jay B. Lusk, John Ervin, James Burke, Richard O’Brien, and Shih-Hsiu J. Wang. “Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation.” Acta Neuropathol Commun 10, no. 1 (March 3, 2022): 27. https://doi.org/10.1186/s40478-022-01330-x.
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    • Wu, Ling, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T. Dougharty, Madeleine Marcus, Frances Henderson, et al. “Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains.” Front Aging Neurosci 14 (2022): 945875. https://doi.org/10.3389/fnagi.2022.945875.
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    • Harrison, William T., Jay B. Lusk, Beiyu Liu, John F. Ervin, Kim G. Johnson, Cynthia L. Green, and Shih-Hsiu J. Wang. “Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is independently associated with dementia and strongly associated with arteriolosclerosis in the oldest-old.” Acta Neuropathol 142, no. 5 (November 2021): 917–19. https://doi.org/10.1007/s00401-021-02360-w.
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    • Harrison, William T., Jay B. Lusk, Beiyu Liu, John F. Ervin, Kim G. Johnson, Cynthia L. Green, and Shih-Hsiu J. Wang. “Correction to: Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is independently associated with dementia and strongly associated with arteriolosclerosis in the oldest-old.” Acta Neuropathol 142, no. 5 (November 2021): 921. https://doi.org/10.1007/s00401-021-02368-2.
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    • Ahn, Janice S., John Ervin, Thomas J. Cummings, Giselle Y. López, and Shih-Hsiu J. Wang. “Papillary Glioneuronal Tumor With a Novel GPR37L1-PRKCA Fusion.” J Neuropathol Exp Neurol 80, no. 10 (October 26, 2021): 1004–6. https://doi.org/10.1093/jnen/nlab055.
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    • Low, Justin Thomas, Shih-Hsiu Wang, and Katherine B Peters. “Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman.” Cns Oncol 10, no. 2 (June 1, 2021): CNS71. https://doi.org/10.2217/cns-2020-0030.
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    • Sokratian, Arpine, Julia Ziaee, Kaela Kelly, Allison Chang, Nicole Bryant, Shijie Wang, Enquan Xu, et al. “Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.” Acta Neuropathol 141, no. 4 (April 2021): 547–64. https://doi.org/10.1007/s00401-021-02288-1.
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    • Eichenberger, Emily M., Jennifer Saullo, Danielle Brander, Shih-Hsiu Wang, John R. Perfect, and Julia A. Messina. “A case of CNS aspergillosis in a patient with chronic lymphocytic leukemia on first-line ibrutinib therapy.” Med Mycol Case Rep 27 (March 2020): 17–21. https://doi.org/10.1016/j.mmcr.2019.12.007.
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    • Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Chiea Chuen, Michael A. Hauser, R Rand Allingham, Tin Aung, Carly J. Van Der Heide, Kent D. Taylor, Jerome I. Rotter, et al. “Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.” Jama 322, no. 17 (November 5, 2019): 1682–91. https://doi.org/10.1001/jama.2019.16161.
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    • Smith, Deborah R., Cheng-Chia Wu, Heva J. Saadatmand, Steven R. Isaacson, Simon K. Cheng, Michael B. Sisti, Jeffrey N. Bruce, et al. “Clinical and molecular characteristics of gliosarcoma and modern prognostic significance relative to conventional glioblastoma.” J Neurooncol 137, no. 2 (April 2018): 303–11. https://doi.org/10.1007/s11060-017-2718-z.
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    • Kinslow, Connor J., Raj S. Rajpara, Cheng-Chia Wu, Samuel S. Bruce, Peter D. Canoll, Shih-Hsiu Wang, Adam M. Sonabend, et al. “Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system.” J Neurooncol 133, no. 2 (June 2017): 409–17. https://doi.org/10.1007/s11060-017-2450-8.
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    • Ma, Kevin K., Alison B. Callahan, Shih-Hsiu J. Wang, James E. Goldman, and Michael Kazim. “Atypical Rapidly Enlarging Orbital Schwannoma.” Ophthalmic Plast Reconstr Surg 33, no. 3S Suppl 1 (2017): S111–14. https://doi.org/10.1097/IOP.0000000000000740.
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    • Donovan, Laura E., Ashley V. Arnal, Shih-Hsiu Wang, and Yazmin Odia. “Widely metastatic atypical pituitary adenoma with mTOR pathway STK11(F298L) mutation treated with everolimus therapy.” Cns Oncol 5, no. 4 (October 2016): 203–9. https://doi.org/10.2217/cns-2016-0011.
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    • Ellis, Jason A., Juan C. Mejia Munne, Shih-Hsiu Wang, Danielle K. McBrian, Cigdem I. Akman, Neil A. Feldstein, and Guy M. McKhann. “Staged laser interstitial thermal therapy and topectomy for complete obliteration of complex focal cortical dysplasias.” J Clin Neurosci 31 (September 2016): 224–28. https://doi.org/10.1016/j.jocn.2016.02.016.
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    • Hollis, Edmund R., Nao Ishiko, Ting Yu, Chin-Chun Lu, Ariela Haimovich, Kristine Tolentino, Alisha Richman, et al. “Ryk controls remapping of motor cortex during functional recovery after spinal cord injury.” Nat Neurosci 19, no. 5 (May 2016): 697–705. https://doi.org/10.1038/nn.4282.
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    • Cohen, M., E. H. Stephens, M. Garshick, S. H. Wang, S. Z. Frager, L. Mautner, F. Remotti, and J. Radhakrishnan. “Native valve emphysematous endocarditis caused by finegoldia magna in a novel pathogenic role.” Infectious Diseases in Clinical Practice 24, no. 1 (January 1, 2016): 57–59. https://doi.org/10.1097/IPC.0000000000000294.
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    • Ung, Timothy H., Christopher Kellner, Justin A. Neira, Shih-Hsiu J. Wang, Randy D’Amico, Phyllis L. Faust, Peter Canoll, Neil A. Feldstein, and Jeffrey N. Bruce. “The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma.” J Neurosurg Pediatr 16, no. 6 (December 2015): 732–35. https://doi.org/10.3171/2015.5.PEDS15142.
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    • Adeleye, Amanda J., Nicholas Palmeri, Shih-Hsiu J. Wang, Xiaolin Liu-Jarin, and Jason D. Wright. “Spindle cell sarcoma of the vulva with myofibroblastic differentiation.” J Low Genit Tract Dis 19, no. 2 (April 2015): e38–39. https://doi.org/10.1097/LGT.0000000000000070.
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    • Georgescu, Maria-Magdalena, Paul Yell, Bret C. Mobley, Ping Shang, Theodora Georgescu, Shih-Hsiu J. Wang, Peter Canoll, Kimmo J. Hatanpaa, Charles L. White, and Jack M. Raisanen. “NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma.” Acta Neuropathol Commun 3 (March 8, 2015): 11. https://doi.org/10.1186/s40478-015-0197-z.
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    • Duan, Yuntao, Shih-Hsiu Wang, Juan Song, Yevgeniya Mironova, Guo-li Ming, Alex L. Kolodkin, and Roman J. Giger. “Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.” Elife 3 (October 14, 2014). https://doi.org/10.7554/eLife.04390.
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    • Wang, Shih-Hsiu J., Ivana Celic, Se-Young Choi, Martin Riccomagno, Qiang Wang, Lu O. Sun, Sarah P. Mitchell, Valera Vasioukhin, Richard L. Huganir, and Alex L. Kolodkin. “Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.” J Neurosci 34, no. 38 (September 17, 2014): 12745–61. https://doi.org/10.1523/JNEUROSCI.1280-14.2014.
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  • Conference Papers

    • Smith, Vanessa, and Shih-Hsiu Wang. “A Case of Fragile X-Associated Tremor/Ataxia Syndrome in Association With an Unclassified Tauopathy.” In Journal of Neuropathology and Experimental Neurology, 81:480–480, 2022.
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    • Wang, Shih-Hsiu, William Harrison, John Ervin, Beiyu Liu, and Cindy Green. “Association of Hippocampal Sclerosis, TDP-43 Proteinopathy, and Cerebral Microvascular Disease in Advanced Age.” In Laboratory Investigation, 100:1626–27. NATURE PUBLISHING GROUP, 2020.
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    • Wang, Shih-Hsiu, William Harrison, John Ervin, Beiyu Liu, and Cindy Green. “Association of Hippocampal Sclerosis, TDP-43 Proteinopathy, and Cerebral Microvascular Disease in Advanced Age.” In Modern Pathology, 33:1626–27. NATURE PUBLISHING GROUP, 2020.
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    • Harrison, William, John Ervin, and Shih-Hsiu Wang. “Neurodegeneration in Advanced Age: A Comparison of Pathologies with Emphasis on Hippocampal Sclerosis, TDP-43, and Microvascular Disease.” In Journal of Neuropathology and Experimental Neurology, 78:572–572. OXFORD UNIV PRESS INC, 2019.
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    • Smith, Vanessa, Richard Hickman, Anne Buckley, James Goldman, and Shih-Hsiu Wang. “Cortical Perivascular Satellitosis found in association with Polymorphous Low-grade Neuroepithelial Tumor of the Young.” In Journal of Neuropathology and Experimental Neurology, 78:542–542. OXFORD UNIV PRESS INC, 2019.
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