Current Appointments & Affiliations
Associate Professor of Pathology
·
2024 - Present
Pathology,
Clinical Science Departments
Associate Professor in Neurology
·
2024 - Present
Neurology, Behavioral Neurology,
Neurology
Faculty Network Member of the Duke Institute for Brain Sciences
·
2022 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Recent Publications
Multi-region spatial transcriptomics reveals region specific differences in response to amyloid beta (Aβ) plaque induced changes in Alzheimer's disease (AD).
Journal Article Hum Genomics · November 29, 2025 BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia affecting 55 million people worldwide. The pathological hallmarks of AD, beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFT), follow distinct stereotypical patterns of progressio ... Full text Link to item CiteLRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.
Journal Article Acta Neuropathol · October 23, 2025 Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein deposits in post ... Full text Link to item CiteNovel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors.
Journal Article Alzheimers Dement · October 2025 INTRODUCTION: Few African American (AA) donors have been included in post mortem Alzheimer's disease (AD) studies compared to European-ancestry (EA) individuals. METHODS: We generated transcriptome-wide bulk pre-frontal cortex (PFC) gene expression data fr ... Full text Link to item CiteRecent Grants
Elucidating the role of vascular dysfunction in LATE, LATE-AD, and FTLD-TDP
ResearchPrincipal Investigator · Awarded by Alzheimer's Association · 2024 - 2027Characterizing Spatial Variations in RNA Isoform Expression with Alzheimer's Disease
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2026Elucidating the molecular basis of normal and resilient human brain aging
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2024 - 2026View All Grants
Education, Training & Certifications
Johns Hopkins University ·
2012
Ph.D.
National Taiwan University (Taiwan) ·
2003
M.D.