Scholars@Duke
Shreyas Mysore Suryanarayana

Shreyas Mysore Suryanarayana

Research Associate, Senior
Neurobiology

Selected Publications

Distinct neurogenic pathways shape the diversification and mosaic organization of cortical output channels.

Journal Article Neuron · March 25, 2026 The cerebral cortex broadcasts its output to subcortical regions through the projections of diverse extratelencephalic (ET) neurons derived from either direct (dNG-ETd) or indirect (iNG-ETi) neurogenesis, but the differential contributions of these neuroge ... Full text Link to item Cite

Corticothalamic communication for action coordination in a skilled motor behavior.

Journal Article Nat Neurosci · March 2026 The coordination of forelimb and orofacial movements to compose an ethological reach-to-consume behavior likely involves neural communication across brain regions. Leveraging wide-field imaging and photoinhibition to survey across the cortex, we identified ... Full text Link to item Cite

Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex.

Journal Article Neuron · August 16, 2023 Variations in size and complexity of the cerebral cortex result from differences in neuron number and composition, rooted in evolutionary changes in direct and indirect neurogenesis (dNG and iNG) that are mediated by radial glia and intermediate progenitor ... Full text Link to item Cite

Conservation and Diversification of Pallial Cell Types across Vertebrates: An Evo-Devo Perspective.

Journal Article Brain, behavior and evolution · January 2023 As the highest center of sensory processing, initiation, and modulation of behavior, the pallium has seen prominent changes during the course of vertebrate evolution, culminating in the emergence of the mammalian isocortex. The processes underlying this re ... Full text Cite

The neural bases of vertebrate motor behaviour through the lens of evolution.

Journal Article Philosophical transactions of the Royal Society of London. Series B, Biological sciences · February 2022 The primary driver of the evolution of the vertebrate nervous system has been the necessity to move, along with the requirement of controlling the plethora of motor behavioural repertoires seen among the vast and diverse vertebrate species. Understanding t ... Full text Cite

The Lamprey Forebrain - Evolutionary Implications.

Journal Article Brain, behavior and evolution · January 2022 The forebrain plays a critical role in a broad range of neural processes encompassing sensory integration and initiation/selection of behaviour. The forebrain functions through an interaction between different cortical areas, the thalamus, the basal gangli ... Full text Cite

Lamprey Thalamus and Beyond

Chapter · January 1, 2022 The lampreys (Cyclostomes) represent the oldest group of now-living vertebrates that diverged from the vertebrate evolutionary line leading to mammals 560 million years ago. It is therefore of particular interest to consider if there is a thalamus similar ... Full text Cite

Olfaction in Lamprey Pallium Revisited-Dual Projections of Mitral and Tufted Cells.

Journal Article Cell reports · January 2021 The presence of two separate afferent channels from the olfactory glomeruli to different targets in the brain is unravelled in the lamprey. The mitral-like cells send axonal projections directly to the piriform cortex in the ventral part of pallium, wherea ... Full text Cite

The microcircuits of striatum in silico.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2020 The basal ganglia play an important role in decision making and selection of action primarily based on input from cortex, thalamus, and the dopamine system. Their main input structure, striatum, is central to this process. It consists of two types of proje ... Full text Cite

The evolutionary origin of visual and somatosensory representation in the vertebrate pallium.

Journal Article Nature ecology & evolution · April 2020 Amniotes, such as mammals and reptiles, have vision and other senses represented in the pallium, whereas anamniotes, such as amphibians, fish and cyclostomes (including lampreys), which diverged much earlier, were historically thought to process olfactory ... Full text Cite

Roles for globus pallidus externa revealed in a computational model of action selection in the basal ganglia.

Journal Article Neural networks : the official journal of the International Neural Network Society · January 2019 The basal ganglia are considered vital to action selection - a hypothesis supported by several biologically plausible computational models. Of the several subnuclei of the basal ganglia, the globus pallidus externa (GPe) has been thought of largely as a re ... Full text Cite

The Lamprey Pallium Provides a Blueprint of the Mammalian Layered Cortex.

Journal Article Current biology : CB · November 2017 The basic architecture of the mammalian neocortex is remarkably similar across species. Pallial structures in the reptilian brain are considered amniote precursors of mammalian neocortex, whereas pallia of anamniotes ("lower" vertebrates) have been deemed ... Full text Cite

Griseum centrale, a homologue of the periaqueductal gray in the lamprey.

Journal Article IBRO reports · June 2017 Fear, a response to threatening stimuli and important for survival, is a behavior found throughout the animal kingdom. One critical structure involved in the expression of fear-related behavior is the periaqueductal gray (PAG) in mammals, and in the zebraf ... Full text Cite

The lamprey pallium provides a blueprint of the mammalian motor projections from cortex.

Journal Article Current biology : CB · February 2015 BackgroundThe frontal lobe control of movement in mammals has been thought to be a specific function primarily related to the layered neocortex with its efferent connections. In contrast, we now show that the same basic organization is present eve ... Full text Cite

Evolutionarily conserved organization of the dopaminergic system in lamprey: SNc/VTA afferent and efferent connectivity and D2 receptor expression.

Journal Article The Journal of comparative neurology · December 2014 The dopaminergic system influences motor behavior, signals reward and novelty, and is an essential component of the basal ganglia in all vertebrates including the lamprey, one of the phylogenetically oldest vertebrates. The intrinsic organization and funct ... Full text Cite

The Blueprint of the Vertebrate Motor System

Conference ACTA PHYSIOLOGICA · August 2014 Link to item Cite

The lamprey blueprint of the mammalian nervous system.

Journal Article Progress in brain research · January 2014 The basic features of the vertebrate nervous system are conserved throughout vertebrate phylogeny to a much higher degree than previously thought. In this mini-review, we show that not only the organization of the different motor programs underlying eye, o ... Full text Cite