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Sid Madhavan

Postdoctoral Scholar
Neurology, Translational Brain Sciences
3 Genome Court, Office 5002, Durham, NC 27710

Overview


Sid Madhavan, PhD, is a clinical-translational scientist developing interventions for chronic diseases of aging. He graduated summa cum laude from Virginia Tech with a B.S. in honors in Clinical Neuroscience. He then completed his Ph.D. in Biology of Aging in a joint program between the University of Southern California and the Buck Institute for Research on Aging. During his doctoral research with Dr. John Newman at the Buck Institute, he identified how ketone bodies and other structurally-related metabolites can bind and clear damaged proteins within the brain. At Duke, he is working in the labs of Dr. Laurie Sanders and Dr. Senthil Selvaraj on a diverse set of clinical trials spanning Parkinson’s disease and heart failure. The ultimate goal of his research is to develop therapeutic molecules which allow older adults to remain independent throughout the entirety of their lives.

Current Appointments & Affiliations


Recent Publications


Beta-hydroxybutyrate

Journal Article Trends in Endocrinology & Metabolism · January 2025 Full text Cite

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.

Journal Article Cell chemical biology · January 2025 Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate during periods of reduced glucose availability, and regul ... Full text Cite
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